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Browse our anti-PERK (EIF2AK3) Antibodies

Full name:
anti-Eukaryotic Translation Initiation Factor 2-alpha Kinase 3 Antibodies (EIF2AK3)
On www.antibodies-online.com are 172 Eukaryotic Translation Initiation Factor 2-alpha Kinase 3 (EIF2AK3) Antibodies from 24 different suppliers available. Additionally we are shipping PERK Kits (21) and PERK Proteins (11) and many more products for this protein. A total of 212 PERK products are currently listed.
Synonyms:
AI427929, EIF2AK3, PEK, PERK, WRS
list all antibodies Gene Name GeneID UniProt
EIF2AK3 13666  
EIF2AK3 29702 Q9Z1Z1
EIF2AK3 9451 Q9NZJ5

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Most Popular Reactivities for anti-PERK (EIF2AK3) Antibodies

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anti-Mouse (Murine) PERK Antibodies:

anti-Rat (Rattus) PERK Antibodies:

anti-Human PERK Antibodies:

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Top referenced anti-PERK Antibodies

  1. Mouse (Murine) Polyclonal PERK Primary Antibody for IF, IHC (p) - ABIN400976 : Harding, Zhang, Ron: Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase. in Nature 1999 (PubMed)
    Show all 8 references for ABIN400976

  2. Human Polyclonal PERK Primary Antibody for IF (cc), IF (p) - ABIN744713 : He, Long, Zhong, Fu, Li, Lin: Sustained endoplasmic reticulum stress inhibits hepatocyte proliferation via downregulation of c-Met expression. in Molecular and cellular biochemistry 2014 (PubMed)
    Show all 7 references for ABIN744713

  3. Human Polyclonal PERK Primary Antibody for EIA, IHC (p) - ABIN360502 : Delépine, Nicolino, Barrett, Golamaully, Lathrop, Julier: EIF2AK3, encoding translation initiation factor 2-alpha kinase 3, is mutated in patients with Wolcott-Rallison syndrome. in Nature genetics 2000 (PubMed)
    Show all 3 references for ABIN360502

  4. Human Monoclonal PERK Primary Antibody for ELISA, WB - ABIN969093 : Yamaguchi, Larkin, Lara-Lemus, Ramos-Castañeda, Liu, Arvan: Endoplasmic reticulum (ER) chaperone regulation and survival of cells compensating for deficiency in the ER stress response kinase, PERK. in The Journal of biological chemistry 2008 (PubMed)
    Show all 2 references for ABIN969093

  5. Human Polyclonal PERK Primary Antibody for IHC (p), WB - ABIN658472 : Kim, Moretti, Mitchell, Jung, Lu: Endoplasmic reticulum stress mediates radiation-induced autophagy by perk-eIF2alpha in caspase-3/7-deficient cells. in Oncogene 2010 (PubMed)
    Show all 2 references for ABIN658472

  6. Human Polyclonal PERK Primary Antibody for IF (p), IHC (p) - ABIN740715 : Yu, Zhang, Zhao, Guo, Li, Li, Zhang, Sun: Gypenoside Protects against Myocardial Ischemia-Reperfusion Injury by Inhibiting Cardiomyocytes Apoptosis via Inhibition of CHOP Pathway and Activation of PI3K/Akt Pathway In Vivo and In Vitro. in Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2016 (PubMed)
    Show all 2 references for ABIN740715

  7. Human Polyclonal PERK Primary Antibody for IHC, IHC (p) - ABIN4344915 : Jwa, Chang: PARP16 is a tail-anchored endoplasmic reticulum protein required for the PERK- and IRE1?-mediated unfolded protein response. in Nature cell biology 2012 (PubMed)

  8. Mouse (Murine) Polyclonal PERK Primary Antibody for IP, IHC - ABIN233768 : Huang, Wu, Chen, Hong: Aquatic birnavirus-induced ER stress-mediated death signaling contribute to downregulation of Bcl-2 family proteins in salmon embryo cells. in PLoS ONE 2011 (PubMed)

  9. Human Polyclonal PERK Primary Antibody for IHC (p), WB - ABIN392617 : Nakayama, Endo, Tsukano, Mori, Oike, Gotoh: Molecular mechanisms of the LPS-induced non-apoptotic ER stress-CHOP pathway. in Journal of biochemistry 2010 (PubMed)

More Antibodies against PERK Interaction Partners

Mouse (Murine) Eukaryotic Translation Initiation Factor 2-alpha Kinase 3 (EIF2AK3) interaction partners

  1. Findings indicate that PERK kinase-activating transcription factor 4 (ATF4 (show ATF4 Antibodies)) pathway affected the efficiency of X-box binding protein 1 (XBP1 (show XBP1 Antibodies)) mRNA splicing by regulating inositol-requiring enzyme 1alpha (IRE1alpha (show ERN1 Antibodies)) expression.

  2. This study demonstrated that Perk Ablation Ameliorates Myelination in S63del-Charcot-Marie-Tooth 1B Neuropathy.

  3. Data show that EIF2AK3/PERK-mediated downregulation of miR (show MLXIP Antibodies)-424(322)-503 cluster regulates optimal activation of IRE1 (show ERN1 Antibodies) protein and activating transcription factor 6 (ATF6 (show ATF6 Antibodies)) during conditions of endoplasmic reticulum stress.

