Browse our Mesothelin Proteins (MSLN)

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Mesothelin Proteins (MSLN)
On are 52 Mesothelin (MSLN) Proteins from 12 different suppliers available. Additionally we are shipping Mesothelin Antibodies (210) and Mesothelin Kits (42) and many more products for this protein. A total of 318 Mesothelin products are currently listed.
6330420K13Rik, CEPR, Ceprl, CMKRL2, DRY12, FEG-1, GPCR-Br, Gper, Gpr30, LERGU, LERGU2, LyGPR, MPF, MSLN, SMRP
list all proteins Gene Name GeneID UniProt
MSLN 2852 Q99527
MSLN 76854 Q8BMP4
MSLN 60333 Q9ERA7

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Mesothelin Proteins (MSLN) by Origin

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Top referenced Mesothelin Proteins

  1. Mouse (Murine) Mesothelin Protein expressed in HEK-293 - ABIN2666851 : Prieve, Moon: Stromelysin-1 and mesothelin are differentially regulated by Wnt-5a and Wnt-1 in C57mg mouse mammary epithelial cells. in BMC developmental biology 2003 (PubMed)
    Show all 6 references for 2666851

  2. Human Mesothelin Protein expressed in HEK-293 - ABIN2666849 : Bharadwaj, Marin-Muller, Li, Chen, Yao: Mesothelin confers pancreatic cancer cell resistance to TNF-α-induced apoptosis through Akt/PI3K/NF-κB activation and IL-6/Mcl-1 overexpression. in Molecular cancer 2011 (PubMed)
    Show all 6 references for 2666849

  3. Human Mesothelin Protein expressed in HEK-293 Cells - ABIN2181518 : Chang, Pastan: Molecular cloning of mesothelin, a differentiation antigen present on mesothelium, mesotheliomas, and ovarian cancers. in Proceedings of the National Academy of Sciences of the United States of America 1996 (PubMed)
    Show all 3 references for 2181518

  4. Human Mesothelin Protein expressed in Wheat germ - ABIN1311461 : Li, Bharadwaj, Zhang, Zhang, Mu, Fisher, Brunicardi, Chen, Yao: Mesothelin is a malignant factor and therapeutic vaccine target for pancreatic cancer. in Molecular cancer therapeutics 2008 (PubMed)

More Proteins for Mesothelin Interaction Partners

Human Mesothelin (MSLN) interaction partners

  1. Mesothelin/mucin 16 (show MUC16 Proteins) signaling in activated portal fibroblasts regulates cholestatic liver fibrosis.(

  2. MiR (show MLXIP Proteins)-21-5p is suggested as novel regulator of MSLN with a possible functional role in cellular growth.

  3. Activation of GPER can suppress migration and angiogenesis of triple negative breast cancer by inhibiting of NF-kappaB (show NFKB1 Proteins)/IL-6 (show IL6 Proteins) signaling.

  4. we report herein that high tumor mesothelin expression predicts a shorter PFS and OS in EOC patients and demonstrates that serum mesothelin predicts local tumor mesothelin expression.

  5. GPER protects against hepatic tumorigenesis by regulating inflammatory responses.

  6. We provide new evidence for the role of MSLN in EMT (show ITK Proteins) regulation, tumorigenesis and metastasis. Knockdown of MSLN led to mesenchymal to epithelial transition and less aggressive behavior of lung carcinoma and mesothelioma cells.

  7. GPER enhances melanogenesis via PKA by upregulating microphthalmia-related transcription factor-tyrosinase (show TYR Proteins) in melanoma

  8. Data suggest that GPR30 increases ERK1/2 activity via two Gi/o-mediated mechanisms, a PDZ-dependent constitutive mechanism and a PDZ-independent Gi/o-stimulated mechanism involving PI3K. (GPR30 = G protein-coupled estrogen receptor 1; ERK1 = extracellular signal-regulated kinase 1; ERK2 = extracellular signal-regulated kinase 2; Gi/0 = GTP-binding protein alpha subunits, Gi-Go; PI3K = phosphoinositide-3-kinase)

  9. present study revealed that BPA (show DST Proteins) can trigger the progression of laryngeal squamous cell carcinoma via GPER-mediated upregulation of IL-6 (show IL6 Proteins). Therefore, more attention should be paid for the BPA (show DST Proteins) exposure on the development of laryngeal cancer.

  10. G protein-coupled estrogen receptor (show ESR1 Proteins) stabilizes HIF-1alpha (show HIF1A Proteins) and thus promotes HIF-1alpha (show HIF1A Proteins)-induced VEGF (show VEGFA Proteins) and MMP9 (show MMP9 Proteins) in endometrial stromal cells, which play critical roles in endometriosis.

