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Browse our anti-MGMT (MGMT) Antibodies

Full name:
anti-O6-Methylguanine-DNA-Methyltransferase Antibodies (MGMT)
On www.antibodies-online.com are 202 O6-Methylguanine-DNA-Methyltransferase (MGMT) Antibodies from 28 different suppliers available. Additionally we are shipping MGMT Kits (29) and MGMT Proteins (25) and many more products for this protein. A total of 268 MGMT products are currently listed.
Synonyms:
Agat, AGT, AI267024
list all antibodies Gene Name GeneID UniProt
MGMT 4255  
MGMT 17314 P26187
MGMT 25332 P24528

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Most Popular Reactivities for anti-MGMT (MGMT) Antibodies

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anti-Human MGMT Antibodies:

anti-Mouse (Murine) MGMT Antibodies:

anti-Rat (Rattus) MGMT Antibodies:

All available anti-MGMT Antibodies

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Top referenced anti-MGMT Antibodies

  1. Human Monoclonal MGMT Primary Antibody for CyTOF, FACS - ABIN151202 : Kokkinakis, Ahmed, Delgado, Fruitwala, Mohiuddin, Albores-Saavedra: Role of O6-methylguanine-DNA methyltransferase in the resistance of pancreatic tumors to DNA alkylating agents. in Cancer research 1998 (PubMed)
    Show all 19 references for ABIN151202

  2. Human Monoclonal MGMT Primary Antibody for IHC (p), IHC - ABIN152115 : Takeshita, Inoshita, Taguchi, Okuda, Fukuhara, Oyama, Ohashi, Sano, Takeuchi, Yamada: High incidence of low O(6)-methylguanine DNA methyltransferase expression in invasive macroadenomas of Cushing's disease. in European journal of endocrinology 2009 (PubMed)
    Show all 5 references for ABIN152115

  3. Human Monoclonal MGMT Primary Antibody for WB - ABIN1882266 : Tano, Shiota, Collier, Foote, Mitra: Isolation and structural characterization of a cDNA clone encoding the human DNA repair protein for O6-alkylguanine. in Proceedings of the National Academy of Sciences of the United States of America 1990 (PubMed)
    Show all 5 references for ABIN1882266

  4. Human Monoclonal MGMT Primary Antibody for FACS, IHC (p) - ABIN180357 : Harris, Potter, Remack, Brent: A comparison of human O6-methylguanine-DNA methyltransferase promoter activity in Mer+ and Mer- cells. in Cancer research 1992 (PubMed)
    Show all 4 references for ABIN180357

  5. Human Polyclonal MGMT Primary Antibody for EIA, WB - ABIN953415 : Svrcek, Buhard, Colas, Coulet, Dumont, Massaoudi, Lamri, Hamelin, Cosnes, Oliveira, Seruca, Gaub, Legrain, Collura, Lascols, Tiret, Fléjou, Duval: Methylation tolerance due to an O6-methylguanine DNA methyltransferase (MGMT) field defect in the colonic mucosa: an initiating step in the development of mismatch repair-deficient colorectal cancers. in Gut 2010 (PubMed)
    Show all 3 references for ABIN953415

  6. Human Polyclonal MGMT Primary Antibody for FACS, IHC (p) - ABIN391514 : Kim, Suh, Choi, Kang, Shin, Lee, Moon, Kim: Inactivation of O6-methylguanine-DNA methyltransferase in soft tissue sarcomas: association with K-ras mutations. in Human pathology 2009 (PubMed)
    Show all 3 references for ABIN391514

  7. Human Polyclonal MGMT Primary Antibody for IF (p), IHC (p) - ABIN730768 : Oláh, Kálmán, Tóth, Zvara, Sántha, Ivitz, Janka, Pákáski: Proteomic Analysis of Cerebrospinal Fluid in Alzheimer's Disease: Wanted Dead or Alive. in Journal of Alzheimer's disease : JAD 2014 (PubMed)

More Antibodies against MGMT Interaction Partners

Human O6-Methylguanine-DNA-Methyltransferase (MGMT) interaction partners

  1. Efficacy of TMZ in adrenocortical carcinoma cells does not seem to be limited by low methylation of MGMT.

  2. MGMT is involved in gastric carcinogenesis via downregulation of MMP2 (show MMP2 Antibodies).

  3. Study suggests that treatment effects of upfront radiotherapy plus concomitant and maintenance temozolomide might offset some of the beneficial effects of cytoreductive surgery in case of a methylated MGMT promoter whereas this unfortunately seems not be true for unmethylated tumors

  4. our results suggest that an aberrant messenger RNA expression may be the outcome of CpG, CHG, and CHH methylation in O(6)-methylguanine-DNA methyltransferase, whereas outcome of CHG and CHH methylation in runt-related transcription factor 3 promoters along with risk factors such as consumption of tobacco, betel nut, and smoking habits in esophageal cancer from Northeast India

  5. Loss of O-6-methylguanine-DNA methyltransferase protein was very frequent in the incidence of esophageal cancer from North Indian patients, and methylation of the promoter region of O-6-methylguanine-DNA methyltransferase was significantly associated in its downregulation

  6. Meta-analysis suggested that MGMT gene-promoter hypermethylation was significantly associated with an increased risk of gastric cancer, especially in Asians.

