Browse our IL-4 Proteins (IL4)

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Interleukin 4 Proteins (IL4)
On are 191 Interleukin 4 (IL4) Proteins from 26 different suppliers available. Additionally we are shipping IL-4 Antibodies (693) and IL-4 Kits (270) and many more products for this protein. A total of 1181 IL-4 products are currently listed.
BCGF-1, BCGF1, BSF-1, BSF1, Il-4, IL2, IL4, Il4e12
list all proteins Gene Name GeneID UniProt
IL4 3565 P05112
IL4 16189 P07750
Rat IL4 IL4 287287 P20096

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IL-4 Proteins (IL4) by Origin

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Top referenced IL-4 Proteins

  1. Mouse (Murine) IL-4 Protein expressed in HEK-293 - ABIN2666589 : Chen, Grabowski, Xin, Coleman, Huang, Espiritu, Alkan, Xie, Zhu, White, Clancy, Huang: IL-4 induces differentiation and expansion of Th2 cytokine-producing eosinophils. in Journal of immunology (Baltimore, Md. : 1950) 2004 (PubMed)
    Show all 9 references for 2666589

  2. Human IL-4 Protein expressed in Escherichia coli (E. coli) - ABIN2666692 : Andrews, Holloway, Holgate, Davies: IL-4 receptor alpha is an important modulator of IL-4 and IL-13 receptor binding: implications for the development of therapeutic targets. in Journal of immunology (Baltimore, Md. : 1950) 2006 (PubMed)
    Show all 7 references for 2666692

  3. Mouse (Murine) IL-4 Protein expressed in CHO - ABIN2018020 : Carr, Aykent, Kimack, Levine: Disulfide assignments in recombinant mouse and human interleukin 4. in Biochemistry 1991 (PubMed)
    Show all 5 references for 2018020

  4. Human IL-4 Protein expressed in CHO - ABIN2018117 : Nguyen, Casale: Immune modulation for treatment of allergic disease. in Immunological reviews 2011 (PubMed)
    Show all 5 references for 2018117

  5. Rat (Rattus) IL-4 Protein expressed in Escherichia coli (E. coli) - ABIN1305130 : McKnight, Barclay, Mason: Molecular cloning of rat interleukin 4 cDNA and analysis of the cytokine repertoire of subsets of CD4+ T cells. in European journal of immunology 1991 (PubMed)
    Show all 4 references for 1305130

  6. Human IL-4 Protein expressed in Escherichia coli (E. coli) - ABIN1305126 : Paul: Interleukin-4: a prototypic immunoregulatory lymphokine. in Blood 1991 (PubMed)
    Show all 2 references for 1305126

  7. Mouse (Murine) IL-4 Protein expressed in Escherichia coli (E. coli) - ABIN1305127 : Noma, Sideras, Naito, Bergstedt-Lindquist, Azuma, Severinson, Tanabe, Kinashi, Matsuda, Yaoita: Cloning of cDNA encoding the murine IgG1 induction factor by a novel strategy using SP6 promoter. in Nature 1986 (PubMed)
    Show all 2 references for 1305127

  8. Human IL-4 Protein expressed in HEK-293 Cells - ABIN2181318 : Finkelman, Shea-Donohue, Morris, Gildea, Strait, Madden, Schopf, Urban: Interleukin-4- and interleukin-13-mediated host protection against intestinal nematode parasites. in Immunological reviews 2004 (PubMed)
    Show all 2 references for 2181318

  9. Human IL-4 Protein expressed in Escherichia coli (E. coli) - ABIN2004839 : Tao, Yang, Jia, Wan, Cheng, Lu: Molecular cloning, recombinant expression and characterization of GMCSF from the rhesus monkey, Macaca mulatta. in Developmental and comparative immunology 2013 (PubMed)

More Proteins for IL-4 Interaction Partners

Human Interleukin 4 (IL4) interaction partners

  1. These data identified the IL-4/CXCL12 (show CXCL12 Proteins) loop as a previously unrecognized pathway involved in lymphoid stroma polarization and as a potential therapeutic target in Follicular lymphoma patients.

