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Browse our anti-Prothrombin (F2) Antibodies

Full name:
anti-Coagulation Factor II (thrombin) Antibodies (F2)
On are 211 Coagulation Factor II (thrombin) (F2) Antibodies from 26 different suppliers available. Additionally we are shipping Prothrombin Kits (116) and Prothrombin Proteins (56) and many more products for this protein. A total of 393 Prothrombin products are currently listed.
AA959438, AI255193, AI327365, C1sa, Cf-2, Cf2, F2, FII, HTRA, HTRA1, prothrombin, PT, RPRGL2, THPH1, thrombin, wu:fb57c10, wu:fd42e09, wu:fd59d01, zgc:66319
list all antibodies Gene Name GeneID UniProt
F2 299602  
F2 14061 P19221
F2 2147 P00734

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Most Popular Reactivities for anti-Prothrombin (F2) Antibodies

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anti-Human Prothrombin Antibodies:

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Top referenced anti-Prothrombin Antibodies

  1. Human Monoclonal Prothrombin Primary Antibody for WB - ABIN394859 : Ikejiri, Wada, Sakamoto, Ito, Nishioka, Nakatani, Tsuji, Yamada, Nakamura, Ito, Nobori: The association of protein S Tokushima-K196E with a risk of deep vein thrombosis. in International journal of hematology 2010 (PubMed)
    Show all 5 references for ABIN394859

  2. Human Monoclonal Prothrombin Primary Antibody for EIA, WB - ABIN954323 : Kazama, Pastuszyn, Wildgoose, Hamamoto, Kisiel: Isolation and characterization of proteolytic fragments of human factor VIIa which inhibit the tissue factor-enhanced amidolytic activity of factor VIIa. in The Journal of biological chemistry 1993 (PubMed)
    Show all 3 references for ABIN954323

  3. Human Monoclonal Prothrombin Primary Antibody for EIA, WB - ABIN954322 : Bharadwaj, Iino, Kontoyianni, Smith, Foster, Kisiel: Factor VII central. A novel mutation in the catalytic domain that reduces tissue factor binding, impairs activation by factor Xa, and abolishes amidolytic and coagulant activity. in The Journal of biological chemistry 1997 (PubMed)
    Show all 3 references for ABIN954322

  4. Cow (Bovine) Polyclonal Prothrombin Primary Antibody for IHC, WB - ABIN2776976 : Rossi, Za, Ciminello, Leone, De Stefano: The risk of symptomatic pulmonary embolism due to proximal deep venous thrombosis differs in patients with different types of inherited thrombophilia. in Thrombosis and haemostasis 2008 (PubMed)

  5. Human Polyclonal Prothrombin Primary Antibody for IHC, ELISA - ABIN1583288 : Fritze, Zhang, Li, Chai, Mulholland: Thrombin mediates vagal apoptosis and dysfunction in inflammatory bowel disease. in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 2014 (PubMed)

More Antibodies against Prothrombin Interaction Partners

Zebrafish Coagulation Factor II (thrombin) (F2) interaction partners

  1. Prothrombin morpholino-injected zebrafish embryos yielded an early phenotype exhibiting severe abnormalities that later showed occasional bleeding

Rhesus Monkey Coagulation Factor II (thrombin) (F2) interaction partners

  1. The great similarity of prothrombin among rhesus, human, and porcine confirm the great value of the pig-to-rhesus xenotransplantation model.

Mouse (Murine) Coagulation Factor II (thrombin) (F2) interaction partners

  1. thrombin/PAR-1 (show MARK2 Antibodies) interaction regulated MCP-1 (show CPT1B Antibodies), TF, MCSF (show CSF1 Antibodies) and IL-6 (show IL6 Antibodies) production.

  2. Observations illustrate the role of thrombin as a pleiotropic atherogenic molecule under conditions of hypercholesterolemia and suggest the utility of its inhibition with locally acting antithrombin (show SERPINC1 Antibodies) nanoparticle therapeutics.

  3. Thrombin-PAR1 (show F2R Antibodies) signaling, via nitric oxide and EPCR (show PROCR Antibodies), promotes hematopoietic stem cell (HSC (show FUT1 Antibodies)) mobilization.

