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The Khc73 stalk/14-3-3 (show YWHAZ Proteins)/NudE pathway defines a physical connection that coordinates the activities of multiple motor proteins to precisely position the spindle.
role of 14-3-3epsilon in germ cell migration
14-3-3epsilon acts as a biochemical control point for axon guidance in Drosophila, silencing Plexin A repulsive axon guidance and regulating a semaphorin repulsion/integrin adhesion switch.
We conclude that 14-3-3epsilon is required for Rab11 (show RAB11A Proteins)-positive vesicle function, which in turn enables antimicrobial peptide (show cAMP Proteins) secretion during an innate immune response.
Hpo (show GFER Proteins) signaling inhibited Yki (show YAP1 Proteins) nuclear localization and activity by phosphorylating Yki (show YAP1 Proteins) and both isoforms of 14-3-3 (show YWHAZ Proteins), 14-3-3varepsilon and 14-3-3zeta (show YWHAZ Proteins), regulate Yki (show YAP1 Proteins) activity through modulating its subcellular localization.
The biochemically conserved regulatory mechanisms of recombinant DTH parallel those from mammals.
maternal as well as embryonic effects on the secretion and/or functionality of Tyrosine hydroxylase (pale) may play roles in the early developmental program of the organism.
activity of tyrosine hydroxylase is also increased by this interaction, in excess (show RCC1 Proteins) of the stimulation resulting from phosphorylation alone
Drosophila 14-3-3/PAR-5 (show YWHAZ Proteins) is an essential mediator of PAR-1 (show F2R Proteins) function in axis formation.
PAR-1 (show F2R Proteins) phosphorylates Bazooka/PAR-3 (show PARD3 Proteins) on two conserved serines to generate 14-3-3 (show YWHAZ Proteins) binding sites. This inhibits formation of the Bazooka (show PARD3 Proteins)/PAR-6 (show PARD6A Proteins)/aPKC complex by blocking Bazooka (show PARD3 Proteins) oligomerization and binding to aPKC.
Data suggest that TH phosphorylated at Ser (show SIGLEC1 Proteins)-31 co-distributes with Golgi complexes and synaptic-like vesicles in rat and human dopaminergic neurons/cell lines; Ser (show SIGLEC1 Proteins)-31 phosphorylation may regulate TH subcellular localization by enabling its transport along microtubules, notably toward the projection terminals.
TH is a robust interaction partner of different 14-3-3 (show YWHAQ Proteins) dimer types with moderate variability between the 14-3-3 (show YWHAQ Proteins) dimers on their regulation of TH.
No statistically significant differences were found between cases and controls for the allele frequencies in five genes: TH, SLC18A2 (show Slc18a2 Proteins), DRD1 (show DRD1 Proteins), DRD3 (show DRD3 Proteins) and COMT (show COMT Proteins). Conversely, some alleles of the 12 sNPs from the DRD2 (show DRD2 Proteins) locus and the 5 from the MAOA (show MAOA Proteins) locus showed significant associations with excessive alcohol consumption.
Results show that metastasis-associated protein 1 (MTA1 (show MTA1 Proteins)) and tyrosine hydroxylase (TH) levels were significantly down-regulated in Parkinson disease (PD) samples as compared with normal brain tissue
the reduction of tyrosine hydroxylase-immunoreactive neurons occurring in the locus coeruleus after perinatal hypoxic insults persists into adulthood
In high-risk metastatic Neuroblastoma (show ARHGEF16 Proteins), TH and DCX (show DCX Proteins) mRNA quantification could be used for the assessment of response to treatment and for early detection of progressive disease or relapses.
the allelic frequency of the TH01 marker in 171 Swiss sudden infant death syndrome (SIDS (show IDS Proteins)) infants and 500 healthy and gender-matched Caucasian adults showed that the 9.3 allele is similarly distributed in SIDS (show IDS Proteins) cases and controls (27.2% vs. 25.6%; p-value = 0.562).
This study showed that a new tyrosine hydroxylase knock-in mouse model of l-DOPA-responsive dystonia.
The mutant tyrosine hydroxylase enzyme was unstable and exhibited deficient stabilization by catecholamines, leading to decline of brain tyrosine hydroxylase-immunoreactivity in the Th knock-in mice.
Thus, the hTH-GFP reporter rat should be a valuable tool for Parkinson's disease research.
These findings reveal that Th and Gad1 share a transcription regulatory mechanism that facilitates odorant-dependent regulation of dopamine and GABA expression levels.
deletion of Th in hematopoietic cells of adult mice neither alters energy expenditure upon cold exposure nor reduces browning in inguinal adipose tissue. Bone marrow-derived macrophages did not release NE in response to stimulation with IL-4 (show IL4 Proteins), and conditioned media from IL-4 (show IL4 Proteins)-stimulated macrophages failed to induce expression of thermogenic genes, such as uncoupling protein 1 (Ucp1 (show UCP1 Proteins)), in adipocytes.
The neurogenic contractions were higher in the sickle cell disease, in association with elevated tyrosine hydroxylase phosphorylated at Ser (show SIGLEC1 Proteins)-31 and total tyrosine hydroxylase protein expression, as well as increased tyrosine hydroxylase mRNA expression.
these data demonstrate a novel interaction between Hsc70 (show HSPA8 Proteins) and TH that regulates the activity and localization of the enzyme to synaptic vesicles, suggesting an important role for Hsc70 (show HSPA8 Proteins) in dopamine homeostasis.
TH gene overexpression promotes the polarization and differentiation of CD4 (show CD4 Proteins)+ cells towards Th2 cells.
The TH-immunopositive fibres detected in the orbitofrontal cortices of the DISC1 (show DISC1 Proteins) KO mice were significantly shorter than those seen in the wild-type mice.
Real-time PCR analyses revealed that social defeat significantly increased tyrosine hydroxylase in the ventral tegmental area.
These results revealed a new role of the canonical Lrp5 (show LRP5 Proteins)/6-beta-catenin (show CTNNB1 Proteins) pathway in regulating the morphogenesis of the cerebellum during postnatal development.
psychostimulants induce downregulation of DRD1a (show DRD1 Proteins) and DRD2 (show DRD2 Proteins) mRNA expression and upregulation of tyrosine hydroxylase protein expression in the testis
Deletion of the CB2 r (show CNR2 Proteins) gene increased preference for and vulnerability to ethanol consumption, at least in part, by increased ethanol-induced sensitivity of the TH and mu-opioid receptor (show OPRM1 Proteins) gene expressions in mesolimbic neurons.
Achilles tendon tenocytes produce tyrosine hydroxylase.
Retinol activates tyrosine hydroxylase via two sequential non-genomic mechanisms, which have not previously been characterized. These mechanisms are likely to operate in vivo to facilitate the stress response.
IFN-alpha (show IFNA Proteins) mediated activation of ERK1/2 appeared to be responsible for the increased phosphorylation of tyrosine hydroxylase.
The protein encoded by this gene is involved in the conversion of tyrosine to dopamine. It is the rate-limiting enzyme in the synthesis of catecholamines, hence plays a key role in the physiology of adrenergic neurons. Mutations in this gene have been associated with autosomal recessive Segawa syndrome. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
, XBB70 group VII
, drosophila tyrosine hydroxylase
, tyrosine hydrodroxylase
, tyrosine hydroxylase
, tyrosine 3-monooxygenase
, suppressor of Ras85D 3-9
, dystonia 14
, tyrosine 3-hydroxylase