Browse our PRKDC Proteins (PRKDC)

Full name:
Protein Kinase, DNA-Activated, Catalytic Polypeptide Proteins (PRKDC)
On are 8 Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC) Proteins from 5 different suppliers available. Additionally we are shipping PRKDC Antibodies (421) and PRKDC Kits (9) and many more products for this protein. A total of 446 PRKDC products are currently listed.
AI326420, AU019811, DNA-PKCS, DNAPDcs, dnapk, dnpk1, DOXNPH, dxnph, hyrc, hyrc1, p350, p460, PRKDC, prkdc-A, scid, slip, xrcc7
list all proteins Gene Name GeneID UniProt
PRKDC 19090 P97313
PRKDC 5591 P78527

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PRKDC Proteins (PRKDC) by Origin

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Top referenced PRKDC Proteins

  1. Human PRKDC Protein expressed in Wheat germ - ABIN1316293 : Pyun, Seo, Lee, Jin, Kim, Kim, Kim, Nam, Yook, Lee: Mutual regulation between DNA-PKcs and Snail1 leads to increased genomic instability and aggressive tumor characteristics. in Cell death & disease 2013 (PubMed)

More Proteins for PRKDC Interaction Partners

Mouse (Murine) Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC) interaction partners

  1. The SAGA deubiquitinase activity was required for optimal irradiation-induced gammaH2AX (show H2AFX Proteins) formation, and failure to remove H2BK120ub inhibits ATM (show ATM Proteins)- and DNAPK-induced gammaH2AX (show H2AFX Proteins) formation.

  2. functional DNA-PKcs T2609 cluster is required to facilitate telomere leading strand maturation and prevention of genomic instability and cancer development.

  3. TMU-35435 enhances etoposide cytotoxicity by regulating ubiquitin-proteasomal degradation of DNA-PKcs and inhibiting the DNA repair pathway in triple negative breast cancer cells.

  4. DNA-PKcs are required to prevent endogenous DNA damage accumulation throughout the adult brain.

  5. AIM2 (show AIM2 Proteins) reduced Akt (show AKT1 Proteins) activation and tumor burden in colorectal cancer models, while an Akt (show AKT1 Proteins) inhibitor reduced tumor load in Aim2 (show AIM2 Proteins)(-/-) mice

  6. PRKDC proteins that mediate non-homologous end joining have been identified as TRIP13 (show TRIP13 Proteins) binding partners in head and neck cancer.

  7. NR5A1 (show NR5A1 Proteins) prevents centriole splitting by inhibiting centrosomal DNA-PK activation and beta-catenin (show CTNNB1 Proteins) accumulation

  8. Results show that DNA-PKcs functions as a selective modulator of transcriptional networks that induce cell migration, invasion, and metastasis of prostate cancer cells.

  9. These experiments define a novel requirement for 53BP1 (show TP53BP1 Proteins) in the fusions of DNA-PKcs-deficient telomeres throughout the cell cycle.

  10. data suggest that DNA-PKcs-SIN1 (show MAPKAP1 Proteins) complexation-mediated Akt (show AKT1 Proteins) activation (Ser (show SIGLEC1 Proteins)-473 phosphorylation) is required for mouse osteoblast differentiation

Human Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC) interaction partners

  1. that EZH2 (show EZH2 Proteins) is phosphorylated by the DNA damage responsive complex DNA-PK and regulates DNA damage-mediated T-cell apoptosis.

  2. DNA-PKcs is a potent regulator of IL-2 (show IL2 Proteins) production in T lymphocytes.

  3. TMU-35435 enhances etoposide cytotoxicity by regulating ubiquitin-proteasomal degradation of DNA-PKcs and inhibiting the DNA repair pathway in triple negative breast cancer cells.

  4. DNA-PK directly phosphorylates hSSB1 (show SSBP1 Proteins) at serine residue 134. While this modification is largely suppressed in undamaged cells by PPP-family protein phosphatases, S134 phosphorylation is enhanced following the disruption of replication forks and promotes cellular survival.

  5. DNA-PK activity in peripheral blood lymphocytes might be a useful marker for predicting prostate-specific antigen (show KLK3 PLURAL_@39934@) relapse and urinary toxicity, possibly contributing to personalized treatment of prostate cancer.

  6. Data suggest that the model can replicate amplified p53 (show TP53 Proteins) responses under DNA-PK inhibition and provide insights into cell fate decision by manipulating p53 (show TP53 Proteins) dynamics.

  7. These studies clarify the role of PKCdelta (show PKCd Proteins) in endothelial cell cytoskeleton regulation.

  8. T204 was identified as a main target for ATM (show ATM Proteins)/DNA-PKcs phosphorylation on human POLL, and this phosphorylation may facilitate the repair of a subset of IR-induced DSBs and the efficient POLL-mediated gap-filling during NHEJ. POLL phosphorylation might favor POLL interaction with the DNA-PK complex at DSBs.

  9. DNA-PKcs inhibitor acriflavine exerts a p53 (show TP53 Proteins)-dependent synergistic efficacy with melphalan against human cancer cells both in vitro and in vivo.

  10. EBV-LMP1 (show PDLIM7 Proteins) suppresses the DNA damage response through DNA-PK/AMPK (show PRKAA1 Proteins) signaling to promote radioresistance in nasopharyngeal carcinoma.

Xenopus laevis Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC) interaction partners

  1. Ku80 (show XRCC5 Proteins) is susceptible to proteolytic degradation when not dimerized with Ku70 (show XRCC6 Proteins); dimer induces DNA-PK activity; evidence that interacting domain(s) of Xenopus DNA-PKcs is conserved so as to interact with human Ku, reconstituting a functional holoenzyme

PRKDC Protein Profile

Protein Summary

This gene encodes the catalytic subunit of the DNA-dependent protein kinase (DNA-PK). It functions with the Ku70/Ku80 heterodimer protein in DNA double strand break repair and recombination. The protein encoded is a member of the PI3/PI4-kinase family.

Alternative names and synonyms associated with PRKDC

  • protein kinase, DNA-activated, catalytic polypeptide (PRKDC)
  • protein kinase, DNA activated, catalytic polypeptide (Prkdc)
  • protein kinase, DNA-activated, catalytic polypeptide (prkdc)
  • AI326420 protein
  • AU019811 protein
  • DNA-PKCS protein
  • DNAPDcs protein
  • dnapk protein
  • dnpk1 protein
  • DOXNPH protein
  • dxnph protein
  • hyrc protein
  • hyrc1 protein
  • p350 protein
  • p460 protein
  • PRKDC protein
  • prkdc-A protein
  • scid protein
  • slip protein
  • xrcc7 protein

Protein level used designations for PRKDC

protein kinase, DNA-activated, catalytic polypeptide , protein kinase catalytic subunit (DNA-dependent protein kinase) , DNA-dependent protein kinase catalytic subunit , DNA-activated protein kinase catalytic polypeptide , DNA-dependent protein kinase catalytic subunit-like , DNA-PK catalytic subunit , doxorubicin nephropathy , severe combined immunodeficiency , hyper-radiosensitivity of murine scid mutation, complementing 1 , p460 , DNA-PKcs

282003 Bos taurus
418814 Gallus gallus
464165 Pan troglodytes
512740 Bos taurus
100125348 Oryctolagus cuniculus
100224961 Taeniopygia guttata
100399020 Callithrix jacchus
100586225 Nomascus leucogenys
100633457 Amphimedon queenslandica
19090 Mus musculus
5591 Homo sapiens
373602 Xenopus laevis
395376 Gallus gallus
474176 Canis lupus familiaris
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