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Browse our Adipsin Proteins (CFD)

Full name:
Complement Factor D Proteins (CFD)
On are 24 Complement Factor D (CFD) Proteins from 11 different suppliers available. Additionally we are shipping Adipsin Antibodies (83) and Adipsin Kits (64) and many more products for this protein. A total of 180 Adipsin products are currently listed.
10.5, 10.9, 14.10, 20.35, ADIPSIN, Adn, CFD, cfdl, CG2328, Df, Dmel\\CG2328, E(eve), Eve, eve2, even, F, l(2)46Ce, l(2)46CFg, l(2)46CFh, l(2)46CFj, l(2)46CFp, l(2)46Cg, PFD, V, VI, wu:fb61f12, zgc:109940
list all proteins Gene Name GeneID UniProt
CFD 1675 P00746
CFD 54249 P32038
CFD 11537 P03953

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Adipsin Proteins (CFD) by Origin

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Top referenced Adipsin Proteins

  1. Human Adipsin Protein expressed in HEK-293 Cells - ABIN2180874 : Sprong, Roos, Weemaes, Neeleman, Geesing, Mollnes, van Deuren: Deficient alternative complement pathway activation due to factor D deficiency by 2 novel mutations in the complement factor D gene in a family with meningococcal infections. in Blood 2006 (PubMed)
    Show all 4 references for ABIN2180874

  2. Human Adipsin Protein expressed in Escherichia coli (E. coli) - ABIN1098727 : Narayana, Carson, el-Kabbani, Kilpatrick, Moore, Chen, Bugg, Volanakis, DeLucas: Structure of human factor D. A complement system protein at 2.0 A resolution. in Journal of molecular biology 1994 (PubMed)
    Show all 2 references for ABIN1098727

More Proteins for Adipsin Interaction Partners

Fruit Fly (Drosophila melanogaster) Complement Factor D (CFD) interaction partners

  1. natural variation in a conserved trait-even-skipped (eve) expression at the cellular blastoderm stage of embryonic development in Drosophila melanogaster, was investigated.

  2. Ubiquitous TER94 expression is "replaced" by expression in an eve pattern when Homie is deleted, and this effect is reversed when the PRE is also removed

  3. Deletion of any individual enhancer reduced Yan occupancy at the other elements, impacting eve expression, cell fate specification, and cardiac function

  4. Data strongly suggests that the eve-grn (show GRN Proteins) transcriptional code controls axon guidance, in part, by regulating the level of unc-5 expression.

  5. even-skipped genes were misexpressed in pho mutant embryos

  6. analysis of combinatorial activation and concentration-dependent repression of the Drosophila even skipped stripe 3+7 enhancer; Zld is required for activation; Kni and Hb are dedicated repressors that function by direct DNA binding

  7. Nmo regulates a subset of Eve activities by stimulating Eve-mediated suppression of the odd-skipped (odd) repressor

  8. The repressor activity of Even-skipped is highly conserved, and is sufficient to activate engrailed and to regulate both the spacing and stability of parasegment boundaries.

  9. three distinct mechanisms are required for anterior repression of a single eve enhancer, each in a specific position

  10. the eve enhancer integrates multiple positive and negative transcription factor inputs to restrict eve expression to a single precursor cell and its motoneuron progeny

Xenopus laevis Complement Factor D (CFD) interaction partners

  1. Isolation and expression pattern of a novel gene, Ami in Xenopus laevis.

Human Complement Factor D (CFD) interaction partners

  1. Overall adipsin levels among male asbestos industry workers were significantly higher than among control subjects.

  2. Data indicate that a urinary protein, adipsin, was significantly increased in patients with preeclampsia.

  3. Study demonstrates that T2DM patients with beta cell failure are deficient in adipsin.

  4. Complement factor D (FD) is activated by its substrate through interactions outside the active site which lock the unbound native state into an ordered inactive conformation via the self-inhibitory loop in FD.

  5. We demonstrate novel secretion of adipsin and ASP (show ASIP Proteins) by placental Hofbauer cells.

  6. Anti factor D Fab (show FANCB Proteins) fragment inhibits FD proteolytic function by interfering with macromolecular substrate access rather than by inhibiting FD catalysis.

