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The data also show that the antibacterial activity of hepcidin-2 depends upon the disulfide bridges.
data support an alternative mechanism for hepcidin regulation during zebrafish embryonic development, which is independent of hemojuvelin (show HFE2 Proteins).
Hepcidin expression is regulated by a transferrin-a (show Tf Proteins)-dependent pathway in the zebrafish embryo.
These results suggest that the ingestion of a high (compared to low) CHO diet over a seven-day training period is ineffective in attenuating post-exercise IL-6 (show IL6 Proteins) and hepcidin responses. Such results may be due to the modest training load, the increased protein intake in the low-CHO trial, and a 48 h recovery period prior to sample collection on day 7, allowing a full recovery of muscle glycogen (show GYS1 Proteins) status between exercise sessi
The NGAL (show LCN2 Proteins)/hepcidin ratio is more strongly associated with severe of acute kidney injury than the single biomarkers alone
serum NGAL (show LCN2 Proteins) and hepcidin levels might be valuable for the evaluation of inflammation in chronic kidney disease, not related through iron metabolism
study shows that patients with CRA (show MTMR11 Proteins) had high expression of BMP6 (show BMP6 Proteins) and hepcidin and low expression of s-HJV (show HFE2 Proteins). BMP6 (show BMP6 Proteins) was found to be negatively correlated with s-HJV (show HFE2 Proteins); both regulate hepcidin expression and play important roles in the development of anemia.
REVIEW: outline of recent discoveries in understanding how hepcidin and its receptor ferroportin (show SLC40A1 Proteins) are regulated, how they contribute to anemia of inflammation, and how this knowledge may help guide new diagnostic and therapeutic strategies for this disease
During pregnancy, in women with sufficient iron supplementation, hepcidin is low and does not reflect iron status. During delivery and the postpartum period, hepcidin functions as a marker of inflammation.
TGF-beta1 (show TGFB1 Proteins) may contribute to hepcidin synthesis during iron overload.
Low hepcidin levels are associated with type 2 diabetes mellitus.
Hepcidin levels are higher in NAFLD with iron overload.
Systemic inflammation and elevated values of IL-6 (show IL6 Proteins) present in exacerbations and stabile chronic obstructive pulmonary disease might be responsible for the observed increased hepcidin level.
Increased hepcidin in transferrin (show Tf Proteins)-treated thalassemic mice correlates with increased liver BMP2 (show BMP2 Proteins) expression and decreased hepatocyte ERK (show EPHB2 Proteins) activation.
The combined data presented here highlighted a crucial role of ERFE in regulating hepcidin expression and systematic iron homeostasis under phenylhydrazine-induced hemolytic anemia.
Results indicate that an efficient induction of hepcidin expression by hemojuvelin (HJV (show HFE2 Proteins)) requires its interaction with neogenin (show NEO1 Proteins).
The results suggest that physiologic hepcidin levels are insufficient to alter Fpn levels within the retinal pigment epithelium and Muller cells, but may limit iron transport into the retina from vascular endothelial cells.
In TNF (show TNF Proteins)(DeltaARE/+) and IL-10 (show IL10 Proteins)(-/-)-mice hepatic hepcidin expression and protein content was significantly lower than in corresponding wild-types.
In Angiotensin II treated mice, duodenal divalent metal transporter-1 (show SLC11A2 Proteins) and ferroportin (show SLC40A1 Proteins) expression levels were increased and hepatic hepcidin mRNA expression and serum hepcidin concentration were reduced.
results clarify how commensal bacteria affect hepcidin expression and reveal a novel connection between IL-1beta and activation of BMP signaling.
Activation of TLR4 (show TLR4 Proteins) signaling and NF-small ka, CyrillicB are involved in the suppression of hepcidin gene transcription by alcohol in the presence of inflammation in the liver.
Study describes extensive blood vessel damage in Alzheimer's disease brain and a reduction in hepcidin and ferroportin (show SLC40A1 Proteins) levels
Hepatic hepcidin plays an important role in sepsis through regulation of iron metabolism
this study demonstrates that urine hepcidin-25 concentrations strongly correlate with hepatic hepcidin mRNA abundance, plasma hepcidin-25 levels, iron transferrin (show Tf Proteins) saturation and non-heme liver iron levels.
Data suugest that hepcidin might had antiinflammatory function and is a candidate regulator of the cross-talk between iron regulation and inflammation.
report the full-length cDNA sequences of porcine hepcidin and liver-expressed antimicrobial peptide-2 (LEAP-2 (show LEAP2 Proteins))
Hepcidin peptide is up-regulated by iron and bacterial components in the trout liver.
The product encoded by this gene is involved in the maintenance of iron homeostasis, and it is necessary for the regulation of iron storage in macrophages, and for intestinal iron absorption. The preproprotein is post-translationally cleaved into mature peptides of 20, 22 and 25 amino acids, and these active peptides are rich in cysteines, which form intramolecular bonds that stabilize their beta-sheet structures. These peptides exhibit antimicrobial activity. Mutations in this gene cause hemochromatosis type 2B, also known as juvenile hemochromatosis, a disease caused by severe iron overload that results in cardiomyopathy, cirrhosis, and endocrine failure.
hepcidin antimicrobial peptide
, antimicrobial peptide
, iron regulatory peptide
, preprohepcidin 1
, liver-expressed antimicrobial peptide 1
, putative liver tumor regressor
, hepcidin antimicrobial peptide 1
, antimicrobial peptide hepcidin
, putative hepcidin antibacterial peptide