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Spatial and temporal regulation of FRL1 protein expression during the gastrula stage are demonstrated.
findings show that vegetal cell-specific translational repression of xCR1 mRNA contributes to the spatially restricted accumulation of the xCR1 protein in Xenopus embryos
Nodal-BMP signaling cascade drives left-right heart morphogenesis by regulating the speed and direction of cardiomyocyte movement
Using mutants in the Nodal receptor cofactor one-eyed pinhead (oep) and the T-box transcription factors spadetail (spt (show AGXT Proteins)) and no tail (ntl), we were able to define distinctive regulation underlying these sequential phases of PGP midline migration
heterozygote mutations in fgf8 (show FGF8 Proteins), shh (show SHH Proteins) or oep lead to a reduced number of ascending dopaminergic neurons in zebrafish and may confer increased susceptibility to the Parkinson disease
Vg1 and GDF1 (show GDF1 Proteins) signaling require one-eyed pinhead.
Interplay between FGF, one-eyed pinhead (zoep), and T-box transcription factors spt (show AGXT Proteins) and ntl during zebrafish posterior
These findings suggest that CRIPTO expression may be a useful serological marker for diagnostic and/or prognostic purposes during germ cell cancer management.
MEF2C (show MEF2C Proteins) has a role in regulating outflow tract alignment and transcriptional control of Tdgf1
Dissection of the mechanism by which this occurs indicates that mCripto-1 activates receptor activator NF-kappaB (show NFKB1 Proteins)/receptor activator NF-kappaB (show NFKB1 Proteins) ligand, and NF-kappaB (show NFKB1 Proteins) signaling pathways.
our findings strongly suggest that Cripto-1 (show CFC1 Proteins) is a potential driver of mammary tumorigenesis
CR1 protein fragments bind tightly to PfRh4 and also function as soluble inhibitors to block PfRh4 binding to red blood cells and to inhibit the PfRh4-CR1 invasion pathway
Data show that Cripto haploinsufficiency may be associated with increased tumorigenesis, suggesting that the effect of Cripto on tumor development is more complex and may strongly depend on the cellular context.
Cripto is transiently expressed in early differentiating myocardial cells of the left ventricle, right ventricle and outflow tract between late head fold stages and E8.5.
Cripto plays a critical role during mouse gastrulation, especially in mesoderm and endoderm formation
Cripto, a regulator of early embryogenesis, is a novel regulator of muscle regeneration and satellite cell progression toward the myogenic lineage.
These data suggest that Cripto/GRP78 signaling is an important pathway that regulates hematopoietic stem cell quiescence.
These results highlight a functional role for CRIPTO and GRP78 (show HSPA5 Proteins) in prostate cancer metastasis and suggest that targeting CRIPTO/GRP78 (show HSPA5 Proteins) signaling may have significant therapeutic potential.
PGAP6 plays a critical role in Nodal signaling modulation through CRIPTO shedding.
Upregulation of cripto-1 (show CFC1 Proteins) is associated with prostate cancer.
the miR (show MLXIP Proteins)-15b expression is negatively associated with the cripto-1 (show CFC1 Proteins) expression in glioma cells. miR (show MLXIP Proteins)-15b may subsequently impair growth and invasion of glioma cells through targeted regulation of cripto-1 (show CFC1 Proteins).
serum CR-1 is a useful diagnostic and prognostic marker for nonsmall cell lung cancer patients.
Cripto-1 (show CFC1 Proteins) overexpression contributes to aggressiveness and poor prognosis of hepatocellular carcinoma
The main signaling pathways mediating Cripto-1 (show CFC1 Proteins) effects include Nodal-dependent (Smad2 (show SMAD2 Proteins)/3) and Nodal-independent (Src (show SRC Proteins)/p44 (show GTF2H2 Proteins)/42/Akt (show AKT1 Proteins)) signaling transduction pathways
Cripto-1 (show CFC1 Proteins) is a novel and dynamically regulated effector of stem cell functions in colorectal cancer.
these findings suggest a novel molecular network, involving CRIPTO, AKT (show AKT1 Proteins), and FGFR (show FGFR2 Proteins) signaling, in favor of the emergence of mesenchymal-like cancer cells during the development of aggressive prostate tumors.
This gene encodes an epidermal growth factor-related protein that contains a cripto, FRL-1, and cryptic domain. The encoded protein is an extracellular, membrane-bound signaling protein that plays an essential role in embryonic development and tumor growth. Mutations in this gene are associated with forebrain defects. Pseudogenes of this gene are found on chromosomes 2, 3, 6, 8, 19 and X. Alternate splicing results in multiple transcript variants.
, fibroblast growth factor receptor ligand 1
, teratocarcinoma-derived growth factor 1
, teratocarcinoma-derived growth factor 3
, cryptic protein
, one eyed pinhead
, TERATOCARCINOMA-DERIVED GROWTH FACTOR PRECURSOR (EPIDERMAL GROWTH FACTOR-LIKE CRIPTO PROTEIN) (CRIPTO GROWTH FACTOR)
, cripto growth factor
, epidermal growth factor-like Cripto protein
, teratocarcinoma-derived growth factor
, cripto-1 growth factor
, epidermal growth factor-like cripto protein CR1