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Human CSF2RA Protein expressed in HEK-293 - ABIN2666820
Burmester, Feist, Sleeman, Wang, White, Magrini: Mavrilimumab, a human monoclonal antibody targeting GM-CSF receptor-α, in subjects with rheumatoid arthritis: a randomised, double-blind, placebo-controlled, phase I, first-in-human study. in Annals of the rheumatic diseases 2011
Show all 6 references for ABIN2666820
Human CSF2RA Protein expressed in Human Cells - ABIN2003270
McClure, Hercus, Cambareri, Woodcock, Bagley, Howlett, Lopez: Molecular assembly of the ternary granulocyte-macrophage colony-stimulating factor receptor complex. in Blood 2003
Show all 5 references for ABIN2003270
Our cohort broadens the spectrum of knowledge about the clinical variability and genotype-phenotype correlations of juvenile PAP (show REG3A Proteins), and illustrates the favorable outcome of WLL treatment in severely affected patients
A possible relationship between dysfunction of the granulocyte-macrophage colony stimulating factor receptor, mapping to the pseudoautosomal X-Y region, may exist in myelodysplastic patients with initially lymphocytic Sweet syndrome.
Studies indicate the action of GM-CSF (show CSF2 Proteins) can be inhibited by at least two approaches: inhibition by GM-CSF (show CSF2 Proteins) neutralising antibodies, or blockade of GM-CSF (show CSF2 Proteins) binding to its receptor by antibodies against the GM-CSF receptor alpha chain (show FCGRT Proteins) CSF2Ralpha.
The GM-CSF (show CSF2 Proteins) Ralpha were ubiquitously but not uniformly expressed in neurons throughout the brain and downregulation in brain in patient with alzheimenr disease.
This study reveals a novel functional role of clathrin-coated structure in GMR signaling and the oncogenesis of JAK2V617F.
Identify defective expression and function of CD116 as a distinguishing feature of IBD and implicate an associated defect in innate immune responses toward granulocyte-macrophage colony-stimulating factor (show CSF2 Proteins).
The expression rate of GM-CSFR in myelodysplastic syndrome patients was significantly higher than in aplastic anemia patients and controls.
67-kDa laminin receptor (show RPSA Proteins) expression influenced the characteristics of leukemia cells toward an aggressive phenotype and increased the number of granulocyte-macrophage colony-stimulating factor (show CSF2 Proteins) receptors
Data show that Deletion of the Ig-like domain of GM-CSFRalpha abolished direct GM-CSF (show CSF2 Proteins) binding and decreased growth signalling in the presence of hbetac.
soluble forms of the GM-CSF receptor alpha chain (show FCGRT Proteins) and beta chain were produced and a novel mechanism of receptor assembly was demonstrated
GM-CSFRalpha levels peaked between E13 and E15 in the brain.
Loss of the CSF2RA gene may be a critical mutation explaining the high incidence of loss of sex chromosomes associated with the t(8;21)(q22;q22) translocation.
ability to detect GM-CSF (show CSF2 Proteins) receptor expression in experimental studies should greatly facilitate the analysis of its role in immune pathologies[GM-CSF receptor alpha]
The protein encoded by this gene is the alpha subunit of the heterodimeric receptor for colony stimulating factor 2, a cytokine which controls the production, differentiation, and function of granulocytes and macrophages. The encoded protein is a member of the cytokine family of receptors. This gene is found in the pseudoautosomal region (PAR) of the X and Y chromosomes. Multiple transcript variants encoding different isoforms have been found for this gene, with some of the isoforms being membrane-bound and others being soluble.
, GM-CSF receptor alpha subunit
, colony stimulating factor 2 receptor alpha subunit
, granulocyte-macrophage colony-stimulating factor receptor alpha chain
, granulocyte-macrophage colony-stimulating factor receptor subunit alpha
, colony stimulating factor 2 receptor alpha chain