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Browse our Methyl CpG Binding Protein 2 Proteins (MECP2)

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Methyl CpG Binding Protein 2 Proteins (MECP2)
On are 14 Methyl CpG Binding Protein 2 (MECP2) Proteins from 8 different suppliers available. Additionally we are shipping Methyl CpG Binding Protein 2 Antibodies (229) and Methyl CpG Binding Protein 2 Kits (12) and many more products for this protein. A total of 267 Methyl CpG Binding Protein 2 products are currently listed.
1500041B07Rik, AUTSX3, BB130002, D630021H01Rik, Mbd5, MRX16, MRX79, MRXS13, MRXSL, PPMX, RS, RTS, RTT, WBP10
list all proteins Gene Name GeneID UniProt
MECP2 29386 Q00566
MECP2 17257 Q9Z2D6
MECP2 4204 P51608

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Methyl CpG Binding Protein 2 Proteins (MECP2) by Origin

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More Proteins for Methyl CpG Binding Protein 2 Interaction Partners

Mouse (Murine) Methyl CpG Binding Protein 2 (MECP2) interaction partners

  1. Repression of TSC1 (show TSC1 Proteins)/TSC2 mediated by MeCP2 regulates human embryo lung fibroblast cell differentiation and proliferation.

  2. Data suggest that newborn Mecp2 null cortical neurons display critical transcriptional defects that lead to reduced neuronal responsiveness, which, in turn, delays and disrupts proper neuronal maturation

  3. absence leads to decreased cortical levels of the GAT-1 GABA transporter, facilitating cortical network hyper-excitability by increasing the activity of cortical GABAB receptors

  4. Knockdown of methyl-CpG-binding protein leads to upregulation of microRNA-137, which in turn represses expression of PTEN protein.

  5. Study demonstrates that the time course of N-methyl-D-aspartate receptor (show GRIN1 Proteins) maturation is cell-type specific, and a new cell-type specific role for Mecp2 in the development of -methyl-D-aspartate receptor subunit composition.

  6. Data highlight functional hypoconnectivity in the medial prefrontal cortex as a potential substrate for behavioral disruption in Rett syndrome and other disorders associated with reduced expression of Mecp2 in frontal cortical regions.

  7. These findings indicate that tongue heat sensitivity and hypersensitivity are dependent on the expression of transient receptor potential vanilloid 1 which is regulated via MeCP2 signaling in trigeminal ganglion neurons innervating the tongue.

  8. We treated MeCP2-null mice from postnatal-day 28 for two weeks with desipramine, already tested in Rett syndrome , or mirtazapine, an antidepressant with limited side-effects, known to promote GABA release

  9. these results suggested that MeCP2 facilitated Tet3 activity, enhanced expression of pluripotency-related genes, and eventually improved the development of NT embryos.

  10. The molecular basis of variable phenotypic severity among common MECP2 missense mutations causing Rett syndrome has been described.

Human Methyl CpG Binding Protein 2 (MECP2) interaction partners

  1. Repression of TSC1 (show TSC1 Proteins)/TSC2 mediated by MeCP2 regulates human embryo lung fibroblast cell differentiation and proliferation.

  2. This study demonstrated that the MECP2 duplication of Autism showed that spine pathology in brain.

  3. Our findings confirm a high mutation frequency in classic RTT (92%) and a correlation between the MECP2 mutation type and clinical severity. We also demonstrate limitations of XCI in explaining all of the phenotypic differences in RTT.

  4. Data show that MeCP2 promotes gastric cancer (GC) cell proliferation via FOXF1 (show FOXF1 Proteins)-mediated Wnt5a (show WNT5A Proteins)/beta-Catenin (show CTNNB1 Proteins) signaling pathway, and suppresses GC cell apoptosis through MYOD1 (show MYOD1 Proteins)-mediated Caspase-3 (show CASP3 Proteins) signaling pathway.

  5. To our knowledge, we describe the first association between MECP2 mutation, chromosomal abnormalities and high sister-chromatid exchange frequency

  6. MECP2 substitutions outside the canonical MeCP2 domains are present in X-linked intellectual disability

  7. We further delineate the phenotype associated with the p.Ala140Val mutation in MECP2 , illustrating a variable expressivity even within a given family, and we compare our patients with previous reported cases in the literature

  8. This is the first large cohort of patients with MECP2 duplication syndrome, including a female, reported in China

  9. The monkeys transmitted both multiple MECP2 genes and social deficits on to a second generation of monkeys, who did not interact as frequently as did normal monkeys

  10. The MECP2 gene is mutated in 80% of patients with classic Rett syndrome, as well as in 40% of those affected by any of its atypical forms

Methyl CpG Binding Protein 2 (MECP2) Protein Profile

Protein Summary

DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females.

Alternative names and synonyms associated with Methyl CpG Binding Protein 2 (MECP2)

  • methyl CpG binding protein 2 (Mecp2)
  • methyl CpG binding protein 2 (Rett syndrome) (MECP2)
  • 1500041B07Rik protein
  • AUTSX3 protein
  • BB130002 protein
  • D630021H01Rik protein
  • Mbd5 protein
  • MRX16 protein
  • MRX79 protein
  • MRXS13 protein
  • MRXSL protein
  • PPMX protein
  • RS protein
  • RTS protein
  • RTT protein
  • WBP10 protein

Protein level used designations for MECP2

meCP-2 protein , methyl-CpG-binding protein 2 , meCp-2 protein

29386 Rattus norvegicus
17257 Mus musculus
4204 Homo sapiens
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