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Browse our DIO2 Proteins (DIO2)

Full name:
Deiodinase, Iodothyronine, Type II Proteins (DIO2)
On are 8 Deiodinase, Iodothyronine, Type II (DIO2) Proteins from 5 different suppliers available. Additionally we are shipping DIO2 Antibodies (63) and DIO2 Kits (33) and many more products for this protein. A total of 107 DIO2 products are currently listed.
5DII, AI324267, cb684, D2, Deio2, DIO2, dio2-A, DIOII, SelY, TXDI2
list all proteins Gene Name GeneID UniProt
DIO2 13371 Q9Z1Y9
DIO2 1734 Q92813
DIO2 65162 P70551

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DIO2 Proteins (DIO2) by Origin

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More Proteins for DIO2 Interaction Partners

Zebrafish Deiodinase, Iodothyronine, Type II (DIO2) interaction partners

  1. This study investigated deiodinase 1 (Dio1 (show DIO1 Proteins)), deiodinase 2 (Dio2), and deiodinase 3 (Dio3 (show DIO3 Proteins)) mRNA expression at the several zebrafish life stages and found life stage specific expression of these genes that were highly localized.

Xenopus laevis Deiodinase, Iodothyronine, Type II (DIO2) interaction partners

  1. No changes in TRb or DI-2 and DI-3 expression in tail tissue collected from Triclosan exposure larvae were found.

Mouse (Murine) Deiodinase, Iodothyronine, Type II (DIO2) interaction partners

  1. Mice subjected to a running regime have significant increased cartilage damage and synovitis scores. Lack of Dio2 protected against cartilage damage in this model and was reflected in a specific gene expression profile.

  2. Data show that type 2 deiodinase (Dio2) inactivation in skeletal myocytes preserves T3 thyroid hormone (show PTH Proteins) content and only mildly disrupts thyroid hormone (show PTH Proteins) signaling.

  3. These studies reveal that tissue-specific differences in D2 ubiquitination are an inherent property of the TRH/TSH feedback mechanism

  4. congenital severe reduction of thyrotroph Dio2 causes a major impairment of the TSH response to hypothyroidism

  5. Systemic changes in thyroid hormone (show PTH Proteins) economy as a result of acute food deprivation are not dependent on the deiodinases D1 or D2 but are mediated in part by sequestration of type 4 and type 3 in tissues and their enhanced metabolism by deiodinase D3.

  6. Data indicate that deiodinase Dio2 was mainly localized in stroma cells before implantation, whereas deiodinase Dio3 (show DIO3 Proteins) was highly expressed in stromal cells after implantation.

  7. Data suggest that hepatic deiodinase type 2 (D2) favors the innate immune response by specifically regulating cellular thyroid hormone (show PTH Proteins) levels in macrophages.

  8. Data suggest that type 2 deiodinase is induced in inflammation of tanycytes (as in inflammation of periventricular area, arcuate nucleus, and median eminence of hypothalamus); this enzyme induction appears to involve NFkappaB signaling.

  9. Data suggest that type 2 deiodinase induction (and kinetics of induction) in animal models of inflammation of leptomeninges, choroid plexus, and brain blood vessels is tissue specific and species specific.

  10. assays showed that hippocampal gene expression of deiodinases 2 and 3, enzymes involved in thyroid hormone (show PTH Proteins) regulation, is increased in resilience to stress-induced depressive syndrome

Human Deiodinase, Iodothyronine, Type II (DIO2) interaction partners

  1. D2-Thr92Ala genetic variant is associated with the severity and the obstetric outcome of preeclampsia, and it also influences thyroid hormone (show PTH Proteins) levels.

  2. Homozygosity for the Dio2 Thr92Ala polymorphism is associated with higher HbA1C levels in type 2 diabetes patients. [Meta-Analysis]

  3. the reduction of SAT DIO2 expression is negatively correlated with DBP and TG levels that are associated with the MetS. This might have an effect on developing MetS.

