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Browse our Mesothelin Proteins (MSLN)

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Mesothelin Proteins (MSLN)
On are 43 Mesothelin (MSLN) Proteins from 12 different suppliers available. Additionally we are shipping Mesothelin Antibodies (177) and Mesothelin Kits (29) and many more products for this protein. A total of 263 Mesothelin products are currently listed.
6330420K13Rik, CEPR, Ceprl, CMKRL2, DRY12, FEG-1, GPCR-Br, Gper, Gpr30, LERGU, LERGU2, LyGPR, MPF, MSLN, SMRP
list all proteins Gene Name GeneID UniProt
MSLN 2852 Q99527
MSLN 76854 Q8BMP4
MSLN 60333 Q9ERA7

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Mesothelin Proteins (MSLN) by Origin

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Top referenced Mesothelin Proteins

  1. Human Mesothelin Protein expressed in HEK-293 - ABIN2666849 : Bharadwaj, Marin-Muller, Li, Chen, Yao: Mesothelin confers pancreatic cancer cell resistance to TNF-α-induced apoptosis through Akt/PI3K/NF-κB activation and IL-6/Mcl-1 overexpression. in Molecular cancer 2011 (PubMed)
    Show all 6 references for ABIN2666849

  2. Mouse (Murine) Mesothelin Protein expressed in HEK-293 - ABIN2666851 : Prieve, Moon: Stromelysin-1 and mesothelin are differentially regulated by Wnt-5a and Wnt-1 in C57mg mouse mammary epithelial cells. in BMC developmental biology 2003 (PubMed)
    Show all 6 references for ABIN2666851

  3. Human Mesothelin Protein expressed in HEK-293 Cells - ABIN2181514 : Chang, Pastan: Molecular cloning of mesothelin, a differentiation antigen present on mesothelium, mesotheliomas, and ovarian cancers. in Proceedings of the National Academy of Sciences of the United States of America 1996 (PubMed)
    Show all 3 references for ABIN2181514

  4. Human Mesothelin Protein expressed in Wheat germ - ABIN1311461 : Li, Bharadwaj, Zhang, Zhang, Mu, Fisher, Brunicardi, Chen, Yao: Mesothelin is a malignant factor and therapeutic vaccine target for pancreatic cancer. in Molecular cancer therapeutics 2008 (PubMed)

More Proteins for Mesothelin Interaction Partners

Human Mesothelin (MSLN) interaction partners

  1. Evaluation of GPER1, EGFR (show EGFR Proteins) and CXCR1 (show CXCR1 Proteins) mRNA/protein expression may be helpful in differential diagnosis of malignant follicular thyroid carcinoma and benign follicular thyroid adenoma.

  2. Results indicate that GPER-1 mediates proliferation of estrogen-induced leiomyoma cells by activating the MAPK (show MAPK1 Proteins) pathway, and not by promoting mitosis.

  3. GPER significantly attenuated the inhibition effect of miR (show MLXIP Proteins)-424 in estradiol-induced cell growth in the endometrial cancer cells.

  4. The G protein-coupled estrogen receptor 1 (GPER-1) contributes to the proliferation and survival of mantle cell lymphoma cells.

  5. Understanding the molecular basis of agonist/antagonist mechanism of GPER1/GPR30 through structural and energetic analyses

  6. Expression and functional roles of estrogen receptor GPR30 in human intervertebral disc

  7. Data show that estrogen mediates control of hepatitis C virus through the G-protein-coupled estrogen receptor (show ESR1 Proteins) 30 (GPR30) pathway leading to cleavage of occludin (show OCLN Proteins) by Matrix Metalloproteinase-9 (MMP-9 (show MMP9 Proteins)).

  8. a significant positive correlation was found between GPER and Gankyrin (show PSMD10 Proteins) both in ectopic and eutopic endometrium of the ovarian endometriosis.

  9. Our results further suggest that GPER expression and FOXO3a localization could be utilized as prognostic markers in breast cancer therapy and that GPER antagonists could promote apoptosis in GPER-positive breast cancers

  10. In estradiol-treated monocytes, GPER1 physically interacts with estrogen receptor-alpha (show ESR1 Proteins) 36-kDa splice variant. It acts an anti-inflammatory coregulator, because its inhibition blocks estrogen's effect on IL-6 (show IL6 Proteins) expression.

