Browse our MBD4 Proteins (MBD4)

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Methyl-CpG Binding Domain Protein 4 Proteins (MBD4)
On are 4 Methyl-CpG Binding Domain Protein 4 (MBD4) Proteins from 2 different suppliers available. Additionally we are shipping MBD4 Antibodies (70) and many more products for this protein. A total of 78 MBD4 products are currently listed.
list all proteins Gene Name GeneID UniProt
MBD4 8930 O95243
MBD4 17193 Q9Z2D7
Rat MBD4 MBD4 680915  

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Human Methyl-CpG Binding Domain Protein 4 (MBD4) interaction partners

  1. a novel molecular mechanism by which MBD4 inhibits GITR (show TNFRSF18 Proteins) expression in a DNMT1 (show DNMT1 Proteins)-dependent manner

  2. these data suggest that MBD4 inactivation may contribute to tumorigenesis, acting as a modifier of mismatch repair-deficient cancer phenotype.

  3. MBD4 rs3138373 A>G and rs2005618 T>C single nucleotide polymorphisms were not associated with esophageal squamous cell carcinoma (ESCC) risk. rs3138355 GG genotype was associated with a decreased risk of ESCC among male patients and the elderly.

  4. The ability of MBD4 to directly interact with and recruit USP7 (show USP7 Proteins) to chromocenters implicates it as an additional factor that can potentially regulate Dnmt1 (show DNMT1 Proteins) activity during cell proliferation.

  5. Interaction between DNMT1 (show DNMT1 Proteins) and MBD4 is involved in controlling gene expression and responding to oxidative stress.

  6. ERCC4 rs1800124 and MBD4 rs10342 non-synonymous single nucleotide polymorphism variants were associated with DNA repair capacity.

  7. the crystal structure of MBD4 bound to 5-hydroxymethylcytosine further demonstrates that MBDMBD4 is able to recognize a wide range of 5-methylcytosine modifications

  8. MBD4 Glu346Lys polymorphism is associated with the risk of cervical cancer in a Chinese population.

  9. Crystal structures of human MBD4(catalytic domain) reveal that MBD4 uses a base flipping mechanism to specifically recognize thymine and 5-hydroxymethyluracil.

  10. specificity of MBD4 for acting at CpG sites depends largely on its methyl-CpG-binding domain, which binds preferably to G.T mispairs in a methylated CpG site

Mouse (Murine) Methyl-CpG Binding Domain Protein 4 (MBD4) interaction partners

  1. Mbd4 is a component of mismatch repair-directed DNA end processing.

  2. A variant Mbd4 transcript spanning exons 1,6-8 is expressed in Mbd4 deficient B cells.

  3. the crystal structure of MBD4 bound to 5-hydroxymethylcytosine further demonstrates that MBDMBD4 is able to recognize a wide range of 5-methylcytosine modifications

  4. studies indicate that, although inactivation of Mbd4 does not by itself cause cancer predisposition in mice, it can alter the mutation spectrum in cancer cells and modify the cancer predisposition phenotype

  5. structure and activity of the mismatch-specific thymine glycosylase domain of MBD4

  6. Mbd4 glycosylase does not significantly contribute to mechanisms of antibody diversification, as analyzed by an in vitro switch assay and by in vivo immunizations in Mbd4-/- knockout mice.

  7. results establish a novel functional role for MBD4 in the cellular response to DNA damage and may have implications for its role in suppressing neoplasia

  8. MED1 has a role in cell cycle arrest and apoptosis induced by DNA damage

  9. in the context of MMR (show MRC1 Proteins) deficiency, additional loss of Mbd4 does not alter spontaneous mutation frequency at the endogenous Dlb-1b locus, nor does it modify tumour onset, tumour spectrum or MSI (show EBP Proteins)

  10. Med1 depleted cells exhibited an exacerbated response to retinoids, both in terms transcriptional responses and of cellular differentiation.

MBD4 Protein Profile

Protein Summary

The protein encoded by this gene is a member of a family of nuclear proteins related by the presence of a methyl-CpG binding domain (MBD). These proteins are capable of binding specifically to methylated DNA, and some members can also repress transcription from methylated gene promoters. This protein contains an MBD domain at the N-terminus that functions both in binding to methylated DNA and in protein interactions and a C-terminal mismatch-specific glycosylase domain that is involved in DNA repair. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Alternative names and synonyms associated with MBD4

  • methyl-CpG binding domain protein 4 (MBD4)
  • methyl-CpG binding domain protein 4 (Mbd4)
  • Med1 protein

Protein level used designations for MBD4

3,N(4)-ethenocytosine glycosylase , G/5-fluorouracil mismatch glycosylase with biphasic kinetics , G/T mismatch glycosylase , G/U mismatch glycosylase , methyl-CpG-binding domain protein 4 , methyl-CpG-binding endonuclease 1 , methyl-CpG-binding protein MBD4 , mismatch-specific DNA N-glycosylase , putative methyl-CpG binding protein

8930 Homo sapiens
17193 Mus musculus
680915 Rattus norvegicus
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