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Browse our Prothrombin Proteins (F2)

Full name:
Coagulation Factor II (thrombin) Proteins (F2)
On www.antibodies-online.com are 56 Coagulation Factor II (thrombin) (F2) Proteins from 14 different suppliers available. Additionally we are shipping Prothrombin Antibodies (202) and Prothrombin Kits (145) and many more products for this protein. A total of 411 Prothrombin products are currently listed.
Synonyms:
AA959438, AI255193, AI327365, C1sa, Cf-2, Cf2, F2, FII, HTRA, HTRA1, prothrombin, PT, RPRGL2, THPH1, thrombin, wu:fb57c10, wu:fd42e09, wu:fd59d01, zgc:66319
list all proteins Gene Name GeneID UniProt
F2 299602  
F2 14061 P19221
F2 2147 P00734

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Prothrombin Proteins (F2) by Origin

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Top referenced Prothrombin Proteins

  1. Mouse (Murine) Prothrombin Protein expressed in Human Cells - ABIN2007695 : Degen, McDowell, Sparks, Scharrer: Prothrombin Frankfurt: a dysfunctional prothrombin characterized by substitution of Glu-466 by Ala. in Thrombosis and haemostasis 1995 (PubMed)
    Show all 3 references for ABIN2007695

  2. Rat (Rattus) Prothrombin Protein expressed in Rat - ABIN491211 : Rancourt, Veress, Ahmad, Hendry-Hofer, Rioux, Garlick, White: Tissue factor pathway inhibitor prevents airway obstruction, respiratory failure and death due to sulfur mustard analog inhalation. in Toxicology and applied pharmacology 2013 (PubMed)

More Proteins for Prothrombin Interaction Partners

Zebrafish Coagulation Factor II (thrombin) (F2) interaction partners

  1. Prothrombin morpholino-injected zebrafish embryos yielded an early phenotype exhibiting severe abnormalities that later showed occasional bleeding

Rhesus Monkey Coagulation Factor II (thrombin) (F2) interaction partners

  1. The great similarity of prothrombin among rhesus, human, and porcine confirm the great value of the pig-to-rhesus xenotransplantation model.

Mouse (Murine) Coagulation Factor II (thrombin) (F2) interaction partners

  1. thrombin/PAR-1 (show MARK2 Proteins) interaction regulated MCP-1 (show CPT1B Proteins), TF, MCSF (show CSF1 Proteins) and IL-6 (show IL6 Proteins) production.

  2. Observations illustrate the role of thrombin as a pleiotropic atherogenic molecule under conditions of hypercholesterolemia and suggest the utility of its inhibition with locally acting antithrombin (show SERPINC1 Proteins) nanoparticle therapeutics.

  3. Thrombin-PAR1 (show F2R Proteins) signaling, via nitric oxide and EPCR (show PROCR Proteins), promotes hematopoietic stem cell (HSC (show FUT1 Proteins)) mobilization.

  4. Primary tumor growth by colon cancer cells was reduced by reduction of circulating prothrombin. There were lower mitotic indices and invasiveness. This growth relied upon 2 targets of thrombin-mediated proteolysis, protease: PAR-1 and fibrinogen.

  5. Thrombin promotes sustained signaling and inflammatory gene expression through the CDC25 and Ras-associating domains of phospholipase C epsilon.

  6. thrombin/PAR1 (show F2R Proteins) pathway as a novel target for developing therapeutic strategies to restore synaptic function in the acute phase of ischemic stroke.

  7. High Factor IIa expression is associated with multiorgan pathologies in sickle cell disease.

  8. Blockage of thrombin exosites with compounds specific for exosite I (hirudin and HD1 (show HDAC1 Proteins) aptamer) or exosite II (heparin and HD22 aptamer) impaired the COMP (show COMP Proteins)-thrombin interaction, indicating a 2-site binding mechanism.

  9. Whole blood thrombin generation assay is capable of detecting a prothrombotic phenotype in Bmal1 (show ARNTL Proteins)-KO mice.

  10. Fyn (show FYN Proteins), but not Lyn (show LYN Proteins), was required for complete Pyk2 (show PTK2B Proteins) phosphorylation by thrombin.

Human Coagulation Factor II (thrombin) (F2) interaction partners

  1. The prothrombin (F2) c.20210G>A mutation was present in 3.3% of 400 ischemic stroke patients in Sri (show SRI Proteins) Lanka. It was not associated significantly with venous thrombosis compared with arterial thrombosis.

  2. thrombin/PAR-1 (show MARK2 Proteins) interaction regulated MCP-1 (show CCL2 Proteins), TF, MCSF (show CSF1 Proteins) and IL-6 (show IL6 Proteins) production.

  3. This review focuses on elucidation of the cerebral thrombin expression, local generation and its role in injury and disease of the central nervous system. [review]

  4. The present data showed that FVL (show F5 Proteins), MTHFR (show MTHFR Proteins) polymorphisms also combined with thrombophilic gene mutations have a strong association with recurrent pregnancy loss.

  5. the co-localization of thrombin and factor XI and the resultant efficient activation of FXI (show F11 Proteins) requires GPIb alpha (show GP1BA Proteins)

  6. Prothrombin G20210 A mutation was present in 2% (4 of 196 patients), and it was not found in the healthy controls.

  7. the accuracy of des (show DES Proteins)-gamma-carboxy prothrombin for distinguishing hepatocellular carcinoma from various controls was 6.2-9.7% higher than that of alpha-fetoprotein (show AFP Proteins)

  8. amino acid sequence Leu(480)-Gln(481): 1) is crucial for proper recognition of the fVa-dependent site(s) for fXa (show F10 Proteins) within prothrombinase (show F10 Proteins) on FII.

