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Browse our PRKDC Proteins (PRKDC)

Full name:
Protein Kinase, DNA-Activated, Catalytic Polypeptide Proteins (PRKDC)
On are 8 Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC) Proteins from 5 different suppliers available. Additionally we are shipping PRKDC Antibodies (407) and PRKDC Kits (9) and many more products for this protein. A total of 432 PRKDC products are currently listed.
AI326420, AU019811, DNA-PKCS, DNAPDcs, dnapk, dnpk1, DOXNPH, dxnph, hyrc, hyrc1, p350, p460, PRKDC, prkdc-A, scid, slip, xrcc7
list all proteins Gene Name GeneID UniProt
PRKDC 19090 P97313
PRKDC 5591 P78527

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PRKDC Proteins (PRKDC) by Origin

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Top referenced PRKDC Proteins

  1. Human PRKDC Protein expressed in Wheat germ - ABIN1316293 : Pyun, Seo, Lee, Jin, Kim, Kim, Kim, Nam, Yook, Lee: Mutual regulation between DNA-PKcs and Snail1 leads to increased genomic instability and aggressive tumor characteristics. in Cell death & disease 2013 (PubMed)

More Proteins for PRKDC Interaction Partners

Mouse (Murine) Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC) interaction partners

  1. AIM2 (show AIM2 Proteins) reduced Akt (show AKT1 Proteins) activation and tumor burden in colorectal cancer models, while an Akt (show AKT1 Proteins) inhibitor reduced tumor load in Aim2 (show AIM2 Proteins)(-/-) mice

  2. PRKDC proteins that mediate non-homologous end joining have been identified as TRIP13 (show TRIP13 Proteins) binding partners in head and neck cancer.

  3. NR5A1 (show NR5A1 Proteins) prevents centriole splitting by inhibiting centrosomal DNA-PK activation and beta-catenin (show CTNNB1 Proteins) accumulation

  4. Results show that DNA-PKcs functions as a selective modulator of transcriptional networks that induce cell migration, invasion, and metastasis of prostate cancer cells.

  5. These experiments define a novel requirement for 53BP1 (show TP53BP1 Proteins) in the fusions of DNA-PKcs-deficient telomeres throughout the cell cycle.

  6. data suggest that DNA-PKcs-SIN1 (show MAPKAP1 Proteins) complexation-mediated Akt (show AKT1 Proteins) activation (Ser (show SIGLEC1 Proteins)-473 phosphorylation) is required for mouse osteoblast differentiation

  7. Activated platelets accumulate in the brain rescue apoptotic neuron cells via activation of EGFR and DNA-dependent protein kinase.

  8. DNA-PK and ATM (show ATM Proteins) acts in parallel upstream of XRCC4 (show XRCC4 Proteins), regulating through phosphorylation

  9. DNA-PKcs is the molecular switch that coordinates end-processing and end-ligation at the DNAends through differential phosphorylations.

  10. DNA-PK/Chk2 (show CHEK2 Proteins) signaling induces centrosome amplification upon long-term HU treatment, therefore increasing our insight into tumor recurrence after initial chemotherapy.

Human Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC) interaction partners

  1. inhibition of DNAPKcs decreases Pgp expression and sensitizes osteosarcoma cancer stem cells to chemotherapeutic agents in vitro

  2. These results suggested potential usefulness of the phosphorylation status of XRCC4 (show XRCC4 Proteins) Ser320 as an indicator of DNA-PK functionality in living cells.

  3. Data show that elevated expression of DNA-dependent protein kinase catalytic subunit (DNA-PKcs), Akt3 (show AKT3 Proteins) protein, and tumor suppressor protein p53 (p53 (show TP53 Proteins)) in ovarian serous adenocarcinoma tissues are an indication of more advanced disease and worse prognosis.

  4. CDK2 (show CDK2 Proteins) and DNA-PK regulate PR transcriptional activity by distinct mechanisms.

  5. Results show that under hypoxia, Ku70 (show XRCC6 Proteins) and DNA-PKcs interact with nuclear RON (show MST1R Proteins) which activates non-homologous end joining DNA repair conferring chemoresistance.

  6. A significantly different distribution was found in the frequency of PRKDC (rs7003908) genotype between the ESCC group and controls. Individuals homozygous for the C allele had a significant (3.185-fold) increased risk of ESCC.

  7. Transient knockdown of PRKDC reduced cell proliferation/survival in HCT116 and DLD1, but not FHC (show FTH1 Proteins) cells. PRKDC down-regulation induced apoptosis partially through inhibiting AKT (show AKT1 Proteins) activation, and sensitized HCT116 cells to chemotherapeutic agents

  8. DNA methylation (show HELLS Proteins) modification plays an important role to regulate the gene expression of XRCC5 (show XRCC5 Proteins) and XRCC7, from the results that the gene methylation level of the glioma group is higher than that of the normal group

  9. The ends are then closely aligned, which requires XLF (show NHEJ1 Proteins), a non-catalytic function of XRCC4 (show XRCC4 Proteins)-LIG4 (show LIG4 Proteins), and DNA-PK activity

  10. suggested that DNA-PK and PARP-dependent recruitment of XRCC1 (show XRCC1 Proteins) is necessary to effectively protect, repair, and restart stalled replication forks, providing new insight into how genomic stability is preserved

Xenopus laevis Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC) interaction partners

  1. Ku80 (show XRCC5 Proteins) is susceptible to proteolytic degradation when not dimerized with Ku70 (show XRCC6 Proteins); dimer induces DNA-PK activity; evidence that interacting domain(s) of Xenopus DNA-PKcs is conserved so as to interact with human Ku, reconstituting a functional holoenzyme

PRKDC Protein Profile

Protein Summary

This gene encodes the catalytic subunit of the DNA-dependent protein kinase (DNA-PK). It functions with the Ku70/Ku80 heterodimer protein in DNA double strand break repair and recombination. The protein encoded is a member of the PI3/PI4-kinase family.

Alternative names and synonyms associated with PRKDC

  • protein kinase, DNA-activated, catalytic polypeptide (PRKDC)
  • protein kinase, DNA activated, catalytic polypeptide (Prkdc)
  • protein kinase, DNA-activated, catalytic polypeptide (prkdc)
  • AI326420 protein
  • AU019811 protein
  • DNA-PKCS protein
  • DNAPDcs protein
  • dnapk protein
  • dnpk1 protein
  • DOXNPH protein
  • dxnph protein
  • hyrc protein
  • hyrc1 protein
  • p350 protein
  • p460 protein
  • PRKDC protein
  • prkdc-A protein
  • scid protein
  • slip protein
  • xrcc7 protein

Protein level used designations for PRKDC

protein kinase, DNA-activated, catalytic polypeptide , protein kinase catalytic subunit (DNA-dependent protein kinase) , DNA-dependent protein kinase catalytic subunit , DNA-activated protein kinase catalytic polypeptide , DNA-dependent protein kinase catalytic subunit-like , DNA-PK catalytic subunit , doxorubicin nephropathy , severe combined immunodeficiency , hyper-radiosensitivity of murine scid mutation, complementing 1 , p460 , DNA-PKcs

282003 Bos taurus
418814 Gallus gallus
464165 Pan troglodytes
512740 Bos taurus
100125348 Oryctolagus cuniculus
100224961 Taeniopygia guttata
100399020 Callithrix jacchus
100586225 Nomascus leucogenys
100633457 Amphimedon queenslandica
19090 Mus musculus
5591 Homo sapiens
373602 Xenopus laevis
395376 Gallus gallus
474176 Canis lupus familiaris
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