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p53R2 (show RRM2B Antibodies) acts as a positive regulator of TrxR2 activity in mitochondria both under normal physiological conditions and during the cellular response to DNA damage
TrxR2 deficiency-induced impaired proliferation and death of chondrocytes may be the pathological mechanism of the osteoarthropathy due to Selenium deficiency.
Evidence that the rs4485648 polymorphism of the TrxR2 gene might exert an independent effect on the development of Diabetic retinopathy.
Data suggest that TXNRD2 may represent a druggable target that could be deployed to reduce the development of fatal pulmonary metastases in patients with osteosarcoma (OS).
A meta-analysis of the top SNPs identified three new associated loci in primary open angle glaucoma--TXNRD2, ATXN2 (show ATXN2 Antibodies), and FOXC1 (show FOXC1 Antibodies)
The TXNRD2 rs 1548357 polymorphism might be a genetic risk factor for Myocardial infarction in subjects with T2 Diabetes mellitus of Slovenian origin.
Data suggest TXNRD1 (show TXNRD1 Antibodies) and TXRNRD2 function at the top of a redox pyramid that governs the oxidation state of peroxiredoxins and other protein factors, thereby dictating a hierarchy of phenotypic responses to oxidative insults.
Absence of TXNRD2 in humans leads to glucocorticoid deficiency.
Single Nucleotide Polymorphisms in the genes GPX1 (show GPX1 Antibodies) (rs1050450, rs1800668 and rs3811699), TrxR2 (rs5748469), and DIO2 (show DIO2 Antibodies) (rs225014) may not be significantly associated with Kashin-Beck disease in a Tibetan population.
Development of subcutaneous fibrosis can be associated with genetic variation in the mitochondrial enzyme TXNRD2, critically involved in removal of ROS (show ROS1 Antibodies), and maintenance of the intracellular redox balance.
Maintenance of mitochondrial ROS (show ROS1 Antibodies) via Txnrd2 in endothelial cells is necessary for an intact vascular homeostasis and remodeling. Txnrd2 plays a vitally important role in balancing mitochondrial ROS (show ROS1 Antibodies) production in the endothelium.
Suggest role for Txnrd2 in sustaining heart function during aging and suggest that Txnrd2 may be a modifier of heart failure.
Regulatory link was discovered between mitochondrial Txnrd and the JNK (show MAPK8 Antibodies)-PHD2 (show EGLN1 Antibodies)-Hif-1alpha (show HIF1A Antibodies) axis, which highlights how the loss of Txnrd2 and the resulting altered mitochondrial redox balance impairs tumor growth as well as tumor-related angiogenesis.
The SirT1 (show SIRT1 Antibodies) regulates the expression of several antioxidant genes in bovine aortic endothelial cells, including Mn superoxide dismutase (show SOD2 Antibodies), catalase (show CAT Antibodies), peroxiredoxins 3 and 5, thioredoxin 2 (show TXN2 Antibodies), thioredoxin reductase 2, and uncoupling protein 2 (show UCP2 Antibodies).
Data indicate that mammalian thioredoxin reductase (H-TrxR) reduces hypothiocyanous acid (HOSCN).
Txnrd2 exerts a crucial function during postischemic reperfusion via thiol regeneration.
Energization of mitochondria increases the antioxidant potential of the TrxR2/Trx2 (show TXN2 Antibodies) system and that inhibition of TrxR2 results in increased H(2)O(2) emission.
Genomic organization and identification of a novel alternative splicing variant of mouse mitochondrial TrxR2 gene
Neither Trx2 (show TXN2 Antibodies) nor TrxR2 gain of function modified the redox regulation of mitochondria-dependent apoptosis in cos-7 cells, Hela cells and Mouse Neuro2a cells.
Thioredoxin reductase (TR) is a dimeric NADPH-dependent FAD containing enzyme that catalyzes the reduction of the active site disulfide of thioredoxin and other substrates. TR is a member of a family of pyridine nucleotide-disulfide oxidoreductases and is a key enzyme in the regulation of the intracellular redox environment. Three thioredoxin reductase genes have been found that encode selenocysteine containing proteins. This gene partially overlaps the COMT gene on chromosome 22.
, thioredoxin reductase
, selenoprotein Z
, thioredoxin reductase 2, mitochondrial
, thioredoxin reductase 3
, thioredoxin reductase TR3
, thioredoxin reductase beta
, TR beta