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these findings demonstrate a novel regulatory role of Gfi1 in the regulation of the Th1 (show HAND1 Proteins)-type immune response.
GFI1 proteins recruit the chromatin-modifying protein LSD1 (show KDM1A Proteins), a member of the CoREST (show Rcor2 Proteins) repressive complex, to epigenetically silence the endothelial program in haemogenic endothelium and allow the emergence of blood cells
GFI1 inhibits NLRP3 (show NLRP3 Proteins) inflammasome activation and IL-1beta (show IL1B Proteins) secretion in macrophages
Gfi-1 is linked to the erythroid gene regulatory network by repressing Id2 expression.
results, supported by evidence from mouse models, identify GFI1 and GFI1B (show GFI1B Proteins) as prominent medulloblastoma oncogenes and implicate 'enhancer hijacking' as an efficient mechanism driving oncogene (show RAB1A Proteins) activation in a childhood cancer
Gfi1 and gfi1b (show GFI1B Proteins) repress rag transcription in plasmacytoid dendritic cells in vitro.
Our data indicate that Gfi1 is required for hematopoietic precursors to withstand Notch1 (show NOTCH1 Proteins) activation and to maintain Notch1 (show NOTCH1 Proteins) dependent transcriptional programming to determine early T-lymphoid lineage identity.
Data indicate that Gfi1 regulates the activation of type 2 innate lymphoid cells (ILC2 cells) cells during infection with Nippostrongylus brasiliensis.
Gfi1 actively controls thymocyte IL-2 (show IL2 Proteins) production, thereby shaping thymic generation of Treg cells.
Compromised IL-7Ralpha expression in TGF-beta-receptor-deficient T cells was associated with increased expression of the Il7ra transcriptional repressor, Gfi-1.
In this study, the influence of prenatal smoking exposure on the childrens' DNA methylation (show HELLS Proteins) state of a CpG island located upstream of the promoter of the growth factor independent 1 (GFI1) gene was analyzed. Significant hypomethylation was observed in this CpG island in SIDS (show IDS Proteins) cases with cigarette smoke exposure compared to non-exposed cases.
Gfi1 gene expression is regulated by cytokines in activated T cells.
miR-495 directly interacts with the Gfi1 3'UTR to regulate Gfi1 at a post-transcriptional level and the expression level of miR-495 is inversely correlated with the Gfi1 protein level in medulloblastoma specimens.
Gfi1 acts as a transcriptional repressor by recruiting histone-modifying enzymes to promoters and enhancers of target genes. Mutations of the C-terminal zinc finger domain causes congenital neutropenia. It may be involved in leukemia and lymphoma. Review.
During infection, the incoming HCMV rapidly downregulates the GFI1 mRNA and protein in both wild-type cells and in cells in which EZH2 (show EZH2 Proteins), NDY1/KDM2B (show KDM2B Proteins) or JARID2 (show JARID2 Proteins) were knocked down.
Data shows that MYB regulates the expression of endogenous human GFI1.
Lymphoid progenitor cells from childhood acute lymphoblastic leukemia are functionally deficient and express high levels of the transcriptional repressor Gfi-1.
GFI1 is repressed by p53 (show TP53 Proteins)
the expression of Gfi-1 contributes to SOCS1 (show SOCS1 Proteins) silencing in AML (show RUNX1 Proteins) cells through epigenetic modification, and suppression of histone methyltransferase can provide new insight in AML (show RUNX1 Proteins) therapy.
This gene encodes a nuclear zinc finger protein that functions as a transcriptional repressor. This protein plays a role in diverse developmental contexts, including hematopoiesis and oncogenesis. It functions as part of a complex along with other cofactors to control histone modifications that lead to silencing of the target gene promoters. Mutations in this gene cause autosomal dominant severe congenital neutropenia, and also dominant nonimmune chronic idiopathic neutropenia of adults, which are heterogeneous hematopoietic disorders that cause predispositions to leukemias and infections. Multiple alternatively spliced variants, encoding the same protein, have been identified for this gene.
growth factor independent protein 1
, zinc finger protein Gfi-1
, growth factor independence-1
, zinc finger protein 163
, growth factor independence 1
, Growth factor independent-1