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anti-Human SSBP1 Antibodies:
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Human Polyclonal SSBP1 Primary Antibody for ICC, IF - ABIN4356022
Rajala, Hensen, Wessels, Ives, Gloerich, Spelbrink: Whole cell formaldehyde cross-linking simplifies purification of mitochondrial nucleoids and associated proteins involved in mitochondrial gene expression. in PLoS ONE 2015
Show all 2 Pubmed References
Human Monoclonal SSBP1 Primary Antibody for ELISA, WB - ABIN520501
Gonçalves, Máximo, Lima, Singh, Soares, Videira: Involvement of p53 in cell death following cell cycle arrest and mitotic catastrophe induced by rotenone. in Biochimica et biophysica acta 2011
Human Polyclonal SSBP1 Primary Antibody for ICC, IF - ABIN438507
Feldhahn, Ferretti, Robbiani, Callen, Deroubaix, Selleri, Nussenzweig, Nussenzweig: The hSSB1 orthologue Obfc2b is essential for skeletogenesis but dispensable for the DNA damage response in vivo. in The EMBO journal 2012
Human Polyclonal SSBP1 Primary Antibody for ICC, IF - ABIN314790
Shapovalov, Hoffman, Zuch, de Mesy Bentley, Eliseev: Mitochondrial dysfunction in cancer cells due to aberrant mitochondrial replication. in The Journal of biological chemistry 2011
Data show that single-stranded DNA binding protein 1 (hSSB1/NABP2/OBFC2B) forms a tetramer and is stabilized by two cysteines (C81 and C99) as well as a subset of charged and hydrophobic residues.
DNA synthesis determines the binding mode of the human mtSSB.
The data presented in this study suggests that while SSBP1 has predominantly been considered in a DNA repair context, it is likely to have roles in many other cellular processes. In particular, the identification of numerous proteins with roles in mRNA metabolism, transcriptional transactions and ribosomal processes, may suggest these as important areas of SSBP1 function.
Data suggest that human mitochondrial SSB shares many physicochemical properties with E coli SSB and that the differences may be explained by the lack of an acidic, disordered C-terminal tail in human mitochondrial SSB protein. (SSB = single-stranded DNA-binding protein (show RPA1 Antibodies))
Data suggest that human mitochondrial SSB and E coli SSB both protect and expose single-stranded DNA; implications from these studies toward understanding DNA replication and DNA repair abound. (SSB = single-stranded DNA-binding protein (show RPA1 Antibodies)) [EDITORIAL]
hSSB1 is directly phosphorylated by DNA-PK at serine residue 134. While this modification is largely suppressed in undamaged cells by PPP-family protein phosphatases, S134 phosphorylation is enhanced following the disruption of replication forks and promotes cellular survival.
the detailed molecular mechanism in solution of ssDNA binding by hSSB1, a major player in the maintenance of genomic stability, is reported.
In the absence of hSSB1, human 8-oxoguanine glycosylase 1 does not localize to chromatin, resulting in the accumulation of 8-oxoguanine in the genome.
The stimulatory effect of mtSSB on Pol gamma (show POLG Antibodies) on these ssDNA templates is not species-specific.
This study determined that hSSB1 acetylation at K94 mediated by the acetyltransferase p300 and the deacetylases SIRT4 and HDAC10 impaired its ubiquitin-mediated degradation by proteasomes.
SSBp1 deletion results in increased chromosomal aberrations and localizes to telomeres and participate in the repair of uncapped telomeres.
Obfc2b deficiency does not affect initiation of DNA damage checkpoints, Atm (show ATM Antibodies) activation, or the maintenance of genomic stability in B lymphocytes & primary fibroblasts. Its role in embryogenesis limited to cell types contributing to bone formation.
overexpression of Mitogenin I (show POLDIP2 Antibodies) or mitochondrial single-stranded DNA-binding protein (show RPA1 Antibodies) increased elongated or fragmented mitochondria in mouse C2C12 myoblast cells, respectively.
Single-stranded DNA (ssDNA)-binding proteins, such as OBFC2B, are ubiquitous and essential for a variety of DNA metabolic processes, including replication, recombination, and detection and repair of damage (Richard et al., 2008
PWP1-interacting protein 17
, single-stranded DNA-binding protein, mitochondrial
, single strand DNA-binding protein P16
, single-stranded DNA binding protein 1
, single-stranded DNA binding
, SOSS complex subunit B1
, nucleic acid-binding protein 2
, oligonucleotide/oligosaccharide-binding fold containing 2B
, oligonucleotide/oligosaccharide-binding fold-containing protein 2B
, sensor of single-strand DNA complex subunit B1
, sensor of ssDNA subunit B1
, single strand DNA-binding protein 1
, single-stranded DNA-binding protein 1
, Oligonucleotide/oligosaccharide-binding fold containing 2B-A
, SOSS complex subunit B1-A
, nucleic acid-binding protein 2-A
, oligonucleotide/oligosaccharide-binding fold-containing protein 2B-A
, sensor of single-strand DNA complex subunit B1-A
, sensor of ssDNA subunit B1-A
, single-stranded DNA-binding protein 1-A