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Chen, Teramura, Iwata: Immobilization of anticoagulant-loaded liposomes on cell surfaces by DNA hybridization. in Biomaterials 2011
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Lim, Joy, Hill, San Brian Chia: Novel agmatine and agmatine-like peptidomimetic inhibitors of the West Nile virus NS2B/NS3 serine protease. in European journal of medicinal chemistry 2011
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Human Prothrombin ELISA Kit for Sandwich ELISA - ABIN612790
Badimon, Badimon, Turitto, Vallabhajosula, Fuster: Platelet thrombus formation on collagen type I. A model of deep vessel injury. Influence of blood rheology, von Willebrand factor, and blood coagulation. in Circulation 1989
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Mouse (Murine) Prothrombin ELISA Kit for Sandwich ELISA - ABIN2010738
Wang, Braun, Zhang, Norström, Thorlacius: Thrombin generation in abdominal sepsis is Rho-kinase-dependent. in Biochemical and biophysical research communications 2015
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Prothrombin morpholino-injected zebrafish embryos yielded an early phenotype exhibiting severe abnormalities that later showed occasional bleeding
The great similarity of prothrombin among rhesus, human, and porcine confirm the great value of the pig-to-rhesus xenotransplantation model.
These findings imply that a thrombin-pericyte interaction in the brain could be a significant mechanism responsible for blood-brain barrier dysfunction under obesity-associated diabetic conditions and thus could represent a therapeutic target for central nervous system complications of diabetes.
mutations were introduced into the endogenous fII gene, resulting in expression of prothrombin carrying 3 amino acid substitutions (R157A, R268A, and K281A) to limit activation events to yield only fIIa(Meizothrombin) Homozygous fII(MZ) mice are viable, express fII levels comparable with fII(Wild type) mice, and have reproductive success.
Biglycan (show BGN ELISA Kits) plays a protective role during the progression of atherosclerosis in ApoE (show APOE ELISA Kits)-deficient mice by inhibiting thrombin generation.
allosteric inhibitor SbO4L targets the glycoprotein Ibalpha (show GP1BA ELISA Kits)-binding and heparin-binding site of thrombin
thrombin/PAR-1 (show MARK2 ELISA Kits) interaction regulated MCP-1 (show CPT1B ELISA Kits), TF, MCSF (show CSF1 ELISA Kits) and IL-6 (show IL6 ELISA Kits) production.
Observations illustrate the role of thrombin as a pleiotropic atherogenic molecule under conditions of hypercholesterolemia and suggest the utility of its inhibition with locally acting antithrombin (show SERPINC1 ELISA Kits) nanoparticle therapeutics.
Thrombin-PAR1 (show F2R ELISA Kits) signaling, via nitric oxide and EPCR (show PROCR ELISA Kits), promotes hematopoietic stem cell (HSC (show FUT1 ELISA Kits)) mobilization.
Primary tumor growth by colon cancer cells was reduced by reduction of circulating prothrombin. There were lower mitotic indices and invasiveness. This growth relied upon 2 targets of thrombin-mediated proteolysis, protease: PAR-1 and fibrinogen.
Thrombin promotes sustained signaling and inflammatory gene expression through the CDC25 (show CDC25C ELISA Kits) and Ras-associating domains of phospholipase C epsilon (show PLCE1 ELISA Kits).
thrombin/PAR1 (show F2R ELISA Kits) pathway as a novel target for developing therapeutic strategies to restore synaptic function in the acute phase of ischemic stroke.
The prevalence of FVL (show F5 ELISA Kits) polymorphism (16.3 %) was higher in retinopathy of prematurity (ROP (show STXBP1 ELISA Kits)) patients than control subjects in this Turkish cohort. We suggest a possible association of FVL (show F5 ELISA Kits) mutation with ROP (show STXBP1 ELISA Kits) at the end of the study.
Data suggest that, for all coagulation proteins tested (prothrombin, factor X, activated factor VII, activated protein C), tighter binding to lipid bilayers (lower Kd) is observed as the proportion of anionic phospholipid increases. These studies were conducted in high-throughput screening using phospholipid bilayers in nanodiscs with multiplexed silicon photonic sensor (micro-ring resonator) array technology.
Factor Va reduced by 100-fold the apparent Kd of myosin for factor Xa (show F10 ELISA Kits) (Kd approximately 0.48 nM), primarily by reducing koff, indicating formation of a stable ternary complex of myosin:Xa:Va.
