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Browse our Mesothelin Proteins (MSLN)

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Mesothelin Proteins (MSLN)
On are 52 Mesothelin (MSLN) Proteins from 12 different suppliers available. Additionally we are shipping Mesothelin Antibodies (205) and Mesothelin Kits (36) and many more products for this protein. A total of 307 Mesothelin products are currently listed.
6330420K13Rik, CEPR, Ceprl, CMKRL2, DRY12, FEG-1, GPCR-Br, Gper, Gpr30, LERGU, LERGU2, LyGPR, MPF, MSLN, SMRP
list all proteins Gene Name GeneID UniProt
MSLN 2852 Q99527
MSLN 76854 Q8BMP4
MSLN 60333 Q9ERA7

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Mesothelin Proteins (MSLN) by Origin

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Top referenced Mesothelin Proteins

  1. Mouse (Murine) Mesothelin Protein expressed in HEK-293 - ABIN2666851 : Prieve, Moon: Stromelysin-1 and mesothelin are differentially regulated by Wnt-5a and Wnt-1 in C57mg mouse mammary epithelial cells. in BMC developmental biology 2003 (PubMed)
    Show all 6 references for ABIN2666851

  2. Human Mesothelin Protein expressed in HEK-293 - ABIN2666849 : Bharadwaj, Marin-Muller, Li, Chen, Yao: Mesothelin confers pancreatic cancer cell resistance to TNF-α-induced apoptosis through Akt/PI3K/NF-κB activation and IL-6/Mcl-1 overexpression. in Molecular cancer 2011 (PubMed)
    Show all 6 references for ABIN2666849

  3. Human Mesothelin Protein expressed in HEK-293 Cells - ABIN2181518 : Chang, Pastan: Molecular cloning of mesothelin, a differentiation antigen present on mesothelium, mesotheliomas, and ovarian cancers. in Proceedings of the National Academy of Sciences of the United States of America 1996 (PubMed)
    Show all 3 references for ABIN2181518

  4. Human Mesothelin Protein expressed in Wheat germ - ABIN1311461 : Li, Bharadwaj, Zhang, Zhang, Mu, Fisher, Brunicardi, Chen, Yao: Mesothelin is a malignant factor and therapeutic vaccine target for pancreatic cancer. in Molecular cancer therapeutics 2008 (PubMed)

More Proteins for Mesothelin Interaction Partners

Human Mesothelin (MSLN) interaction partners

  1. GPER enhances melanogenesis via PKA by upregulating microphthalmia-related transcription factor-tyrosinase (show TYR Proteins) in melanoma

  2. Data suggest that GPR30 increases ERK1/2 activity via two Gi/o-mediated mechanisms, a PDZ-dependent constitutive mechanism and a PDZ-independent Gi/o-stimulated mechanism involving PI3K. (GPR30 = G protein-coupled estrogen receptor 1; ERK1 = extracellular signal-regulated kinase 1; ERK2 = extracellular signal-regulated kinase 2; Gi/0 = GTP-binding protein alpha subunits, Gi-Go; PI3K = phosphoinositide-3-kinase)

  3. present study revealed that BPA (show DST Proteins) can trigger the progression of laryngeal squamous cell carcinoma via GPER-mediated upregulation of IL-6 (show IL6 Proteins). Therefore, more attention should be paid for the BPA (show DST Proteins) exposure on the development of laryngeal cancer.

  4. G protein-coupled estrogen receptor (show ESR1 Proteins) stabilizes HIF-1alpha (show HIF1A Proteins) and thus promotes HIF-1alpha (show HIF1A Proteins)-induced VEGF (show VEGFA Proteins) and MMP9 (show MMP9 Proteins) in endometrial stromal cells, which play critical roles in endometriosis.

  5. MSLN expression increases cell migration and invasion in vitro.

  6. GPR30 activation by G-1 interfered expression of cell cycle regulators and machinery elements to modulate prostate cancer cell growth

  7. A novel mechanism whereby GPR30 limits ERalpha expression via inhibition of the cAMP/protein kinase A signaling pathway. This suggests that stem-like cells within the stroma are a possible source of prostate Cancer-associated fibroblasts and that the negative regulation of ERalpha expression by GPR30 is centrally involved in prostate stromal cell activation.

  8. These results provide evidence that (1) GPR30 is involved in regulating cell proliferation and apoptosis; (2) pharmacologic upregulation of GPR30 is beneficial for preeclampsia (PE) management; (3) GPR30 may therefore be an interventional target for pregnancies complicated by PE.

