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Human Prostate Specific Antigen Protein expressed in Human - ABIN934764
Harris, Lenz, Hankey, MacVittie, Farese, Nakajima, Hasumi, Mann: Products of anti-CD3/anti-CD28 activated lymphocytes induce differentiation and maturation of dendritic cells and have adjuvant-like activity in vitro and in vivo. in Clinical immunology (Orlando, Fla.) 2008
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Human Prostate Specific Antigen Protein expressed in Human - ABIN934667
Marshall, Rudnick, McCarthy, Mateo, Harris, McCauley, Snyder: Interleukin-18 enhances Th1 immunity and tumor protection of a DNA vaccine. in Vaccine 2005
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Microenvironmental acidity determines qualitatively and quantitatively the release of extracellular vesicles by malignant prostate tumors. This leads to the spill-over of nanovesicles into the peripheral blood of prostate cancer patients, where the levels of tumor biomarkers expressed by exosomes, such as PSA-exosomes, may represent a novel, non-invasive diagnostic tool.
Promoter methylation of MCAM, ERalpha and ERbeta have a potential to be utilized as biomarker for the early detection of prostate cancer (PC) as their sensitivity and specificity seem to be better than serum PSA.
Data suggest no influence of chronic periodontitis treatment on PSA levels in asymptomatic men.
Circulating total PSA levels were strongly associated to leukocyte telomere length in a national sample of men without prostate cancer.
I might also point out that whether a particular surgical procedure did more good than harm at that time was highly dependent on whether it was conducted with good sterile procedure. PSA screening is a contemporary example of this historical lesson
Data show that forkhead box M1 protein (FOXM1) directly binds to the FHK binding motifs in the prostate specific antigen (PSA) promoter/enhancer regions.
Study suggests that the prognostic value of PSA declines in heavily treated patients receiving enzalutamide
novel urinary gene expression signature that may be the least invasive of available options by not requiring a digital rectal examination or phlebotomy as a reflex test in men for whom PSA testing raises the suspicion of prostate cancer
For PSA screening to be cost-effective, it needs to be used conservatively and ideally in combination with a conservative management approach for low-risk disease
Both the incidence of early-stage prostate cancer and rates of PSA screening have declined and coincide with 2012 USPSTF recommendation to omit PSA screening from routine primary care for men. Longer follow-up is needed to see whether these decreases are associated with trends in mortality.
Plasma kallikrein (show KLKB1 Proteins) mediates brain hemorrhage and edema caused by tissue plasminogen activator (show PLAT Proteins) therapy in mice after stroke.
we found that post-ejaculated semen from fertile wild-type males was solidified and the sperm were entrapped in Wnt7aCre/+;Esr1f/f uteri, compared to the watery semen (liquefied) found in Esr1f/f controls.Kallikrein-related peptidases 3 (KLK3) and other kallikrein (show KLK1 Proteins)-related peptidases from male prostate glands are responsible for semen liquefaction by cleaving gel-forming proteins
Klkb1 (show KLKB1 Proteins)(-/-) mice have a novel mechanism for thrombosis protection in addition to reduced contact activation. This pathway arises when bradykinin delivery to vasculature is compromised and mediated by increased receptor Mas (show MAS1 Proteins), prostacyclin, Sirt1 (show SIRT1 Proteins), and KLF4 (show KLF4 Proteins)
Plasma kallikrein (show KLKB1 Proteins) deletion prevents occlusive thrombus formation in mice with a minimal role in provoked bleeding.
PKK (show RIPK4 Proteins) or fXII (show F12 Proteins) deficiency reduced thrombus formation in both arterial and venous thrombosis models, without an apparent effect on hemostasis.
Data suggest that LGG secreting PSA (show NPEPPS Proteins) may activate antigen specific immune responses when instilled intravesically and IL15 (show IL15 Proteins) could enhance this response.
the prekallikrein gene (Klkb1 (show KLKB1 Proteins)) is expressed highly in the mammary gland during stromal remodeling periods including puberty and postlactational involution.
This gene encodes the puromycin-sensitive aminopeptidase, a zinc metallopeptidase which hydrolyzes amino acids from the N-terminus of its substrate. The protein has been localized to both the cytoplasm and to cellular membranes. This enzyme degrades enkaphalins in the brain, and studies in mouse suggest that it is involved in proteolytic events regulating the cell cycle.
, prostate specific antigen
, prostate-specific antigen
, cytosol alanyl aminopeptidase
, metalloproteinase MP100
, puromycin-sensitive aminopeptidase
, kallikrein-related peptidase 3
, plasma kallikrein B1
, S1 kallikrein
, glandular kallikrein-3, submandibular
, kallikrein 1-related peptidase c10-like 2
, kallikrein 3
, submaxillary gland S1 kallikrein
, tissue kallikrein
, antigen, prostate specific
, fletcher factor
, kallikrein 3, plasma
, plasma kallikrein
, plasma prekallikrein