Browse our PNKP Proteins (PNKP)

Full name:
Polynucleotide Kinase 3'-Phosphatase Proteins (PNKP)
On are 9 Polynucleotide Kinase 3'-Phosphatase (PNKP) Proteins from 4 different suppliers available. Additionally we are shipping PNKP Antibodies (56) and PNKP Kits (2) and many more products for this protein. A total of 73 PNKP products are currently listed.
21.m03011, 1810009G08Rik, C21orf97, C21orf124, EIEE10, MCSZ, PKH, PNK, Tb06.28P18.320
list all proteins Gene Name GeneID UniProt
PNKP 59047  
PNKP 11284 Q96T60
Rat PNKP PNKP 308576  

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PNKP Proteins (PNKP) by Origin

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More Proteins for PNKP Interaction Partners

Mouse (Murine) Polynucleotide Kinase 3'-Phosphatase (PNKP) interaction partners

  1. The work indicates that the phosphatase domain of Pnkp binds 3'-phosphorylated single-stranded DNAs in a manner that is highly dependent on the presence of the 3'-phosphate.

  2. Directed postnatal neural inactivation of PNKP affected specific subpopulations including oligodendrocytes, indicating a broad requirement for genome maintenance, both during and after neurogenesis.

  3. Structure of dsDNA bound to PNK 5'-kinase domain reveals DNA bending facilitating recognition of DNA ends in the context of single-strand/double-strand breaks, suggesting close functional cooperation in between the kinase/phosphatase active sites.

Human Polynucleotide Kinase 3'-Phosphatase (PNKP) interaction partners

  1. In a recombinant PNKP-XRCC4 (show XRCC4 Proteins)-LigIV complex, stable binding of PNKP requires XRCC4 (show XRCC4 Proteins) phosphorylation. Only one PNKP protomer binds per XRCC4 (show XRCC4 Proteins) dimer. Both the PNKP FHA (show CRY2 Proteins) and catalytic domains contact the XRCC4 (show XRCC4 Proteins) coiled-coil and LigIV BRCT repeats. A surface on the PNKP phosphatase domain may contact XRCC4 (show XRCC4 Proteins)-LigIV. A mutation on this surface (E326K) impairs PNKP recruitment to damaged DNA and causes microcephaly with seizures.

  2. Mutations in TDP1 and APTX have been linked to Spinocerebellar ataxia with axonal neuropathy (SCAN1) and Ataxia-ocular motor apraxia 1 (AOA1), respectively, while mutations in PNKP are considered to be responsible for Microcephaly with seizures (MCSZ) and Ataxia-ocular motor apraxia 4 (AOA4).

  3. the role for PNKP in maintaining brain function and how perturbation in its activity can account for the varied pathology of neurodegeneration or microcephaly present in microcephaly with seizures and ataxia with oculomotor apraxia 4 respectively.

  4. In 11 Portuguese patients, PNKP mutations cause ataxia with oculomotor apraxia type 4.

  5. Here we report that purified wild-type (WT) ATXN3 (show ATXN3 Proteins) stimulates, and by contrast the mutant form specifically inhibits, PNKP's 3' phosphatase activity in vitro. ATXN3 (show ATXN3 Proteins)-deficient cells also show decreased PNKP activity

  6. We now report that the mutant ATXN3 (show ATXN3 Proteins) protein interacts with and inactivates PNKP (polynucleotide kinase 3'-phosphatase), an essential DNA strand break repair enzyme

  7. We identified homozygous or compound-heterozygous PNKP mutations in eight of the nine Portuguese families we studied, suggesting that, in Portugal, mutations in PNKP are the most frequent cause of ataxia with oculomotor apraxia.

  8. we show that modest inhibition of PNKP in a PTEN knockout background enhances cellular radiosensitivity, suggesting that such a "synthetic sickness" approach involving the combination of PNKP inhibition with radiotherapy

  9. Mutations in PNKP have previously been associated with a syndrome of microcephaly, seizures and developmental delay (MIM (show MTSS1 Proteins) 613402), and is now associated with a neurodegenerative disorder.

  10. the interaction between PNKP and XRCC1 (show XRCC1 Proteins) has roles in the retention of XRCC1 (show XRCC1 Proteins) at DNA damage sites and in DNA alkylation damage repair

PNKP Protein Profile

Protein Summary

The protein encoded by this gene phosphorylates vitamin B6, a step required for the conversion of vitamin B6 to pyridoxal-5-phosphate, an important cofactor in intermediary metabolism. The encoded protein is cytoplasmic and probably acts as a homodimer. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.

Alternative names and synonyms associated with PNKP

  • polynucleotide kinase 3'-phosphatase (Tc00.1047053507017.50)
  • polynucleotide kinase 3'-phosphatase (Tc00.1047053505807.190)
  • polynucleotide kinase 3'-phosphatase (Tb927.6.1580)
  • polynucleotide kinase 3'-phosphatase (BBOV_IV000690)
  • polynucleotide kinase 3'-phosphatase (CC1G_05202)
  • polynucleotide kinase 3'-phosphatase (PGTG_20262)
  • polynucleotide kinase 3'-phosphatase (PGTG_18987)
  • polynucleotide kinase 3'-phosphatase (pnkp)
  • polynucleotide kinase 3'- phosphatase (Pnkp)
  • polynucleotide kinase 3'-phosphatase (PNKP)
  • polynucleotide kinase 3'-phosphatase (Pnkp)
  • pyridoxal (pyridoxine, vitamin B6) kinase (PDXK)
  • 21.m03011 protein
  • 1810009G08Rik protein
  • C21orf97 protein
  • C21orf124 protein
  • EIEE10 protein
  • MCSZ protein
  • PKH protein
  • PNK protein
  • Tb06.28P18.320 protein

Protein level used designations for PNKP

polynucleotide kinase 3'-phosphatase , DNA 5'-kinase/3'-phosphatase , bifunctional polynucleotide phosphatase/kinase , polynucleotide kinase-3'-phosphatase , Homo sapiens polynucleotide kinase 3'-phosphatase (PNKP) , pyridoxal kinase , pyridoxamine kinase , pyridoxine kinase , vitamin B6 kinase

3544419 Trypanosoma cruzi strain CL Brener
3548557 Trypanosoma cruzi strain CL Brener
3657794 Trypanosoma brucei brucei strain 927/4 GUTat10.1
5477454 Babesia bovis T2Bo
6009998 Coprinopsis cinerea okayama7130
10527435 Puccinia graminis f. sp. tritici CRL 75-36-700-3
10542867 Puccinia graminis f. sp. tritici CRL 75-36-700-3
100137702 Xenopus laevis
100145800 Xenopus (Silurana) tropicalis
59047 Mus musculus
11284 Homo sapiens
484373 Canis lupus familiaris
308576 Rattus norvegicus
747683 Pan troglodytes
8566 Homo sapiens
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