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Findings indicate that long-term exposure to IM results in dysregulation of stem cell renewal-regulatory Hippo (MST1 (show MST1 ELISA Kits)/2)/YAP (show YAP1 ELISA Kits) signaling, and that inhibition of miR (show MLXIP ELISA Kits)-181a using a microRNA sponge inhibitor resulted in decreased transcription of SOX2 and SALL4 (show SALL4 ELISA Kits).
The authors found that high/positive SOX2 alterations, either DNA amplification or protein expression, were favorable for overall survival (OS) in non-small cell lung cancer. On the contrary, high/positive Nestin (show NES ELISA Kits) protein expression was poor for OS.
Data show that tunicamycin reduces the expression of self-renewal regulator Sox2 at translation level.
Increasing SOX2 reduces growth inhibition mediated by MEK (show MAP2K1 ELISA Kits) and AKT (show AKT1 ELISA Kits) inhibitors; whereas knockdown of SOX2 further reduces growth when Pancreatic ductal adenocarcinoma cells are treated with these inhibitors. Thus, targeting SOX2, or its mode of action, could improve the treatment of Pancreatic ductal adenocarcinoma.
miR (show MLXIP ELISA Kits)-371-5p expression is strongly upregulated in gastric cancer tissues and negatively correlated with SOX2 expression.
This study discloses novel SOX2 target genes driving neuroendocrine differentiation and spread of PC and proposes SOX2 as a functional biomarker of LN metastasization for prostate cancer.
These results suggest that SOX2 may play an important role in carcinogenesis and progression of invasive carcinoma ex pleomorphic adenoma
A positive feedback loop involving the Wnt (show WNT2 ELISA Kits)/beta-catenin (show CTNNB1 ELISA Kits)/MYC (show MYC ELISA Kits)/Sox2 axis defines a highly tumorigenic cell subset in ALK (show ALK ELISA Kits) + anaplastic large cell lymphoma.
highly conserved Sox2/Pax6 (show PAX6 ELISA Kits) bound site near the Sprouty2 (show SPRY2 ELISA Kits) locus was verified to promote cooperative dimerization designating Sprouty2 (show SPRY2 ELISA Kits) as a potential target reliant on Sox2/Pax6 (show PAX6 ELISA Kits) cooperativity in several neural cell types.
High SOX2 expression is associated with brain neoplasms.
Sox2 is necessary for spinal cord regeneration and suggest a model whereby spinal cord injury activates proliferation of Sox2/3 expressing cells and their differentiation into neurons, a mechanism that is lost in non-regenerative froglets.
Tail amputation results in a global increase of Sox2 levels and proliferation of Sox2-positive cells after spinal cord injury.
Data indicate that pluripotency genes sox2, p63 and oct60 are upregulated early during the process of lens regeneration.
Suggest that SOX2 directly upregulates FGF8 (show FGF8 ELISA Kits) gene expression in the early embryonic development of Xenopus.
Continuous expression of Sox1 (show SOX1 ELISA Kits) and Sox2 in transgenic embryos represses neuron differentiation and inhibits anterior development while increasing cell proliferation.
direct interaction and interdependence between the Otx2 (show OTX2 ELISA Kits) and Sox2 proteins coordinate Rax (show RAX ELISA Kits) expression in eye development, providing molecular linkages among the genes responsible for ocular malformation.
Sox3 functions as an activator to induce expression of the early neural genes, sox2 and geminin in the absence of protein synthesis and to indirectly inhibit the Bmp target Xvent2
A directional Wnt (show WNT2 ELISA Kits)/beta-catenin (show CTNNB1 ELISA Kits)-Sox2-proneural pathway regulates the transition from proliferation to differentiation in the retina.
