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TdT Products

(Deoxynucleotidyltransferase, terminal (DNTT))
This gene is a member of the DNA polymerase type-X family and encodes a template-independent DNA polymerase that catalyzes the addition of deoxynucleotides to the 3'-hydroxyl terminus of oligonucleotide primers. In vivo, the encoded protein is expressed in a restricted population of normal and malignant pre-B and pre-T lymphocytes during early differentiation, where it generates antigen receptor diversity by synthesizing non-germ line elements (N-regions) at the junctions of rearranged Ig heavy chain and T cell receptor gene segments. Alternatively spliced transcript variants encoding different isoforms of this gene have been described. [provided by RefSeq, Jul 2008].

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Featured TdT Categories

TdT Antibodies

High quality antibodies with extensive validation data.

TdT ELISA Kits

Reliable ELISA kits for a wide range of species.

TdT Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended TdT Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Rat
Application ELISA, FACS, ICC, IHC, WB
Validations
  • (5)
Cat. No. ABIN5542551
Quantity 0.1 mg
Datasheet Datasheet
Reactivity Human
Application WB
Validations
  • (9)
  • (2)
Cat. No. ABIN3043577
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application ELISA, WB
Validations
  • (3)
Cat. No. ABIN560634
Quantity 100 μg
Datasheet Datasheet

Recommended TdT ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6966320
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method
Validations
Cat. No. ABIN1130055
Quantity 96 tests
Datasheet Datasheet
Reactivity Cow
Analytical Method
Validations
Cat. No. ABIN1130053
Quantity 96 tests
Datasheet Datasheet

Recommended TdT Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3073778
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3132708
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN5709413
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our TdT products

Mann, Newberg, Black, Jones, Amaya-Manzanares, Guzman-Rojas, Kodama, Ward, Rust, van der Weyden, Yew, Waters, Leung, Rogers, Rogers, McNoe, Selvanesan, Navin, Jenkins, Copeland, Mann: "Analyzing tumor heterogeneity and driver genes in single myeloid leukemia cells with SBCapSeq." in: Nature biotechnology, Vol. 34, Issue 9, pp. 962-72, (2016) (PubMed).

Troshchynsky, Dzneladze, Chen, Sheng, Saridakis, Wu: "Functional analyses of polymorphic variants of human terminal deoxynucleotidyl transferase." in: Genes and immunity, Vol. 16, Issue 6, pp. 388-98, (2015) (PubMed).

Zhang, Pei, Ru, Li, Liu: "Bone morphogenetic protein 7 upregulates the expression of nestin and glial fibrillary acidic protein in rats with cerebral ischemia-reperfusion injury." in: Biomedical reports, Vol. 1, Issue 6, pp. 895-900, (2014) (PubMed).

Yang, Zhang, Ding, Huang, Chen, Wu, Wang, Wang, Chen: "Antitumour activity of the recombination polypeptide GST-NT21MP is mediated by inhibition of CXCR4 pathway in breast cancer." in: British journal of cancer, Vol. 110, Issue 5, pp. 1288-97, (2014) (PubMed).

Tochinai, Ando, Suzuki, Suzuki, Nagata, Hata, Uchida, Kobayashi, Kado, Kaneko: "Histopathological studies of microtubule disassembling agent-induced myocardial lesions in rats." in: Experimental and toxicologic pathology : official journal of the Gesellschaft fu?r Toxikologische Pathologie, Vol. 65, Issue 6, pp. 737-43, (2013) (PubMed).

Zeng, Ke, Song, Yao, Hu, Zhang, Li, Yin: "Annexin A3 is associated with a poor prognosis in breast cancer and participates in the modulation of apoptosis in vitro by affecting the Bcl-2/Bax balance." in: Experimental and molecular pathology, Vol. 95, Issue 1, pp. 23-31, (2013) (PubMed).

Xi, Wang, Ye, Luo, Ning: "Combined adenovirus-mediated artificial microRNAs targeting mfgl2, mFas, and mTNFR1 protect against fulminant hepatic failure in mice." in: PLoS ONE, Vol. 8, Issue 11, pp. e82330, (2013) (PubMed).

Gong, Zheng, Wang, Chen, Pang, Hu, Cao: "Coexistence of hyperlipidemia and acute cerebral ischemia/reperfusion induces severe liver damage in a rat model." in: World journal of gastroenterology, Vol. 18, Issue 35, pp. 4934-43, (2012) (PubMed).

Luo, Xia: "A small dose of hydrogen peroxide enhances tumor necrosis factor-alpha toxicity in inducing human vascular endothelial cell apoptosis: reversal with propofol." in: Anesthesia and analgesia, Vol. 103, Issue 1, pp. 110-6, table of contents, (2006) (PubMed).

Luo, Xia, Ansley, Ouyang, Granville, Li, Xia, Zhou, Liu: "Propofol dose-dependently reduces tumor necrosis factor-alpha-Induced human umbilical vein endothelial cell apoptosis: effects on Bcl-2 and Bax expression and nitric oxide generation." in: Anesthesia and analgesia, Vol. 100, Issue 6, pp. 1653-9, (2005) (PubMed).

Synonyms and alternative names related to TdT

DNA nucleotidylexotransferase (DNTT), deoxynucleotidyltransferase, terminal (dntt), deoxynucleotidyltransferase, terminal (Dntt), DNA nucleotidylexotransferase L homeolog (dntt.L), DNA nucleotidylexotransferase (Dntt), terminal deoxynucleotidyl transferase (tdt), BB160593, dntt, dntt-A, TdT, TDT, Tdt

Protein level used designations for TdT

  • terminal deoxynucleotidyltransferase
  • DNA nucleotidylexotransferase
  • terminal deoxynucleotidyl transferase
  • TDT
  • terminal addition enzyme
  • terminal transferase
  • deoxynucleotidyltransferase, terminal
  • nucleosidetriphosphate:DNA deoxynucleotidylexotransferase
  • terminal deoxyribonucleotidyltransferase
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