  4. Primary tumor growth by colon cancer cells was reduced by reduction of circulating prothrombin. There were lower mitotic indices and invasiveness. This growth relied upon 2 targets of thrombin-mediated proteolysis, protease: PAR-1 and fibrinogen.

  5. Thrombin promotes sustained signaling and inflammatory gene expression through the CDC25 and Ras-associating domains of phospholipase C epsilon.

  6. thrombin/PAR1 (show F2R Antibodies) pathway as a novel target for developing therapeutic strategies to restore synaptic function in the acute phase of ischemic stroke.

  7. High Factor IIa expression is associated with multiorgan pathologies in sickle cell disease.

  8. Blockage of thrombin exosites with compounds specific for exosite I (hirudin and HD1 (show HDAC1 Antibodies) aptamer) or exosite II (heparin and HD22 aptamer) impaired the COMP (show COMP Antibodies)-thrombin interaction, indicating a 2-site binding mechanism.

  9. Whole blood thrombin generation assay is capable of detecting a prothrombotic phenotype in Bmal1 (show ARNTL Antibodies)-KO mice.

  10. Fyn (show FYN Antibodies), but not Lyn (show LYN Antibodies), was required for complete Pyk2 (show PTK2B Antibodies) phosphorylation by thrombin.

Human Coagulation Factor II (thrombin) (F2) interaction partners

  1. Global prevalence of prothrombin gene mutation G20210A varied from 0 to 15.9% among ethnic groups, with higher rates seen in the thromboembolism affected cohort compared with the unaffected cohort. (Review)

  2. investigated the impact of serum sex hormone-binding globulin (SHBG (show SHBG Antibodies)) on thrombin generation (TG) in women according to hormonal contraception

  3. The prevalence of factor V G1691A, prothrombin G20210A and MTHFR (show MTHFR Antibodies) C677T single nucleotide polymorphism among Syrians is 11.5%, 2.5% and 84.5%, respectively.

  4. Study showed a significant but not independent association between the G20210A polymorphism of the prothrombin gene and myocardial infraction in the Tunisian population.

  5. A family with prothrombin G20210A mutation is reported, including a symptomatic homozygous male, an asymptomatic homozygous female, and their symptomatic heterozygous father and asymptomatic heterozygous mother.

  6. In patients with HBV-related hepatocellular carcinoma, post-ablation serum des (show DES Antibodies)-gamma-carboxy prothrombin is a useful biomarker for predicting survival and recurrence after curative radiofrequency catheter ablation.

  7. Data does not support a role for factor V Leiden (show F5 Antibodies) and G20210A prothrombin gene mutations in the susceptibility to infective endocarditis.

  8. Prothrombin kringle-2 expression is is increased in the substantia nigra of patients with Parkinson disease.

  9. Thrombin is produced from the C-terminal half of prothrombin following its proteolytic activation. The N-terminal half, released as the propiece Fragment 12 (F12 (show F12 Antibodies)), is composed of an N-terminal gamma-carboxyglutamate domain (Gla (show NAT8 Antibodies)) followed by two kringles (K1 and K2). The propiece plays essential roles in regulating prothrombin activation and proteinase function.

  10. Data suggest that a folded alpha-helix cannot be proteolytically cleaved by thrombin.

Cow (Bovine) Coagulation Factor II (thrombin) (F2) interaction partners

  1. the weaker rapid interaction between prothrombin and membranes is the most important in vivo when considering the activation of prothrombin at the cell surface.

  2. novel pyranosic sulfated (show SULF1 Antibodies) arabinan Ab1 exerts its anticoagulant activity on thrombin by a mechanism different from those found previously for other sulfated (show SULF1 Antibodies) polysaccharides and glycosaminoglycans

  3. Exogenous delivery of thrombin enhances microvascular collateral development in response to ischemic insult, and accelerates tissue reperfusion.

  4. the signaling pathways of MAPK (show MAPK1 Antibodies), MSK1 (show RPS6KA5 Antibodies), and NF-kappaB (show NFKB1 Antibodies) play important roles in thrombin-induced iNOS (show NOS2 Antibodies) expression in alveolar macrophages

  5. High glucose enhances smooth muscle cell responsiveness to thrombin through transcriptional upregulation of PAR-4, mediated via PKC and NFkappaB.

