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CRFr1 activation mediates intestinal mucosa barrier dysfunction and hypersecretion in early-weaned piglets, whereas CRFr2 (show CRHR2 Proteins) activation may be responsible for novel protective properties in the porcine intestine in response to early life stress.
The expression of UCN, CRHR1, CRHR2 and CRHBP by immunohistochemistry, Western blot and reverse transcription with the polymerase chain reaction (RT-PCR) in the horse thyroid gland, was investigated
This study found that the expressions of CRH (show CRH Proteins) and CRHR1 were significantly higher in the epileptogenic tissues of patients with IS than in the control group.
The minor allele of rs17689918 was found to significantly increase risk for Panic Disorder in females after Bonferroni correction and furthermore decreased CRHR1 mRNA expression in human forebrains and amygdalae.the risk allele of rs17689918 led to less flight behavior during fear-provoking situations but rather increased anxious apprehension and went along with increased anxiety sensitivity.
Study showed that alterations in CRHR1 gene were associated with higher levels of IL-1beta (show IL1B Proteins), and increased risk for suicide, reinforcing the importance of multifactorial interactions of biological markers for psychiatric disorders.
This study suggests that interactions between anandamide and CRF1 represent a fundamental molecular mechanism regulating amygdala function and anxiety.
This study demonstrated that several candidate SNPs in CRHR1 were associated with theta-Fz energy at a threshold of p < 0.05.
cardiac expression of CRFR1, CRF (show CRH Proteins), and Ucn3 (show UCN3 Proteins) genes is elevated in heart failure and may contribute to the activation of the CRF (show CRH Proteins)/Ucn system in these patients. A common variant within the CRFR1 gene and a novel CRFR1 splice variant may modulate CRFR1 expression and signaling.
there are brain region- and cell type-specific effects of CRFR signalling that are influenced by the individual's prior experience and that shape molecular, cellular and ultimately behavioural responses to stressful challenges.
This study showed that associations between BPD and haplotype combinations of the genes FKBP5 (show FKBP5 Proteins) and CRHR1.
replicated the initially reported association of the CRHR1 rs878886 G-allele with cued fear acquisition deficits, albeit with a different pattern of results regarding the interaction with 5-HTT (show SLC6A4 Proteins) variation
hsa (show CD24 Proteins)-miR (show MLXIP Proteins)-34a can regulate the CRH (show CRH Proteins)/CRHR1/POMC (show POMC Proteins) axis and may influence body mass index.
Study characterized the influences of early-life stress on the developmental trajectory of hippocampal pyramidal neurons, and highlighted the critical role of CRHR1 in modulating these negative outcomes evoked by early-life stress.
the beneficial effects of CRFR1 antagonism seen in transgenic mice may be mechanistically linked to the modulation of oxidative stress pathways
CRF plays a marked anxiogenic role at CRF1 receptors in the amygdala of mice exposed to the elevated plus maze.
found that corticotropin-releasing factor type 1 receptor within the paraventricular nucleus of the hypothalamus is an important central component of hypothalamic-pituitary-adrenal axis regulation that prepares the organism for successive exposure to stressful stimuli.
Excitability of genetically isolated CRF (show CRH Proteins)-receptive (CRFR1) neurons in the central nucleus of the amygdala (CeA (show CEA Proteins)) is potently enhanced by CRF (show CRH Proteins) and that CRFR1 signaling in the CeA (show CEA Proteins) is critical for discriminative fear
Study demonstrated that CRF1 receptor-deficiency prolongs whereas CRF2 receptor (show CRHR2 Proteins)-deficiency shortens the duration of recognition memory deficits induced by morphine discontinuation, unraveling opposite roles for the two known CRF (show CRH Proteins) receptor subtypes in cognitive dysfunction associated with opiate withdrawal.
CRFR1, in a subset of AgRP (show AGRP Proteins) neurons, plays a regulatory role that enables appropriate sympathetic nervous system activation and consequently protects the organism from hypothermia and hypoglycemia.
the cyclic AMP (show TMPRSS5 Proteins) (cAMP) response of CRHR1 in physiologically relevant scenarios engages separate cAMP sources, involving the atypical soluble adenylyl cyclase (sAC (show ADCY10 Proteins)) in addition to transmembrane adenylyl cyclases (tmACs).
Data suggest a physiologically relevant role for local corticotropin-releasing hormone (show CRH Proteins) signaling towards shaping the neuronal circuitry within the mouse olfactory bulb.
A role was found for extra-hypothalamic CRF-R1 in stress-escalated alcohol drinking.
These results suggest that a regulatory system exists in the bovine thyroid gland based on UCN, CRHR1 and CRHR2 and that UCN plays a role in the regulation of thyroid physiological functions through an autocrine/paracrine mechanism.
CRHR1 and CRHR2 (show CRHR2 Proteins) are expressed in the bovine adrenal gland.
results indicate that arginine vasopressin (show AVP Proteins) receptor V3 and corticotropin-releasing factor receptor 1 mRNAs are coordinately downregulated in the anterior pituitary during systemic inflammatory stress in cattle[AVP receptor V3 (show AVPR1B Proteins)]
The results of this study suggested that variation in CRHR1 may influence brain function before any childhood adversity and may be a diathesis for the interaction between CRHR1 genotypes and childhood trauma reported to affect human psychopathology
CRF (show CRH Proteins) is expressed in tadpole tail, is up-regulated by environmental stressors, and is cytoprotective
This gene encodes a G-protein coupled receptor that binds neuropeptides of the corticotropin releasing hormone family that are major regulators of the hypothalamic-pituitary-adrenal pathway. The encoded protein is essential for the activation of signal transduction pathways that regulate diverse physiological processes including stress, reproduction, immune response and obesity. Alternative splicing results in multiple transcript variants, one of which represents a read-through transcript with the neighboring gene MGC57346.
corticotropin releasing hormone receptor type I
, corticotropin-releasing factor receptor 1
, corticotropin releasing hormone receptor 1
, corticotropin releasing hormone receptor variant 1e
, corticotropin releasing hormone receptor variant 1g
, corticotropin-releasing factor type 1 receptor
, corticotropin-releasing hormone receptor 1
, seven transmembrane helix receptor
, CRF 1 receptor
, CRH-R 1
, corticotrophin releasing hormone receptor 1
, corticotropin releasing hormone 1
, corticotropin releasing factor receptor type 1
, corticotrophin-releasing factor type 1 alpha receptor