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Human Mesothelin Protein expressed in Wheat germ - ABIN1311459
Chang, Chen, Chen, Chiang, Chen, Mao, Lin, Lin Chiang, Cheng: Mesothelin enhances invasion of ovarian cancer by inducing MMP-7 through MAPK/ERK and JNK pathways. in The Biochemical journal 2012
Mesothelin/mucin 16 (show MUC16 Proteins) signaling in activated portal fibroblasts regulates cholestatic liver fibrosis.(
MiR (show MLXIP Proteins)-21-5p is suggested as novel regulator of MSLN with a possible functional role in cellular growth.
we report herein that high tumor mesothelin expression predicts a shorter PFS and OS in EOC patients and demonstrates that serum mesothelin predicts local tumor mesothelin expression.
We provide new evidence for the role of MSLN in EMT (show ITK Proteins) regulation, tumorigenesis and metastasis. Knockdown of MSLN led to mesenchymal to epithelial transition and less aggressive behavior of lung carcinoma and mesothelioma cells.
MSLN expression increases cell migration and invasion in vitro.
SMRP (show ABCC5 Proteins) but not FBLN3 (show FBLN3 Proteins) has a role in pleural effusions in in malignant pleural mesothelioma
High mesothelin expression is associated with malignant pleural mesothelioma.
Calretinin (show CALB2 Proteins), D2-40 and mesothelin are aberrantly expressed in a proportion of CRC (show CALR Proteins) cases.
Our results showed that IMP3 (show IGF2BP3 Proteins) immunostaining has a higher sensitivity and specificity than mesothelin for the diagnosis of pancreatic ductal adenocarcinoma. IMP3 (show IGF2BP3 Proteins) and mesothelin may be useful markers in distinguishing neoplastic from reactive lesions of the pancreas in instances where this is impossible by morphology alone in surgical pathology practice.
Results indicate a specific mesothelin-driven tumor uptake of targeted 89zirconium-labeled antibody which visualizes mesothelin expressing pancreatic cancer in real time.
this study revealed a role for GPER activity in regulating Nox1 (show NOX1 Proteins) abundance and associated O2(-)-mediated structural and functional damage that contributes to disease pathology
These findings provide strong evidence for aldosterone serving a causal role in renal cell cancer regulation via its GPER receptor; thus, antagonism of GPER represents a potential new target for treatment to reduce metastatic spread.
GPER protects against hepatic tumorigenesis by regulating inflammatory responses.
Data suggest that prenatal exposure to p,p'-DDT (show DDT Proteins) (an endocrine disrupting pesticide) causes sex- and age-independent attenuation of Gper1 in brain which appears to play key role in propagation of DDT (show DDT Proteins)-induced depressive-like neurotoxicity.
Study suggested that the neuroprotective effect of estrogen requires intact GPER1-associated signaling in an in vitro model of ischemia. The membrane-associated signaling mediates the estrogen actions, and depends on PI3K/Akt (show AKT1 Proteins) signaling for Ask1 (show MAP3K5 Proteins) inhibition that prevents the cell death triggered by ischemia. These mechanisms may help for a therapeutic strategy to target on GPER1 for the treatment of neurological disorders.
Phosphorylation of myosin regulatory light chain triggered by E2 was found to be mediated by estrogen receptor-beta (show ESR2 Proteins) and the G protein-coupled estrogen receptor (show ESR1 Proteins).
Our study demonstrated the ameliorative role of GPR30 in NOR memory impaired by AD pathology in female mice
identified a novel regulatory mechanism through which the endogenous Gper facilitates the age-dependent increase in myocardial expression of ECE-2 and the ETB receptor, which is compatible with an activating role of GPER for the local endothelin system with aging
We suggest that activation of GPER exerts an inhibitory effect on colonic motility by promoting nitric oxide release from myenteric nitrergic nerves
This gene encodes a precursor protein that is cleaved into two products, megakaryocyte potentiating factor and mesothelin. Megakaryocyte potentiation factor functions as a cytokine that can stimulate colony formation in bone marrow megakaryocytes. Mesothelian is a glycosylphosphatidylinositol-anchored cell-surface protein that may function as a cell adhesion protein. This protein is overexpressed in epithelial mesotheliomas, ovarian cancers and in specific squamous cell carcinomas. Alternative splicing results in multiple transcript variants.
, megakaryocyte potentiating factor
, pre-pro-megakaryocyte-potentiating factor
, soluble MPF mesothelin related protein
, G protein-coupled receptor 30
, G-protein coupled estrogen receptor 1
, G-protein coupled receptor 30
, chemoattractant receptor-like 2
, constitutively expressed peptide-like receptor like
, membrane estrogen receptor
, protein expressed in renal carcinoma