Browse our EPS8 Proteins (EPS8)

Full name:
Epidermal Growth Factor Receptor Pathway Substrate 8 Proteins (EPS8)
On are 4 Epidermal Growth Factor Receptor Pathway Substrate 8 (EPS8) Proteins from 3 different suppliers available. Additionally we are shipping EPS8 Antibodies (110) and EPS8 Kits (5) and many more products for this protein. A total of 125 EPS8 products are currently listed.
AW261790, MGC81285, MGC146320
list all proteins Gene Name GeneID UniProt
EPS8 2059 Q12929
EPS8 13860 Q08509
Rat EPS8 EPS8 312812  

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EPS8 Proteins (EPS8) by Origin

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More Proteins for EPS8 Interaction Partners

Human Epidermal Growth Factor Receptor Pathway Substrate 8 (EPS8) interaction partners

  1. Immunohistochemistry revealed that Eps8 was significantly increased in cervical cancer specimens compared with squamous intraepithelial lesion and normal cervical tissues. Additionally, it was revealed that Eps8 expression not only correlated with cervical cancer progression, but also exhibited a close correlation with the epithelialmesenchymal transition (EMT (show ITK Proteins)) markers, Ecadherin and vimentin (show VIM Proteins).

  2. Eps8 is required for continuous membrane blebbing.

  3. Erk (show EPHB2 Proteins) activity promotes actin bundling by Eps8 to enhance cortex tension and drive the bleb-based migration of cancer cells under non-adhesive confinement.

  4. Eps8 is a crucial mediator of Src (show SRC Proteins)- and FAK (show PTK2 Proteins)-regulated processes.

  5. Eps8 is overexpressed in human breast cancers, possibly by regulating ERK (show EPHB2 Proteins) signaling, MMP9 (show MMP9 Proteins), p53 (show TP53 Proteins) and EMT (show ITK Proteins)-like transition to affect breast cancer cell growth, migration and invasion.

  6. EPS8, as MDR1 and WT1 (show WT1 Proteins), may be a clinically valuable biomarker for assessing the outcome of ALL patients.

  7. These results indicate that employing the native and modified epitopes identified here in Eps8-based immunotherapy for HLA-A2.1 positive cancer patients may result in efficient anticancer immune responses for diverse tumor types.

  8. determined the alpha-synuclein-binding domain of beta-III tubulin and demonstrated that a short fragment containing this domain can suppress alpha-synuclein accumulation in the primary cultured cells

  9. The ITSN2 interacts with Eps8 and stimulates the degradation of Eps8 proteins.

  10. EPS8 is an F-actin capping and bundling protein. Mutant mice lacking EPS8 (Eps8-/- mice), which is present in the hair bundle, the sensory antenna of the auditory sensory cells that operate the mechano-electrical transduction

Mouse (Murine) Epidermal Growth Factor Receptor Pathway Substrate 8 (EPS8) interaction partners

  1. Absence of Eps8 produces a weaker phenotype in vestibular hair cells compared to cochlear inner hair cells, since it affects the hair bundle morphology but not the basolateral membrane currents. This difference is likely to explain the absence of obvious vestibular dysfunction in Eps8 knockout mice.

  2. Results implicate N-methyl-d-aspartate receptor (show GRIN1 Proteins) hyperfunction in the cognitive deficits observed in Epidermal growth factor receptor (show EGFR Proteins) substrate 8 (Eps8) knockout mice and demonstrate a novel role for Eps8 in regulating hippocampal long-term synaptic plasticity and cognitive function.

  3. These findings demonstrate a novel role for Wnt (show WNT2 Proteins)-Dvl1 (show DVL1 Proteins) signalling through Eps8 in the regulation of axonal remodeling.

  4. It shows that EPS8, a signaling adapter regulating actin dynamics, is a novel partner of VE-cadherin (show CDH5 Proteins) and is able to modulate YAP (show YAP1 Proteins) activity.

  5. The actin-binding proteins eps8 and gelsolin (show GSN Proteins) have complementary roles in regulating the growth and stability of mechanosensory hair bundles of mammalian cochlear outer hair cells.

  6. These results reveal a previously unknown cell type-specific expression pattern of endogenous Eps8 protein in the mouse hippocampus.

  7. the key role of Eps8 actin-capping activity in spine morphogenesis and plasticity and indicate that reductions in actin-capping proteins may characterize forms of intellectual disabilities associated with spine defects.

  8. identified Eps8 as a unique actin capping protein (show TMOD4 Proteins) specifically required for Dendritic cell migration

  9. epidermal growth factor receptor pathway substrate 8 is critical in coordinating the development and functionality of mammalian auditory hair cells

  10. critical role for JNK2 (show MAPK9 Proteins) and EPS8 in receptor tyrosine kinase (show ERBB3 Proteins) signaling and trafficking to convey distinctly different effects on cell migration.

Pig (Porcine) Epidermal Growth Factor Receptor Pathway Substrate 8 (EPS8) interaction partners

  1. the SSC5:60296617 SNP may affect teat number by regulating the interaction of EPS8 and RAPGEF1 (show RAPGEF1 Proteins) and, finally, affecting the mammogenesis of pigs

  2. Coexpression of ezrin with Eps8 promotes the formation of membrane ruffles and tufts of microvilli, whereas expression of ezrin and Eps8L1a induces the clustering of actin-containing structures at the cell surface.

EPS8 Protein Profile

Protein Summary

This gene encodes a member of the EPS8 family. This protein contains one PH domain and one SH3 domain. It functions as part of the EGFR pathway, though its exact role has not been determined. Highly similar proteins in other organisms are involved in the transduction of signals from Ras to Rac and growth factor-mediated actin remodeling. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.

Alternative names and synonyms associated with EPS8

  • epidermal growth factor receptor pathway substrate 8 (EPS8)
  • epidermal growth factor receptor pathway substrate 8 (eps8)
  • epidermal growth factor receptor pathway substrate 8 (Eps8)
  • AW261790 protein
  • MGC81285 protein
  • MGC146320 protein

Protein level used designations for EPS8

epidermal growth factor receptor pathway substrate 8 , epidermal growth factor receptor kinase substrate 8

100067366 Equus caballus
414529 Xenopus laevis
418174 Gallus gallus
473379 Pan troglodytes
779963 Xenopus (Silurana) tropicalis
100343649 Oryctolagus cuniculus
2059 Homo sapiens
13860 Mus musculus
312812 Rattus norvegicus
100525921 Sus scrofa
100735652 Cavia porcellus
100174737 Pongo abelii
477686 Canis lupus familiaris
538419 Bos taurus
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