  9. Thus, the presence or absence of these GPR30 species is a simple and rapid manner to determine whether a given cell line is suitable for pharmacological or molecular studies of GPR30 modulation.

  10. Data define novel insights into the stromal GPER-mediated multiple drug resistance from the point of reprogramming of tumor energy metabolism and provide the rationale for CAFs as a promising target for clinical therapy.

Mouse (Murine) Mesothelin (MSLN) interaction partners

  1. Phosphorylation of myosin regulatory light chain triggered by E2 was found to be mediated by estrogen receptor-beta (show ESR2 Proteins) and the G protein-coupled estrogen receptor (show ESR1 Proteins).

  2. Our study demonstrated the ameliorative role of GPR30 in NOR memory impaired by AD pathology in female mice

  3. identified a novel regulatory mechanism through which the endogenous Gper facilitates the age-dependent increase in myocardial expression of ECE-2 and the ETB receptor, which is compatible with an activating role of GPER for the local endothelin system with aging

  4. We suggest that activation of GPER exerts an inhibitory effect on colonic motility by promoting nitric oxide release from myenteric nitrergic nerves

  5. GPR30 is expressed in diverse intracellular compartments in undifferentiated and differentiated C2C12 cells and mediates estradiol actions.

  6. Results demonstrate that ERalpha (show ESR1 Proteins), ERbeta (show ESR2 Proteins), and GPER1 all participate in the rapid effects of 17beta-estradiol-3-benzoate on hippocampal synaptic function

  7. Results show that mouse mesothelin is similar to human mesothelin. Its stable overexpression in a pancreatic cancer cell line did not increase cell proliferation, suggesting that mesothelin is not necessarily a tumor progression factor.

  8. GPR30 can mediate the fast effect of estrogen on blastocysts and play an important role in embryo implantation.

  9. E2 activates GPR30 and ERa to produce liquid crystalline versus anhydrous crystalline metastable intermediates evolving to cholesterol monohydrate crystals . GPR30 produces a synergistic lithogenic action with ERa to enhance E2-induced gallstone formation

  10. Suggest that the effects of diethylstilbestrol on mouse gubernaculum testis cells are mediated at least partially by the regulation of GPER expression.

Mesothelin (MSLN) Protein Profile

Protein Summary

This gene encodes a precursor protein that is cleaved into two products, megakaryocyte potentiating factor and mesothelin. Megakaryocyte potentiation factor functions as a cytokine that can stimulate colony formation in bone marrow megakaryocytes. Mesothelian is a glycosylphosphatidylinositol-anchored cell-surface protein that may function as a cell adhesion protein. This protein is overexpressed in epithelial mesotheliomas, ovarian cancers and in specific squamous cell carcinomas. Alternative splicing results in multiple transcript variants.

Alternative names and synonyms associated with Mesothelin (MSLN)

  • mesothelin (MSLN)
  • G protein-coupled estrogen receptor 1 (GPER1)
  • G protein-coupled estrogen receptor 1 (Gper1)
  • mesothelin (Msln)
  • mesothelin-like (LOC100524016)
  • 6330420K13Rik protein
  • CEPR protein
  • Ceprl protein
  • CMKRL2 protein
  • DRY12 protein
  • FEG-1 protein
  • GPCR-Br protein
  • Gper protein
  • Gpr30 protein
  • LERGU protein
  • LERGU2 protein
  • LyGPR protein
  • MPF protein
  • MSLN protein
  • SMRP protein

Protein level used designations for Mesothelin Proteins (MSLN)

mesothelin , G protein-coupled receptor 30 , G-protein coupled estrogen receptor 1 , G-protein coupled receptor 30 , IL8-related receptor DRY12 , chemoattractant receptor-like 2 , chemokine receptor-like 2 , constitutively expressed peptide-like receptor , flow-induced endothelial G-protein coupled receptor 1 , heptahelix receptor , leucine rich protein in GPR30 3'UTR , lymphocyte-derived G-protein coupled receptor , mER , membrane estrogen receptor , constitutively expressed peptide-like receptor like , CAK1 antigen , megakaryocyte potentiating factor , pre-pro-megakaryocyte-potentiating factor , soluble MPF mesothelin related protein , ERC/mesothelin , protein expressed in renal carcinoma

611363 Canis lupus familiaris
698095 Macaca mulatta
2852 Homo sapiens
76854 Mus musculus
10232 Homo sapiens
516237 Bos taurus
56047 Mus musculus
60333 Rattus norvegicus
416534 Gallus gallus
100722390 Cavia porcellus
453806 Pan troglodytes
100524016 Sus scrofa
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