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The expression of TSPO was found to be increased in the peri (show POSTN Proteins)-hematomal brain region after intracerebral hemorrhage.
TSPO expression increases ( approximately 9-fold) in rodent-derived macrophages and microglia upon pro-inflammatory stimulation.
Data suggest that up-regulation of translocator protein 18kDa level during neuroinflammation may be an adaptive response mechanism, a way to provide more neurosteroids.
This study confirms TSPO deficiency does not affect viability and bronchial alveolar immune homeostasis.
These results suggested that Wuling powder exhibited an obvious antidepressant effect, which could be due to the improvement of TSPO-mediated mitophagy signaling pathway.
The loss of TSPO in the Central Nervous System did not result in overt developmental defects or phenotypes. The TSPO-/- mouse showed a decrease in glial fibrillary acidic protein (show GFAP Proteins) expression, correlating with a decrease in astrogliosis in response to neural injury during Autoimmune Experimental Encephalomyelitis.
Study reviews the physiological functions of TSPO gene in the mitochondrial permeability transition pore, steroidogenesis and energy metabolism especially in knockout mice. [review]
Study highlights the 3D structure of mTSPO/PBR and in complex with PK11195 providing an important step towards a more detailed understanding of the molecular mechanism of mammalian TSPO/PBR and its interaction with small molecules. [review]
TSPO expression in Sandhoff disease mice is brain region-specific and depends on the age of the animal as disease progresses with the thalamus providing the earliest signal of disease based on TSPO expression and other markers of neurodegeneration
TSPO deficiency does not adversely affect erythropoiesis, heme biosynthesis, bioconversion of ALA to PPIX, and porphyrin-mediated phototoxic cell death.
demonstrate a consistent down-regulation of TSPO mRNA and protein in macrophages activated to a pro-inflammatory, or 'M1' phenotype
These findings have important implications for understanding the biology of TSPO in activated macrophages and microglia in humans.
TSPO may serve a range of functions that can be viewed as downstream regulatory effects of its primary, evolutionary conserved role in cell metabolism and energy production.
We report for the first time, to our knowledge, the kinetic properties of the novel third-generation TSPO PET ligand (18)F-GE180 in humans: 2TCM4k is the optimal method to quantify the brain uptake, 90 min is the optimal scan length, and the Logan approach could be used to generate parametric maps. Although these control subjects have shown relatively low VT, the methodology presented here forms the basis for quantificati
demonstrate rapid decrease in TSPO binding to the high affinity site induced by exposure to cigarette smoke
Study shows that TSPO's mitochondrial functions include modulation of nuclear gene expression via mitochondrial-nuclear signaling which can suggests whereby TSPO can control several vital cell functions, which has major implications for the whole organism in health and disease.
TSPO is an ancient bacterial receptor/stress sensor that has developed additional interactions, partners, and roles in its mitochondrial outer membrane environment in eukaryotes.
Unlike the strictly mitochondrial localisation of PBR/TSPO, PBR-S (isoform which lacks exon 2) has a punctate distribution throughout the cytosol that co-localises with lysosomes in HeLa, HEK (show EPHA3 Proteins)-293, MDA-MB-231, BJ and U87-MG cells.
[(18)F]PBR102 and [(18)F]PBR111 have distinct metabolic profiles in rat and non-human primates. Radiometabolites contributed to non-specific binding and confounded in vivo brain analysis of [(18)F]PBR102 in rodents; the impact in primates was less pronounced. Both [(18)F]PBR102 and [(18)F]PBR111 are suitable for PET imaging of TSPO in vivo. In vitro metabolite studies can be used to predict in vivo radioligand metabolism
the epigenetic regulation of TSPO
PBR mRNA was the more abundant detected form in pig tissues and in warm kidney that underwent ischemia suggesting functional implications of PBR during the renal repair process.
Changes in TSPO expression in kidney regenerating tissue could be important for renal protection and maintenance of kidney function.
Present mainly in the mitochondrial compartment of peripheral tissues, the protein encoded by this gene interacts with some benzodiazepines and has different affinities than its endogenous counterpart. The protein is a key factor in the flow of cholesterol into mitochondria to permit the initiation of steroid hormone synthesis. Alternatively spliced transcript variants have been reported\; one of the variants lacks an internal exon and is considered non-coding, and the other variants encode the same protein.
peripheral-type benzodiazepine receptor
, Peripheral-type benzodiazepine receptor
, translocator protein
, benzodiazepine receptor, peripheral
, isoquinoline-binding protein
, mitochondrial benzodiazepine receptor
, Benzodiazepin receptor (peripheral)
, benzodiazepine peripheral binding site
, peripheral benzodiazepine receptor
, benzodiazepine receptor (peripheral)