CDC6 antibody (AA 32-61)

Catalog No. ABIN3030464

Product Details anti-CDC6 Antibody

Target: CDC6 (Cell Division Cycle 6 Homolog (S. Cerevisiae) (CDC6))

Binding Specificity: AA 32-61

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CDC6 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purification: Antigen affinity purified

Immunogen: A portion of amino acids 32-61 from the human protein was used as the immunogen for this CDC6 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the CDC6 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the CDC6 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Target Details for CDC6

Target: CDC6 (Cell Division Cycle 6 Homolog (S. Cerevisiae) (CDC6))

Alternative Name: CDC6 (CDC6 Products)

Synonyms: CDC18L antibody, HsCDC18 antibody, HsCDC6 antibody, cell division cycle 6 antibody, CDC6 antibody, Cdc6 antibody

Background: Human CDC6 is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in cell nucleus during cell cyle G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during cell cyle is regulated through its phosphorylation by Cdks. Transcription of this protein was reported to be regulated in response to mitogenic signals through transcriptional control mechanism involving E2F proteins.

UniProt: Q99741

Pathways: DNA Replication, Synthesis of DNA