  7. CFD regulates activation of the alternative complement pathway, which is implicated in age related macular degeneration pathogenesis.

  8. CFD may not play a major role in the genetic susceptibility to age-related macular degeneration.

  9. crystal structure of C3bB at 4 A and complex with factor D at 3.5 A; data show how factor B (show ATP5S Proteins) binding to C3b forms open "activation" state of C3bB; Factor D binds open conformation of factor B (show ATP5S Proteins) through a site distant from the catalytic center

  10. As adiponectin (show ADIPOQ Proteins) and adipsin levels in CSF (show CSF2 Proteins) did not correlate with their levels in plasma, it seems that there could be a secondary intrathecal synthesis of these adipocytokines in multiple sclerosis

Mouse (Murine) Complement Factor D (CFD) interaction partners

  1. The present study identifies adipsin, one of the most abundant and specifically expressed adipose proteins, as a circulating factor linking fat cells and obesity to beta cell function.

  2. Two sides of MGP (show MGP Proteins) null arterial disease: chondrogenic lesions dependent on transglutaminase 2 (show TGM2 Proteins) and elastin (show ELN Proteins) fragmentation associated with induction of adipsin.

  3. local expression of adipsin has a reproductive effect at the feto-maternal interface and possibly plays a role in spontaneous abortion

  4. MASP-1 converted pro-Df to the active form in vitro, although the activation mechanism of pro-Df by MASP-1 is still unclear. Thus, it is clear that MASP-1 is an essential protease of both the lectin and alternative complement pathways.

  5. Adipsin expression was not detected in any transfected clones of 3T3L1 cells exhibiting a complete blockage to differentiation.

  6. Adipsin is a biomarker of gastrointestinal toxicity mediated by a functional gamma-secretase inhibitor

  7. Mesangial immune complex glomerulonephritis is due to Cfd deficiency.

  8. In the process of spontaneous abortion, the innate immune system through adipsin and complement C3 (show C3 Proteins) appears to be influential.

Adipsin (CFD) Protein Profile

Protein Summary

The protein encoded by this gene is a member of the trypsin family of peptidases. The encoded protein is a component of the alternative complement pathway best known for its role in humoral suppression of infectious agents. This protein is also a serine protease that is secreted by adipocytes into the bloodstream. Finally, the encoded protein has a high level of expression in fat, suggesting a role for adipose tissue in immune system biology.

Alternative names and synonyms associated with Adipsin (CFD)

  • even skipped (eve)
  • complement factor D (adipsin) (CFD)
  • complement factor D (adipsin) (cfd)
  • complement factor D (LOC396877)
  • complement factor D (adipsin) (Cfd)
  • 10.5 protein
  • 10.9 protein
  • 14.10 protein
  • 20.35 protein
  • ADIPSIN protein
  • Adn protein
  • CFD protein
  • cfdl protein
  • CG2328 protein
  • Df protein
  • Dmel\\CG2328 protein
  • E(eve) protein
  • Eve protein
  • eve2 protein
  • even protein
  • F protein
  • l(2)46Ce protein
  • l(2)46CFg protein
  • l(2)46CFh protein
  • l(2)46CFj protein
  • l(2)46CFp protein
  • l(2)46Cg protein
  • PFD protein
  • V protein
  • VI protein
  • wu:fb61f12 protein
  • zgc:109940 protein

Protein level used designations for Complement Factor D Proteins (CFD)

CG2328-PA , EVEN-SKIPPED , complementation group F , eve-PA , even-skiped , evenskip , evenskipped , group V , group VI , lethal(2)46Ce , complement factor D (adipsin) , serine protease ami , Ami , complement factor D , complement factor D (adipsin) like , fb61f12 , adipsin , C3 convertase activator , properdin factor D , D component of complement (adipsin) , complement factor D preproprotein , endogenous vascular elastase , 28 kDa adipocyte protein , D component (adipsin) of complement

36039 Drosophila melanogaster
455533 Pan troglodytes
494791 Xenopus laevis
553553 Danio rerio
791100 Ornithorhynchus anatinus
396877 Sus scrofa
1675 Homo sapiens
54249 Rattus norvegicus
11537 Mus musculus
505647 Bos taurus
485095 Canis lupus familiaris
100857593 Gallus gallus
101115705 Ovis aries
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