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mTORC2 (show CRTC2 Proteins) responds to glutamine catabolite levels to modulate the hexosamine biosynthesis enzyme GFAT1, and is essential for proper expression and nuclear accumulation of the GFAT1 transcriptional regulator, Xbp1s.
GFAT-1 plays a critical role in modulating adipogenesis
High GFAT1 expression is associated with hepatocellular carcinoma.
GFAT1 phosphorylation by AMPK promotes VEGF-induced angiogenesis.
The AMPK (show PRKAA1 Proteins)-GFAT1 signaling axis serves as an important communication point between two nutrient-sensitive signaling pathways and is likely to play a significant role in controlling physiological processes in many other tissues.
Increased GFPT1 expression is associated with triple-negative breast cancer.
This study demonstrated that Congenital myasthenic syndrome with tubular aggregates caused by GFPT1 mutations.
3'-UTR mutation creates a microRNA target site in the GFPT1 gene of patients with congenital myasthenic syndrome
Two GFPT1 untranslated mutations may cause limb-girdle myasthenia by reducing GFPT1 expression and ultimately impairing protein glycosylation.
Inhibition of GFPT1 enzymatic activity or siRNA silencing of GFPT1 expression resulted in reduced AChR expression.
The results found no correlation between end plate morphology and physiology or between genotype and phenotype in GFPT1-myasthenia.
Data suggest that enzymes in hexosamine biosynthesis pathway and downstream protein O-GlcNAcylation are important for preimplantation development; these include Gfpt, Oga (O-GlcNAcase), and Ogt (O-GlcNAc transferase).
cDNA sequence of the porcine GFAT1 gene was cloned and a GFAT1 splice variant (designed GFAT1-L) that contains a 54 bp insertion within the coding region, was identified.
This gene encodes the first and rate-limiting enzyme of the hexosamine pathway and controls the flux of glucose into the hexosamine pathway. The product of this gene catalyzes the formation of glucosamine 6-phosphate.
glucosamine--fructose-6-phosphate aminotransferase [isomerizing] 1
, glutamine-fructose-6-phosphate transaminase 1
, glutamine--fructose-6-phosphate transaminase 1
, D-fructose-6-phosphate amidotransferase 1
, GFAT 1
, glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1
, glutamine:fructose 6 phosphate amidotransferase 1
, glutamine:fructose-6-phosphate amidotransferase 1
, hexosephosphate aminotransferase 1
, glutamine fructose aminotransferase
, glutamine-fructose-6-phosphate aminotransferase 1