Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
Show all synonyms
Select your origin of interest
Human PRKDC Protein expressed in Wheat germ - ABIN1316293
Pyun, Seo, Lee, Jin, Kim, Kim, Kim, Nam, Yook, Lee: Mutual regulation between DNA-PKcs and Snail1 leads to increased genomic instability and aggressive tumor characteristics. in Cell death & disease 2013
this study suggests that improved anti-proliferative and cytotoxic effects of Ag-np treatment in cancer cells can be achieved by the inhibition of DNA-PKcs.
this study has solved the PRKDC structure in complex with the C-terminal peptide of Ku80 (show XRCC5 Proteins) at 4.3 angstrom resolution using x-ray crystallography.
DNA-PKcs, which is integral to the non-homologous end joining pathway, negatively regulates ATM (show ATM Proteins) activity through phosphorylation of ATM (show ATM Proteins).
that EZH2 (show EZH2 Proteins) is phosphorylated by the DNA damage responsive complex DNA-PK and regulates DNA damage-mediated T-cell apoptosis.
DNA-PKcs is a potent regulator of IL-2 (show IL2 Proteins) production in T lymphocytes.
TMU-35435 enhances etoposide cytotoxicity by regulating ubiquitin-proteasomal degradation of DNA-PKcs and inhibiting the DNA repair pathway in triple negative breast cancer cells.
DNA-PK directly phosphorylates hSSB1 (show SSBP1 Proteins) at serine residue 134. While this modification is largely suppressed in undamaged cells by PPP-family protein phosphatases, S134 phosphorylation is enhanced following the disruption of replication forks and promotes cellular survival.
DNA-PK activity in peripheral blood lymphocytes might be a useful marker for predicting prostate-specific antigen relapse and urinary toxicity, possibly contributing to personalized treatment of prostate cancer.
Data suggest that the model can replicate amplified p53 (show TP53 Proteins) responses under DNA-PK inhibition and provide insights into cell fate decision by manipulating p53 (show TP53 Proteins) dynamics.
These studies clarify the role of PKCdelta (show PKCd Proteins) in endothelial cell cytoskeleton regulation.
Ku80 (show XRCC5 Proteins) is susceptible to proteolytic degradation when not dimerized with Ku70 (show XRCC6 Proteins); dimer induces DNA-PK activity; evidence that interacting domain(s) of Xenopus DNA-PKcs is conserved so as to interact with human Ku, reconstituting a functional holoenzyme
DNA-PKcs deficiency caused inefficient DSB repair at later time points post-IR in both conditions. These observations suggest that DNA-PKcs contributes to the fast and slow repair of DSBs by NHEJ.
The SAGA deubiquitinase activity was required for optimal irradiation-induced gammaH2AX (show H2AFX Proteins) formation, and failure to remove H2BK120ub inhibits ATM (show ATM Proteins)- and DNAPK-induced gammaH2AX (show H2AFX Proteins) formation.
functional DNA-PKcs T2609 cluster is required to facilitate telomere leading strand maturation and prevention of genomic instability and cancer development.
DNA-PKcs are required to prevent endogenous DNA damage accumulation throughout the adult brain.
AIM2 (show AIM2 Proteins) reduced Akt (show AKT1 Proteins) activation and tumor burden in colorectal cancer models, while an Akt (show AKT1 Proteins) inhibitor reduced tumor load in Aim2 (show AIM2 Proteins)(-/-) mice
PRKDC proteins that mediate non-homologous end joining have been identified as TRIP13 (show TRIP13 Proteins) binding partners in head and neck cancer.
NR5A1 (show NR5A1 Proteins) prevents centriole splitting by inhibiting centrosomal DNA-PK activation and beta-catenin (show CTNNB1 Proteins) accumulation
Results show that DNA-PKcs functions as a selective modulator of transcriptional networks that induce cell migration, invasion, and metastasis of prostate cancer cells.
These experiments define a novel requirement for 53BP1 (show TP53BP1 Proteins) in the fusions of DNA-PKcs-deficient telomeres throughout the cell cycle.
This gene encodes the catalytic subunit of the DNA-dependent protein kinase (DNA-PK). It functions with the Ku70/Ku80 heterodimer protein in DNA double strand break repair and recombination. The protein encoded is a member of the PI3/PI4-kinase family.
DNA-PK catalytic subunit
, DNA-dependent protein kinase catalytic subunit
, hyper-radiosensitivity of murine scid mutation, complementing 1
, protein kinase, DNA-activated, catalytic polypeptide
, protein kinase catalytic subunit (DNA-dependent protein kinase)
, DNA-activated protein kinase catalytic polypeptide
, DNA-dependent protein kinase catalytic subunit-like
, doxorubicin nephropathy
, severe combined immunodeficiency