Complement Factor I Protein (CFI) (Myc-DYKDDDDK Tag)
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- Target See all Complement Factor I (CFI) Proteins
- Complement Factor I (CFI)
- Protein Type
- Recombinant
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This Complement Factor I protein is labelled with Myc-DYKDDDDK Tag.
- Application
- Antibody Production (AbP), Standard (STD)
- Characteristics
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- Recombinant human Complement factor I protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
- Purity
- > 80 % as determined by SDS-PAGE and Coomassie blue staining
- Top Product
- Discover our top product CFI Protein
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- Application Notes
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays - Comment
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The tag is located at the C-terminal.
- Restrictions
- For Research Use only
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- Concentration
- 50 μg/mL
- Buffer
- 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
- Storage
- -80 °C
- Storage Comment
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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- Target
- Complement Factor I (CFI)
- Alternative Name
- Complement Factor I (CFI Products)
- Synonyms
- cfi Protein, MGC53615 Protein, Cfi Protein, factor I Protein, IF Protein, gb:ai721528 Protein, ahus3 Protein, c3b-ina Protein, c3bc4bi Protein, c3bina Protein, kaf Protein, CFI Protein, AHUS3 Protein, C3BINA Protein, C3b-INA Protein, FI Protein, KAF Protein, complement factor I S homeolog Protein, complement factor I L homeolog Protein, complement factor I Protein, complement component factor i Protein, cfi.S Protein, cfi.L Protein, CFI Protein, cfi Protein, Cfi Protein
- Background
- This gene encodes a serine proteinase that is essential for regulating the complement cascade. The encoded preproprotein is cleaved to produce both heavy and light chains, which are linked by disulfide bonds to form a heterodimeric glycoprotein. This heterodimer can cleave and inactivate the complement components C4b and C3b, and it prevents the assembly of the C3 and C5 convertase enzymes. Defects in this gene cause complement factor I deficiency, an autosomal recessive disease associated with a susceptibility to pyogenic infections. Mutations in this gene have been associated with a predisposition to atypical hemolytic uremic syndrome, a disease characterized by acute renal failure, microangiopathic hemolytic anemia and thrombocytopenia. Primary glomerulonephritis with immune deposits and age-related macular degeneration are other conditions associated with mutations of this gene.
- Molecular Weight
- 63.4 kDa
- NCBI Accession
- NP_000195
- Pathways
- Complement System
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