Over the first 500 s, approximately 92,000 molecules of thrombin were generated per surface TF molecule for the 250-mum-long coating.
EPCR (show PROCR ELISA Kits) occupancy recruits G-protein coupled receptor kinase 5 (show GRK5 ELISA Kits), thereby inducing beta-arrestin-2 (show ARRB2 ELISA Kits) biased PAR1 (show MARK2 ELISA Kits) signaling by both APC (show APC ELISA Kits) and thrombin. In
Data suggest that subtilisin, a serine protease secreted by non-pathogenic bacterium Bacillus subtilis, induces plasma clotting by proteolytically activating prothrombin with single "non-canonical" cleavage at Ala470-Asn471 bond.
An in silico and in vitro approach to elucidate the impact of residues flanking the cleavage scissile bonds of FVIII (show F8 ELISA Kits) by thrombin has been presented.
These studies clarify the role of PKCdelta (show PKCd ELISA Kits) in endothelial cell cytoskeleton regulation.
Findings indicate functional effects of thrombin allostery and suggest that individual active site-directed thrombin inhibitors uniquely modulate exosite function.
Acute Coronary Syndrome patients had an enhanced prothrombotic profile, demonstrated by an increased thrombin generation potential, factor XIa and D-dimer levels.
the weaker rapid interaction between prothrombin and membranes is the most important in vivo when considering the activation of prothrombin at the cell surface.
novel pyranosic sulfated (show SULF1 ELISA Kits) arabinan Ab1 exerts its anticoagulant activity on thrombin by a mechanism different from those found previously for other sulfated (show SULF1 ELISA Kits) polysaccharides and glycosaminoglycans
Exogenous delivery of thrombin enhances microvascular collateral development in response to ischemic insult, and accelerates tissue reperfusion.
the signaling pathways of MAPK (show MAPK1 ELISA Kits), MSK1 (show RPS6KA5 ELISA Kits), and NF-kappaB (show NFKB1 ELISA Kits) play important roles in thrombin-induced iNOS (show NOS2 ELISA Kits) expression in alveolar macrophages
High glucose enhances smooth muscle cell responsiveness to thrombin through transcriptional upregulation of PAR-4, mediated via PKC and NFkappaB.
Thrombin induces a sustained contraction in the normal pulmonary artery, by activating PAR(1 (show F2R ELISA Kits)) and thereby increasing the sensitivity of the myofilament to Ca(2 (show CA2 ELISA Kits)+).
kinetic and structural analysis of interactions between thrombin and the Factor XIII (show UGDH ELISA Kits) activation peptide
analysis of staphylocoagulase-mediated bovine prothrombin activation
thrombin and factor Xa (show F10 ELISA Kits) diffusion along the heparin molecule explains the effects of extended heparin chain lengths
A comparison of recombinant thrombin to bovine thrombin as a hemostatic ancillary in patients undergoing peripheral arterial bypass and arteriovenous graft procedures.
thrombin stimulates transglutaminase activity in articular cartilage by directly cleaving factor XIII (show UGDH ELISA Kits) and by receptor-mediated up-regulation of factor XIII (show UGDH ELISA Kits) synthesis
In conclusion, thrombin activates pro-MMP-2 (show MMP2 ELISA Kits) in the absence of elevated pro-MMP-2 (show MMP2 ELISA Kits) expression and secretion in CSMCs, and thrombin induces CSMC mitogenesis involving its action on MMP-2 (show MMP2 ELISA Kits)
Thrombin stimulates swine smooth muscle cell differentiation from peripheral blood mononuclear cells via protease-activated receptor-1 (show F2R ELISA Kits), RhoA (show RHOA ELISA Kits), and myocardin (show MYOCD ELISA Kits).
Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Mutations in F2 leads to various forms of thrombosis and dysprothrombinemia.
, cell division cycle 34 homolog
, serine protease
, ubiquitin-conjugating enzyme Cdc34
, ubiquitin-conjugating enzyme E2 R1
, mast cell chymase
, mast cell protease I
, coagulation factor 2
, prepro-coagulation factor II
, prothrombin B-chain
, C1 esterase
, complement C1s-A subcomponent
, complement component 1 subcomponent s-A
, complement component C1SA