Sox2 has a role in pluripotency in pig embryos
Overexpression of Sox2 or Oct4 (show POU5F1 ELISA Kits) in bone mesenchymal stem cells in culture media containing a basic fibroblast growth factor (show FGF2 ELISA Kits) results in higher proliferation and differentiation compared to controls.
cells isolated from umbilical cord express three transcription factors,Oct-4, Sox-2 & Nanog, found in pluripotent stem cell markers both at the mRNA and protein level
SOX2 localizes exclusively in the inner cell mass of bovine blastocysts, and its downregulation negatively impacts preimplantation development (show MTA2 ELISA Kits).
analysis of pluripotency gene expression of OCT4, SOX2 and NANOG and mRNA levels of some of their downstream targets in bovine oocytes and early embryos
Sox2 displayed relatively the same methylation levels between sperm and oocytes
Tbx6 (show TBX6 ELISA Kits) and Sox2 co-expression marks a new transient progenitor state of the neuromesoderm lineage. Tbx6 (show TBX6 ELISA Kits) and Sox2 co-expression marks neuromesoderm progenitors in the tail bud.
Stem cell and mesenchymal markers, including sex-determining region Y-box 2 (Sox2), are upregulated in aortic ECs of fat-fed ApoE (show APOE ELISA Kits)(-/-) mice, which suggests that endothelial-mesenchymal transitions (EndMTs) contribute to atherosclerotic lesion calcification
miR (show MLXIP ELISA Kits)-145 modulation of Sox2-Lin28 (show LIN28A ELISA Kits)/let-7 network is crucial for neurogenesis progression.
widespread destruction of airway and alveolar epithelial cells following severe influenza infection triggers a wound-healing response that initiates in the airways with the proliferation of rare airway-resident SOX2+ Lin- progenitor cells. These cells then give rise to nascent KRT5 (show KRT5 ELISA Kits)+ cells in remodeled airways and populate the damaged alveolar parenchyma.
The data identify Sox2 as a context-dependent tumor suppressor protein (show TP53 ELISA Kits) that is dispensable for normal tissue regeneration, but restrains stomach adenoma formation through modulation of Wnt (show WNT2 ELISA Kits)-responsive and intestinal genes.
Chd7 (show CHD3 ELISA Kits) is a key regulator of oligodendrocyte precursor cell activation, in which it cooperates with Sox2.
CRISPR/Cas9-assisted gene swap provides strong evidence that SOX2 and SOX3 (show SOX3 ELISA Kits) proteins are functionally equivalent in developing brain and testes.
Sox2 is required to specify prosensory competence, but subsequent down-regulation of Sox2 must occur to allow Atoh1 (show ATOH1 ELISA Kits) expression, most likely through a direct interaction with the Atoh1 (show ATOH1 ELISA Kits) promoter.
These findings identify Sox2 as a physiological regulator of Schwann cell myelination in vivo and its potential to play a role in disorders of myelination in the peripheral nervous system.
Sox2 plays an essential role in melanocyte transformation and melanoma growth.
Both sox2 and p27kip are regulated by the retinoic acid signal pathway and are essential for hair cell regeneration.
a role of Sox2 as one of the proliferation initiators in ependymal cells after spinal cord injury
Sox2 is identified as the unknown factor responsible for pineal photoreceptor prepatterning and performs this function independently of the BMP signaling.
significant decreases in sox2 (up to 4-fold) expression following chilling and increase of sox2 (up to 3-fold) during warming of chilled embryos.
Knockdown of the four B1 sox (show PIPOX ELISA Kits) genes sox2/3/19a/19b resulted in severe developmental abnormalities.
sox2 is required for hair cell survival, as well as for transdifferentiation of support cells into hair cells during regeneration
shows the occurrence and cell localization of the Sox-2 in chemosensory and mechanosensory organs of zebrafish during the embryonic stage to adult, suggest an involvement of Sox-2 in cell renewal of zebrafish sensory organs
zebrafish sox2 gene is strongly expressed in neuromast progenitor cells, including those of the migrating lateral line
Sox2 overlapping transcript has multiple transcription start sites associated with genomic features that indicate regulated expression, including highly conserved elements and chromatin marks characteristic of gene promoters.
This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT).
SRY (sex determining region Y)-box 2
, FAD-dependent sulfhydryl oxidase-2
, sulfhydryl oxidase 1
, SRY-related HMG-box gene 2
, transcription factor SOX-2
, transcription factor SOX2
, SRY-box containing gene 2
, Sox2 transcription factor
, delta EF2a
, sex-determining region Y-box 2
, transcription factor Sox-2
, SRY-box 2
, SRY-related HMG-box 2
, sex determining region Y-box 2