  9. Data suggest that thrombin can directly activate PAR2 (show F2RL1 Proteins) vasorelaxation, signal transduction (stimulating both calcium and MAP kinase (show MAPK1 Proteins) responses), and triggering beta-arrestin recruitment (both beta-arrestin 1 (show ARRB1 Proteins) and 2).

  10. Studies indicate that prothrombin G20210A mutation is significantly associated with cerebral venous thrombosis when compared to healthy controls, although this association is highly dependent on the country of origin.

Cow (Bovine) Coagulation Factor II (thrombin) (F2) interaction partners

  1. the weaker rapid interaction between prothrombin and membranes is the most important in vivo when considering the activation of prothrombin at the cell surface.

  2. novel pyranosic sulfated (show SULF1 Proteins) arabinan Ab1 exerts its anticoagulant activity on thrombin by a mechanism different from those found previously for other sulfated (show SULF1 Proteins) polysaccharides and glycosaminoglycans

  3. Exogenous delivery of thrombin enhances microvascular collateral development in response to ischemic insult, and accelerates tissue reperfusion.

  4. the signaling pathways of MAPK (show MAPK1 Proteins), MSK1 (show RPS6KA5 Proteins), and NF-kappaB (show NFKB1 Proteins) play important roles in thrombin-induced iNOS (show NOS2 Proteins) expression in alveolar macrophages

  5. High glucose enhances smooth muscle cell responsiveness to thrombin through transcriptional upregulation of PAR-4, mediated via PKC and NFkappaB.

  6. Thrombin induces a sustained contraction in the normal pulmonary artery, by activating PAR(1 (show F2R Proteins)) and thereby increasing the sensitivity of the myofilament to Ca(2 (show CA2 Proteins)+).

  7. kinetic and structural analysis of interactions between thrombin and the Factor XIII (show UGDH Proteins) activation peptide

  8. analysis of staphylocoagulase-mediated bovine prothrombin activation

  9. thrombin and factor Xa (show F10 Proteins) diffusion along the heparin molecule explains the effects of extended heparin chain lengths

  10. A comparison of recombinant thrombin to bovine thrombin as a hemostatic ancillary in patients undergoing peripheral arterial bypass and arteriovenous graft procedures.

Pig (Porcine) Coagulation Factor II (thrombin) (F2) interaction partners

  1. thrombin stimulates transglutaminase activity in articular cartilage by directly cleaving factor XIII (show UGDH Proteins) and by receptor-mediated up-regulation of factor XIII (show UGDH Proteins) synthesis

  2. The great similarity of prothrombin among rhesus, human, and porcine confirm the great value of the pig-to-rhesus xenotransplantation model.

  3. In conclusion, thrombin activates pro-MMP-2 (show MMP2 Proteins) in the absence of elevated pro-MMP-2 (show MMP2 Proteins) expression and secretion in CSMCs, and thrombin induces CSMC mitogenesis involving its action on MMP-2 (show MMP2 Proteins)

  4. Thrombin stimulates swine smooth muscle cell differentiation from peripheral blood mononuclear cells via protease-activated receptor-1, RhoA, and myocardin.

Prothrombin (F2) Protein Profile

Protein Summary

Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Mutations in F2 leads to various forms of thrombosis and dysprothrombinemia.

Alternative names and synonyms associated with Prothrombin (F2)

  • coagulation factor II (thrombin) (f2)
  • coagulation factor II (thrombin) (F2)
  • cell division cycle 34 (Cdc34)
  • chymase 1, mast cell (CMA1)
  • coagulation factor II (F2)
  • complement component 1, s subcomponent (C1s)
  • HtrA serine peptidase 1 (Htra1)
  • HtrA serine peptidase 2 (HTRA2)
  • melanoma antigen family B, 17-like (LOC783975)
  • prothrombin-like (LOC100856539)
  • serine protease (HTRA)
  • THROMBIN protein (THROMBIN)
  • AA959438 protein
  • AI255193 protein
  • AI327365 protein
  • C1sa protein
  • Cf-2 protein
  • Cf2 protein
  • F2 protein
  • FII protein
  • HTRA protein
  • HTRA1 protein
  • prothrombin protein
  • PT protein
  • RPRGL2 protein
  • THPH1 protein
  • thrombin protein
  • wu:fb57c10 protein
  • wu:fd42e09 protein
  • wu:fd59d01 protein
  • zgc:66319 protein

Protein level used designations for F2

prothrombin , cell division cycle 34 homolog , serine protease , ubiquitin-conjugating enzyme Cdc34 , ubiquitin-conjugating enzyme E2 R1 , alpha-chymase , chymase , mast cell chymase , mast cell protease I , coagulation factor 2 , thrombin , prepro-coagulation factor II , prothrombin B-chain , C1 esterase , complement C1s-A subcomponent , complement component 1 subcomponent s-A , complement component C1SA

GENE ID SPECIES
325881 Danio rerio
712729 Macaca mulatta
299602 Rattus norvegicus
490628 Canis lupus familiaris
14061 Mus musculus
29251 Rattus norvegicus
2147 Homo sapiens
280685 Bos taurus
100144442 Sus scrofa
395306 Gallus gallus
100725988 Cavia porcellus
100307041 Ovis aries
50908 Mus musculus
100716225 Cavia porcellus
395990 Gallus gallus
783975 Bos taurus
100856539 Canis lupus familiaris
100008705 Oryctolagus cuniculus
100009146 Oryctolagus cuniculus
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