  4. In subjects who are alcohol dependent, the rs225014 DIO2 gene was associated with significant differences in the amount of naturalistic alcohol drinking.

  5. Data provide evidence in humans that genetic predisposition combined with early osteoarthritis-related changes results in loff of epigenetic silencing of DIO2.

  6. DIO2 gene plays a role in the etiology of recurrent depressive disorder.Association of the DIO2 gene single nucleotide polymorphisms with recurrent depressive disorder.

  7. DIO2 gene polymorphisms may play a role in the incidence of MCI (show MCIN Proteins) in male patients.

  8. conversion of T4 to T3 by D2 is required for TRalpha1/PI3K (show PIK3CA Proteins)-mediated nongenomic actions of T4 in HUVECs, including stimulation of Akt (show AKT1 Proteins) phosphorylation and Rac (show AKT1 Proteins) activation, which result in cell migration.

  9. Thyroid hormone (show PTH Proteins) deiodinases D1, D2, and D3 are differentially expressed in endothelial cells following thyroid hormone (show PTH Proteins) exposure.

  10. The rs225017 polymorphism in the 3'UTR of the human DIO2 gene is associated with increased insulin (show INS Proteins) resistance.

Pig (Porcine) Deiodinase, Iodothyronine, Type II (DIO2) interaction partners

Cow (Bovine) Deiodinase, Iodothyronine, Type II (DIO2) interaction partners

  1. Increased expression of mammary TRbeta1 (show THRB Proteins) and DIO2, and decreased RXRalpha (show RXRA Proteins), provide a mechanism to increase thyroid hormone (show PTH Proteins) activity within the mammary gland during lactation.

DIO2 Protein Profile

Protein Summary

The protein encoded by this gene belongs to the iodothyronine deiodinase family. It activates thyroid hormone by converting the prohormone thyroxine (T4) by outer ring deiodination (ORD) to bioactive 3,3',5-triiodothyronine (T3). It is highly expressed in the thyroid, and may contribute significantly to the relative increase in thyroidal T3 production in patients with Graves disease and thyroid adenomas. This protein contains selenocysteine (Sec) residues encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in multiple transcript variants encoding different isoforms.

Alternative names and synonyms associated with DIO2

  • deiodinase, iodothyronine, type II (DIO2)
  • deiodinase, iodothyronine, type II (dio2)
  • type II iodothyronine deiodinase (LOC100135896)
  • deiodinase, iodothyronine, type II (LOC100224791)
  • deiodinase, iodothyronine, type II (LOC100354221)
  • type II iodothyronine deiodinase (dio2-A)
  • deiodinase, iodothyronine, type 2 (dio2)
  • deiodinase, iodothyronine, type II (Dio2)
  • 5DII protein
  • AI324267 protein
  • cb684 protein
  • D2 protein
  • Deio2 protein
  • DIO2 protein
  • dio2-A protein
  • DIOII protein
  • SelY protein
  • TXDI2 protein

Protein level used designations for DIO2

type II iodothyronine deiodinase , D2 , deiodinase, iodothyronine, type II , iodothyronine type II deiodinase , deiodinase 2 , deiodinase, iodothyronine, type 2 , type 2 deiodinase , type 2 DI , type-II 5' deiodinase , type-II 5'-deiodinase , thyroxine deiodinase, type II , type 2 iodothyronine deiodinase , type-II 5'deiodinase , 5DII , DIOII

100052547 Equus caballus
352937 Danio rerio
467521 Pan troglodytes
707484 Macaca mulatta
100101569 Oryctolagus cuniculus
100135896 Oncorhynchus mykiss
100224791 Taeniopygia guttata
100310793 Ovis aries
100354221 Oryctolagus cuniculus
373842 Xenopus laevis
100036737 Xenopus (Silurana) tropicalis
13371 Mus musculus
1734 Homo sapiens
414379 Sus scrofa
65162 Rattus norvegicus
490813 Canis lupus familiaris
494548 Bos taurus
373903 Gallus gallus
100721073 Cavia porcellus
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