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Browse our IL-4 Proteins (IL4)

Full name:
Interleukin 4 Proteins (IL4)
On are 189 Interleukin 4 (IL4) Proteins from 25 different suppliers available. Additionally we are shipping IL-4 Antibodies (683) and IL-4 Kits (278) and many more products for this protein. A total of 1177 IL-4 products are currently listed.
BCGF-1, BCGF1, BSF-1, BSF1, Il-4, IL2, IL4, Il4e12
list all proteins Gene Name GeneID UniProt
IL4 3565 P05112
IL4 16189 P07750
Rat IL4 IL4 287287 P20096

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IL-4 Proteins (IL4) by Origin

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Top referenced IL-4 Proteins

  1. Mouse (Murine) IL-4 Protein expressed in HEK-293 - ABIN2666589 : Chen, Grabowski, Xin, Coleman, Huang, Espiritu, Alkan, Xie, Zhu, White, Clancy, Huang: IL-4 induces differentiation and expansion of Th2 cytokine-producing eosinophils. in Journal of immunology (Baltimore, Md. : 1950) 2004 (PubMed)
    Show all 9 references for ABIN2666589

  2. Human IL-4 Protein expressed in Escherichia coli (E. coli) - ABIN2666692 : Andrews, Holloway, Holgate, Davies: IL-4 receptor alpha is an important modulator of IL-4 and IL-13 receptor binding: implications for the development of therapeutic targets. in Journal of immunology (Baltimore, Md. : 1950) 2006 (PubMed)
    Show all 7 references for ABIN2666692

  3. Mouse (Murine) IL-4 Protein expressed in CHO - ABIN2018020 : Carr, Aykent, Kimack, Levine: Disulfide assignments in recombinant mouse and human interleukin 4. in Biochemistry 1991 (PubMed)
    Show all 5 references for ABIN2018020

  4. Human IL-4 Protein expressed in CHO - ABIN2018117 : Nguyen, Casale: Immune modulation for treatment of allergic disease. in Immunological reviews 2011 (PubMed)
    Show all 5 references for ABIN2018117

  5. Rat (Rattus) IL-4 Protein expressed in Escherichia coli (E. coli) - ABIN1305130 : McKnight, Barclay, Mason: Molecular cloning of rat interleukin 4 cDNA and analysis of the cytokine repertoire of subsets of CD4+ T cells. in European journal of immunology 1991 (PubMed)
    Show all 4 references for ABIN1305130

  6. Human IL-4 Protein expressed in Escherichia coli (E. coli) - ABIN1305126 : Paul: Interleukin-4: a prototypic immunoregulatory lymphokine. in Blood 1991 (PubMed)
    Show all 2 references for ABIN1305126

  7. Mouse (Murine) IL-4 Protein expressed in Escherichia coli (E. coli) - ABIN1305127 : Noma, Sideras, Naito, Bergstedt-Lindquist, Azuma, Severinson, Tanabe, Kinashi, Matsuda, Yaoita: Cloning of cDNA encoding the murine IgG1 induction factor by a novel strategy using SP6 promoter. in Nature 1986 (PubMed)
    Show all 2 references for ABIN1305127

  8. Human IL-4 Protein expressed in HEK-293 Cells - ABIN2181318 : Finkelman, Shea-Donohue, Morris, Gildea, Strait, Madden, Schopf, Urban: Interleukin-4- and interleukin-13-mediated host protection against intestinal nematode parasites. in Immunological reviews 2004 (PubMed)
    Show all 2 references for ABIN2181318

  9. Human IL-4 Protein expressed in Escherichia coli (E. coli) - ABIN2004839 : Tao, Yang, Jia, Wan, Cheng, Lu: Molecular cloning, recombinant expression and characterization of GMCSF from the rhesus monkey, Macaca mulatta. in Developmental and comparative immunology 2013 (PubMed)

More Proteins for IL-4 Interaction Partners

Human Interleukin 4 (IL4) interaction partners

  1. IL-4 induces demethylation of specific CpG sites within the pendrin (show SLC26A4 Proteins) promoter. These epigenetic alterations are cell type specific, and may in part dictate pendrin (show SLC26A4 Proteins) mRNA transcription

  2. results suggest that certain polymorphisms of IL4 and IL4R (show IL4R Proteins) may affect susceptibility to gastrointestinal cancer [meta-analysis]

  3. the IL-4 -590C/T polymorphism may contribute to atopic dermatitis susceptibility in the overall population and children, especially for Asian children [meta-analysis]

  4. present findings suggest that IL-1b (show IL1B Proteins) T-31C and IL-4 VNTR polymorphisms but not IL-1b (show IL1B Proteins) C-511T polymorphism may contribute in systemic lupus erythematosus (SLE) pathogenesis. In addition, CT and TT genotypes of IL-1b (show IL1B Proteins) C-511T polymorphism were associated with SLE.

