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Browse our Prothrombin Proteins (F2)

Full name:
Coagulation Factor II (thrombin) Proteins (F2)
On are 55 Coagulation Factor II (thrombin) (F2) Proteins from 14 different suppliers available. Additionally we are shipping Prothrombin Antibodies (211) and Prothrombin Kits (122) and many more products for this protein. A total of 396 Prothrombin products are currently listed.
AA959438, AI255193, AI327365, C1sa, Cf-2, Cf2, F2, FII, HTRA, HTRA1, prothrombin, PT, RPRGL2, THPH1, thrombin, wu:fb57c10, wu:fd42e09, wu:fd59d01, zgc:66319
list all proteins Gene Name GeneID UniProt
F2 299602  
F2 14061 P19221
F2 2147 P00734

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Prothrombin Proteins (F2) by Origin

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Top referenced Prothrombin Proteins

  1. Mouse (Murine) Prothrombin Primary Antibody for - ABIN2007695 : Degen, McDowell, Sparks, Scharrer: Prothrombin Frankfurt: a dysfunctional prothrombin characterized by substitution of Glu-466 by Ala. in Thrombosis and haemostasis 1995 (PubMed)
    Show all 3 references for ABIN2007695

  2. Rat (Rattus) Prothrombin Primary Antibody for - ABIN491211 : Rancourt, Veress, Ahmad, Hendry-Hofer, Rioux, Garlick, White: Tissue factor pathway inhibitor prevents airway obstruction, respiratory failure and death due to sulfur mustard analog inhalation. in Toxicology and applied pharmacology 2013 (PubMed)

More Proteins for Prothrombin Interaction Partners

Zebrafish Coagulation Factor II (thrombin) (F2) interaction partners

  1. Prothrombin morpholino-injected zebrafish embryos yielded an early phenotype exhibiting severe abnormalities that later showed occasional bleeding

Rhesus Monkey Coagulation Factor II (thrombin) (F2) interaction partners

  1. The great similarity of prothrombin among rhesus, human, and porcine confirm the great value of the pig-to-rhesus xenotransplantation model.

Mouse (Murine) Coagulation Factor II (thrombin) (F2) interaction partners

  1. allosteric inhibitor SbO4L targets the glycoprotein Ibalpha (show GP1BA Proteins)-binding and heparin-binding site of thrombin

  2. thrombin/PAR-1 (show MARK2 Proteins) interaction regulated MCP-1 (show CPT1B Proteins), TF, MCSF (show CSF1 Proteins) and IL-6 (show IL6 Proteins) production.

  3. Observations illustrate the role of thrombin as a pleiotropic atherogenic molecule under conditions of hypercholesterolemia and suggest the utility of its inhibition with locally acting antithrombin (show SERPINC1 Proteins) nanoparticle therapeutics.

  4. Thrombin-PAR1 (show F2R Proteins) signaling, via nitric oxide and EPCR (show PROCR Proteins), promotes hematopoietic stem cell (HSC (show FUT1 Proteins)) mobilization.

  5. Primary tumor growth by colon cancer cells was reduced by reduction of circulating prothrombin. There were lower mitotic indices and invasiveness. This growth relied upon 2 targets of thrombin-mediated proteolysis, protease: PAR-1 and fibrinogen.

  6. Thrombin promotes sustained signaling and inflammatory gene expression through the CDC25 (show CDC25C Proteins) and Ras-associating domains of phospholipase C epsilon (show PLCE1 Proteins).

  7. thrombin/PAR1 (show F2R Proteins) pathway as a novel target for developing therapeutic strategies to restore synaptic function in the acute phase of ischemic stroke.

  8. High Factor IIa expression is associated with multiorgan pathologies in sickle cell disease.

  9. Blockage of thrombin exosites with compounds specific for exosite I (hirudin and HD1 (show HDAC1 Proteins) aptamer) or exosite II (heparin and HD22 aptamer) impaired the COMP (show COMP Proteins)-thrombin interaction, indicating a 2-site binding mechanism.

  10. Whole blood thrombin generation assay is capable of detecting a prothrombotic phenotype in Bmal1 (show ARNTL Proteins)-KO mice.

Human Coagulation Factor II (thrombin) (F2) interaction partners

  1. This study demonstrates that impaired EPCR (show PROCR Proteins) function can be detected by thrombin generation and clot (show TXNDC17 Proteins) lysis assays on cells expressing thrombomodulin (show THBD Proteins) and EPCR (show PROCR Proteins). Deficiency in EPCR (show PROCR Proteins) has procoagulant effects that lead to a delay in clot (show TXNDC17 Proteins) lysis.

  2. Significantly higher serum levels of GP-73 (show GOLM1 Proteins) and PIVKA-II were detected in the hepatocellular carcinoma patients than in controls.

  3. This study investigated whether type 1 diabetes in children is associated with a hypercoagulable state by performing a global function test of coagulation - the thrombin generation assay. The study found only minor changes of thrombin generation in children and adolescents with type 1 diabetes which - in contrast to type 2 diabetes - do not argue for a hypercoagulable state.

  4. These findings suggest a higher prevalence of prothrombin G20210A in patients with atrial fibrillation when compared to healthy controls.

  5. Trauma is associated with coagulation and increased thrombin generation capacity. Evidence of hypercoagulable state was observed in trauma patients.

  6. Boosted thrombin generation shortened the spontaneous plasma clot (show TXNDC17 Proteins) lysis time. The shortening was apparent when the inhibitors of FXIIIa and TAFIa existed. The shortening by thrombin was masked when tissue plasminogen activator (show PLAT Proteins) was added to overcome PAI-1 (show SERPINE1 Proteins).

