ERCC1 Products
(Excision Repair Cross Complementing Polypeptide-1 (ERCC1))
Categories
The product of this gene functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF endonuclease (also known as ERCC4), and the heterodimeric endonuclease catalyzes the 5' incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved in recombinational DNA repair and in the repair of inter-strand crosslinks. Mutations in this gene result in cerebrooculofacioskeletal syndrome, and polymorphisms that alter expression of this gene may play a role in carcinogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. The last exon of this gene overlaps with the CD3e molecule, epsilon associated protein gene on the opposite strand. [provided by RefSeq, Oct 2009].
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Featured ERCC1 Categories
ERCC1 Antibodies
High quality antibodies with extensive validation data.
ERCC1 ELISA Kits
Reliable ELISA kits for a wide range of species.
ERCC1 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended ERCC1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro)
Validations
- (6)
Cat. No.
ABIN733553
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, ELISA, IHC, FACS
Validations
- (7)
Cat. No.
ABIN7193699
Quantity
0.1 mg
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC, FACS, ICC
Validations
- (5)
Cat. No.
ABIN5542431
Quantity
0.1 mg
Datasheet
Datasheet
Recommended ERCC1 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN6955669
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6966615
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human, Mouse
Analytical Method
Qualitative Cell ELISA
Validations
Cat. No.
ABIN1381118
Quantity
96 tests
Datasheet
Datasheet
Recommended ERCC1 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7122859
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7122858
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1353029
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our ERCC1 products
: "ERCC1 as predictive biomarker to platinum-based chemotherapy in adrenocortical carcinomas." in: European journal of endocrinology, Vol. 178, Issue 2, pp. 181-188, (2018) (PubMed).: "A novel antibody-based approach to detect the functional ERCC1-202 isoform." in: DNA repair, Vol. 64, pp. 34-44, (2018) (PubMed).
: "The age-related expression decline of ERCC1 and XPF for forensic age estimation: A preliminary study." in: Journal of forensic and legal medicine, Vol. 49, pp. 15-19, (2017) (PubMed).
: "Development and Validation of an ERCC1 Immunohistochemistry Assay for Solid Tumors." in: Archives of pathology & laboratory medicine, Vol. 140, Issue 12, pp. 1397-1403, (2016) (PubMed).
: "Aging asymmetry: systematic survey of changes in age-related biomarkers in the annual fish Nothobranchius guentheri." in: Fish physiology and biochemistry, (2016) (PubMed).
: "Classic biphasic pulmonary blastoma with brain and axillary metastases: a case report with molecular analysis and review of literature." in: International journal of clinical and experimental pathology, Vol. 8, Issue 1, pp. 983-8, (2015) (PubMed).
: "Accumulation of an endogenous tryptophan-derived metabolite in colorectal and breast cancers." in: PLoS ONE, Vol. 10, Issue 4, pp. e0122046, (2015) (PubMed).
: "The clue of a possible etiology about spontaneous regression of hepatocellular carcinoma: a perspective on pathology." in: OncoTargets and therapy, Vol. 8, pp. 395-400, (2015) (PubMed).
: "Primary urinary bladder adenosquamous carcinoma complicated with lower limb deep venous thromboses: a case report." in: International journal of clinical and experimental pathology, Vol. 7, Issue 12, pp. 9032-7, (2015) (PubMed).
: "A phase 2 cooperative group adjuvant trial using a biomarker-based decision algorithm in patients with stage I non-small cell lung cancer (SWOG-0720, NCT00792701)." in: Cancer, Vol. 120, Issue 15, pp. 2343-51, (2014) (PubMed).
Synonyms and alternative names related to ERCC1
ERCC excision repair 1, endonuclease non-catalytic subunit (ERCC1), excision repair cross-complementing rodent repair deficiency, complementation group 1 (Ercc1), ERCC excision repair 1, endonuclease non-catalytic subunit (Ercc1), DNA excision repair protein ERCC-1 (CC1G_04546), DNA excision repair protein ERCC-1 (CpipJ_CPIJ013903), DNA excision repair protein ERCC-1 (PITG_13719), ERCC excision repair 1, endonuclease non-catalytic subunit (ercc1), nucleotide repair protein (ERCC1), excision repair cross-complementation group 1 L homeolog (ercc1.L), excision repair cross-complementation group 1 (ercc1), COFS4, Ercc-1, ercc1, RAD10, T12H1.18, T12H1_18, UV20, UVR7, UV REPAIR DEFICIENT 7Protein level used designations for ERCC1
- DNA excision repair protein ERCC-1
- excision repair 1
- excision repair cross-complementing 1
- excision repair protein
- excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)
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