Browse our anti-DIO2 (DIO2) Antibodies

Full name:
anti-Deiodinase, Iodothyronine, Type II Antibodies (DIO2)
On www.antibodies-online.com are 64 Deiodinase, Iodothyronine, Type II (DIO2) Antibodies from 15 different suppliers available. Additionally we are shipping DIO2 Kits (33) and DIO2 Proteins (8) and many more products for this protein. A total of 108 DIO2 products are currently listed.
Synonyms:
5DII, AI324267, cb684, D2, Deio2, DIO2, dio2-A, DIOII, SelY, TXDI2

Most Popular Reactivities for anti-DIO2 (DIO2) Antibodies

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anti-Mouse (Murine) DIO2 Antibodies:

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anti-Rat (Rattus) DIO2 Antibodies:

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Top referenced anti-DIO2 Antibodies

  1. Mouse (Murine) Polyclonal DIO2 Primary Antibody for ELISA, IHC - ABIN314280 : Langford, Baron, Joy, Del Valle, Shack: Contributions of HIV infection in the hypothalamus and substance abuse/use to HPT dysregulation. in Psychoneuroendocrinology 2011 (PubMed)
    Show all 4 references for 314280

  2. Human Polyclonal DIO2 Primary Antibody for EIA, IHC (p) - ABIN453620 : He, Li, Wang, Ju, Lu, Shi, He, Zhong: Association of genetic polymorphisms in the type II deiodinase gene with bipolar disorder in a subset of Chinese population. in Progress in neuro-psychopharmacology & biological psychiatry 2009 (PubMed)
    Show all 2 references for 453620

  3. Mouse (Murine) Polyclonal DIO2 Primary Antibody for IHC, ELISA - ABIN190862 : Gumieniak, Perlstein, Williams, Hopkins, Brown, Raby, Williams: Ala92 type 2 deiodinase allele increases risk for the development of hypertension. in Hypertension 2007 (PubMed)
    Show all 2 references for 190862

More Antibodies against DIO2 Interaction Partners

Zebrafish Deiodinase, Iodothyronine, Type II (DIO2) interaction partners

  1. This study investigated deiodinase 1 (Dio1 (show DIO1 Antibodies)), deiodinase 2 (Dio2), and deiodinase 3 (Dio3 (show DIO3 Antibodies)) mRNA expression at the several zebrafish life stages and found life stage specific expression of these genes that were highly localized.

Xenopus laevis Deiodinase, Iodothyronine, Type II (DIO2) interaction partners

  1. No changes in TRb or DI-2 and DI-3 expression in tail tissue collected from Triclosan exposure larvae were found.

Mouse (Murine) Deiodinase, Iodothyronine, Type II (DIO2) interaction partners

  1. Dio3 (show DIO3 Antibodies)-/- mice display degeneration of retinal cones, the photoreceptors that mediate daylight and color vision. In Dio2-/- mice, cone function was largely normal but deletion of Dio2 in Dio3 (show DIO3 Antibodies)-/- mice markedly recovered cone numbers and electroretinogram responses, suggesting counterbalancing roles for both enzymes in cone survival.

  2. The consistent association between Calr (show CALR Antibodies) and Dio2 expression suggests that enhanced expression of these two genes facilitate detrimental effects on cartilage integrity.

  3. mice with astrocyte-specific Dio2 inactivation (Astro-D2KO) have normal serum T3 but exhibit anxiety-depression-like behavior as found in open field and elevated plus maze studies and when tested for depression using the tail-suspension and the forced-swimming tests

  4. Mice subjected to a running regime have significant increased cartilage damage and synovitis scores. Lack of Dio2 protected against cartilage damage in this model and was reflected in a specific gene expression profile.

  5. Data show that type 2 deiodinase (Dio2) inactivation in skeletal myocytes preserves T3 thyroid hormone (show PTH Antibodies) content and only mildly disrupts thyroid hormone (show PTH Antibodies) signaling.

  6. These studies reveal that tissue-specific differences in D2 ubiquitination are an inherent property of the TRH/TSH feedback mechanism

  7. congenital severe reduction of thyrotroph Dio2 causes a major impairment of the TSH response to hypothyroidism

  8. Systemic changes in thyroid hormone (show PTH Antibodies) economy as a result of acute food deprivation are not dependent on the deiodinases D1 or D2 but are mediated in part by sequestration of type 4 and type 3 in tissues and their enhanced metabolism by deiodinase D3.

  9. Data indicate that deiodinase Dio2 was mainly localized in stroma cells before implantation, whereas deiodinase Dio3 (show DIO3 Antibodies) was highly expressed in stromal cells after implantation.

  10. Data suggest that hepatic deiodinase type 2 (D2) favors the innate immune response by specifically regulating cellular thyroid hormone (show PTH Antibodies) levels in macrophages.

