Hepcidin Protein (AA 59-83) (GST tag)
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- Target See all Hepcidin (HAMP) Proteins
- Hepcidin (HAMP) (Hepcidin Antimicrobial Peptide (HAMP))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 59-83
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Origin
- Mouse
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This Hepcidin protein is labelled with GST tag.
- Purpose
- Mouse Hepcidin/HAMP Protein
- Sequence
- Asp59-Thr83
- Characteristics
- Recombinant Mouse Hepcidin/HAMP Protein is expressed from E.coli with GST tag at the N-Terminus.It contains Asp59-Thr83.
- Purity
- > 95 % as determined by Tris-Bis PAGE
- Sterility
- 0.22 μm filtered
- Endotoxin Level
- Less than 1EU per μg by the LAL method.
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.
- Buffer
- Lyophilized from 0.22μm filtered solution in 50 mM Tris-HCl, 150 mM NaCl, 2 mM DTT ( pH 7.5). Normally 8 % trehalose is added as protectant before lyophilization.
- Preservative
- Dithiothreitol (DTT)
- Precaution of Use
- This product contains Dithiothreitol (DTT): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C,-80 °C
- Storage Comment
- -20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3-6 months after reconstitution.,2-8°C for 2-7 days after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
- Expiry Date
- 12 months
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- Target
- Hepcidin (HAMP) (Hepcidin Antimicrobial Peptide (HAMP))
- Alternative Name
- Hepcidin (HAMP Products)
- Synonyms
- HEPC Protein, HFE2B Protein, LEAP1 Protein, PLTR Protein, Hepcidin Protein, Hamp1 Protein, Hepc Protein, Hepc1 Protein, HAMP Protein, hepcidin Protein, hamp1 Protein, hep1 Protein, hepcidin antimicrobial peptide Protein, hepcidin-like Protein, hepcidin-1 Protein, Ham percentage Protein, HAMP Protein, Hamp Protein, hamp Protein, LOC100135935 Protein, LOC106584587 Protein
- Background
- Hepcidin, the main regulator of iron metabolism, is synthesized and released by hepatocytes in response to increased body iron concentration and inflammation. Deregulation of hepcidin expression is a common feature of genetic and acquired iron disorders: in Hereditary Hemochromatosis (HH) and iron-loading anemias low hepcidin causes iron overload, while in Iron Refractory Iron Deficiency Anemia (IRIDA) and anemia of inflammation (AI), high hepcidin levels induce iron-restricted erythropoiesis.
- Molecular Weight
- 29.05 kDa same as Tris-Bis PAGE result.
- UniProt
- Q9EQ21
- Pathways
- Hormone Activity, Transition Metal Ion Homeostasis
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