CRHR1 Protein (AA 23-121) (His tag)

Catalog No. ABIN5713378

This Recombinant CRHR1 protein is expressed in Yeast.

Quick Overview for CRHR1 Protein (AA 23-121) (His tag) (ABIN5713378)

Target: CRHR1 (Corticotropin Releasing Hormone Receptor 1 (CRHR1))

Protein Type: Recombinant

Origin: Human

Source: Yeast

Application: SDS-PAGE (SDS)

Purity: > 90 %

Product Details

Protein Characteristics: AA 23-121

Purification tag / Conjugate: This CRHR1 protein is labelled with His tag.

Sequence: MSLQDQHCES LSPASNVSGL QCNASVDLIG TCWPRSPARQ LVVRPCPAFF YGVRYNTTNN GYRECLANGS WAARVNYSEC QEILNEEKKS KVHYHVAVI

Purification: SDS-PAGE

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.1-2 mg/mL

Buffer: 20 mM Tris-HCl based buffer, pH 8.0

Storage: -80 °C,4 °C,-20 °C

Storage Comment: Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Target Details

Target: CRHR1 (Corticotropin Releasing Hormone Receptor 1 (CRHR1))

Alternative Name: CRFR1

Background: G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal bryonic development of the adrenal gland and for normal hormonal responses to stress. Plays a role in the response to anxiogenic stimuli.

Molecular Weight: 13.1 kDa

UniProt: P34998

Pathways: Hormone Transport, cAMP Metabolic Process, Myometrial Relaxation and Contraction, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Feeding Behaviour, Negative Regulation of Transporter Activity