  2. IL-4 genetic variations associated with susceptibility to or protection against chronic periodontitis are directly associated with influencing the response of immune cells to periodontopathogens

  3. in HIV/AIDS patients under antiretroviral therapy, IL-4 and IL-10 (show IL10 Proteins) levels were significantly lower in lipodystrophy vs. non-lipodystrophy

  4. autologous CD4 (show CD4 Proteins)(+) T cells that are exposed to EVs from CD40 (show CD40 Proteins)/IL-4-stimulated CLL cells exhibit enhanced migration, immunological synapse signaling, and interactions with tumor cells.

  5. IL-4 substantially restores CD79b (show CD79B Proteins) protein expression, sIgM expression, and BCR (show BCR Proteins) signaling.

  6. Tandem repeat polymorphisms of IL4 is associated with the severity of chronic periodontitis.

  7. Keratinocyte gene expression is critically shaped by IL-4, altering cell fate decisions, which are likely important for the clinical manifestations and pathology of allergic skin disease

  8. Inhibition of protein kinase C zeta (show PRKCZ Proteins) expression in prostate cancer cells promoted chemotaxis of peripheral macrophages and acquisition of M2 phenotypic features. These results were further supported by the finding that silencing of endogenous protein kinase C zeta (show PRKCZ Proteins) promoted the expression of prostate cancer cell-derived interleukin-4 and interleukin-10 (show IL10 Proteins)

  9. IL-12 pretreatment increased TCR-induced IFN-gamma, TNF-alpha, IL-13, IL-4 and IL-10 production. This suggests that prior exposure to IL-12 potentiates the TCR-induced release of a range of cytokines

  10. Studies in colonic T84 cell monolayers revealed that barrier disruption by the colitis-associated Th2-type cytokines, IL-4 and IL-13 (show IL13 Proteins), down-regulates matriptase (show ST14 Proteins) as well as prostasin (show PRSS8 Proteins) through phosphorylation of the transcriptional regulator STAT6 (show STAT6 Proteins)

Mouse (Murine) Interleukin 4 (IL4) interaction partners

  1. priming of T helper cells by IL-6 (show IL6 Proteins)-deficient antigen-presenting dendritic cells preferentially leads to accumulation of a subset of Follicular helper T cells characterized by high expression of GATA3 (show GATA3 Proteins) and IL-4.

  2. eosinophils drive progression of myocarditis to Inflammatory dilated cardiomyopathy (DCMi), cause severe DCMi when present in large numbers, and mediate this process through IL-4.

  3. These data suggest that although IL-4-stimulated alternatively activated macrophages upregulate fatty acid oxidation, fatty acid oxidation is dispensable for macrophage polarization and high-fat diet-induced metabolic dysfunction. Macrophage fatty acid oxidation likely plays a correlative, rather than causative, role in systemic metabolic dysfunction.

  4. Excessive IL-4 levels in the mesenteric lymph nodes (MLNs) directly inhibited the induction of aiTregs and caused enteropathy. The aiTregs generated in the attenuation of T cell-dependent food allergic enteropathy may function differently than aiTregs induced in a tolerance model.

  5. this study shows that IL-4 and IL-10 (show IL10 Proteins) are important for the altered peptide ligand-induced attenuation of experimental arthritis

  6. this study shows that wild-type mice develop an eosinophilic Th2 airway disease in response to Alternaria alternata exposure, whereas IL-4-deficient mice exhibit a primarily neutrophilic response

  7. Study showed that the intraperitoneal administration of the exogenous cytokines IFN-gamma (show IFNG Proteins) (to promote M1 microglia ) and IL-4 (to promote M2 microglia) can correctly modulate the timing of the M1 to M2 ratio to affect epileptogenesis and to improve cognitive function in pilocarpine-induced status epilepticus.

  8. These findings indicate that IL-4, a canonical Th2 cell cytokine, can sometimes promote rather than impair Th1 (show HAND1 Proteins) cell-type immune responses

  9. Keratinocyte gene expression is critically shaped by IL-4, altering cell fate decisions, which are likely important for the clinical manifestations and pathology of allergic skin disease

  10. Data show that lactic acid in tumor microenvironments inhibited interferon-gamma (show IFNG Proteins) (IFNgamma) and intert=leukin-4 (IL4) productions from NKT (show CTSL1 Proteins) cells by inhibiting mammalian target of rapamycin (mTOR (show FRAP1 Proteins)) signaling.

Cow (Bovine) Interleukin 4 (IL4) interaction partners

  1. These results support pregnancy as type 2 immune response biased, with increases of IFN-gamma (show IFNG Proteins) occurring after parturition and an increase in IL-4 production before calving.