  5. this study shows that that IL-12 (show IL12A Proteins) and IL-4 govern group 2 innate lymphoid cells functional identity and that their imbalance results in the perpetuation of type 1 or type 2 inflammation

  6. these data highlight two novel regulatory proteins that could be therapeutically manipulated to limit IL-4-induced IRS-2 (show IRS2 Proteins) signaling and polarization of M2 macrophages in allergic inflammation.

  7. TGFbeta1 (show TGFB1 Proteins) may be key in controlling the glycosylation of IgA1, in part via the downregulation of C1GalT1 (show C1GALT1 Proteins) and Cosmc (show C1GALT1C1 Proteins). TGF-beta1 (show TGFB1 Proteins) mimics the effect of IL-4 on the glycosylation of IgA1 by downregulating C1GalT1 (show C1GALT1 Proteins) and Cosmc (show C1GALT1C1 Proteins).

  8. The IL-4 -33 CT genotype is negatively associated with the occurrence of aggressive periodontitis.

  9. findings provide novel insight into how dysregulated expression of SOCS (show CISH Proteins) increases IL-4 responses in allergic monocytes, and this may represent a new therapeutic avenue for managing allergic disease.

  10. We observed that the TT genotype, compared to the CC genotype, of IL-4 C-590T harbored a lower risk of pre-eclampsia. The CT+TT genotype, compared to the CC genotype, harbored a lower risk of pre-eclampsia in the dominant model. In the recessive model, the TT genotype harbored a lower risk of pre-eclampsia. No significant correlation was observed between the IL-4 C+33T and G-1098T polymorphism.

Mouse (Murine) Interleukin 4 (IL4) interaction partners

  1. this study shows that IL-4-mediated control of the precursor population affects the development of virus-specific CD8 (show CD8A Proteins)+ T-cell memory

  2. IL-4 secretion by group 2 innate lymphoid cells contributes to the allergic response in food allergy by reducing allergen-specific Treg cell and activating mast cell counts

  3. These studies clearly show a crucial role for IL-4 in the induction of airway hyperresponsiveness following Strongyloides venezuelensis infection and for IL-33/ST2 in maintaining airway hyperresponsiveness and lung Th2 responses.

  4. we used recombinant herpes simplex virus vector S4IL4 that encode mouse il4 gene to evaluate the therapeutic potential of IL-4 in naloxone-precipitation morphine withdrawal (MW). One week after microinjection of the vector S4IL4 into the PAG (show PRDX1 Proteins) LacZ (show GLB1 Proteins) or mouse IL-4 immunoreactivity in the vlPAG was visualized. ELISA assay showed that vector S4IL4 into the PAG (show PRDX1 Proteins) induced the expression of IL-4

  5. this study shows that IL-4 is increased in the brain of T cell receptor transgenic mice, which exhibit impaired memory and adult hippocampal neurogenesis

  6. Ellagic acid treatment augmented specific IL-10 (show IL10 Proteins) production in response to S. mansoni antigenic stimulation. However, specific IL-1beta (show IL1B Proteins), IL-4, IL-12 (show IL12A Proteins), IL-13 (show IL13 Proteins), IL-17A (show IL17A Proteins), TNF-alpha (show TNF Proteins) and IFN-gamma (show IFNG Proteins) production were significantly reduced with ex vivo and in vivo ellagic acid treatment.

  7. this study shows that il-4 plays an important role in ESAT-6-induced MCP-1 (show CPT1B Proteins) production by macrophages, and suggest a pathway with significance in tuberculosis pathogenesis

  8. indicate that Siglec-9 (show SIGLEC9 Proteins) affects several different signaling pathways in IL-4-stimulated macrophages, which resulted in enhanced induction of Arg1 (show ARG1 Proteins) in Siglec-9 (show SIGLEC9 Proteins)-expressing RAW264 cells

  9. Oct-1 and Oct-2 bound within the Il4 promoter region and the Th2 LCR

  10. Loss of IL-4 promoted expression of M1 microglia/macrophage markers and impaired expression of M2 markers after transient or permanent middle cerebral artery occlusion.

