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anti-Human ERCC1 Antibodies:
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Chinese Hamster Monoclonal ERCC1 Primary Antibody for ICC, IF - ABIN269278
Al-Minawi, Saleh-Gohari, Helleday: The ERCC1/XPF endonuclease is required for efficient single-strand annealing and gene conversion in mammalian cells. in Nucleic acids research 2008
Show all 15 Pubmed References
Human Monoclonal ERCC1 Primary Antibody for ICC, IF - ABIN2720418
Ma, Baruch, Shu, Yuan, Sun, Ma, Hoang, Fu, Min, Lan, Wang, Mull, He: Using protein microarray technology to screen anti-ERCC1 monoclonal antibodies for specificity and applications in pathology. in BMC biotechnology 2012
Show all 4 Pubmed References
Human Monoclonal ERCC1 Primary Antibody for WB - ABIN1882194
Hoeijmakers, van Duin, Westerveld, Yasui, Bootsma: Identification of DNA repair genes in the human genome. in Cold Spring Harbor symposia on quantitative biology 1987
Show all 3 Pubmed References
Human Monoclonal ERCC1 Primary Antibody for IHC (p) - ABIN1688063
Muley, Sianidou, Thomas, Bischoff, Dienemann, Meister, Schneider, Schnabel, Warth: Comparison of two ERCC1 antibodies as prognostic and predictive biomarkers for early non-small cell lung cancer. in Anticancer research 2014
Show all 2 Pubmed References
Human Monoclonal ERCC1 Primary Antibody for IP, WB - ABIN967531
Kenigsberg, Elliott, Cuello: Two distinct monoclonal antibodies raised against mouse beta nerve growth factor. Generation of bi-specific anti-nerve growth factor anti-horseradish peroxidase antibodies for use in a homogeneous enzyme immunoassay. in Journal of immunological methods 1991
Human Monoclonal ERCC1 Primary Antibody for ICC, IF - ABIN151044
Tentori, Muzi, Dorio, Dolci, Campolo, Vernole, Lacal, Praz, Graziani: MSH3 expression does not influence the sensitivity of colon cancer HCT116 cell line to oxaliplatin and poly(ADP-ribose) polymerase (PARP) inhibitor as monotherapy or in combination. in Cancer chemotherapy and pharmacology 2013
Human Polyclonal ERCC1 Primary Antibody for ELISA, WB - ABIN314230
Zhang, Liu, Li, Legerski: Double-strand breaks induce homologous recombinational repair of interstrand cross-links via cooperation of MSH2, ERCC1-XPF, REV3, and the Fanconi anemia pathway. in DNA repair 2007
We demonstrated an association between six previously published single nucleotide polymorphisms (rs15869 [ BRCA2 (show BRCA2 Antibodies)], rs1805389 [ LIG4 (show LIG4 Antibodies)], rs8079544 [ TP53 (show TP53 Antibodies)], rs25489 [ XRCC1 (show XRCC1 Antibodies)], rs1673041 [ POLD1 (show POLD1 Antibodies)], and rs11615 [ ERCC1]) and subsequent CNS tumors in survivors of childhood cancer treated by radiation therapy.
Genetic polymorphism in ERCC1 gene is associated with response to chemotherapy in osteosarcoma.
ERCC1 was not detectable in the nucleus of the XPF (show ERCC4 Antibodies) knockout cells indicating the necessity of a functional XPF (show ERCC4 Antibodies)/ERCC1 heterodimer to allow ERCC1 to enter the nucleus.
There is no association between the ERCC1 C19007T polymorphism and platinum-based chemotherapy effectiveness in ovarian cancer. The polymorphism did not have a significant impact on platinum-based chemotherapy in non-responders and responders.
The T allele at ERCC1 rs11615 may interact with smoking and alcohol drinking status to determine personal susceptibility to colorectal cancer.
Strikingly, the addition of the single-stranded DNA (ssDNA)-binding replication protein A (RPA) selectively restores XPF-ERCC1 endonuclease activity on this structure. The 5'-3' exonuclease SNM1A can load from the XPF-ERCC1-RPA-induced incisions and digest past the crosslink to quantitatively complete the unhooking reaction.
