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Mouse (Murine) EPO Protein expressed in Escherichia coli (E. coli) - ABIN1305139
JACOBSON, GOLDWASSER, FRIED, PLZAK: Role of the kidney in erythropoiesis. in Nature 1957
Show all 6 Pubmed References
Human EPO Protein expressed in Wheat germ - ABIN1352975
Zhang, Wang, Wang, Shi, Deng, Fu: rhEPO/EPO discrimination with ultrasensitive electrochemical biosensor based on sandwich-type nano-Au/ZnO sol-gel/nano-Au signal amplification. in Biosensors & bioelectronics 2013
Data show that erythropoietin (EPO) mRNA was upregulated in the lung, from the metamorphic climax (stage 60) onward.
Fetal plasma EPO concentrations are selectively increased in monochorionic twin pregnancies with intrauterine growth restriction.
SYK (show SYK Proteins) mediates the actions of EPO and GM-CSF (show CSF2 Proteins) and coordinates with TGF-beta (show TGFB1 Proteins) in erythropoiesis.
this study shows that EPO is involved in the pathogenesis of sepsis-induced acute kidney injury
Erythropoietin is superior to the standard prognostic scores in predicting 28-day mortality in patients with acute-on-chronic liver failure.
EPO levels were also found correlated positively with heme, TNF-alpha (show TNF Proteins), IL-10 (show IL10 Proteins), IP-10 (show CXCL10 Proteins) and MCP-1 (show CCL2 Proteins) during cerebral malaria.
CK1delta enhances EPO secretion from liver cancer cells under hypoxia by modifying HIF-2alpha (show EPAS1 Proteins) and promoting its nuclear accumulation.
Three single nucleotide polymorphisms are associated with increased risk of diabetic retinopathy in a Chinese Han population.
Pharmacokinetic animal studies revealed strongly 15.6-fold plasma half-life extension for the PASylated EPO (83.16 +/- 13.28 h) in comparison to epoetin alpha (8.5 +/- 2.4 h) and darbepoetin alpha (25.3 +/- 2.2h).
Secreted MIR122 reached the kidney and reduced expression of erythropoietin, contributing to inflammation-induced anemia.
this paper shows that Epo could directly down-regulate pro-inflammatory T cell responses without affecting T cell activation status
EPO expression in myoblasts and myotubes is increased by hypoxia and exercise
these findings define a cis (show CISH Proteins)-regulatory enhancer network for Epo signaling during erythropoiesis, and provide the framework for future studies involving the interplay of epigenetics and Epo signaling.
FOXD1 (show FOXD1 Proteins) lineage renal interstitial cells consist of distinct subpopulations that differ in their responsiveness to Phd2 (show EGLN1 Proteins) inactivation and thus regulation of HIF-2 activity and EPO production under hypoxia or conditions of pharmacologic or genetic PHD (show PDC Proteins) inactivation.
This study suggests a possible role of EPO in embryonic endodermal development and a new agent for directing the differentiation into endodermal lineages like pancreatic beta-cells.
Smad1 (show SMAD1 Proteins) and Smad5 (show SMAD5 Proteins) have overlapping functions to govern hepcidin (show HAMP Proteins) transcription. Moreover, erythropoietin and erythroferrone target Smad1 (show SMAD1 Proteins)/5 signaling and require Smad1 (show SMAD1 Proteins)/5 to suppress hepcidin (show HAMP Proteins) expression.
EPO role in the glucose homeostasis, thermogenesis and endocrine function of classical brown adipose tissue
Epo transcription in brain pericytes was HIF-2 dependent and cocontrolled by PHD2 (show EGLN1 Proteins) and PHD3 (show EGLN3 Proteins), oxygen- and 2-oxoglutarate-dependent prolyl-4-hydroxylases that regulate HIF activity.
This study showed that polycythemia alone and increased levels of plasma Epo blunt the hypercapnic ventilatory response (HCVR); mice with an augmented level of cerebral Epo also had a decreased HCVR.
Epo gene regulation in EPO-producing cells is a complex process that utilizes multiple regulatory influences.
this study shows that EPO could directly promote tumor progression via EPO receptor-expressing macrophages
EPO might play a role as a survival factor or as a mitogen in developing cartilage tissue.
Pyruvate-fortified cardioplegia evokes myocardial erythropoietin signaling in swine undergoing cardiopulmonary bypass.
A single intramuscular injection of recombinant adeno (show ADORA2A Proteins)-associated virus carrying mutant Epo (R76E) preserves retinal ganglion cells and visual function in glaucomatous mice.
The zebrafish epo cDNA was cloned and the expression of zepo mRNA was mainly in the heart and liver.
characterization of zebrafish epo and epor (show EPOR Proteins) demonstrates the conservation of an ancient program that ensures proper red blood cell numbers during normal homeostasis and under hypoxic conditions
This gene is a member of the EPO/TPO family and encodes a secreted, glycosylated cytokine composed of four alpha helical bundles. The protein is found in the plasma and regulates red cell production by promoting erythroid differentiation and initiating hemoglobin synthesis. This protein also has neuroprotective activity against a variety of potential brain injuries and antiapoptotic functions in several tissue types.