  4. Inhibition of eIF2alpha phosphorylation via PERK suppression and reversal of de novo protein synthesis deficits can mitigate cognitive deficits in neurodegenerative diseases.

  5. PlGF (show PGF Antibodies) inhibition attenuates PERK activation, likely by tempering hypoxia in HCC (show FAM126A Antibodies) via vessel normalisation. The UPR is able to regulate PlGF (show PGF Antibodies) expression, suggesting the existence of a feedback mechanism for hypoxia-mediated UPR

  6. this study demonstrates novel roles for the endoplasmic reticulum stress-response transducer PERK and a downstream effector of its activation, CHOP (show DDIT3 Antibodies), in tubule cell production of fibronectin (show FN1 Antibodies)

  7. Nck1 silencing in pancreatic beta cells promotes PERK activation and signaling to protect beta cells against pathological stresses.

  8. Nitric oxide can S-nitrosylate the endoplasmic reticulum stress sensors IRE1alapha and PERK.

  9. Results show that PERK-eIF2alpha (show EIF2A Antibodies)-mediated translational failure is a key process leading to neuronal loss in a mouse model of frontotemporal dementia, where the misfolded protein is a form of mutant tau

  10. whole-body or pancreas-specific Perk ablation in mice leads to an increase in IFNAR1 (show IFNAR1 Antibodies) protein levels and signaling in pancreatic tissues.

Human Eukaryotic Translation Initiation Factor 2-alpha Kinase 3 (EIF2AK3) interaction partners

  1. A novel homozygous nonsense mutation (p.Q333) in exon 5 of the eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3) gene in a Wolcott-Rallison syndrome patient, and her parents were first-degree cousins with heterozygous mutations of EIF2AK3 gene.

  2. BiP/GRP78 (show HSPA5 Antibodies) and PERK were highly expressed.

  3. plasma exposure resulted in expression of unfolded protein response (UPR) proteins such as glucoserelated protein 78 (GRP78 (show HSPA5 Antibodies)), protein kinase (show CDK7 Antibodies) R (PKR (show PKLR Antibodies))like ER kinase (PERK), and inositolrequiring enzyme 1 (IRE1 (show ERN1 Antibodies)). Elevated expression of spliced Xbox binding protein 1 (XBP1 (show XBP1 Antibodies)) and CCAAT/enhancerbinding protein homologous protein (CHOP (show DDIT3 Antibodies)) further confirmed that ROS (show ROS1 Antibodies) generatedby NTGP induces apoptosis through the ER stress

  4. PERK-eIF2alpha (show EIF2A Antibodies)-ATF4 (show ATF4 Antibodies) signaling pathway mediated by endoplasmic reticulum stress involved in osteoblast differentiation of periodontal ligament cells under cyclic mechanical force.

  5. EnR (show LARGE Antibodies) stress assessed by expression of PERK and p-eIF2alpha (show EIF2A Antibodies) was significantly associated with tumor infiltrating lymphocytes in HER2 (show ERBB2 Antibodies)-positive breast cancer.

  6. Influenza A virus downregulates the host unfolded protein response mediated by the PERK protein.

  7. Using drugs that specifically inhibit or activate the PERK or IRE1alpha sensors, we demonstrate that signalling through the PERK axis activates this expression, through a transcriptional mechanism

  8. Data show CGK733 induced microtubule associated protein LC3B (show MAP1LC3B Antibodies) formation upstream of AMP-activated protein kinase (show PRKAA2 Antibodies) and protein kinase (show CDK7 Antibodies) RNA-like endoplasmic reticulum kinase/CCAAT-enhancer-binding protein homologous protein (show DDIT3 Antibodies) pathways and p21 Cip1 (show CDKN1A Antibodies) expression.

  9. Nitric oxide can S-nitrosylate the endoplasmic reticulum stress sensors IRE1alapha and PERK.

  10. Data from 2 consanguineous families suggest EIF2AK3 mutations (c.1337_1338insT/p.K346*; c.3009C>T/p.R903*) account for Wolcott-Rallison syndrome; ultrastructural features of autopsy materials suggest endoplasmic reticulum dysfunction. [CASE STUDIES]

PERK (EIF2AK3) Antigen Profile

Antigen Summary

The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome.

Alternative names and synonyms associated with PERK (EIF2AK3)

  • eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3) antibody
  • eukaryotic translation initiation factor 2 alpha kinase 3 (Eif2ak3) antibody
  • AI427929 antibody
  • EIF2AK3 antibody
  • PEK antibody
  • PERK antibody
  • WRS antibody

Protein level used designations for EIF2AK3

eukaryotic translation initiation factor 2-alpha kinase 3 , eukaryotic translation initiation factor 2-alpha kinase 3-like , PRKR-like endoplasmic reticulum kinase , pancreatic eIF2-alpha kinase , eukaryotic translation initiation factor 2 alpha kinase 3 , hsPEK , pancreatic EIF2-alpha kinase

GENE ID SPECIES
459388 Pan troglodytes
475756 Canis lupus familiaris
699575 Macaca mulatta
100029557 Monodelphis domestica
100066488 Equus caballus
100394186 Callithrix jacchus
100447385 Pongo abelii
100479743 Ailuropoda melanoleuca
13666 Mus musculus
29702 Rattus norvegicus
9451 Homo sapiens
535820 Bos taurus
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