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Browse our Mesothelin Proteins (MSLN)

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Mesothelin Proteins (MSLN)
On are 52 Mesothelin (MSLN) Proteins from 12 different suppliers available. Additionally we are shipping Mesothelin Antibodies (207) and Mesothelin Kits (31) and many more products for this protein. A total of 304 Mesothelin products are currently listed.
6330420K13Rik, CEPR, Ceprl, CMKRL2, DRY12, FEG-1, GPCR-Br, Gper, Gpr30, LERGU, LERGU2, LyGPR, MPF, MSLN, SMRP
list all proteins Gene Name GeneID UniProt
MSLN 2852 Q99527
MSLN 76854 Q8BMP4
MSLN 60333 Q9ERA7

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Mesothelin Proteins (MSLN) by Origin

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Top referenced Mesothelin Proteins

  1. Mouse (Murine) Mesothelin Protein expressed in HEK-293 - ABIN2666851 : Prieve, Moon: Stromelysin-1 and mesothelin are differentially regulated by Wnt-5a and Wnt-1 in C57mg mouse mammary epithelial cells. in BMC developmental biology 2003 (PubMed)
    Show all 6 references for ABIN2666851

  2. Human Mesothelin Protein expressed in HEK-293 - ABIN2666849 : Bharadwaj, Marin-Muller, Li, Chen, Yao: Mesothelin confers pancreatic cancer cell resistance to TNF-α-induced apoptosis through Akt/PI3K/NF-κB activation and IL-6/Mcl-1 overexpression. in Molecular cancer 2011 (PubMed)
    Show all 6 references for ABIN2666849

  3. Human Mesothelin Protein expressed in HEK-293 Cells - ABIN2181514 : Chang, Pastan: Molecular cloning of mesothelin, a differentiation antigen present on mesothelium, mesotheliomas, and ovarian cancers. in Proceedings of the National Academy of Sciences of the United States of America 1996 (PubMed)
    Show all 3 references for ABIN2181514

  4. Human Mesothelin Protein expressed in Wheat germ - ABIN1311461 : Li, Bharadwaj, Zhang, Zhang, Mu, Fisher, Brunicardi, Chen, Yao: Mesothelin is a malignant factor and therapeutic vaccine target for pancreatic cancer. in Molecular cancer therapeutics 2008 (PubMed)

More Proteins for Mesothelin Interaction Partners

Human Mesothelin (MSLN) interaction partners

  1. Studies identified an important role of GPER activation in the regulation of cardiovascular function especially in women. [review]

  2. Calretinin (show CALB2 Proteins), D2-40 and mesothelin are aberrantly expressed in a proportion of CRC (show CALR Proteins) cases.

  3. GPR30, ERalpha (show ESR1 Proteins), and ERbeta (show ESR2 Proteins) mRNA expression in testis of Klinefelter syndrome men, were evaluated.

  4. GPER negatively regulates TNFalpha-induced IL-6 expression, probably through inhibition of NF-kappaB promoter activity by a signal(s) derived from the C-terminal region of GPER.

  5. Results demonstrated that GPER protein down-regulation significantly correlated with GPER promoter hypermethylation. Comparison of 108 tumors and matched normal breast tissues indicated a significant GPER down-regulation in cancer tissues correlating with GPER promoter hypermethylation.

  6. Data suggest that expression of GPER1/GPR30 can be up-regulated by dietary factors; dietary supplementation with flaxseed-derived lignan, secoisolariciresinol diglycoside, up-regulates expression of GPER1/GPR30 in prostate and may prevent progression of benign prostatic hyperplasia.

  7. Our results showed that IMP3 (show IGF2BP3 Proteins) immunostaining has a higher sensitivity and specificity than mesothelin for the diagnosis of pancreatic ductal adenocarcinoma. IMP3 (show IGF2BP3 Proteins) and mesothelin may be useful markers in distinguishing neoplastic from reactive lesions of the pancreas in instances where this is impossible by morphology alone in surgical pathology practice.

  8. the presence of the GG genotype of the GPR30 rs3808351 polymorphism and the G allele of the GPR30 rs3808351 polymorphism affect the characteristics and development of leiomyomas in the Turkish population

  9. GPER expression was mainly con (show DISP1 Proteins) fi ned in the basal epithelial layer of benign prostate, where this receptor could mediate estrogen action on normal cellular activity.

  10. Studies indicate that prostate cancer stem cells lack the androgen receptor, and express classical alpha and/or beta and GPR30 estrogen receptors.

