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This study shows that hepcidin knockdown in zebrafish using morpholinos leads to iron overload.
The data also show that the antibacterial activity of hepcidin-2 depends upon the disulfide bridges.
data support an alternative mechanism for hepcidin regulation during zebrafish embryonic development, which is independent of hemojuvelin (show HFE2 Proteins).
Hepcidin expression is regulated by a transferrin-a (show Tf Proteins)-dependent pathway in the zebrafish embryo.
modification of HS structure mediated by heparanase (show HPSE Proteins) overexpression affects hepcidin expression and iron homeostasis
Serum hepcidin levels increased in premenopausal women participating in brisk walking exercises.
Gene-based meta-analyses revealed 19 genes that showed significant association with hepcidin. Our results suggest the absence of common SNVs and rare exonic SNVs explaining a large proportion of phenotypic variation in serum hepcidin
hepcidin induction by endoplasmic reticulum stress involves the central SMAD1 (show GARS Proteins)/5/8 pathway
a selective splicing variant of hepcidin mRNA lacking exon 2 of HAMP gene, producing the transcript that encodes truncated peptide lacking 20 amino acids at the middle of preprohepcidin, was found in hepatocellular carcinoma cell lines
Gastric H. pylori infection is a common cause of IDA of unknown origin in adult patients. Our results provide evidence indicating that hepcidin level decreases after successful H. pylori eradication with improvement in IDA.
The data of in vitro and in vivo research evidenced on involvement of Hepc in formation of breast cancer cells malignant phenotype and their resistance to doxorubicin.
Hepcidin was a more influential determinant of iron stores than blood loss and dietary factors combined, and increased hepcidin diminished the positive association between iron intake and iron stores.
These results suggest that the ingestion of a high (compared to low) CHO diet over a seven-day training period is ineffective in attenuating post-exercise IL-6 (show IL6 Proteins) and hepcidin responses. Such results may be due to the modest training load, the increased protein intake in the low-CHO trial, and a 48 h recovery period prior to sample collection on day 7, allowing a full recovery of muscle glycogen (show GYS1 Proteins) status between exercise sessi
The NGAL (show LCN2 Proteins)/hepcidin ratio is more strongly associated with severe of acute kidney injury than the single biomarkers alone
the function of matriptase-2 (show TMPRSS6 Proteins) is dominant over that of ERFE and is essential in facilitating hepcidin suppression by attenuating the BMP-SMAD (show SMAD1 Proteins) signaling.
hepcidin induction by endoplasmic reticulum stress involves the central SMAD1 (show SMAD1 Proteins)/5/8 pathway
Increased hepcidin in transferrin (show Tf Proteins)-treated thalassemic mice correlates with increased liver BMP2 (show BMP2 Proteins) expression and decreased hepatocyte ERK (show EPHB2 Proteins) activation.
The combined data presented here highlighted a crucial role of ERFE in regulating hepcidin expression and systematic iron homeostasis under phenylhydrazine-induced hemolytic anemia.
Results indicate that an efficient induction of hepcidin expression by hemojuvelin (HJV (show HFE2 Proteins)) requires its interaction with neogenin (show NEO1 Proteins).
The results suggest that physiologic hepcidin levels are insufficient to alter Fpn levels within the retinal pigment epithelium and Muller cells, but may limit iron transport into the retina from vascular endothelial cells.
In TNF (show TNF Proteins)(DeltaARE/+) and IL-10 (show IL10 Proteins)(-/-)-mice hepatic hepcidin expression and protein content was significantly lower than in corresponding wild-types.
In Angiotensin II treated mice, duodenal divalent metal transporter-1 (show SLC11A2 Proteins) and ferroportin (show SLC40A1 Proteins) expression levels were increased and hepatic hepcidin mRNA expression and serum hepcidin concentration were reduced.
results clarify how commensal bacteria affect hepcidin expression and reveal a novel connection between IL-1beta and activation of BMP signaling.
Activation of TLR4 (show TLR4 Proteins) signaling and NF-small ka, CyrillicB are involved in the suppression of hepcidin gene transcription by alcohol in the presence of inflammation in the liver.
this study demonstrates that urine hepcidin-25 concentrations strongly correlate with hepatic hepcidin mRNA abundance, plasma hepcidin-25 levels, iron transferrin (show Tf Proteins) saturation and non-heme liver iron levels.
Data suugest that hepcidin might had antiinflammatory function and is a candidate regulator of the cross-talk between iron regulation and inflammation.
report the full-length cDNA sequences of porcine hepcidin and liver-expressed antimicrobial peptide-2 (LEAP-2 (show LEAP2 Proteins))
Hepcidin peptide is up-regulated by iron and bacterial components in the trout liver.
The product encoded by this gene is involved in the maintenance of iron homeostasis, and it is necessary for the regulation of iron storage in macrophages, and for intestinal iron absorption. The preproprotein is post-translationally cleaved into mature peptides of 20, 22 and 25 amino acids, and these active peptides are rich in cysteines, which form intramolecular bonds that stabilize their beta-sheet structures. These peptides exhibit antimicrobial activity. Mutations in this gene cause hemochromatosis type 2B, also known as juvenile hemochromatosis, a disease caused by severe iron overload that results in cardiomyopathy, cirrhosis, and endocrine failure.
hepcidin antimicrobial peptide
, antimicrobial peptide
, iron regulatory peptide
, preprohepcidin 1
, liver-expressed antimicrobial peptide 1
, putative liver tumor regressor
, hepcidin antimicrobial peptide 1
, antimicrobial peptide hepcidin
, putative hepcidin antibacterial peptide