Cow (Bovine) Interleukin 4 (IL4) interaction partners

  1. These results support pregnancy as type 2 immune response biased, with increases of IFN-gamma (show IFNG Proteins) occurring after parturition and an increase in IL-4 production before calving.

  2. IL-4 may play a role in coordinating the adrenal response to inflammatory stress.

  3. T helper (Th) type 2 cell cytokine IL-4 modulates airway contraction by secreting matrix metalloproteinase-1 (show MMP1 Proteins) from the smooth muscle cells via phosphatidylinositol 3-kinase activation and changing cell-to-matrix interactions.

Pig (Porcine) Interleukin 4 (IL4) interaction partners

  1. IL-4- and IL-10 (show IL10 Proteins)-producing invariant NKT (show SLC22A6 Proteins) cells inhibit the Th1 (show TH1L Proteins) cell response, but not the Th17 cell response

  2. IL-4 induced activation of Akt/SREBP-1/lipid biosynthesis in EC, resulting in protection against membrane attack complex and melittin, in association with mitochondrial protection.

  3. There was no significant difference of IL-4 production between fresh and frozen peripheral blood mononuclear cells.

  4. The endothelium and subendothelium of porcine iliac arteries that are transduced with recombinant pig IL-4 are effectively protected from complement-dependent immediate injury after perfusion with human blood.

  5. unlike in humans and mice, porcine IL-4 blocks antibody and IL-6 (show IL6 Proteins) secretion and suppresses antigen-stimulated proliferation of B cells

Guinea Pig Interleukin 4 (IL4) interaction partners

  1. Data indicate that animals exposed to high lead concentration, the levels of IFNgamma and IFNgamma/IL-4 ratio were significantly lower than those exposed to its low concentration.

  2. IL-4 and STAT6 (show STAT6 Proteins) are related to the pathogenesis of allergic rhinitis and may be the main factors for eosinophil infiltration in allergic rhinitis.

Horse (Equine) Interleukin 4 (IL4) interaction partners

  1. The data suggested in foals there is an impaired Th2 response, the immune response is Th1 (show TH1L Proteins) biased, interferon-gamma (show IFNG Proteins) production is qualitatively similar to adult horses, and regulatory IL-10 (show IL10 Proteins) production by T cells is mature.

  2. This study showed that pronounced lung eosinophilia in horses can be transient, abate without specific treatment, and in this instance, lack correlation to upregulation of expression of either IL-4 or IL-5 (show IL5 Proteins).

Rhesus Monkey Interleukin 4 (IL4) interaction partners

  1. Low Sociable animals showed alterations in lymph node expression of the immunoregulatory cytokine genes IL4.

  2. Mycobacterial infections of macaques induce mRNA encoding a variant IL-4 that functions as a growth factor to promote expansion of 4-hydroxy-3-methyl-but-2-enyl pyrophosphate-specific Vgamma2Vdelta2 T effector cells.

IL-4 (IL4) Protein Profile

Protein Summary

The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. This gene, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Alternative names and synonyms associated with IL-4 (IL4)

  • interleukin 4 (IL4)
  • interleukin 4 (Il4)
  • interleukin 4 (Il-4)
  • BCGF-1 protein
  • BCGF1 protein
  • BSF-1 protein
  • BSF1 protein
  • Il-4 protein
  • IL2 protein
  • IL4 protein
  • Il4e12 protein

Protein level used designations for Interleukin 4 Proteins (IL4)

interleukin 4 , B cell growth factor 1 , B_cell stimulatory factor 1 , binetrakin , interleukin-4 , lymphocyte stimulatory factor 1 , pitrakinra , B-cell IgG differentiation factor , B-cell growth factor 1 , B-cell stimulatory factor 1 , IGG1 induction factor , B-cell IGG differentiation factor , BSF-1 , IL-4 , Lymphocyte stimulatory factor 1

100126747 Papio anubis
3565 Homo sapiens
16189 Mus musculus
287287 Rattus norvegicus
280824 Bos taurus
397225 Sus scrofa
403785 Canis lupus familiaris
100860814 Capra hircus
443327 Ovis aries
416330 Gallus gallus
101801081 Anas platyrhynchos
100720403 Cavia porcellus
100302454 Oryctolagus cuniculus
100034225 Equus caballus
751514 Felis catus
574281 Macaca mulatta
100482473 Ailuropoda melanoleuca
101843742 Mesocricetus auratus
449565 Pan troglodytes
101338293 Tursiops truncatus
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