Mouse (Murine) Mesothelin (MSLN) interaction partners

  1. identified a novel regulatory mechanism through which the endogenous Gper facilitates the age-dependent increase in myocardial expression of ECE-2 and the ETB receptor, which is compatible with an activating role of GPER for the local endothelin system with aging

  2. We suggest that activation of GPER exerts an inhibitory effect on colonic motility by promoting nitric oxide release from myenteric nitrergic nerves

  3. GPR30 is expressed in diverse intracellular compartments in undifferentiated and differentiated C2C12 cells and mediates estradiol actions.

  4. Results demonstrate that ERalpha (show ESR1 Proteins), ERbeta (show ESR2 Proteins), and GPER1 all participate in the rapid effects of 17beta-estradiol-3-benzoate on hippocampal synaptic function

  5. Results show that mouse mesothelin is similar to human mesothelin. Its stable overexpression in a pancreatic cancer cell line did not increase cell proliferation, suggesting that mesothelin is not necessarily a tumor progression factor.

  6. GPR30 can mediate the fast effect of estrogen on blastocysts and play an important role in embryo implantation.

  7. E2 activates GPR30 and ERa to produce liquid crystalline versus anhydrous crystalline metastable intermediates evolving to cholesterol monohydrate crystals . GPR30 produces a synergistic lithogenic action with ERa to enhance E2-induced gallstone formation

  8. Suggest that the effects of diethylstilbestrol on mouse gubernaculum testis cells are mediated at least partially by the regulation of GPER expression.

  9. The stimulating effect of estradiol on progesterone synthesis relies on the estrogen no-classical protein-coupled receptor 30, and MAP3K8 (show MAP3K8 Proteins).

  10. Results suggest that ERalpha (show ESR1 Proteins) requires GPER1 in protection of dopamine neurons and modulation of signaling pathways, and that the effect of GPER1 occurs independently of ERalpha (show ESR1 Proteins)/beta, whereas GPER1 require ERalpha (show ESR1 Proteins)/beta to increase BDNF (show BDNF Proteins) levels

Mesothelin (MSLN) Protein Profile

Protein Summary

This gene encodes a precursor protein that is cleaved into two products, megakaryocyte potentiating factor and mesothelin. Megakaryocyte potentiation factor functions as a cytokine that can stimulate colony formation in bone marrow megakaryocytes. Mesothelian is a glycosylphosphatidylinositol-anchored cell-surface protein that may function as a cell adhesion protein. This protein is overexpressed in epithelial mesotheliomas, ovarian cancers and in specific squamous cell carcinomas. Alternative splicing results in multiple transcript variants.

Alternative names and synonyms associated with Mesothelin (MSLN)

  • mesothelin (MSLN)
  • G protein-coupled estrogen receptor 1 (GPER1)
  • G protein-coupled estrogen receptor 1 (Gper1)
  • mesothelin (Msln)
  • mesothelin-like (LOC100524016)
  • 6330420K13Rik protein
  • CEPR protein
  • Ceprl protein
  • CMKRL2 protein
  • DRY12 protein
  • FEG-1 protein
  • GPCR-Br protein
  • Gper protein
  • Gpr30 protein
  • LERGU protein
  • LERGU2 protein
  • LyGPR protein
  • MPF protein
  • MSLN protein
  • SMRP protein

Protein level used designations for Mesothelin Proteins (MSLN)

mesothelin , G protein-coupled receptor 30 , G-protein coupled estrogen receptor 1 , G-protein coupled receptor 30 , IL8-related receptor DRY12 , chemoattractant receptor-like 2 , chemokine receptor-like 2 , constitutively expressed peptide-like receptor , flow-induced endothelial G-protein coupled receptor 1 , heptahelix receptor , leucine rich protein in GPR30 3'UTR , lymphocyte-derived G-protein coupled receptor , mER , membrane estrogen receptor , constitutively expressed peptide-like receptor like , CAK1 antigen , megakaryocyte potentiating factor , pre-pro-megakaryocyte-potentiating factor , soluble MPF mesothelin related protein , ERC/mesothelin , protein expressed in renal carcinoma

611363 Canis lupus familiaris
698095 Macaca mulatta
2852 Homo sapiens
76854 Mus musculus
10232 Homo sapiens
516237 Bos taurus
56047 Mus musculus
60333 Rattus norvegicus
416534 Gallus gallus
100722390 Cavia porcellus
453806 Pan troglodytes
100524016 Sus scrofa
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