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Browse our Complement Factor I Proteins (CFI)

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Complement Factor I Proteins (CFI)
On are 16 Complement Factor I (CFI) Proteins from 8 different suppliers available. Additionally we are shipping Complement Factor I Antibodies (106) and Complement Factor I Kits (41) and many more products for this protein. A total of 167 Complement Factor I products are currently listed.
AHUS3, C3b-INA, c3bc4bi, C3BINA, CFI, factor I, FI, gb:ai721528, IF, KAF, MGC53615
list all proteins Gene Name GeneID UniProt
CFI 12630 Q61129
CFI 3426 P05156
CFI 79126 Q9WUW3

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Complement Factor I Proteins (CFI) by Origin

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More Proteins for Complement Factor I Interaction Partners

Mouse (Murine) Complement Factor I (CFI) interaction partners

  1. Factor I-mediated generation of activated C3 fragments in the circulation is a critical determinant for the development of MPGN2 associated with factor H (show CFH Proteins) deficiency.

Human Complement Factor I (CFI) interaction partners

  1. Patients with advanced atrophic AMD (show AMD1 Proteins) carried these rare variants more frequently than patients with neovascular AMD (show AMD1 Proteins) (11 of 93 [11.8%] vs 40 of 835 [4.8%]; P = .04).

  2. Low FI levels are strongly associated with rare CFI variants and age-related macular degeneration.

  3. A missense variant (p.V412M) in CFI was discovered in two Tunisian Jewish families with early-onset age-related macular degeneration.

  4. Regulatory components of the alternative complement pathway in endothelial cell cytoplasm, factor H (show CFH Proteins) and factor I, are not packaged in Weibel-Palade bodies.

  5. In this study, the odds of AMD (show AMD1 Proteins) were highest in those with deficient vitamin D status and 2 risk alleles for the CFH (show CFH Proteins) and CFI genotypes, suggesting a synergistic effect between vitamin D status and complement cascade protein function.

  6. association between rs10033900 and age-related macular degeneration risk in Han Chinese population

  7. The mutations in the regulators CFH (show CFH Proteins), CFI and MCP (show CD46 Proteins) involve loss-of-function, whereas those for C3 involve gain-of-function.

  8. The CFI p.Gly119Arg mutation was identified in 7/521 age-related macular degeneration cases compared to 1/627 age-matched controls; this mutation confers a high risk of disease.

  9. CFI genetic variants played an important role in the development of NSCLC in Chinese population.

  10. High expression of complement factor I is associated with recurrence in breast cancer.

Complement Factor I (CFI) Protein Profile

Protein Summary

This gene encodes a serine proteinase that is essential for regulating the complement cascade. The encoded preproprotein is cleaved to produce both heavy and light chains, which are linked by disulfide bonds to form a heterodimeric glycoprotein. This heterodimer can cleave and inactivate the complement components C4b and C3b, and it prevents the assembly of the C3 and C5 convertase enzymes. Defects in this gene cause complement factor I deficiency, an autosomal recessive disease associated with a susceptibility to pyogenic infections. Mutations in this gene have been associated with a predisposition to atypical hemolytic uraemic syndrome, a disease characterized by acute renal failure, microangiopathic hemolytic anemia and thrombocytopenia. Primary glomerulonephritis with immmune deposits is another condition associated with mutation of this gene.

Alternative names and synonyms associated with Complement Factor I (CFI)

  • complement factor I (cfi)
  • Factor I C3b/C4b inactivator (serine protease) (Cfi)
  • complement factor I (CFI)
  • complement component factor i (Cfi)
  • complement factor I (Cfi)
  • complement factor I-like (LOC100516921)
  • AHUS3 protein
  • C3b-INA protein
  • c3bc4bi protein
  • C3BINA protein
  • CFI protein
  • factor I protein
  • FI protein
  • gb:ai721528 protein
  • IF protein
  • KAF protein
  • MGC53615 protein

Protein level used designations for Complement Factor I Proteins (CFI)

complement factor I , I factor (complement) , complement factor 1 , C3B/C4B inactivator , C3b-inactivator , Konglutinogen-activating factor , complement component I , complement control protein factor I , complement factor I heavy chain , light chain of factor I , complement component 1

379108 Xenopus laevis
399318 Xenopus laevis
471271 Pan troglodytes
557557 Danio rerio
613100 Xenopus (Silurana) tropicalis
100072852 Equus caballus
100306949 Ictalurus punctatus
12630 Mus musculus
3426 Homo sapiens
79126 Rattus norvegicus
100338923 Oryctolagus cuniculus
100713918 Cavia porcellus
513197 Bos taurus
478515 Canis lupus familiaris
428773 Gallus gallus
101119307 Ovis aries
100174703 Pongo abelii
100516921 Sus scrofa
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