  7. Signaling levels of thrombin can be generated during moderate hemophilia to sufficiently activate platelets to achieve primary hemostasis, even if fibrin formation remains defective.

  8. allosteric inhibitor SbO4L targets the glycoprotein Ibalpha (show GP1BA Proteins)-binding and heparin-binding site of thrombin

  9. serum level differentiates hepatocellular carcinoma from liver cirrhosis, especially when combined with alpha-fetoprotein (show AFP Proteins)

  10. Global prevalence of prothrombin gene mutation G20210A varied from 0 to 15.9% among ethnic groups, with higher rates seen in the thromboembolism affected cohort compared with the unaffected cohort. (Review)

Cow (Bovine) Coagulation Factor II (thrombin) (F2) interaction partners

  1. the weaker rapid interaction between prothrombin and membranes is the most important in vivo when considering the activation of prothrombin at the cell surface.

  2. novel pyranosic sulfated (show SULF1 Proteins) arabinan Ab1 exerts its anticoagulant activity on thrombin by a mechanism different from those found previously for other sulfated (show SULF1 Proteins) polysaccharides and glycosaminoglycans

  3. Exogenous delivery of thrombin enhances microvascular collateral development in response to ischemic insult, and accelerates tissue reperfusion.

  4. the signaling pathways of MAPK (show MAPK1 Proteins), MSK1 (show RPS6KA5 Proteins), and NF-kappaB (show NFKB1 Proteins) play important roles in thrombin-induced iNOS (show NOS2 Proteins) expression in alveolar macrophages

  5. High glucose enhances smooth muscle cell responsiveness to thrombin through transcriptional upregulation of PAR-4, mediated via PKC and NFkappaB.

  6. Thrombin induces a sustained contraction in the normal pulmonary artery, by activating PAR(1 (show F2R Proteins)) and thereby increasing the sensitivity of the myofilament to Ca(2 (show CA2 Proteins)+).

  7. kinetic and structural analysis of interactions between thrombin and the Factor XIII (show UGDH Proteins) activation peptide

  8. analysis of staphylocoagulase-mediated bovine prothrombin activation

  9. thrombin and factor Xa (show F10 Proteins) diffusion along the heparin molecule explains the effects of extended heparin chain lengths

  10. A comparison of recombinant thrombin to bovine thrombin as a hemostatic ancillary in patients undergoing peripheral arterial bypass and arteriovenous graft procedures.

Pig (Porcine) Coagulation Factor II (thrombin) (F2) interaction partners

  1. thrombin stimulates transglutaminase activity in articular cartilage by directly cleaving factor XIII (show UGDH Proteins) and by receptor-mediated up-regulation of factor XIII (show UGDH Proteins) synthesis

  2. The great similarity of prothrombin among rhesus, human, and porcine confirm the great value of the pig-to-rhesus xenotransplantation model.

  3. In conclusion, thrombin activates pro-MMP-2 (show MMP2 Proteins) in the absence of elevated pro-MMP-2 (show MMP2 Proteins) expression and secretion in CSMCs, and thrombin induces CSMC mitogenesis involving its action on MMP-2 (show MMP2 Proteins)

  4. Thrombin stimulates swine smooth muscle cell differentiation from peripheral blood mononuclear cells via protease-activated receptor-1, RhoA, and myocardin.

Prothrombin (F2) Protein Profile

Protein Summary

Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Mutations in F2 leads to various forms of thrombosis and dysprothrombinemia.

Alternative names and synonyms associated with Prothrombin (F2)

  • coagulation factor II (thrombin) (f2)
  • coagulation factor II (thrombin) (F2)
  • cell division cycle 34 (Cdc34)
  • chymase 1, mast cell (CMA1)
  • coagulation factor II (F2)
  • complement component 1, s subcomponent (C1s)
  • HtrA serine peptidase 1 (Htra1)
  • HtrA serine peptidase 2 (HTRA2)
  • melanoma antigen family B, 17-like (LOC783975)
  • prothrombin-like (LOC100856539)
  • serine protease (HTRA)
  • AA959438 protein
  • AI255193 protein
  • AI327365 protein
  • C1sa protein
  • Cf-2 protein
  • Cf2 protein
  • F2 protein
  • FII protein
  • HTRA protein
  • HTRA1 protein
  • prothrombin protein
  • PT protein
  • RPRGL2 protein
  • THPH1 protein
  • thrombin protein
  • wu:fb57c10 protein
  • wu:fd42e09 protein
  • wu:fd59d01 protein
  • zgc:66319 protein

Protein level used designations for F2

prothrombin , cell division cycle 34 homolog , serine protease , ubiquitin-conjugating enzyme Cdc34 , ubiquitin-conjugating enzyme E2 R1 , alpha-chymase , chymase , mast cell chymase , mast cell protease I , coagulation factor 2 , thrombin , prepro-coagulation factor II , prothrombin B-chain , C1 esterase , complement C1s-A subcomponent , complement component 1 subcomponent s-A , complement component C1SA

325881 Danio rerio
712729 Macaca mulatta
299602 Rattus norvegicus
490628 Canis lupus familiaris
14061 Mus musculus
29251 Rattus norvegicus
2147 Homo sapiens
280685 Bos taurus
100144442 Sus scrofa
395306 Gallus gallus
100725988 Cavia porcellus
100307041 Ovis aries
50908 Mus musculus
100716225 Cavia porcellus
395990 Gallus gallus
783975 Bos taurus
100856539 Canis lupus familiaris
100008705 Oryctolagus cuniculus
100009146 Oryctolagus cuniculus
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