  6. Thrombin induces a sustained contraction in the normal pulmonary artery, by activating PAR(1 (show F2R Antibodies)) and thereby increasing the sensitivity of the myofilament to Ca(2 (show CA2 Antibodies)+).

  7. kinetic and structural analysis of interactions between thrombin and the Factor XIII (show UGDH Antibodies) activation peptide

  8. analysis of staphylocoagulase-mediated bovine prothrombin activation

  9. thrombin and factor Xa (show F10 Antibodies) diffusion along the heparin molecule explains the effects of extended heparin chain lengths

  10. A comparison of recombinant thrombin to bovine thrombin as a hemostatic ancillary in patients undergoing peripheral arterial bypass and arteriovenous graft procedures.

Pig (Porcine) Coagulation Factor II (thrombin) (F2) interaction partners

  1. thrombin stimulates transglutaminase activity in articular cartilage by directly cleaving factor XIII (show UGDH Antibodies) and by receptor-mediated up-regulation of factor XIII (show UGDH Antibodies) synthesis

  2. The great similarity of prothrombin among rhesus, human, and porcine confirm the great value of the pig-to-rhesus xenotransplantation model.

  3. In conclusion, thrombin activates pro-MMP-2 (show MMP2 Antibodies) in the absence of elevated pro-MMP-2 (show MMP2 Antibodies) expression and secretion in CSMCs, and thrombin induces CSMC mitogenesis involving its action on MMP-2 (show MMP2 Antibodies)

  4. Thrombin stimulates swine smooth muscle cell differentiation from peripheral blood mononuclear cells via protease-activated receptor-1 (show F2R Antibodies), RhoA (show RHOA Antibodies), and myocardin (show MYOCD Antibodies).

Prothrombin (F2) Antigen Profile

Antigen Summary

Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Mutations in F2 leads to various forms of thrombosis and dysprothrombinemia.

Alternative names and synonyms associated with Prothrombin (F2)

  • coagulation factor II (thrombin) (f2) antibody
  • coagulation factor II (thrombin) (F2) antibody
  • cell division cycle 34 (Cdc34) antibody
  • chymase 1, mast cell (CMA1) antibody
  • coagulation factor II (F2) antibody
  • complement component 1, s subcomponent (C1s) antibody
  • HtrA serine peptidase 1 (Htra1) antibody
  • HtrA serine peptidase 2 (HTRA2) antibody
  • melanoma antigen family B, 17-like (LOC783975) antibody
  • prothrombin-like (LOC100856539) antibody
  • serine protease (HTRA) antibody
  • THROMBIN protein (THROMBIN) antibody
  • AA959438 antibody
  • AI255193 antibody
  • AI327365 antibody
  • C1sa antibody
  • Cf-2 antibody
  • Cf2 antibody
  • F2 antibody
  • FII antibody
  • HTRA antibody
  • HTRA1 antibody
  • prothrombin antibody
  • PT antibody
  • RPRGL2 antibody
  • THPH1 antibody
  • thrombin antibody
  • wu:fb57c10 antibody
  • wu:fd42e09 antibody
  • wu:fd59d01 antibody
  • zgc:66319 antibody

Protein level used designations for F2

prothrombin , cell division cycle 34 homolog , serine protease , ubiquitin-conjugating enzyme Cdc34 , ubiquitin-conjugating enzyme E2 R1 , alpha-chymase , chymase , mast cell chymase , mast cell protease I , coagulation factor 2 , thrombin , prepro-coagulation factor II , prothrombin B-chain , C1 esterase , complement C1s-A subcomponent , complement component 1 subcomponent s-A , complement component C1SA

325881 Danio rerio
712729 Macaca mulatta
299602 Rattus norvegicus
490628 Canis lupus familiaris
14061 Mus musculus
29251 Rattus norvegicus
2147 Homo sapiens
280685 Bos taurus
100144442 Sus scrofa
395306 Gallus gallus
100725988 Cavia porcellus
100307041 Ovis aries
50908 Mus musculus
100716225 Cavia porcellus
395990 Gallus gallus
783975 Bos taurus
100856539 Canis lupus familiaris
100008705 Oryctolagus cuniculus
100009146 Oryctolagus cuniculus
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