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Browse our ERN1 Proteins (ERN1)

Full name:
Endoplasmic Reticulum To Nucleus Signaling 1 Proteins (ERN1)
On are 14 Endoplasmic Reticulum To Nucleus Signaling 1 (ERN1) Proteins from 7 different suppliers available. Additionally we are shipping ERN1 Antibodies (158) and ERN1 Kits (32) and many more products for this protein. A total of 218 ERN1 products are currently listed.
9030414B18Rik, AI225830, C85377, Ern1, hIRE1p, IRE1, IRE1a, Ire1alpha, Ire1b, IRE1P, RGD1559716
list all proteins Gene Name GeneID UniProt
ERN1 78943 Q9EQY0
ERN1 2081 O75460
ERN1 498013  

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ERN1 Proteins (ERN1) by Origin

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Top referenced ERN1 Proteins

  1. Human ERN1 Protein expressed in Baculovirus infected Insect Cells - ABIN2004877 : Trentmann: ERN1, a novel ethylene-regulated nuclear protein of Arabidopsis. in Plant molecular biology 2000 (PubMed)
    Show all 5 references for ABIN2004877

  2. Human ERN1 Protein expressed in Human - ABIN2720502 : Lee, Wang, Reyes, Armstrong, Kulikowicz, Santos, Lee, Koehler, Martin: Hypothermia and Rewarming Activate a Macroglial Unfolded Protein Response Independent of Hypoxic-Ischemic Brain Injury in Neonatal Piglets. in Developmental neuroscience 2016 (PubMed)

More Proteins for ERN1 Interaction Partners

Mouse (Murine) Endoplasmic Reticulum To Nucleus Signaling 1 (ERN1) interaction partners

  1. Findings indicate that PERK (show EIF2AK3 Proteins) kinase-activating transcription factor 4 (ATF4 (show ATF4 Proteins)) pathway affected the efficiency of X-box binding protein 1 (XBP1 (show XBP1 Proteins)) mRNA splicing by regulating inositol-requiring enzyme 1alpha (IRE1alpha) expression.

  2. Palmitate increased TRB3 (show TRIB3 Proteins) expression, activated IRE1alpha signaling, and reduced the insulin (show INS Proteins)-dependent Akt (show AKT1 Proteins) phosphorylation. Knocking down TRB3 (show TRIB3 Proteins) or IRE1alpha did not prevent the inhibitory effect of palmitate on Akt (show AKT1 Proteins) phosphorylation. Results support the idea that ER stress is not responsible for lipid-induced IR in C2C12 myotubes.

  3. Data show that EIF2AK3/PERK (show EIF2AK3 Proteins)-mediated downregulation of miR (show MLXIP Proteins)-424(322)-503 cluster regulates optimal activation of IRE1 protein and activating transcription factor 6 (ATF6 (show ATF6 Proteins)) during conditions of endoplasmic reticulum stress.

  4. PKA-dependent IRE1alpha-XBP1 (show XBP1 Proteins) activation is crucial for the transcriptional induction of Ucp1 (show UCP1 Proteins) in brown adipocytes.

  5. Nitric oxide can S-nitrosylate the endoplasmic reticulum stress sensors IRE1alapha and PERK.

  6. Data show that inositol requiring enzyme 1alpha (IRE1alpha), the sensor of the unfolded protein response (UPR), is a bona fide substrate of the Sel1L (show SEL1L Proteins) proten-Hrd1 protein (show SYVN1 Proteins) endoplasmic reticulum (ER)-associated degradation (ERAD) complex.

  7. Our results reveal a role for IRE1 in preventing a cell death-initializing step that emanates from the ER and provide a potential target for treating diseases characterized by ER stress, including diabetes and Wolfram syndrome.

  8. Our data indicate that removal of XBP-1 (show XBP1 Proteins) confers a kinetic delay in early stages of MCMV infection and suggest that the late targeting of IRE1 is aimed at inhibiting activities other than the splicing of XBP-1 (show XBP1 Proteins) mRNA

  9. SphK1 (show SPHK1 Proteins) inhibited the IRE1alpha pathway by reducing IRE1alpha expression at the transcriptional level.

