Browse our anti-Patched 1 (PTCH1) Antibodies

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anti-Patched 1 Antibodies (PTCH1)
On are 167 Patched 1 (PTCH1) Antibodies from 21 different suppliers available. Additionally we are shipping Patched 1 Proteins (18) and Patched 1 Kits (5) and many more products for this protein. A total of 197 Patched 1 products are currently listed.
A230106A15Rik, BCNS, HPE7, lep, mes, NBCCS, patched, patched1, Ptc, Ptc-1, Ptc1, ptc2, Ptch, ptch1, Ptch2, PTCH11, XPtc1
list all antibodies Gene Name GeneID UniProt
PTCH1 5727 Q13635
PTCH1 89830  
PTCH1 19206 Q61115

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anti-Human Patched 1 Antibodies:

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Top referenced anti-Patched 1 Antibodies

  1. Human Polyclonal Patched 1 Primary Antibody for ICC, IHC (fro) - ABIN152262 : Kaminagakura, Almeida, Carvalho, Franco, Soares, Rocha, Kowalski: Keratocyst of the buccal mucosa: case report and immunohistochemical comparative study with sporadic intraosseous keratocystic odontogenic tumor. in Oral surgery, oral medicine, oral pathology and oral radiology 2013 (PubMed)
    Show all 3 references for 152262

  2. Human Polyclonal Patched 1 Primary Antibody for IHC, ELISA - ABIN185521 : Nagao, Togawa, Fujii, Uchikawa, Kohno, Yamada, Miyashita: Detecting tissue-specific alternative splicing and disease-associated aberrant splicing of the PTCH gene with exon junction microarrays. in Human molecular genetics 2005 (PubMed)
    Show all 3 references for 185521

  3. Human Polyclonal Patched 1 Primary Antibody for ELISA, WB - ABIN185667 : Gerardo Valadez, Grover, Carter, Calcutt, Abiria, Lundberg, Williams, Cooper: Identification of Hedgehog pathway responsive glioblastomas by isocitrate dehydrogenase mutation. in Cancer letters 2012 (PubMed)
    Show all 2 references for 185667

  4. Cow (Bovine) Polyclonal Patched 1 Primary Antibody for IHC, WB - ABIN2773841 : Meerang, Bérard, Felley-Bosco, Lauk, Vrugt, Boss, Kenkel, Broggini-Tenzer, Stahel, Arni, Weder, Opitz: Antagonizing the Hedgehog Pathway with Vismodegib Impairs Malignant Pleural Mesothelioma Growth In Vivo by Affecting Stroma. in Molecular cancer therapeutics 2016 (PubMed)

  5. Human Polyclonal Patched 1 Primary Antibody for ELISA, WB - ABIN1585872 : Gordon, Mansh, Kinsman, Morris: Xenopus sonic hedgehog guides retinal axons along the optic tract. in Developmental dynamics : an official publication of the American Association of Anatomists 2010 (PubMed)

  6. Human Monoclonal Patched 1 Primary Antibody for ICC, IF - ABIN4343790 : Bolaños, Milla, Lira, Ramírez, Checa, Barrera, García-Alvarez, Carbajal, Becerril, Gaxiola, Pardo, Selman: Role of Sonic Hedgehog in idiopathic pulmonary fibrosis. in American journal of physiology. Lung cellular and molecular physiology 2012 (PubMed)

More Antibodies against Patched 1 Interaction Partners

Zebrafish Patched 1 (PTCH1) interaction partners

  1. Results demonstrate a direct link between overproliferation and retinal dysplasia in the ptc2 (show PTCH2 Antibodies)-/- juvenile retina and establish ectopic proliferation as the likely cellular underpinning of retinal dysplasia in juvenile ptc2 (show PTCH2 Antibodies)-/- mutants.

  2. The Hedgehog (show SHH Antibodies) co-receptors patched1 and patched2 are expressed in regions of the perichondrium that will form bone before the onset of ossification.

  3. The generation and characterization of the ptc1;ptc2 (show PTCH2 Antibodies) double mutant assigned novel and unexpected functions to the Hh signaling pathway.

  4. Positional cloning of blowout identified a nonsense mutation in patched1, a negative regulator of the Hedgehog (show SHH Antibodies) pathway, as the underlying cause of the blowout phenotype.

Human Patched 1 (PTCH1) interaction partners

  1. the significant increase of blunt-ended, double-stranded DNA breaks, but not other types of DNA breaks, in normal cells from patients with RET/PTC (show RET Antibodies)-driven tumors suggests that blunt-ended double-stranded DNA breaks are a preferred substrate for rearrangement formation, and implicate involvement of the non-homologous end joining pathway in the formation of RET/PTC (show RET Antibodies) rearrangements.

  2. Thus, our study clearly demonstrated the unique involvement of the two novel PTCH1 splice variants in HH signal transduction.

  3. These data reveal an interaction between the cytoplasmic domains of Ptch1 and that these domains modulate Ptch1 activity but are not essential for regulation of the Hh pathway.

  4. epigenetic silencing of PTCH is a mechanism contributing to chronic lymphocytic leukemia tumorigenesis

  5. PTCH1 mutations contribute to as much as 10% of ODA, identify the SHH (show SHH Antibodies) signaling pathway as a novel effector of SOX2 (show SOX2 Antibodies) activity during human ocular development, and indicate that ODA is likely the result of overactive SHH (show SHH Antibodies) signaling in humans harboring mutations in either PTCH1 or SOX2 (show SOX2 Antibodies).