Mouse (Murine) Mesothelin (MSLN) interaction partners

  1. E2 activates GPR30 and ERa to produce liquid crystalline versus anhydrous crystalline metastable intermediates evolving to cholesterol monohydrate crystals . GPR30 produces a synergistic lithogenic action with ERa to enhance E2-induced gallstone formation

  2. Suggest that the effects of diethylstilbestrol on mouse gubernaculum testis cells are mediated at least partially by the regulation of GPER expression.

  3. The stimulating effect of estradiol on progesterone synthesis relies on the estrogen no-classical protein-coupled receptor 30, and MAP3K8 (show MAP3K8 Proteins).

  4. Results suggest that ERalpha (show ESR1 Proteins) requires GPER1 in protection of dopamine neurons and modulation of signaling pathways, and that the effect of GPER1 occurs independently of ERalpha (show ESR1 Proteins)/beta, whereas GPER1 require ERalpha (show ESR1 Proteins)/beta to increase BDNF (show BDNF Proteins) levels

  5. Treatment with 17beta-estradiol is renoprotective after whole-body ischemia-reperfusion in ovariectomized female mice irrespective of GPR30 gene deletion.

  6. GPR30 activation induced anxiolytic effects but did not affect the nociceptive threshold of mice under chronic pain. The anxiolytic effects of GPR30 were partially due to Glur1 (show GRIA1 Proteins) upregulation and GABA-A receptor downregulation in the basolateral amygdala.

  7. this study reveals an atheroprotective function of GPER and introduces selective GPER activation as a novel therapeutic approach to inhibit postmenopausal atherosclerosis and inflammation in the absence of uterotrophic activity.

  8. Study demonstrates that activation of GPR30 stimulates social behavior in a rodent model in a manner similar to 17beta-estradiol benzoate

  9. This is the first description of a role for the novel estrogen receptor GPER in breast tumorigenesis and metastasis.

  10. MSLN has an important role in the growth of lung cancer cells in vivo raising the possibility that inactivation of MPF may be a useful treatment for lung and other MSLN expressing cancers.

Mesothelin (MSLN) Protein Profile

Protein Summary

This gene encodes a precursor protein that is cleaved into two products, megakaryocyte potentiating factor and mesothelin. Megakaryocyte potentiation factor functions as a cytokine that can stimulate colony formation in bone marrow megakaryocytes. Mesothelian is a glycosylphosphatidylinositol-anchored cell-surface protein that may function as a cell adhesion protein. This protein is overexpressed in epithelial mesotheliomas, ovarian cancers and in specific squamous cell carcinomas. Alternative splicing results in multiple transcript variants.

Alternative names and synonyms associated with Mesothelin (MSLN)

  • mesothelin (MSLN)
  • G protein-coupled estrogen receptor 1 (GPER1)
  • G protein-coupled estrogen receptor 1 (Gper1)
  • mesothelin (Msln)
  • mesothelin-like (LOC100524016)
  • 6330420K13Rik protein
  • CEPR protein
  • Ceprl protein
  • CMKRL2 protein
  • DRY12 protein
  • FEG-1 protein
  • GPCR-Br protein
  • Gper protein
  • Gpr30 protein
  • LERGU protein
  • LERGU2 protein
  • LyGPR protein
  • MPF protein
  • MSLN protein
  • SMRP protein

Protein level used designations for Mesothelin Proteins (MSLN)

mesothelin , G protein-coupled receptor 30 , G-protein coupled estrogen receptor 1 , G-protein coupled receptor 30 , IL8-related receptor DRY12 , chemoattractant receptor-like 2 , chemokine receptor-like 2 , constitutively expressed peptide-like receptor , flow-induced endothelial G-protein coupled receptor 1 , heptahelix receptor , leucine rich protein in GPR30 3'UTR , lymphocyte-derived G-protein coupled receptor , mER , membrane estrogen receptor , constitutively expressed peptide-like receptor like , CAK1 antigen , megakaryocyte potentiating factor , pre-pro-megakaryocyte-potentiating factor , soluble MPF mesothelin related protein , ERC/mesothelin , protein expressed in renal carcinoma

611363 Canis lupus familiaris
698095 Macaca mulatta
2852 Homo sapiens
76854 Mus musculus
10232 Homo sapiens
516237 Bos taurus
56047 Mus musculus
60333 Rattus norvegicus
416534 Gallus gallus
100722390 Cavia porcellus
453806 Pan troglodytes
100524016 Sus scrofa
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