  7. The meta-analysis results demonstrated that the frequency of MGMT promoter methylation was higher in gastric cancer tissues compared with adjacent tissues and normal tissues (OR=4.06, 95% CI: 2.55-6.46, p<0.001; OR=8.85, 95% CI: 1.15-68.23, p=0.036; respectively). MGMT promoter hypermethylation was significantly associated with tumor-node-metastasis stage, lymph node metastasis, and distant metastasis.

  8. Eleven studies were included to evaluate the relationship between the status of MGMT promoter methylation and glioblastoma patients' survival. [meta-analysis]

  9. Experimental analysis showed that the edema/necrosis volume ratio, tumor/necrosis volume ratio, edema volume, and tumor location and enhancement characteristics were the most significant variables in respect to the status of MGMT promoter methylation in GBM

  10. Data show that patients with MGMT protein promoter methylation and isocitrate dehydrogenase 1 (IDH1 (show IDH1 Antibodies)) somatic mutation had a better prognosis than those with MGMT methylation alone.

Mouse (Murine) O6-Methylguanine-DNA-Methyltransferase (MGMT) interaction partners

  1. Snell, GHKRO, and PAPPA (show PAPPA Antibodies)-KO mice express high levels of two proteins involved in DNA repair, O-6-methylguanine-DNA methyltransferase (MGMT) and N-myc downstream-regulated gene 1 (NDRG1 (show NDRG1 Antibodies)).

  2. This study demonstrates for the first time a non-linear dose-response for alkylation-induced colorectal carcinogenesis and reveals DNA repair by MGMT, but not AAG (show C16orf35 Antibodies), as a key node in determining a carcinogenic threshold.

  3. Findings suggest that O6-methylguanine-DNA methyltransferase (MGMT)-mediated temozolomide resistance is associated with increased histone acetylation.

  4. Loss of MGMT expression and high Ezrin (show EZR Antibodies) protein expression leads to esophageal cancer.

  5. Both base excision repair and O6-methylguanine-DNA methyltransferase protect against methylation-induced colon carcinogenesis.

  6. ta indicate that Zik1 and Gja9 (show GJD2 Antibodies) demonstrated cancer-specific aberrant DNA methylation (show HELLS Antibodies), whereas, Cdkn2a/p16 (show CDKN2A Antibodies), Igfbp3 (show IGFBP3 Antibodies), Mgmt, Id4 (show ID4 Antibodies), and Cxcr4 (show CXCR4 Antibodies) were methylated in both the AOM (show COL2A1 Antibodies) tumors and normal colon mucosa.

  7. Roles of MGMT and MLH1 (show MLH1 Antibodies) proteins in alkylation-induced apoptosis and mutagenesis.

  8. Repression of MGMT is associated with precancerous conditions in hyperplastic mucosa adjacent to colon cancer

  9. GAMT (show GAMT Antibodies) and AGAT (show GATM Antibodies) mRNA are up-regulated 5.4- and 1.9-fold respectively in adult mdx (show DMD Antibodies) muscle compared to C57

  10. MGMT-deficient cells would likely exhibit an increased mutational burden, but only following exposures to specific environmental mutagens such as the tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK).

MGMT Antigen Profile

Antigen Summary

Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a

Alternative names and synonyms associated with MGMT

  • O-6-methylguanine-DNA methyltransferase (MGMT) antibody
  • O-6-methylguanine-DNA methyltransferase (Mgmt) antibody
  • Agat antibody
  • AGT antibody
  • AI267024 antibody

Protein level used designations for MGMT

6-O-methylguanine-DNA methyltransferase , O-6-methylguanine-DNA-alkyltransferase , O6-methylguanine-DNA methyltransferase , methylated-DNA--protein-cysteine methyltransferase , methylguanine-DNA methyltransferase , O-6-alkylguanine-DNA alkyltransferase , 0-6-methylguanine-DNA methyltransferase , O(6)-alkylguanine-DNA alkyltransferase , O6-alkylguanine-DNA alkyltransferase , O6-methylguanine-DNA methyltranferase , O6-alkylguanine-DNA-alkyltransferase , O6-methylguanine-DNA-methyltransferase

GENE ID SPECIES
4255 Homo sapiens
17314 Mus musculus
25332 Rattus norvegicus
100733185 Cavia porcellus
100155050 Sus scrofa
616091 Bos taurus
442978 Canis lupus familiaris
423965 Gallus gallus
101106897 Ovis aries
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