  10. IRE1alpha may promote liver regeneration through acting as a signaling platform to regulate the STAT3 (show STAT3 Proteins) pathway.

Human Endoplasmic Reticulum To Nucleus Signaling 1 (ERN1) interaction partners

  1. Results indicate that excessive activation of the endoplasmic reticulum stress-associated IRE1alpha pathway is involved in LC neuronal apoptosis induced by single prolonged stress exposure; this may be a crucial mechanism of the pathogenesis of post- traumatic stress disorder

  2. these results confirmed that ER stress-mediated apoptosis contributes to the protection effects of naringenin against H/R injury, which is potentially involved in ATF6, IRE1alpha and PERK signaling activation.

  3. Structural and mechanistic studies of IRE1

  4. Inhibition of IRE1 signaling enzyme function affects the expression of NR3C1 (show NR3C1 Proteins) and related genes in U87 glioma cells in gene specific manner and all these genes are regulated by hypoxia preferentially through IRE1 signaling pathway of the endoplasmic reticulum stress.

  5. Data suggest that ubiquitin D (UBD (show UBD Proteins)) provides a negative feedback on cytokine-induced activation of the endoplasmic reticulum to nucleus signaling 1 (IRE1alpha)/c-Jun N-terminal kinase (JNK) pro-apoptotic pathway in cytokine-exposed beta cells.

  6. we used KO hepatocytes to demonstrate that PA-induced EV release was mediated by inositol requiring enzyme 1alpha (IRE1alpha)/X-box binding protein-1 (show XBP1 Proteins)

  7. Using drugs that specifically inhibit or activate the PERK or IRE1alpha sensors, we demonstrate that signalling through the PERK axis activates this expression, through a transcriptional mechanism

  8. Overexpression of IRE1 is associated with breast cancer.

  9. Nitric oxide can S-nitrosylate the endoplasmic reticulum stress sensors IRE1alapha and PERK.

  10. Data indicate that site-directed mutagenesis of inositol requiring enzyme 1 alpha (IRE1alpha) altered the enzymatic activities.

ERN1 Protein Profile

Protein Summary

The protein encoded by this gene is the ER to nucleus signalling 1 protein, a human homologue of the yeast Ire1 gene product. This protein possesses intrinsic kinase activity and an endoribonuclease activity and it is important in altering gene expression as a response to endoplasmic reticulum-based stress signals.

Alternative names and synonyms associated with ERN1

  • endoplasmic reticulum (ER) to nucleus signalling 1 (Ern1)
  • endoplasmic reticulum (ER) to nucleus signalling 2 (Ern2)
  • endoplasmic reticulum to nucleus signaling 1 (ERN1)
  • endoplasmic reticulum to nucleus signaling 1 (Ern1)
  • endoplasmic reticulum to nucleus signalling 1 (LOC100357346)
  • 9030414B18Rik protein
  • AI225830 protein
  • C85377 protein
  • Ern1 protein
  • hIRE1p protein
  • IRE1 protein
  • IRE1a protein
  • Ire1alpha protein
  • Ire1b protein
  • IRE1P protein
  • RGD1559716 protein

Protein level used designations for ERN1

endoplasmic reticulum-to-nucleus signaling 1 , inositol-requiring 1 alpha , inositol-requiring protein 1 , ire1-alpha , serine/threonine-protein kinase/endoribonuclease IRE1 , endoplasmic reticulum-to-nucleus signaling 2 , inositol-requiring 1 (Yeast homologue) , inositol-requiring 1 beta , inositol-requiring protein 2 , ire1-beta , mIre1 , serine/threonine-protein kinase/endoribonuclease IRE2 , ER to nucleus signalling 1 , inositol-requiring 1 , inositol-requiring enzyme 1 , protein kinase/endoribonuclease , endoplasmic reticulum (ER) to nucleus signalling 1 , endoplasmic reticulum to nucleus signalling 1

78943 Mus musculus
26918 Mus musculus
2081 Homo sapiens
498013 Rattus norvegicus
100733391 Cavia porcellus
100510978 Sus scrofa
610766 Canis lupus familiaris
524719 Bos taurus
771230 Gallus gallus
101102746 Ovis aries
100357346 Oryctolagus cuniculus
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