Browse our Methyl CpG Binding Protein 2 Proteins (MECP2)

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Methyl CpG Binding Protein 2 Proteins (MECP2)
On www.antibodies-online.com are 13 Methyl CpG Binding Protein 2 (MECP2) Proteins from 7 different suppliers available. Additionally we are shipping Methyl CpG Binding Protein 2 Antibodies (225) and Methyl CpG Binding Protein 2 Kits (13) and many more products for this protein. A total of 264 Methyl CpG Binding Protein 2 products are currently listed.
Synonyms:
1500041B07Rik, AUTSX3, BB130002, D630021H01Rik, Mbd5, MRX16, MRX79, MRXS13, MRXSL, PPMX, RS, RTS, RTT, WBP10
list all proteins Gene Name GeneID UniProt
MECP2 29386 Q00566
MECP2 17257 Q9Z2D6
MECP2 4204 P51608

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Methyl CpG Binding Protein 2 Proteins (MECP2) by Origin

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More Proteins for Methyl CpG Binding Protein 2 Interaction Partners

Mouse (Murine) Methyl CpG Binding Protein 2 (MECP2) interaction partners

  1. that histone deacetylase 3 (show HDAC3 Proteins) interaction with MeCP2 positively regulates a subset of neuronal genes through FOXO (show FOXO3 Proteins) deacetylation, and disruption of HDAC3 (show HDAC3 Proteins) contributes to cognitive and social impairment

  2. provide new insight into the upstream regulation of Sap90/Psd95 (show DLG4 Proteins)-associated protein 3 (show HSPB3 Proteins) and establish the essential role of striatal Hdac1 (show HDAC1 Proteins), Hdac2 (show HDAC2 Proteins) and MeCP2 for suppression of repetitive behaviors

  3. These findings position MeCP2 as a novel component in metabolic homeostasis. We previously showed that treatment of Mecp2 mice with statin drugs alleviated motor symptoms and improved health and longevity. Lipid metabolism is a highly treatable target; therefore, our results shed light on new metabolic pathways for treatment of Rett syndrome

  4. MeCP2 dysfunction in excitatory neurons mediated elevated synchrony at baseline, while MeCP2 dysfunction in inhibitory neurons increased susceptibility to hypersynchronization in response to perturbations.

  5. Loss of MeCP2 causes urological dysfunction and contributes to death by kidney failure in a mouse model of Rett syndrome.

  6. MeCP2 expression in the medullary respiratory network is sufficient for normal respiratory rhythm and preventing apnea. MeCP2 expression in the HoxA4 (show HOXA4 Proteins) domain alone is critical for survival.

  7. Mecp2 is responsive to neuronal stimulation and IGF1 (show IGF1 Proteins), and different stimuli have different effects on Mecp2 expression; this differential response may have downstream effects on functional mechanisms regulating brain development and plasticity.

  8. MeCP2 binding to chromosomal DNA in mouse brain is proportional to mCAC (show SLC25A20 Proteins) + mCG density.

  9. Results confirm and extend earlier published findings that specific aspects of cholesterol metabolism in the CNS, particularly the biosynthetic pathway, are disrupted in mouse models with loss-of-function mutations in Mecp2

  10. Repression of TSC1 (show TSC1 Proteins)/TSC2 mediated by MeCP2 regulates human embryo lung fibroblast cell differentiation and proliferation.

Human Methyl CpG Binding Protein 2 (MECP2) interaction partners

  1. that histone deacetylase 3 (show HDAC3 Proteins) interaction with MeCP2 positively regulates a subset of neuronal genes through FOXO (show FOXO3 Proteins) deacetylation, and disruption of HDAC3 (show HDAC3 Proteins) contributes to cognitive and social impairment

  2. C- and N-terminal interactions are required for healthy function of MeCP2.

  3. These findings position MeCP2 as a novel component in metabolic homeostasis. We previously showed that treatment of Mecp2 mice with statin drugs alleviated motor symptoms and improved health and longevity. Lipid metabolism is a highly treatable target; therefore, our results shed light on new metabolic pathways for treatment of Rett syndrome

  4. Based on these findings, the authors suggest that MeCP2 recognition of methylated/hydroxymethylated CpA (show CPA1 Proteins) dinucleotides functions as an epigenetic switch redistributing MeCP2 among mCG and mCA (show RSPH1 Proteins) loci.

  5. Following the recent demonstration of phenotype reversal in a mouse model of MECP2 Duplication, a clear understanding of the natural history is crucial to the design and implementation of future therapeutic strategies.

  6. we could not find any significant correlation between specific MECP2 mutations and individual clinical features or global clinical score in Rett syndrome patients

  7. findings demonstrate clear phenotype differences between FOXG1 (show FOXG1 Proteins) and MECP2 disorders.

  8. Binding cooperativity makes MeCP2 an effective competitor with histone H1 (show H1F0 Proteins) for accessible DNA sites. The relationship between MeCP2 binding specificity and cooperativity is discussed in the context of chromatin binding, neuronal function, and neuronal development.

  9. Our data indicate that these motifs are secondary contributors to DNA binding by MeCP2, and this view is supported by the absence of disease-causing missense mutations at these sites

  10. Six patients (5 females and 1 male) with intellectual disability and present with some Rett syndrome features showed missense methyl-CpG binding protein 2 (MECP2) variants.

Methyl CpG Binding Protein 2 (MECP2) Protein Profile

Protein Summary

DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females.

Alternative names and synonyms associated with Methyl CpG Binding Protein 2 (MECP2)

  • methyl CpG binding protein 2 (Mecp2)
  • methyl CpG binding protein 2 (Rett syndrome) (MECP2)
  • 1500041B07Rik protein
  • AUTSX3 protein
  • BB130002 protein
  • D630021H01Rik protein
  • Mbd5 protein
  • MRX16 protein
  • MRX79 protein
  • MRXS13 protein
  • MRXSL protein
  • PPMX protein
  • RS protein
  • RTS protein
  • RTT protein
  • WBP10 protein

Protein level used designations for MECP2

meCP-2 protein , methyl-CpG-binding protein 2 , meCp-2 protein

GENE ID SPECIES
29386 Rattus norvegicus
17257 Mus musculus
4204 Homo sapiens
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