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Browse our Polymerase (DNA Directed), eta Proteins (POLH)

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Polymerase (DNA Directed), eta Proteins (POLH)
On are 5 Polymerase (DNA Directed), eta (POLH) Proteins from 4 different suppliers available. Additionally we are shipping Polymerase (DNA Directed), eta Antibodies (46) and many more products for this protein. A total of 54 Polymerase (DNA Directed), eta products are currently listed.
fc50a12, POLH, RAD30, RAD30A, wu:fc50a12, XP-V, XPV, zgc:136881, zgc:152642
list all proteins Gene Name GeneID UniProt
POLH 5429 Q9Y253
Rat POLH POLH 316235  
POLH 80905 Q9JJN0

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Polymerase (DNA Directed), eta Proteins (POLH) by Origin

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More Proteins for Polymerase (DNA Directed), eta Interaction Partners

Xenopus laevis Polymerase (DNA Directed), eta (POLH) interaction partners

  1. Error-free insertion in cyclobutane pyrimidine bypass is due mainly to pol eta (translesion synthesis TLS3) in oocyte extracts during DNA replication.

Human Polymerase (DNA Directed), eta (POLH) interaction partners

  1. These results provide important knowledge about the effects of the length and structure of the alkyl group in O(4)-alkylthymidine lesions on the fidelity and efficiency of DNA replication mediated by human DNA polymerase eta.

  2. The described is cooperative motion of a key positively charged residue and metal ions for DNA replication catalyzed by human DNA Polymerase eta.

  3. free energy difference is slightly greater for binding at the 5' thymine position than at the 3' thymine position, presumably because of stabilization arising from the A:T base pair formed at the 3' position of the TTD in previous step of Pol eta function

  4. PolH721 variant present in XP-V patients is unstable. Extra 8 amino acids of PolH721 do not act as degron but induce conformational change of PolH C-terminus exposing its bipartite NLS and sequence close to its UBZ to the ubiquitin/proteasome system.

  5. Poleta has three PCNA (show PCNA Proteins)-interacting protein (PIP (show PIP Proteins)) boxes (PIP1 (show PAK1IP1 Proteins), 2, 3) that contribute differentially to two distinct functions, stimulation of DNA synthesis and promotion of PCNA (show PCNA Proteins) ubiquitination.

  6. our findings reveal a modulatory role of USP7 (show USP7 Proteins) in PCNA (show PCNA Proteins) ubiquitination-mediated stress-tolerance pathways by fine-tuning Poleta turnover.

  7. Arg-61 and Gln-38 of human DNA polymerase (show POLB Proteins) (hpol) eta play important roles in the catalytic reaction.

  8. The results show that the FF483-484 amino acids in the human Poleta (designated F1 motif) are necessary for the interaction of this polymerase with POLD2 (show POLD2 Proteins), the B subunit of the replicative DNA polymerase delta (show POLD1 Proteins), both in vitro and in vivo.

  9. ovarian CSCs have intrinsically enhanced Pol eta-mediated translesion DNA synthesis, allowing CSCs to survive cisplatin treatment, leading to tumor relapse

  10. Human pol eta, a major copying enzyme with abasic sites, follows a purine rule, which can also lead to frameshifts. The phenomenon can be explained with H-bonds.

Mouse (Murine) Polymerase (DNA Directed), eta (POLH) interaction partners

  1. the functions of REV3L in maintaining cell viability, embryonic viability and genomic stability are directly dependent on its polymerase activity, and cannot be ameliorated by an additional deletion of pol eta.

  2. XP-V has a role in adipose tissue senescence and metabolic syndrome

  3. Increase in UV-induced mutations at both G:C and A:T pairs associated with PolH deficiency suggests that PolH contributes to accurate translesion synthesis (TLS (show FUS Proteins)) past both T- & C-containing dimers.

  4. POLH deficiency did not affect the frequency and patterns of C:G mutations and UNG (show UNG Proteins) POLH double deficiency showed an additive effect of single deficiency.

  5. REV1 and Polkappa are involved in DNA damage tolerance via Poleta-REV1 interaction when Poleta fails to bypass its cognate substrates.

  6. These results reveal genetic interactions between REV1 catalytic activity and POLH and identify an alternative pathway in the generation of C to G and G to C transversions.

  7. these data support the existence of PCNA (show PCNA Proteins) ubiquitination-dependent and -independent activation pathways of Poleta during somatic hypermutation and DNA damage tolerance.

  8. inaccurate DNA synthesis by mammalian DNA polymerase eta (pol eta) contributes to somatic hypermutation (SHM (show CNTNAP1 Proteins)) of Ig genes

  9. suggest the involvement of the Pol eta and Pol iota (show POLI Proteins) proteins in UV-induced skin carcinogenesis

  10. Results reveal genetic and biochemical interactions between DNA polymerases eta (POLH) and theta (POLQ) and suggest that POLQ might cooperate with POLH to generate some of the A/T mutations during the somatic hypermutation of Ig genes.

Polymerase (DNA Directed), eta (POLH) Protein Profile

Protein Summary

This gene encodes a member of the Y family of specialized DNA polymerases. It copies undamaged DNA with a lower fidelity than other DNA-directed polymerases. However, it accurately replicates UV-damaged DNA\; when thymine dimers are present, this polymerase inserts the complementary nucleotides in the newly synthesized DNA, thereby bypassing the lesion and suppressing the mutagenic effect of UV-induced DNA damage. This polymerase is thought to be involved in hypermutation during immunoglobulin class switch recombination. Mutations in this gene result in XPV, a variant type of xeroderma pigmentosum.

Alternative names and synonyms associated with Polymerase (DNA Directed), eta (POLH)

  • polymerase (DNA directed), eta (polh)
  • polymerase (DNA directed), eta (POLH)
  • DNA polymerase eta (Tb10.70.6190)
  • DNA polymerase eta (LinJ21.0530)
  • polymerase (DNA directed), eta (Polh)
  • polymerase (DNA directed), eta (RAD 30 related) (Polh)
  • fc50a12 protein
  • POLH protein
  • RAD30 protein
  • RAD30A protein
  • wu:fc50a12 protein
  • XP-V protein
  • XPV protein
  • zgc:136881 protein
  • zgc:152642 protein

Protein level used designations for POLH

DNA-directed DNA polymerase eta , DNA polymerase eta , polymerase (DNA directed), eta , DNA polymerase eta-like , polymerase eta , RAD30 homolog A , xeroderma pigmentosum variant type protein , polymerase (DNA directed), eta (RAD 30 related) , xeroderma pigmentosum variant type protein homolog

446909 Xenopus laevis
462720 Pan troglodytes
474915 Canis lupus familiaris
513606 Bos taurus
678520 Danio rerio
700772 Macaca mulatta
3661974 Trypanosoma brucei brucei strain 927/4 GUTat10.1
5068792 Leishmania infantum JPCM5
100011953 Monodelphis domestica
100067518 Equus caballus
100124112 Nasonia vitripennis
100357494 Oryctolagus cuniculus
100392158 Callithrix jacchus
100443019 Pongo abelii
100473341 Ailuropoda melanoleuca
395102 Gallus gallus
100558919 Anolis carolinensis
100602084 Nomascus leucogenys
5429 Homo sapiens
316235 Rattus norvegicus
80905 Mus musculus
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