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anti-Human CDC6 Antibodies:
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Human Polyclonal CDC6 Primary Antibody for EIA, IHC (p) - ABIN358103
Alexandrow, Hamlin: Cdc6 chromatin affinity is unaffected by serine-54 phosphorylation, S-phase progression, and overexpression of cyclin A. in Molecular and cellular biology 2004
Show all 5 references for ABIN358103
Human Monoclonal CDC6 Primary Antibody for WB - ABIN1106638
Blagosklonny: Basic cell cycle and cancer research: is harmony impossible? in Cell cycle (Georgetown, Tex.) 2002
Show all 3 references for ABIN1106638
Human Polyclonal CDC6 Primary Antibody for EIA, WB - ABIN358768
Yim, Jin, Park, Choi, Lee: Caspase-3-mediated cleavage of Cdc6 induces nuclear localization of p49-truncated Cdc6 and apoptosis. in Molecular biology of the cell 2003
Show all 3 references for ABIN358768
Human Monoclonal CDC6 Primary Antibody for IP, WB - ABIN180410
Petersen, Lukas, Sørensen, Bartek, Helin: Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization. in The EMBO journal 1999
Human Monoclonal CDC6 Primary Antibody for IP, WB - ABIN268295
Hubbi, Kshitiz, Gilkes, Rey, Wong, Luo, Kim, Dang, Levchenko, Semenza: A nontranscriptional role for HIF-1α as a direct inhibitor of DNA replication. in Science signaling 2013
Human Polyclonal CDC6 Primary Antibody for IHC (p), WB - ABIN389537
Clay-Farrace, Pelizon, Santamaria, Pines, Laskey: Human replication protein Cdc6 prevents mitosis through a checkpoint mechanism that implicates Chk1. in The EMBO journal 2003
the level of Cdc6 phosphorylation at serine 54 (S54P) was increased in E7-expressing cells. S54P was associated with an increase in the total amount of Cdc6 and chromatin-bound Cdc6. DNA damage-enhanced upregulation and chromatin binding of Cdc6 appeared to be due to downregulation of cyclin-dependent kinase 1 (Cdk1 (show CDK1 Antibodies)) as Cdk1 (show CDK1 Antibodies) knockdown increased Cdc6 levels
this study provides a novel regulatory signaling pathway of CDC6-regulated epithelial ovarian cancer growth
The data demonstrate that Cdc6 serves as a regulator of ribosomal DNA transcription initiation, and indicate a mechanism by which initiation of ribosomal DNA transcription and DNA replication can be coordinated in cells.
CDC6 and Cyclin F (show CCNF Antibodies) interact through defined sequence motifs that promote CDC6 ubiquitylation and degradation.
Cdc6 interacts with centrosomes during mitotic cell division.
The current study suggests that miR26a, miR26b, and CDC6 and factors regulating their expression represent potential cancer diagnostic and prognostic markers as well as anticancer targets.
The cell cycle-dependent centrosomal localization of Cdc6 in S and G2 phases suggest a novel function of Cdc6 in centrosomes.
Cdk1 (show CDK1 Antibodies) contributes to the nuclear export of Cdc6 at the S-to-G2 transition.
Aberrant expression of both cyclin D1 (show CCND1 Antibodies) and CDC6 by YB-1 (show YBX1 Antibodies) over-expression may collaboratively participate in lung carcinogenesis.
The Cdc6 is the AAA (show APP Antibodies)+ ATPase (show DNAH8 Antibodies) that assembles prereplicative complexes on replication origins in eukaryotic chromosomes and two more functions in mammalian cells to promote cell proliferation and survival.
CDK1 (show CDK1 Antibodies) activation proceeds with concomitant inhibition by CDC6, which tunes the timing of the M-phase entry during the embryonic cell cycle
Cdc6 continued to block apoptosome assembly induced by a non-cytochrome c (show CYCS Antibodies) or some other mechanism, suppressing seemingly unintended apoptosis when promoting cell proliferation
show that MyoD can occupy an E-box within the promoter of Cdc6 and that this association, along with E2F3a, is required for its activity.
CDC6 is essential for spindle formation in mouse oocytes
The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in cell nucleus during cell cyle G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during cell cyle is regulated through its phosphorylation by Cdks. Transcription of this protein was reported to be regulated in response to mitogenic signals through transcriptional control mechanism involving E2F proteins.
CDC6 cell division cycle 6 homolog
, CDC6-related protein
, cdc18-related protein
, cell division control protein 6 homolog
, cell division cycle 6 homolog