  6. Naevoid basal cell carcinoma syndrome (NBCCS) is a rare autosomal dominantly inherited disorder with primary mutations in the Patched (PTCH1) gene

  7. This is the first report describing a GS-associated ovarian tumor carrying a second hit in the PTCH1 region.

  8. In Nigerian patients with ameloblastoma, moderate and strong expressions for PTCH in ameloblast and stellate reticulum were 78.6% and 60.7% respectively

  9. suggest that CUL2 (show CUL2 Antibodies)-based E3 ligase complex may play a role in Shh (show SHH Antibodies)- and Ptc1-dependent signaling pathways

  10. Increased SHH (show SHH Antibodies), PTCH, and GLI1 (show GLI1 Antibodies) protein correlated positively with tumor grade, tumor depth and lymph node metastasis in Peutz-Jeghers syndrome.

Cow (Bovine) Patched 1 (PTCH1) interaction partners

  1. study suggests that modifications affecting the Ptch1 cis (show CISH Antibodies)-regulatory landscape have contributed to evolutionary diversification of artiodactyl limbs

Mouse (Murine) Patched 1 (PTCH1) interaction partners

  1. Ptch1 required for ductal outgrowth and proper hormone receptor (show NR4A1 Antibodies) expression in the mammary epithelium.

  2. Thus, our study clearly demonstrated the unique involvement of the two novel PTCH1 splice variants in HH signal transduction.

  3. These data reveal an interaction between the cytoplasmic domains of Ptch1 and that these domains modulate Ptch1 activity but are not essential for regulation of the Hh pathway.

  4. Data indicate that Sonic hedgehog (Shh (show SHH Antibodies)) stimulate branching morphogenesis (BrM (show SMARCA2 Antibodies)) and induced synthesis of mRNAs for Ptch1 protein, epidermal growth factor (EGF (show EGF Antibodies)) and receptors of the ErbB (show EGFR Antibodies) receptors ErbB1 (show EGFR Antibodies), ErbB2 (show ERBB2 Antibodies) and ErbB3 (show ERBB3 Antibodies).

  5. Data show that the ketogenic diet does not affect growth of Ptch1+/-Trp53 (show TP53 Antibodies)-/- Hedgehog (show SHH Antibodies) (HH) pathway medulloblastoma.

  6. Targeted single gene deletion of Ptch1 in mouse brain causes medulloblastoma.

  7. Transcriptional upregulation of the inhibitory receptor Ptch1 regulates Shh (show SHH Antibodies) signaling during neural tube development.

  8. There was a lower degree of DNA-methylation (show HELLS Antibodies) in methylation-sensitive CpG regions of the Ptch promoter in RMS compared to normal muscle from heterozygous Ptch animals.

  9. results indicate that whereas ciliary localization of Patched is essential for suppression of Smoothened activation, the primary event enabling Smoothened activation

  10. Dsg2 (show DSG2 Antibodies)-mediated hyperproliferation, MEK (show MDK Antibodies)/Erk1/2 (show MAPK1/3 Antibodies) activation, and accelerated squamous tumor development are enhanced on the Ptc1+/lacZ (show GLB1 Antibodies) background.

Patched 1 (PTCH1) Antigen Profile

Antigen Summary

This gene encodes a member of the patched gene family. The encoded protein is the receptor for sonic hedgehog, a secreted molecule implicated in the formation of embryonic structures and in tumorigenesis, as well as the desert hedgehog and indian hedgehog proteins. This gene functions as a tumor suppressor. Mutations of this gene have been associated with basal cell nevus syndrome, esophageal squamous cell carcinoma, trichoepitheliomas, transitional cell carcinomas of the bladder, as well as holoprosencephaly. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional splice variants have been described, but their full length sequences and biological validity cannot be determined currently.

Alternative names and synonyms associated with Patched 1 (PTCH1)

  • patched 2 (ptch2) antibody
  • patched 1 (PTCH1) antibody
  • patched protein-like protein (PTCH1) antibody
  • patched 1 (ptch1) antibody
  • patched 1 (Ptch1) antibody
  • patched homolog 1 (Ptch1) antibody
  • Protein PTC-1 (ptc-1) antibody
  • A230106A15Rik antibody
  • BCNS antibody
  • HPE7 antibody
  • lep antibody
  • mes antibody
  • NBCCS antibody
  • patched antibody
  • patched1 antibody
  • Ptc antibody
  • Ptc-1 antibody
  • Ptc1 antibody
  • ptc2 antibody
  • Ptch antibody
  • ptch1 antibody
  • Ptch2 antibody
  • PTCH11 antibody
  • XPtc1 antibody

Protein level used designations for anti-Patched 1 (PTCH1) Antibodies

blowout , blw , etID309849.2 , patched 1 , protein patched homolog 1 , patched homolog 1 , patched protein-like protein , patched-like , protein patched homolog 1-like , PTC1 , patched protein , patched-like protein , PTCH protein +12b , PTCH protein +4' , PTCH protein -10 , PTCH protein -3,4,5 , patched homolog 2 , leprechaun , patched 2 , patched-1 , Patched 1 , Ptch1 protein +12b , mesenchymal dysplasia

30181 Danio rerio
465254 Pan troglodytes
718751 Macaca mulatta
7230532 Branchiostoma floridae
100033936 Equus caballus
100345046 Oryctolagus cuniculus
100475966 Ailuropoda melanoleuca
100492061 Xenopus (Silurana) tropicalis
100581789 Nomascus leucogenys
395806 Gallus gallus
5727 Homo sapiens
89830 Rattus norvegicus
30189 Danio rerio
484137 Canis lupus familiaris
100627504 Sus scrofa
520994 Bos taurus
398215 Xenopus laevis
19206 Mus musculus
174274 Caenorhabditis elegans
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