Mouse (Murine) Mesothelin (MSLN) interaction partners

  1. Mesothelin/mucin 16 (show MUC16 Proteins) signaling in activated portal fibroblasts regulates cholestatic liver fibrosis.(

  2. These findings provide strong evidence for aldosterone serving a causal role in renal cell cancer regulation via its GPER receptor; thus, antagonism of GPER represents a potential new target for treatment to reduce metastatic spread.

  3. GPER protects against hepatic tumorigenesis by regulating inflammatory responses.

  4. Data suggest that prenatal exposure to p,p'-DDT (show DDT Proteins) (an endocrine disrupting pesticide) causes sex- and age-independent attenuation of Gper1 in brain which appears to play key role in propagation of DDT (show DDT Proteins)-induced depressive-like neurotoxicity.

  5. Study suggested that the neuroprotective effect of estrogen requires intact GPER1-associated signaling in an in vitro model of ischemia. The membrane-associated signaling mediates the estrogen actions, and depends on PI3K/Akt (show AKT1 Proteins) signaling for Ask1 (show MAP3K5 Proteins) inhibition that prevents the cell death triggered by ischemia. These mechanisms may help for a therapeutic strategy to target on GPER1 for the treatment of neurological disorders.

  6. Phosphorylation of myosin regulatory light chain triggered by E2 was found to be mediated by estrogen receptor-beta (show ESR2 Proteins) and the G protein-coupled estrogen receptor (show ESR1 Proteins).

  7. Our study demonstrated the ameliorative role of GPR30 in NOR memory impaired by AD pathology in female mice

  8. identified a novel regulatory mechanism through which the endogenous Gper facilitates the age-dependent increase in myocardial expression of ECE-2 and the ETB receptor, which is compatible with an activating role of GPER for the local endothelin system with aging

  9. We suggest that activation of GPER exerts an inhibitory effect on colonic motility by promoting nitric oxide release from myenteric nitrergic nerves

  10. GPR30 is expressed in diverse intracellular compartments in undifferentiated and differentiated C2C12 cells and mediates estradiol actions.

Mesothelin (MSLN) Protein Profile

Protein Summary

This gene encodes a precursor protein that is cleaved into two products, megakaryocyte potentiating factor and mesothelin. Megakaryocyte potentiation factor functions as a cytokine that can stimulate colony formation in bone marrow megakaryocytes. Mesothelian is a glycosylphosphatidylinositol-anchored cell-surface protein that may function as a cell adhesion protein. This protein is overexpressed in epithelial mesotheliomas, ovarian cancers and in specific squamous cell carcinomas. Alternative splicing results in multiple transcript variants.

Alternative names and synonyms associated with Mesothelin (MSLN)

  • mesothelin (MSLN)
  • G protein-coupled estrogen receptor 1 (GPER1)
  • G protein-coupled estrogen receptor 1 (Gper1)
  • mesothelin (Msln)
  • mesothelin-like (LOC100524016)
  • 6330420K13Rik protein
  • CEPR protein
  • Ceprl protein
  • CMKRL2 protein
  • DRY12 protein
  • FEG-1 protein
  • GPCR-Br protein
  • Gper protein
  • Gpr30 protein
  • LERGU protein
  • LERGU2 protein
  • LyGPR protein
  • MPF protein
  • MSLN protein
  • SMRP protein

Protein level used designations for Mesothelin Proteins (MSLN)

mesothelin , G protein-coupled receptor 30 , G-protein coupled estrogen receptor 1 , G-protein coupled receptor 30 , IL8-related receptor DRY12 , chemoattractant receptor-like 2 , chemokine receptor-like 2 , constitutively expressed peptide-like receptor , flow-induced endothelial G-protein coupled receptor 1 , heptahelix receptor , leucine rich protein in GPR30 3'UTR , lymphocyte-derived G-protein coupled receptor , mER , membrane estrogen receptor , constitutively expressed peptide-like receptor like , CAK1 antigen , megakaryocyte potentiating factor , pre-pro-megakaryocyte-potentiating factor , soluble MPF mesothelin related protein , ERC/mesothelin , protein expressed in renal carcinoma

611363 Canis lupus familiaris
698095 Macaca mulatta
2852 Homo sapiens
76854 Mus musculus
10232 Homo sapiens
516237 Bos taurus
56047 Mus musculus
60333 Rattus norvegicus
416534 Gallus gallus
100722390 Cavia porcellus
453806 Pan troglodytes
100524016 Sus scrofa
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