Browse our anti-PERK (EIF2AK3) Antibodies

Full name:
anti-Eukaryotic Translation Initiation Factor 2-alpha Kinase 3 Antibodies (EIF2AK3)
On www.antibodies-online.com are 170 Eukaryotic Translation Initiation Factor 2-alpha Kinase 3 (EIF2AK3) Antibodies from 23 different suppliers available. Additionally we are shipping PERK Kits (20) and PERK Proteins (12) and many more products for this protein. A total of 210 PERK products are currently listed.
Synonyms:
AI427929, EIF2AK3, PEK, PERK, WRS
list all antibodies Gene Name GeneID UniProt
EIF2AK3 13666  
EIF2AK3 29702 Q9Z1Z1
EIF2AK3 9451 Q9NZJ5

Show all species

Show all synonyms

Most Popular Reactivities for anti-PERK (EIF2AK3) Antibodies

Select your species and application

anti-Mouse (Murine) PERK Antibodies:

anti-Rat (Rattus) PERK Antibodies:

anti-Human PERK Antibodies:

All available anti-PERK Antibodies

Go to our pre-filtered search.

Top referenced anti-PERK Antibodies

  1. Mouse (Murine) Polyclonal PERK Primary Antibody for IF, IHC (p) - ABIN400976 : Harding, Zhang, Ron: Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase. in Nature 1999 (PubMed)
    Show all 8 references for 400976

  2. Human Polyclonal PERK Primary Antibody for IF (cc), IF (p) - ABIN744713 : He, Long, Zhong, Fu, Li, Lin: Sustained endoplasmic reticulum stress inhibits hepatocyte proliferation via downregulation of c-Met expression. in Molecular and cellular biochemistry 2014 (PubMed)
    Show all 7 references for 744713

  3. Human Polyclonal PERK Primary Antibody for EIA, IHC (p) - ABIN360502 : Delépine, Nicolino, Barrett, Golamaully, Lathrop, Julier: EIF2AK3, encoding translation initiation factor 2-alpha kinase 3, is mutated in patients with Wolcott-Rallison syndrome. in Nature genetics 2000 (PubMed)
    Show all 3 references for 360502

  4. Human Polyclonal PERK Primary Antibody for IF (p), IHC (p) - ABIN740715 : Yu, Zhang, Zhao, Guo, Li, Li, Zhang, Sun: Gypenoside Protects against Myocardial Ischemia-Reperfusion Injury by Inhibiting Cardiomyocytes Apoptosis via Inhibition of CHOP Pathway and Activation of PI3K/Akt Pathway In Vivo and In Vitro. in Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2016 (PubMed)
    Show all 2 references for 740715

  5. Human Polyclonal PERK Primary Antibody for IHC (p), WB - ABIN658472 : Kim, Moretti, Mitchell, Jung, Lu: Endoplasmic reticulum stress mediates radiation-induced autophagy by perk-eIF2alpha in caspase-3/7-deficient cells. in Oncogene 2010 (PubMed)
    Show all 2 references for 658472

  6. Human Monoclonal PERK Primary Antibody for ELISA, WB - ABIN969093 : Yamaguchi, Larkin, Lara-Lemus, Ramos-Castañeda, Liu, Arvan: Endoplasmic reticulum (ER) chaperone regulation and survival of cells compensating for deficiency in the ER stress response kinase, PERK. in The Journal of biological chemistry 2008 (PubMed)
    Show all 2 references for 969093

  7. Human Polyclonal PERK Primary Antibody for IHC, IHC (p) - ABIN4344915 : Jwa, Chang: PARP16 is a tail-anchored endoplasmic reticulum protein required for the PERK- and IRE1?-mediated unfolded protein response. in Nature cell biology 2012 (PubMed)

  8. Mouse (Murine) Polyclonal PERK Primary Antibody for IP, IHC - ABIN233768 : Huang, Wu, Chen, Hong: Aquatic birnavirus-induced ER stress-mediated death signaling contribute to downregulation of Bcl-2 family proteins in salmon embryo cells. in PLoS ONE 2011 (PubMed)

  9. Human Polyclonal PERK Primary Antibody for IHC (p), WB - ABIN392617 : Nakayama, Endo, Tsukano, Mori, Oike, Gotoh: Molecular mechanisms of the LPS-induced non-apoptotic ER stress-CHOP pathway. in Journal of biochemistry 2010 (PubMed)

More Antibodies against PERK Interaction Partners

Mouse (Murine) Eukaryotic Translation Initiation Factor 2-alpha Kinase 3 (EIF2AK3) interaction partners

  1. regulates both Ca2 (show CA2 Antibodies)+ -dependent working memory and protein synthesis-dependent memory flexibility

  2. SLC30A10 (show SLC30A10 Antibodies) has a protective role in 1-methyl-4-phenylpyridinium-induced toxicity via PERK-ATF4 (show ATF4 Antibodies) pathway.

  3. In many endoplasmic reticulum (ER) stress-related disorders, activation of the unfolded protein sensor protein kinase RNA-like ER kinase (PERK) kinase is beneficial. Nonetheless, in Charcot-Marie-Tooth 1B neuropathy mice, we show that activation of PERK in Schwann cells, but not in neurons, is detrimental for myelination. PERK may interfere with myelination, independent of its role in ER stress.

