Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
Show all synonyms
Select your origin of interest
Of the non-HFE (show HFE Proteins) forms of iron overload, TFR2 (show TFR2 Proteins)-, HFE2 (show HFE2 Proteins)-, and HAMP-related forms are predicted to be rare, with pathogenic allele frequencies in the range of 0.00007 to 0.0005. Significantly, SLC40A1 (show SLC40A1 Proteins) variants that have been previously associated with autosomal-dominant ferroportin (show SLC40A1 Proteins) disease were identified in several populations (pathogenic allele frequency 0.0004), being most prevalent among Africans
Data (including data from studies using knockout mice) suggest that MT2 (show MT2 Proteins)/TMPRSS6 (show TMPRSS6 Proteins) suppresses hepcidin expression in hepatocytes independently of HJV (show HFE2 Proteins); MT2 (show MT2 Proteins)/TMPRSS6 (show TMPRSS6 Proteins) cleaves ALK2 (show ACRV1 Proteins), ALK3 (show BMPR1A Proteins), ACTRIIA (show ACVR2A Proteins), BMPR2 (show BMPR2 Proteins), HFE (show HFE Proteins), and, to a lesser extent, HJV (show HFE2 Proteins) and TFR2 (show TFR2 Proteins); thus, MT2 (show MT2 Proteins)/TMPRSS6 (show TMPRSS6 Proteins) suppresses hepcidin expression by cleaving multiple components of the hepcidin induction pathway. (MT2 (show MT2 Proteins)/TMPRSS6 (show TMPRSS6 Proteins) = matriptase-2 (show TMPRSS6 Proteins); HJV (show HFE2 Proteins) = hemojuvelin (show HFE2 Proteins))
two unrelated hepatocellular carcinoma patients bore the HAMP:c.-153C>T mutation at the heterozygous state, which is associated with increased risk of iron overload and severe hemochromatosis (show HFE Proteins)
Hepcidin-25 released from plaque macrophages and other cell surfaces contributed to the plaque instability by inducing endothelial cell death.
Hepcidin plasma levels were increased in patients with early rheumatoid arthritis compared with healthy volunteers.
study followed the dynamics of hepcidin-mediated ferroportin (show SLC40A1 Proteins) internalization; also showed that the novel p.D84E mutation, associated with the classical form of ferroportin (show SLC40A1 Proteins) disease, is both iron transport defective and hepcidin insensitive
During regulation of hepcidin synthesis, multiple promoter elements in the HAMP gene respond to variable signaling pathways corresponding to different extracellular situations.
Our findings indicate that the HAMP-P -582A>G polymorphism (rs10421768) is associated with susceptibility to extrapulmonary TB, but not pulmonary TB. CD14 (show NDUFA2 Proteins)+ monocytes from individuals with the rs10421768 GG genotype secreted significantly less hepcidin in response to M. tuberculosis lipoarabinomannan compared with cells from individuals with either the AA or AG genotypes.
Expression of Hepcidin and Ferroportin (show SLC40A1 Proteins) in the Placenta, and Ferritin (show FTL Proteins) and Transferrin Receptor 1 (show TFR Proteins) Levels in Maternal and Umbilical Cord Blood in Pregnant Women with and without Gestational Diabetes
this study shows that hepcidin is involved in the pathogenesis of sepsis-induced acute kidney injury
These data suggest that, in Hjv (show HFE2 Proteins)(-/-) females, Bmp6 (show BMP6 Proteins) can provide a signal adequate to maintain hepcidin to a level sufficient to avoid extrahepatic iron loading.
The authors generated mice with cardiomyocyte-specific deletion of hepcidin, or knock-in of hepcidin-resistant ferroportin (show SLC40A1 Proteins). They find that while both models maintain normal systemic iron homeostasis, the mice nonetheless develop fatal contractile and metabolic dysfunction as a consequence of cardiomyocyte iron deficiency.
Erythroferrone and matriptase-2 (show TMPRSS6 Proteins) independently regulate hepcidin expression.
Acute tacrolimus treatment transiently increases hepcidin in wild-type mice. FKBP12 (show FKBP1A Proteins) preferentially targets the BMP receptor (show BMPR1A Proteins) ALK2 (show ACRV1 Proteins). ALK2 (show ACRV1 Proteins) mutants defective in binding FKBP12 (show FKBP1A Proteins) increase hepcidin expression in a ligand-independent manner, through BMP-SMAD (show SMAD1 Proteins) signaling.
Hamp1 mRNA and plasma hepcidin levels are not good predictors of tissue iron levels, at least in males
The lack of effect of erythropoietin (show EPO Proteins) on hepcidin expression in mask mice can not be explained by changes in erythroferrone synthesis, as splenic erythroferrone content increased after erythropoietin (show EPO Proteins) administration in both C57BL/6 and mask mice.
these results characterise a new model of rapidly inducible hepcidin disruption, and demonstrate the critical contribution of hepcidin to the hypoferraemia of inflammation
Hepatic gene expression of hepcidin is regulated in beta-thalassemia by ATOH8 (show ATOH8 Proteins).
Endogenous hepcidin and its agonist mediate resistance to selected infections by clearing non-transferrin (show Tf Proteins)-bound iron.
The data demonstrate that endothelial cells are the predominant source of BMP6 (show BMP6 Proteins) in the liver and support a model in which endothelial cells BMP6 (show BMP6 Proteins) has paracrine actions on hepatocyte hemojuvelin (show HFE2 Proteins) to regulate hepcidin transcription and maintain systemic iron homeostasis.
This study shows that hepcidin knockdown in zebrafish using morpholinos leads to iron overload.
The data also show that the antibacterial activity of hepcidin-2 depends upon the disulfide bridges.
data support an alternative mechanism for hepcidin regulation during zebrafish embryonic development, which is independent of hemojuvelin (show HFE2 Proteins).
Hepcidin expression is regulated by a transferrin-a (show Tf Proteins)-dependent pathway in the zebrafish embryo.
this study demonstrates that urine hepcidin-25 concentrations strongly correlate with hepatic hepcidin mRNA abundance, plasma hepcidin-25 levels, iron transferrin (show Tf Proteins) saturation and non-heme liver iron levels.
Data suugest that hepcidin might had antiinflammatory function and is a candidate regulator of the cross-talk between iron regulation and inflammation.
report the full-length cDNA sequences of porcine hepcidin and liver-expressed antimicrobial peptide-2 (LEAP-2 (show LEAP2 Proteins))
Hepcidin peptide is up-regulated by iron and bacterial components in the trout liver.
The product encoded by this gene is involved in the maintenance of iron homeostasis, and it is necessary for the regulation of iron storage in macrophages, and for intestinal iron absorption. The preproprotein is post-translationally cleaved into mature peptides of 20, 22 and 25 amino acids, and these active peptides are rich in cysteines, which form intramolecular bonds that stabilize their beta-sheet structures. These peptides exhibit antimicrobial activity. Mutations in this gene cause hemochromatosis type 2B, also known as juvenile hemochromatosis, a disease caused by severe iron overload that results in cardiomyopathy, cirrhosis, and endocrine failure.
, liver-expressed antimicrobial peptide 1
, putative liver tumor regressor
, hepcidin antimicrobial peptide 1
, hepcidin antimicrobial peptide
, antimicrobial peptide
, iron regulatory peptide
, preprohepcidin 1
, antimicrobial peptide hepcidin
, putative hepcidin antibacterial peptide