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DIO2 Products

(Deiodinase, Iodothyronine, Type II (DIO2))
The protein encoded by this gene belongs to the iodothyronine deiodinase family. It activates thyroid hormone by converting the prohormone thyroxine (T4) by outer ring deiodination (ORD) to bioactive 3,3',5-triiodothyronine (T3). It is highly expressed in the thyroid, and may contribute significantly to the relative increase in thyroidal T3 production in patients with Graves disease and thyroid adenomas. This protein contains selenocysteine (Sec) residues encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].

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Featured DIO2 Categories

DIO2 Antibodies

High quality antibodies with extensive validation data.

DIO2 ELISA Kits

Reliable ELISA kits for a wide range of species.

DIO2 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended DIO2 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse
Application ELISA, FACS, IF, IHC
Validations
  • (1)
  • (3)
Cat. No. ABIN190862
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application FACS, IHC (p), WB
Validations
  • (3)
Cat. No. ABIN5531011
Quantity 400 μL
Datasheet Datasheet
Reactivity Human
Application ELISA, IF, IHC
Validations
  • (2)
Cat. No. ABIN7173972
Quantity 100 μg
Datasheet Datasheet

Recommended DIO2 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Competition ELISA
Validations
  • (1)
Cat. No. ABIN6966307
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6955327
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6955328
Quantity 96 tests
Datasheet Datasheet

Recommended DIO2 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3120328
Quantity 0.25 mg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3082080
Quantity 0.5 mg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1351608
Quantity 10 μg
Datasheet Datasheet

Latest Publications for our DIO2 products

Zuo, Liu, Gao, Yin, Wang, Hou, Fu, Liu, Wang, Xu, Pi: "Prolonged inorganic arsenic exposure via drinking water impairs brown adipose tissue function in mice." in: The Science of the total environment, Vol. 668, pp. 310-317, (2019) (PubMed).

Ma, Brouwer, Wesseling, Raj, van der Want, Boddeke, Balasubramaniyan, Copray: "Multipotent stem cell factor UGS148 is a marker for tanycytes in the adult hypothalamus." in: Molecular and cellular neurosciences, Vol. 65, pp. 21-30, (2015) (PubMed).

Kishida, Ejima, Yamamoto, Tanaka, Yamamoto, Mazda: "Reprogrammed Functional Brown Adipocytes Ameliorate Insulin Resistance and Dyslipidemia in Diet-Induced Obesity and Type 2 Diabetes." in: Stem cell reports, Vol. 5, Issue 4, pp. 569-81, (2015) (PubMed).

Vose, Vinukonda, Jo, Miry, Diamond, Korumilli, Arshad, Zia, Hu, Kayton, La Gamma, Bansal, Bianco, Ballabh: "Treatment with thyroxine restores myelination and clinical recovery after intraventricular hemorrhage." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 33, Issue 44, pp. 17232-46, (2013) (PubMed).

Langford, Baron, Joy, Del Valle, Shack: "Contributions of HIV infection in the hypothalamus and substance abuse/use to HPT dysregulation." in: Psychoneuroendocrinology, Vol. 36, Issue 5, pp. 710-9, (2011) (PubMed).

Gumieniak, Perlstein, Williams, Hopkins, Brown, Raby, Williams: "Ala92 type 2 deiodinase allele increases risk for the development of hypertension." in: Hypertension, Vol. 49, Issue 3, pp. 461-6, (2007) (PubMed).

Synonyms and alternative names related to DIO2

iodothyronine deiodinase 2 (DIO2), deiodinase, iodothyronine, type II (Dio2), iodothyronine deiodinase 2 (dio2), deiodinase, iodothyronine, type II (dio2), deiodinase, iodothyronine, type 2 L homeolog (dio2.L), deiodinase, iodothyronine, type 2 (dio2), iodothyronine deiodinase 2 (Dio2), type II iodothyronine deiodinase (LOC100861220), 5DII, 5dii, AI324267, cb684, D2, Deio2, DIO2, dio2-A, DIOII, SelY, sely, TXDI2, txdi2

Protein level used designations for DIO2

  • thyroxine deiodinase, type II
  • type 2 DI
  • type 2 iodothyronine deiodinase
  • type II iodothyronine deiodinase
  • type-II 5'-deiodinase
  • type-II 5'deiodinase
  • iodothyronine type II deiodinase
  • type-II 5' deiodinase
  • deiodinase, iodothyronine, type 2
  • D2
  • 5DII
  • DIOII
  • deiodinase, iodothyronine, type II
  • deiodinase 2
  • type 2 deiodinase
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