ERCC1 mutation along with BRCA1 mutation confers chemoresistance in breast cancer.
The authors have discovered a major sub-pathway of conventional long-patch base excision repair that involves formation of a 9-nucleotide gap 5' to the lesion. This new sub-pathway is mediated by RECQ1 (show RECQL Antibodies) DNA helicase and ERCC1-XPF (show ERCC4 Antibodies) endonuclease in cooperation with PARP1 poly(ADP-ribose) polymerase (show PARP1 Antibodies) and RPA (show RPA1 Antibodies).
Based on structural models, NMR titrations, DNA-binding studies, site-directed mutagenesis, charge distribution, and sequence conservation, we propose that the HhH (show SLC25A15 Antibodies) domain of ERCC1 binds to dsDNA upstream of the damage, and XPF (show ERCC4 Antibodies) binds to the non-damaged strand within a repair bubble
Meta-analysis indicated that the ERCC1 rs3212986 polymorphism and 2 polymorphisms in ERCC2 (show ERCC2 Antibodies) gene (rs13181 and rs1799793) contributed to the susceptibility of glioma.
Dietary tryptophan restriction increased microbial diversity and made the gut (show GUSB Antibodies) microbiota composition of old Ercc1(-/Delta7) mice more similar to that of young WT mice.
ERCC1-XPF (show ERCC4 Antibodies) cooperates with CTCF (show CTCF Antibodies) and cohesin to facilitate the developmental silencing of imprinted genes and that persistent DNA damage triggers chromatin changes that affect gene expression programs associated with NER (show NR1H2 Antibodies) disorders.
we quantified the frequency of aneuploidy of three autosomes in the cerebral cortex and cerebellum of adult and developing brain of Bub1b (show BUB1B Antibodies)(H/H) mice, which have a faulty mitotic checkpoint (show BUB3 Antibodies), and Ercc1(-/Delta7) mice, defective in nucleotide excision repair and inter-strand crosslink repair. we found that Bub1b (show BUB1B Antibodies)(H/H), but not Ercc1(-/Delta7) mice, have a significantly higher frequency of aneuploid nuclei relative to wild-t...
these results establish USP45 as a new regulator of XPF (show ERCC4 Antibodies)-ERCC1 crucial for efficient DNA repair
ERCC1 is critical for protecting chondrocytes from catabolic stress and is associated with the pathophysiology of osteoarthritis.
SLX4 (show BTBD12 Antibodies) is a tumor suppressor, which activates XPF (show ERCC4 Antibodies)-ERCC1 nuclease (show DCLRE1C Antibodies) specificity in DNA crosslink repair.
ERCC1 is essential for melanoma growth and resistance to cisplatin.
Smad4 (show SMAD4 Antibodies) loss-associated Snail (show SNAI1 Antibodies) reduction compromises Ercc1-mediated DNA repair, contributing to increased UV-induced skin carcinogenesis.
analysis of accelerated loss of hearing and vision in the DNA-repair deficient Ercc1(delta/-) mouse
This study demonistrated that the ERCC1 deficiency-associated downregulation of the cholesterol biosynthesis pathway is at least in part due to lowered expression of its master transcription factor SREBF2 (show SREBF2 Antibodies)
ERCC1 and XPF (show ERCC4 Antibodies) protect short telomeres from homologous recombination.
These data support a model in which the interstrand crosslink repair-specific function of XPF-ERCC1 is dependent on recruitment, positioning and substrate recognition.
The product of this gene functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF endonuclease (also known as ERCC4), and the heterodimeric endonuclease catalyzes the 5' incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved in recombinational DNA repair and in the repair of inter-strand crosslinks. Mutations in this gene result in cerebrooculofacioskeletal syndrome, and polymorphisms that alter expression of this gene may play a role in carcinogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. The last exon of this gene overlaps with the CD3e molecule, epsilon associated protein gene on the opposite strand.
DNA excision repair protein ERCC-1
, excision repair 1
, excision repair cross-complementing 1
, excision repair protein
, excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)