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TdT expression was most prominent in thymus, pro- and mesonephros, the primary lymphoid organs in teleost fish and in spleen, intestine, and the tissue around the intestine.
Ubiquitylation of terminal deoxynucleotidyltransferase inhibits its activity.
TdT is essential for the generation of the predominant higher-affinity DEX-responsive J558 clone
Production of M603-id antibody is TdT dependent, while generation of M167-id antibody is TdT independent.
onset of terminal deoxynucleotidyl transferase gene activation during T cell differentiation and thymic ontogeny
The role of this locus in autoantibody production in MRL/lpr (show FAS Proteins) mouse strain, and subsequent development of kidney disease.
tdt may be involved in learning and memory saving.
There is an observed decrease in the incidence of autoimmune disease, including absence of diabetes and decreased pancreatic infiltration in NOD TdT-deficient mice, and reduced glomerulonephritis and increased life span in MRL-Fas(lpr (show FAS Proteins)) TdT-deficient mice.
Structure-function analysis of proposed domains and motifs for known activity of TdT reveals nonessential role for tumor suppressor BRCA1 (show BRCA1 Proteins) C-terminal (BRCT) domain and essential roles for second helix-hairpin-helix motif and entire C terminus of TdT.
third hypervariable region assumes for each immunoglobulin chain, with DNA polymerase (show POLB Proteins) (pol) lambda (show POLL Proteins) maintaining a large heavy chain junctional heterogeneity and pol mu (show POLM Proteins) ensuring a restricted light chain junctional variability
TdT plays a critical role in the magnitude and breadth of anti-viral T(CD8 (show CD8A Proteins)+) responses toward individual determinants
The role of TdT ensures enhanced diversity and selection of private T cell receptor repertoires and promotes optimal CD8 (show CD8A Proteins)-positive T cell immunity, both within individuals and across the species as a whole.
Absence of TdT expression identifies a subset of high-risk T-acute lymphoblastic leukemia/lymphoma that overlaps with, but is not identical to, the ETP leukemia, providing additional prognostic value.
Our study confirms that PAX5 (show PAX5 Proteins) and TdT expression can be expressed in a high percentage of Merkel cell carcinomas and so when positive are not diagnostic of lymphoblastic leukemia/lymphoma.
Overexpression of newly discovered alternatively spliced short or long human TdT isoforms greatly reduces the efficiency of recombination, which is reverted to normal levels by the simultaneous expression of both enzymes.
In spleen, appendix and branchial cleft cysts the range of TdT-positivity was 0-13, 0-96 and 0-6 TdT+ cells per high-power field.
The TdT binding, DNA binding and dimerization regions, and nuclear localization signal (NLS (show ALDH1A2 Proteins)) in TdIF1 (show DNTTIP1 Proteins), were identified.
This gene is a member of the DNA polymerase type-X family and encodes a template-independent DNA polymerase that catalyzes the addition of deoxynucleotides to the 3'-hydroxyl terminus of oligonucleotide primers. In vivo, the encoded protein is expressed in a restricted population of normal and malignant pre-B and pre-T lymphocytes during early differentiation, where it generates antigen receptor diversity by synthesizing non-germ line elements (N-regions) at the junctions of rearranged Ig heavy chain and T cell receptor gene segments. Alternatively spliced transcript variants encoding different isoforms of this gene have been described.
, DNA nucleotidylexotransferase
, terminal deoxynucleotidyl transferase
, terminal addition enzyme
, terminal transferase
, deoxynucleotidyltransferase, terminal
, nucleosidetriphosphate:DNA deoxynucleotidylexotransferase
, terminal deoxyribonucleotidyltransferase