Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

ERBB3 Proteins

(Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3))
This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. [provided by RefSeq, Jul 2008].
ERBB3 Protein (AA 20-643) (His-Avi Tag) ERBB3 Protein (AA 20-643) (His-Avi Tag) ERBB3 Protein (AA 20-643) (His-Avi Tag) (ABIN7274801)

ERBB3 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

ERBB3 Protein (AA 20-643) (Fc Tag) ERBB3 Protein (AA 20-643) (Fc Tag) ERBB3 Protein (AA 20-643) (Fc Tag) (ABIN7274797)

ERBB3 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

ERBB3 Protein (AA 20-641) (His tag) ERBB3 Protein (AA 20-641) (His tag) ERBB3 Protein (AA 20-641) (His tag) (ABIN7274795)

ERBB3 Origin: Cynomolgus, Rhesus Monkey Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

ERBB3 Proteins by Grade

Find ERBB3 Proteins with a specific Grade. The Grade listed below are among those available. Click on a link to go to the corresponding products.

ERBB3 Proteins by Origin

Find ERBB3 Proteins for a variety of species such as anti-Human ERBB3, anti-Mouse ERBB3, anti-Cynomolgus ERBB3. The species listed below are among those available. Click on a link to go to the corresponding products.

ERBB3 Proteins by Source

Here you will find ERBB3 Proteins proteins organized by several key sources. By clicking on a link, you can access the products. For additional sources, please use our search function.

ERBB3 Proteins by Protein Type

Here you can find ERBB3 Proteins proteins categorized by available protein types. Additional protein types can be located using our search function.

ERBB3 Proteins by Application

Find ERBB3 Proteins validated for a specific application such as WB, ELISA, SDS, AbP. Some of the available applications are listed below. Click on a link to go to the corresponding products.

ERBB3 Proteins by Biological Activity

Find ERBB3 Proteins with a specific Biological Activity. The Biological Activity listed below are among those available. Click on a link to go to the corresponding products.

Popular ERBB3 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (5)
Cat. No. ABIN7274801
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (3)
Cat. No. ABIN7274797
Quantity 100 μg
Datasheet Datasheet
Reactivity Cynomolgus, Rhesus Monkey
Source HEK-293 Cells
Validations
  • (3)
Cat. No. ABIN7274795
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (3)
Cat. No. ABIN7274802
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (3)
Cat. No. ABIN6961140
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (4)
  • (3)
Cat. No. ABIN2181038
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Human Cells
Validations
  • (1)
Cat. No. ABIN7319862
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7124803
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1353019
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1353017
Quantity 10 μg
Datasheet Datasheet
Reactivity Mouse
Source HEK-293 Cells
Validations
  • (1)
Cat. No. ABIN7320073
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Human Cells
Validations
  • (1)
Cat. No. ABIN7319879
Quantity 100 μg
Datasheet Datasheet
Reactivity Mouse
Source Insect Cells
Validations
Cat. No. ABIN3122985
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
Cat. No. ABIN3092426
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (2)
Cat. No. ABIN6938840
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our ERBB3 Proteins

DAgostino, Gentile, Ponziani, Di Vittorio, Dituri, Giannelli, Rossi, Marzullo, Giansanti, De Laurenzi, Iacobelli, Ippoliti, Capone, Sala: "EV20‑sss‑vc/MMAF, an HER‑3 targeting antibody‑drug conjugate displays antitumor activity in liver cancer." in: Oncology reports, Vol. 45, Issue 2, pp. 776-785, (2021) (PubMed).

Shinozaki, Hashimoto, Fukui, Uchiyama: "Efficient generation of single domain antibodies with high affinities and enhanced thermal stabilities." in: Scientific reports, Vol. 7, Issue 1, pp. 5794, (2019) (PubMed).

Capone, Lamolinara, DAgostino, Rossi, De Laurenzi, Iezzi, Iacobelli, Sala: "EV20-mediated delivery of cytotoxic auristatin MMAF exhibits potent therapeutic efficacy in cutaneous melanoma." in: Journal of controlled release : official journal of the Controlled Release Society, Vol. 277, pp. 48-56, (2019) (PubMed).

Sala, Rapposelli, Ghasemi, Piccolo, Traini, Capone, Rossi, Pelliccia, Di Risio, DEgidio, Tinari, Muraro, Iacobelli: "EV20, a Novel Anti-ErbB-3 Humanized Antibody, Promotes ErbB-3 Down-Regulation and Inhibits Tumor Growth In Vivo." in: Translational oncology, Vol. 6, Issue 6, pp. 676-84, (2014) (PubMed).

Nilvebrant, Astrand, Löfblom, Hober: "Development and characterization of small bispecific albumin-binding domains with high affinity for ErbB3." in: Cellular and molecular life sciences : CMLS, Vol. 70, Issue 20, pp. 3973-85, (2013) (PubMed).

Aliases for ERBB3 Proteins

erb-b2 receptor tyrosine kinase 3 (ERBB3) Proteins
v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) (ERBB3) Proteins
erb-b2 receptor tyrosine kinase 3 (Erbb3) Proteins
c-erbB-3 Proteins
c-erbB3 Proteins
C76256 Proteins
ErbB-3 Proteins
Erbb-3 Proteins
ERBB3 Proteins
erbB3-S Proteins
Erbb3r Proteins
HER3 Proteins
Her3 Proteins
LCCS2 Proteins
MDA-BF-1 Proteins
nuc-ErbB3 Proteins
p45-sErbB3 Proteins
p85-sErbB3 Proteins
p180-ErbB3 Proteins
You are here:
Support