  2. IL-4 may play a role in coordinating the adrenal response to inflammatory stress.

  3. T helper (Th) type 2 cell cytokine IL-4 modulates airway contraction by secreting matrix metalloproteinase-1 (show MMP1 Proteins) from the smooth muscle cells via phosphatidylinositol 3-kinase activation and changing cell-to-matrix interactions.

Pig (Porcine) Interleukin 4 (IL4) interaction partners

  1. IL-4- and IL-10 (show IL10 Proteins)-producing invariant NKT (show SLC22A6 Proteins) cells inhibit the Th1 (show TH1L Proteins) cell response, but not the Th17 cell response

  2. IL-4 induced activation of Akt/SREBP-1/lipid biosynthesis in EC, resulting in protection against membrane attack complex and melittin, in association with mitochondrial protection.

  3. There was no significant difference of IL-4 production between fresh and frozen peripheral blood mononuclear cells.

  4. The endothelium and subendothelium of porcine iliac arteries that are transduced with recombinant pig IL-4 are effectively protected from complement-dependent immediate injury after perfusion with human blood.

  5. unlike in humans and mice, porcine IL-4 blocks antibody and IL-6 (show IL6 Proteins) secretion and suppresses antigen-stimulated proliferation of B cells

Guinea Pig Interleukin 4 (IL4) interaction partners

  1. Data indicate that animals exposed to high lead concentration, the levels of IFNgamma and IFNgamma/IL-4 ratio were significantly lower than those exposed to its low concentration.

  2. IL-4 and STAT6 (show STAT6 Proteins) are related to the pathogenesis of allergic rhinitis and may be the main factors for eosinophil infiltration in allergic rhinitis.

Horse (Equine) Interleukin 4 (IL4) interaction partners

  1. The data suggested in foals there is an impaired Th2 response, the immune response is Th1 (show TH1L Proteins) biased, interferon-gamma (show IFNG Proteins) production is qualitatively similar to adult horses, and regulatory IL-10 (show IL10 Proteins) production by T cells is mature.

  2. This study showed that pronounced lung eosinophilia in horses can be transient, abate without specific treatment, and in this instance, lack correlation to upregulation of expression of either IL-4 or IL-5 (show IL5 Proteins).

Rhesus Monkey Interleukin 4 (IL4) interaction partners

  1. Low Sociable animals showed alterations in lymph node expression of the immunoregulatory cytokine genes IL4.

  2. Mycobacterial infections of macaques induce mRNA encoding a variant IL-4 that functions as a growth factor to promote expansion of 4-hydroxy-3-methyl-but-2-enyl pyrophosphate-specific Vgamma2Vdelta2 T effector cells.

IL-4 (IL4) Protein Profile

Protein Summary

The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. This gene, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Alternative names and synonyms associated with IL-4 (IL4)

  • interleukin 4 (IL4)
  • interleukin 4 (Il4)
  • interleukin 4 (Il-4)
  • BCGF-1 protein
  • BCGF1 protein
  • BSF-1 protein
  • BSF1 protein
  • Il-4 protein
  • IL2 protein
  • IL4 protein
  • Il4e12 protein

Protein level used designations for Interleukin 4 Proteins (IL4)

interleukin 4 , B cell growth factor 1 , B_cell stimulatory factor 1 , binetrakin , interleukin-4 , lymphocyte stimulatory factor 1 , pitrakinra , B-cell IgG differentiation factor , B-cell growth factor 1 , B-cell stimulatory factor 1 , IGG1 induction factor , B-cell IGG differentiation factor , BSF-1 , IL-4 , Lymphocyte stimulatory factor 1

100126747 Papio anubis
3565 Homo sapiens
16189 Mus musculus
287287 Rattus norvegicus
280824 Bos taurus
397225 Sus scrofa
403785 Canis lupus familiaris
100860814 Capra hircus
443327 Ovis aries
416330 Gallus gallus
101801081 Anas platyrhynchos
100720403 Cavia porcellus
100302454 Oryctolagus cuniculus
100034225 Equus caballus
751514 Felis catus
574281 Macaca mulatta
100482473 Ailuropoda melanoleuca
101843742 Mesocricetus auratus
449565 Pan troglodytes
101338293 Tursiops truncatus
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