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ErbB2/Her2 Proteins

(Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))
This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008].
ErbB2/Her2 Protein (AA 23-652) (His-Avi Tag) ErbB2/Her2 Protein (AA 23-652) (His-Avi Tag) ErbB2/Her2 Protein (AA 23-652) (His-Avi Tag) (ABIN7274799)

ErbB2/Her2 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

ErbB2/Her2 Protein (AA 23-652) (Fc Tag) ErbB2/Her2 Protein (AA 23-652) (Fc Tag) ErbB2/Her2 Protein (AA 23-652) (Fc Tag) (ABIN7274796)

ErbB2/Her2 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

ErbB2/Her2 Protein (His-Avi Tag,Biotin) ErbB2/Her2 Protein (His-Avi Tag,Biotin) ErbB2/Her2 Protein (His-Avi Tag,Biotin) (ABIN7274800)

ErbB2/Her2 Origin: Human Host: HEK-293 Cells Recombinant > 95% as determined by Tris-Bis PAGE,> 95% as determined by HPLC

ErbB2/Her2 Proteins by Grade

Find ErbB2/Her2 Proteins with a specific Grade. The Grade listed below are among those available. Click on a link to go to the corresponding products.

ErbB2/Her2 Proteins by Origin

Find ErbB2/Her2 Proteins for a variety of species such as anti-Human ErbB2/Her2, anti-Mouse ErbB2/Her2, anti-Rat ErbB2/Her2. The species listed below are among those available. Click on a link to go to the corresponding products.

ErbB2/Her2 Proteins by Source

Here you will find ErbB2/Her2 Proteins proteins organized by several key sources. By clicking on a link, you can access the products. For additional sources, please use our search function.

ErbB2/Her2 Proteins by Protein Type

Here you can find ErbB2/Her2 Proteins proteins categorized by available protein types. Additional protein types can be located using our search function.

ErbB2/Her2 Proteins by Application

Find ErbB2/Her2 Proteins validated for a specific application such as WB, SDS, ELISA, Crys. Some of the available applications are listed below. Click on a link to go to the corresponding products.

ErbB2/Her2 Proteins by Biological Activity

Find ErbB2/Her2 Proteins with a specific Biological Activity. The Biological Activity listed below are among those available. Click on a link to go to the corresponding products.

Popular ErbB2/Her2 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (5)
Cat. No. ABIN7274799
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (4)
Cat. No. ABIN7274796
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (4)
Cat. No. ABIN7274800
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (15)
  • (3)
Cat. No. ABIN2181214
Quantity 100 μg
Datasheet Datasheet
Reactivity Cynomolgus
Source HEK-293 Cells
Validations
  • (3)
Cat. No. ABIN7274794
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (2)
  • (1)
Cat. No. ABIN1353011
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (2)
Cat. No. ABIN7274804
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (2)
  • (2)
Cat. No. ABIN2181216
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (2)
  • (2)
Cat. No. ABIN6809903
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (3)
Cat. No. ABIN7013682
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (1)
  • (2)
Cat. No. ABIN5954984
Quantity 200 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (2)
  • (2)
Cat. No. ABIN2444140
Quantity 200 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7124801
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1353013
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (2)
Cat. No. ABIN6964074
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our ErbB2/Her2 Proteins

Farràs, Román, Camps, Miret, Martínez, Pujol, Casablancas, Cairó: "Heavy chain dimers stabilized by disulfide bonds are required to promote in vitro assembly of trastuzumab." in: BMC molecular and cell biology, Vol. 21, Issue 1, pp. 2, (2020) (PubMed).

Murakami, Matsumoto, Kanamori: "Constructive approach for synthesis of a functional IgG using a reconstituted cell-free protein synthesis system." in: Scientific reports, Vol. 9, Issue 1, pp. 671, (2020) (PubMed).

Hao, Yu, Bai, McBride, Huang: "Cryo-EM Structure of HER2-trastuzumab-pertuzumab complex." in: PLoS ONE, Vol. 14, Issue 5, pp. e0216095, (2020) (PubMed).

Turner, Kilgour, Stine, Daniele, Menegatti: "Dual-Affinity Ratiometric Quenching (DARQ) Assay for the Quantification of Therapeutic Antibodies in CHO-S Cell Culture Fluids." in: Analytical chemistry, Vol. 92, Issue 24, pp. 16274-16283, (2020) (PubMed).

Hutterer, Polozova, Kuhns, McBride, Cao, Liu: "Assessing Analytical and Functional Similarity of Proposed Amgen Biosimilar ABP 980 to Trastuzumab." in: BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy, Vol. 33, Issue 3, pp. 321-333, (2019) (PubMed).

Hussack, Raphael, Lowden, Henry: "Isolation and characterization of camelid single-domain antibodies against HER2." in: BMC research notes, Vol. 11, Issue 1, pp. 866, (2019) (PubMed).

Shinozaki, Hashimoto, Fukui, Uchiyama: "Efficient generation of single domain antibodies with high affinities and enhanced thermal stabilities." in: Scientific reports, Vol. 7, Issue 1, pp. 5794, (2019) (PubMed).

Wang, Forterre, Zhao, Frimannsson, Delcayre, Antes, Efron, Jeffrey, Pegram, Matin: "Anti-HER2 scFv-Directed Extracellular Vesicle-Mediated mRNA-Based Gene Delivery Inhibits Growth of HER2-Positive Human Breast Tumor Xenografts by Prodrug Activation." in: Molecular cancer therapeutics, Vol. 17, Issue 5, pp. 1133-1142, (2019) (PubMed).

Mortensen, Skovsgaard, Okholm, Scavenius, Dupont, Rosen, Enghild, Kjems, Gothelf: "Small-Molecule Probes for Affinity-Guided Introduction of Biocompatible Handles on Metal-Binding Proteins." in: Bioconjugate chemistry, Vol. 29, Issue 9, pp. 3016-3025, (2019) (PubMed).

Vivier, Sharma, Adumeau, Rodriguez, Fung, Zeglis: "The Impact of FcγRI Binding on ImmunoPET." in: Journal of nuclear medicine : official publication, Society of Nuclear Medicine, (2019) (PubMed).

Aliases for ErbB2/Her2 Proteins

erb-b2 receptor tyrosine kinase 2 (ERBB2) Proteins
erb-b2 receptor tyrosine kinase 2 (Erbb2) Proteins
erb-b2 receptor tyrosine kinase 2 (erbb2) Proteins
c-erbB2 Proteins
c-neu Proteins
CD340 Proteins
erb2 Proteins
Erbb-2 Proteins
HER-2 Proteins
HER-2/neu Proteins
HER2 Proteins
mKIAA3023 Proteins
MLN 19 Proteins
NEU Proteins
Neu Proteins
NGL Proteins
TKR1 Proteins
wu:fv70f10 Proteins
zgc:63601 Proteins
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