Human Deiodinase, Iodothyronine, Type II (DIO2) interaction partners

  1. Thyroidectomized patients carrying DIO2 Thr92Ala are at increased risk of reduced intracellular and serum T3 concentrations that are not adequately compensated for by LT4, thus providing evidence in favor of customized treatment of hypothyroidism in athyreotic patients.

  2. D2-Thr92Ala genetic variant is associated with the severity and the obstetric outcome of preeclampsia, and it also influences thyroid hormone (show PTH Antibodies) levels.

  3. Homozygosity for the Dio2 Thr92Ala polymorphism is associated with higher HbA1C levels in type 2 diabetes patients. [Meta-Analysis]

  4. the reduction of SAT DIO2 expression is negatively correlated with DBP (show GC Antibodies) and TG levels that are associated with the MetS (show ETV3 Antibodies). This might have an effect on developing MetS (show ETV3 Antibodies).

  5. In subjects who are alcohol dependent, the rs225014 DIO2 gene was associated with significant differences in the amount of naturalistic alcohol drinking.

  6. Data provide evidence in humans that genetic predisposition combined with early osteoarthritis-related changes results in loff of epigenetic silencing of DIO2.

  7. DIO2 gene plays a role in the etiology of recurrent depressive disorder.Association of the DIO2 gene single nucleotide polymorphisms with recurrent depressive disorder.

  8. DIO2 gene polymorphisms may play a role in the incidence of MCI (show MCIN Antibodies) in male patients.

  9. conversion of T4 to T3 by D2 is required for TRalpha1/PI3K (show PIK3CA Antibodies)-mediated nongenomic actions of T4 in HUVECs, including stimulation of Akt (show AKT1 Antibodies) phosphorylation and Rac (show AKT1 Antibodies) activation, which result in cell migration.

  10. Thyroid hormone (show PTH Antibodies) deiodinases D1, D2, and D3 are differentially expressed in endothelial cells following thyroid hormone (show PTH Antibodies) exposure.

Pig (Porcine) Deiodinase, Iodothyronine, Type II (DIO2) interaction partners

Cow (Bovine) Deiodinase, Iodothyronine, Type II (DIO2) interaction partners

  1. Increased expression of mammary TRbeta1 (show THRB Antibodies) and DIO2, and decreased RXRalpha (show RXRA Antibodies), provide a mechanism to increase thyroid hormone (show PTH Antibodies) activity within the mammary gland during lactation.

DIO2 Antigen Profile

Antigen Summary

The protein encoded by this gene belongs to the iodothyronine deiodinase family. It activates thyroid hormone by converting the prohormone thyroxine (T4) by outer ring deiodination (ORD) to bioactive 3,3',5-triiodothyronine (T3). It is highly expressed in the thyroid, and may contribute significantly to the relative increase in thyroidal T3 production in patients with Graves disease and thyroid adenomas. This protein contains selenocysteine (Sec) residues encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in multiple transcript variants encoding different isoforms.

Alternative names and synonyms associated with DIO2

  • deiodinase, iodothyronine, type II (DIO2) antibody
  • deiodinase, iodothyronine, type II (dio2) antibody
  • type II iodothyronine deiodinase (LOC100135896) antibody
  • deiodinase, iodothyronine, type II (LOC100224791) antibody
  • deiodinase, iodothyronine, type II (LOC100354221) antibody
  • type II iodothyronine deiodinase (dio2-A) antibody
  • deiodinase, iodothyronine, type 2 (dio2) antibody
  • deiodinase, iodothyronine, type II (Dio2) antibody
  • 5DII antibody
  • AI324267 antibody
  • cb684 antibody
  • D2 antibody
  • Deio2 antibody
  • DIO2 antibody
  • dio2-A antibody
  • DIOII antibody
  • SelY antibody
  • TXDI2 antibody

Protein level used designations for DIO2

type II iodothyronine deiodinase , D2 , deiodinase, iodothyronine, type II , iodothyronine type II deiodinase , deiodinase 2 , deiodinase, iodothyronine, type 2 , type 2 deiodinase , type 2 DI , type-II 5' deiodinase , type-II 5'-deiodinase , thyroxine deiodinase, type II , type 2 iodothyronine deiodinase , type-II 5'deiodinase , 5DII , DIOII

GENE ID SPECIES
100052547 Equus caballus
352937 Danio rerio
467521 Pan troglodytes
707484 Macaca mulatta
100101569 Oryctolagus cuniculus
100135896 Oncorhynchus mykiss
100224791 Taeniopygia guttata
100310793 Ovis aries
100354221 Oryctolagus cuniculus
373842 Xenopus laevis
100036737 Xenopus (Silurana) tropicalis
13371 Mus musculus
1734 Homo sapiens
414379 Sus scrofa
65162 Rattus norvegicus
490813 Canis lupus familiaris
494548 Bos taurus
373903 Gallus gallus
100721073 Cavia porcellus
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