  4. ER-stressed astrocytes can drive an inflammatory M1-like phenotype in microglia, and this can be attenuated with inhibition of PERK. Importantly, targeting PERK neither disrupted normal cytokine signaling in astrocytes or microglia nor impaired macrophage phagocytosis or T cell polarization.

  5. These results suggest that PERK signaling promotes medulloblastoma tumorigenesis by attenuating apoptosis of premalignant granule cell precursors during the course of malignant transformation.

  6. These results suggest that the PERK arm of the unfolded protein response plays a pivotal role in the regulation of satellite cell homeostasis during regenerative myogenesis.

  7. Findings indicate that PERK kinase-activating transcription factor 4 (ATF4 (show ATF4 Antibodies)) pathway affected the efficiency of X-box binding protein 1 (XBP1 (show XBP1 Antibodies)) mRNA splicing by regulating inositol-requiring enzyme 1alpha (IRE1alpha (show ERN1 Antibodies)) expression.

  8. This study demonstrated that Perk Ablation Ameliorates Myelination in S63del-Charcot-Marie-Tooth 1B Neuropathy.

  9. Data show that EIF2AK3/PERK-mediated downregulation of miR (show MLXIP Antibodies)-424(322)-503 cluster regulates optimal activation of IRE1 (show ERN1 Antibodies) protein and activating transcription factor 6 (ATF6 (show ATF6 Antibodies)) during conditions of endoplasmic reticulum stress.

  10. Inhibition of eIF2alpha phosphorylation via PERK suppression and reversal of de novo protein synthesis deficits can mitigate cognitive deficits in neurodegenerative diseases.

Human Eukaryotic Translation Initiation Factor 2-alpha Kinase 3 (EIF2AK3) interaction partners

  1. SLC30A10 has a protective role in 1-methyl-4-phenylpyridinium-induced toxicity via PERK-ATF4 (show ATF4 Antibodies) pathway.

  2. We reveal distinct binding affinities between the binary and ternary complexes thus formed, that suggest a preference for the PERK signaling branch under stress, and a predilection for the GRP78 (show HSPA5 Antibodies)-UPR sensor complex formation upon stressor removal. These results imply a gated UPR mechanism that tunes the overall cellular behavior to the accumulation of unfolded proteins.

  3. PERK is involved in multivesicular body information during endoplasmic reticulum stress.

  4. These results suggest that PERK signaling promotes medulloblastoma tumorigenesis by attenuating apoptosis of premalignant granule cell precursors during the course of malignant transformation.

  5. we demonstrate that small molecule PERK inhibitors exhibit single agent efficacy against BrafV600E-dependent tumors highlighting the clinical value of targeting PERK

  6. A novel homozygous nonsense mutation (p.Q333) in exon 5 of the eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3) gene in a Wolcott-Rallison syndrome patient, and her parents were first-degree cousins with heterozygous mutations of EIF2AK3 gene.

  7. BiP/GRP78 (show HSPA5 Antibodies) and PERK were highly expressed.

  8. plasma exposure resulted in expression of unfolded protein response (UPR) proteins such as glucoserelated protein 78 (GRP78 (show HSPA5 Antibodies)), protein kinase (show CDK7 Antibodies) R (PKR (show PKLR Antibodies))like ER kinase (PERK), and inositolrequiring enzyme 1 (IRE1 (show ERN1 Antibodies)). Elevated expression of spliced Xbox binding protein 1 (XBP1 (show XBP1 Antibodies)) and CCAAT/enhancerbinding protein homologous protein (CHOP (show DDIT3 Antibodies)) further confirmed that ROS (show ROS1 Antibodies) generatedby NTGP induces apoptosis through the ER stress

  9. PERK-eIF2alpha (show EIF2A Antibodies)-ATF4 (show ATF4 Antibodies) signaling pathway mediated by endoplasmic reticulum stress involved in osteoblast differentiation of periodontal ligament cells under cyclic mechanical force.

  10. EnR (show LARGE Antibodies) stress assessed by expression of PERK and p-eIF2alpha (show EIF2A Antibodies) was significantly associated with tumor infiltrating lymphocytes in HER2 (show ERBB2 Antibodies)-positive breast cancer.

PERK (EIF2AK3) Antigen Profile

Antigen Summary

The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome.

Alternative names and synonyms associated with PERK (EIF2AK3)

  • eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3) antibody
  • eukaryotic translation initiation factor 2 alpha kinase 3 (Eif2ak3) antibody
  • AI427929 antibody
  • EIF2AK3 antibody
  • PEK antibody
  • PERK antibody
  • WRS antibody

Protein level used designations for EIF2AK3

eukaryotic translation initiation factor 2-alpha kinase 3 , eukaryotic translation initiation factor 2-alpha kinase 3-like , PRKR-like endoplasmic reticulum kinase , pancreatic eIF2-alpha kinase , eukaryotic translation initiation factor 2 alpha kinase 3 , hsPEK , pancreatic EIF2-alpha kinase

GENE ID SPECIES
459388 Pan troglodytes
475756 Canis lupus familiaris
699575 Macaca mulatta
100029557 Monodelphis domestica
100066488 Equus caballus
100394186 Callithrix jacchus
100447385 Pongo abelii
100479743 Ailuropoda melanoleuca
13666 Mus musculus
29702 Rattus norvegicus
9451 Homo sapiens
535820 Bos taurus
Selected quality suppliers for anti-PERK (EIF2AK3) Antibodies
Did you look for something else?