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Browse our PNKP Proteins (PNKP)

Full name:
Polynucleotide Kinase 3'-Phosphatase Proteins (PNKP)
On www.antibodies-online.com are 6 Polynucleotide Kinase 3'-Phosphatase (PNKP) Proteins from 4 different suppliers available. Additionally we are shipping PNKP Antibodies (59) and PNKP Kits (2) and many more products for this protein. A total of 74 PNKP products are currently listed.
Synonyms:
21.m03011, 1810009G08Rik, C21orf97, C21orf124, EIEE10, MCSZ, PKH, PNK, Tb06.28P18.320
list all proteins Gene Name GeneID UniProt
PNKP 59047  
PNKP 11284 Q96T60
Rat PNKP PNKP 308576  

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PNKP Proteins (PNKP) by Origin

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Mouse (Murine) Polynucleotide Kinase 3'-Phosphatase (PNKP) interaction partners

  1. Directed postnatal neural inactivation of PNKP affected specific subpopulations including oligodendrocytes, indicating a broad requirement for genome maintenance, both during and after neurogenesis.

  2. Structure of dsDNA bound to PNK 5'-kinase domain reveals DNA bending facilitating recognition of DNA ends in the context of single-strand/double-strand breaks, suggesting close functional cooperation in between the kinase/phosphatase active sites.

Human Polynucleotide Kinase 3'-Phosphatase (PNKP) interaction partners

  1. Here we report that purified wild-type (WT) ATXN3 (show ATXN3 Proteins) stimulates, and by contrast the mutant form specifically inhibits, PNKP's 3' phosphatase activity in vitro. ATXN3 (show ATXN3 Proteins)-deficient cells also show decreased PNKP activity

  2. We now report that the mutant ATXN3 (show ATXN3 Proteins) protein interacts with and inactivates PNKP (polynucleotide kinase 3'-phosphatase), an essential DNA strand break repair enzyme

  3. We identified homozygous or compound-heterozygous PNKP mutations in eight of the nine Portuguese families we studied, suggesting that, in Portugal, mutations in PNKP are the most frequent cause of ataxia (show USP14 Proteins) with oculomotor apraxia.

  4. we show that modest inhibition of PNKP in a PTEN knockout background enhances cellular radiosensitivity, suggesting that such a "synthetic sickness" approach involving the combination of PNKP inhibition with radiotherapy

  5. Mutations in PNKP have previously been associated with a syndrome of microcephaly, seizures and developmental delay (MIM (show MTSS1 Proteins) 613402), and is now associated with a neurodegenerative disorder.

  6. the interaction between PNKP and XRCC1 (show XRCC1 Proteins) has roles in the retention of XRCC1 (show XRCC1 Proteins) at DNA damage sites and in DNA alkylation damage repair

  7. The data suggest that all four known mutations associated with microcephaly, seizures and developmental delay reduce the cellular stability and level of PNKP protein, with three mutations likely ablating cellular DNA 5'-kinase activity and all of the mutations greatly reducing cellular DNA 3'-phosphatase activity.

  8. the critical role of NEIL2 (show NEIL2 Proteins) and PNKP in maintenance of the mammalian mitochondrial genome.

  9. PNKP distorts target DNA structures to access damaged substrate DNA ends, thus providing a molecular mechanism for the involvement of PNKP in the repair of both single- and double-strand breaks.

  10. Results reveal that ionizing radiation-induced phosphorylation of PNKP by ATM (show ATM Proteins) and DNA-PK regulates PNKP function at DNA double strand breaks.

PNKP Protein Profile

Protein Summary

The protein encoded by this gene phosphorylates vitamin B6, a step required for the conversion of vitamin B6 to pyridoxal-5-phosphate, an important cofactor in intermediary metabolism. The encoded protein is cytoplasmic and probably acts as a homodimer. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.

Alternative names and synonyms associated with PNKP

  • polynucleotide kinase 3'-phosphatase (Tc00.1047053507017.50)
  • polynucleotide kinase 3'-phosphatase (Tc00.1047053505807.190)
  • polynucleotide kinase 3'-phosphatase (Tb927.6.1580)
  • polynucleotide kinase 3'-phosphatase (BBOV_IV000690)
  • polynucleotide kinase 3'-phosphatase (CC1G_05202)
  • polynucleotide kinase 3'-phosphatase (PGTG_20262)
  • polynucleotide kinase 3'-phosphatase (PGTG_18987)
  • polynucleotide kinase 3'-phosphatase (pnkp)
  • polynucleotide kinase 3'- phosphatase (Pnkp)
  • polynucleotide kinase 3'-phosphatase (PNKP)
  • polynucleotide kinase 3'-phosphatase (Pnkp)
  • pyridoxal (pyridoxine, vitamin B6) kinase (PDXK)
  • 21.m03011 protein
  • 1810009G08Rik protein
  • C21orf97 protein
  • C21orf124 protein
  • EIEE10 protein
  • MCSZ protein
  • PKH protein
  • PNK protein
  • Tb06.28P18.320 protein

Protein level used designations for PNKP

polynucleotide kinase 3'-phosphatase , DNA 5'-kinase/3'-phosphatase , bifunctional polynucleotide phosphatase/kinase , polynucleotide kinase-3'-phosphatase , Homo sapiens polynucleotide kinase 3'-phosphatase (PNKP) , pyridoxal kinase , pyridoxamine kinase , pyridoxine kinase , vitamin B6 kinase

GENE ID SPECIES
3544419 Trypanosoma cruzi strain CL Brener
3548557 Trypanosoma cruzi strain CL Brener
3657794 Trypanosoma brucei brucei strain 927/4 GUTat10.1
5477454 Babesia bovis T2Bo
6009998 Coprinopsis cinerea okayama7130
10527435 Puccinia graminis f. sp. tritici CRL 75-36-700-3
10542867 Puccinia graminis f. sp. tritici CRL 75-36-700-3
100137702 Xenopus laevis
100145800 Xenopus (Silurana) tropicalis
59047 Mus musculus
11284 Homo sapiens
484373 Canis lupus familiaris
308576 Rattus norvegicus
747683 Pan troglodytes
8566 Homo sapiens
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