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Human GNMT Protein expressed in Escherichia coli (E. coli) - ABIN666718
Huang, Chen, Shyr, Su, Chen, Li, Ho, Chen: Glycine N-methyltransferase is a favorable prognostic marker for human cholangiocarcinoma. in Journal of gastroenterology and hepatology 2008
Show all 2 references for ABIN666718
Hepatic GNMT regulates lipid and glucose homeostasis, and provide insight into the development of insulin (show INS Proteins) resistance through modulating the PI3K/Akt (show AKT1 Proteins) pathway.
GNMT is involved in the pathogenesis of experimental autoimmune encephalomyelitis and plays a crucial role in the regulation of CD4 (show CD4 Proteins)+ T-cell functions
GNMT is found in the hippocampus and regulates intracellular SAMe levels. GNMT deficiency in mice results in high SAMe levels within the hippocampus, reduced neurogenic capacity, and spatial learning and memory impairment.
It may be a crucial molecule in the pathogenesis of DSS (show PMP22 Proteins)-induced colitis.
Gnmt plays important role in maintaining normal function of brain; deficiency of Gnmt causes dysfunction of important signaling pathways and results in alterations of neurotransmitter secretion as well as changes in neuropsychological behavior.
Reduced expression of GNMT in mouse hepatoma cells appears to increase the activity of LKB1/RAS signaling.
NK cells from GNMT(-/-) mice were spontaneously activated, expressed more TRAIL, and had strong cytotoxic activity, suggesting their contribution to the proinflammatory environment in the liver.
This is the first report demonstrating that GNMT plays an important role in regulating cholesterol homeostasis via interaction with NPC2 (show NPC2 Proteins)
Higher susceptibility to aflatoxin B(1)-related hepatoma in Gnmt deficient mice.
Loss of GNMT induces aberrant methylation of DNA and histones, resulting in epigenetic modulation of critical carcinogenic pathways.
In men of European descent, the GNMT rs10948059 and short tandem repeat polymorphism 1 were associated with prostate cancer risk.
GNMT is an androgen receptor (show AR Proteins)-targeted gene with its functional androgen response element located at +19/+33 of the first exon.
The studies identify GNMT as a direct transcriptional target of the AR.
DNA hypermethylation plays an important role in the repression of GNMT in hepatocellular carcinoma (HCC (show FAM126A Proteins)), and loss of GNMT in human HCC (show FAM126A Proteins) could promote the establishment of aberrant DNA methylation (show HELLS Proteins) patterns at specific gene promoters
single-nucleotide polymorphisms in VEGF (show VEGFA Proteins), IL-10 (show IL10 Proteins) and GNMT genes might have a synergistic role in the development of Prostate cancer
Report SNPs that are highly associated with hepatic GNMT protein expression and the coordinate regulation of MAT1A (show MAT1A Proteins) levels.
GNMT plays important role in maintaining normal function of brain; lack of GNMT causes dysfunction of important signaling pathways and results in alterations of neurotransmitter secretion as well as changes in neuropsychological behavior.
GNMT is a crucial regulator in cholesterol metabolism and in inflammation, and contributes to the pathogenesis of atherosclerosis.
In conclusion, GNMT regulates hepatocellular carcinoma growth in part through interacting with DEPDC6/DEPTOR (show DEPTOR Proteins) and modulating mTOR (show FRAP1 Proteins)/raptor (show RPTOR Proteins) signaling pathway
The protein encoded by this gene is an enzyme that catalyzes the conversion of S-adenosyl-L-methionine (along with glycine) to S-adenosyl-L-homocysteine and sarcosine. The encoded protein is found in the cytoplasm and acts as a homotetramer. Defects in this gene are a cause of GNMT deficiency (hypermethioninemia).
, glycine N methyl transferase
, folate-binding protein
, glycine methyltransferase