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Browse our IL-4 Proteins (IL4)

Full name:
Interleukin 4 Proteins (IL4)
On are 190 Interleukin 4 (IL4) Proteins from 25 different suppliers available. Additionally we are shipping IL-4 Antibodies (742) and IL-4 Kits (251) and many more products for this protein. A total of 1210 IL-4 products are currently listed.
BCGF-1, BCGF1, BSF-1, BSF1, Il-4, IL2, IL4, Il4e12
list all proteins Gene Name GeneID UniProt
IL4 3565 P05112
IL4 16189 P07750
Rat IL4 IL4 287287 P20096

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IL-4 Proteins (IL4) by Origin

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Top referenced IL-4 Proteins

  1. Mouse (Murine) IL-4 Protein expressed in HEK-293 - ABIN2666589 : Chen, Grabowski, Xin, Coleman, Huang, Espiritu, Alkan, Xie, Zhu, White, Clancy, Huang: IL-4 induces differentiation and expansion of Th2 cytokine-producing eosinophils. in Journal of immunology (Baltimore, Md. : 1950) 2004 (PubMed)
    Show all 9 references for ABIN2666589

  2. Human IL-4 Protein expressed in Escherichia coli (E. coli) - ABIN2666692 : Andrews, Holloway, Holgate, Davies: IL-4 receptor alpha is an important modulator of IL-4 and IL-13 receptor binding: implications for the development of therapeutic targets. in Journal of immunology (Baltimore, Md. : 1950) 2006 (PubMed)
    Show all 7 references for ABIN2666692

  3. Human IL-4 Protein expressed in HEK-293 Cells - ABIN2181318 : Finkelman, Shea-Donohue, Morris, Gildea, Strait, Madden, Schopf, Urban: Interleukin-4- and interleukin-13-mediated host protection against intestinal nematode parasites. in Immunological reviews 2004 (PubMed)
    Show all 2 references for ABIN2181318

  4. Mouse (Murine) IL-4 Protein expressed in Escherichia coli (E. coli) - ABIN1305127 : Noma, Sideras, Naito, Bergstedt-Lindquist, Azuma, Severinson, Tanabe, Kinashi, Matsuda, Yaoita: Cloning of cDNA encoding the murine IgG1 induction factor by a novel strategy using SP6 promoter. in Nature 1986 (PubMed)
    Show all 2 references for ABIN1305127

  5. Human IL-4 Protein expressed in Escherichia coli (E. coli) - ABIN1305126 : Paul: Interleukin-4: a prototypic immunoregulatory lymphokine. in Blood 1991 (PubMed)
    Show all 2 references for ABIN1305126

  6. Human IL-4 Protein expressed in Escherichia coli (E. coli) - ABIN2004839 : Tao, Yang, Jia, Wan, Cheng, Lu: Molecular cloning, recombinant expression and characterization of GMCSF from the rhesus monkey, Macaca mulatta. in Developmental and comparative immunology 2013 (PubMed)

More Proteins for IL-4 Interaction Partners

Human Interleukin 4 (IL4) interaction partners

  1. A constitutively activated form of STAT6 (show STAT6 Proteins) is able to bypass IL-4 upstream signalling and instruct dendritic-cell-specific functional DNA methylation (show HELLS Proteins) changes

  2. interleukin-4 regulates hematopoietic lineage choice by activating the JAK3 (show JAK3 Proteins)-STAT6 (show STAT6 Proteins) pathway, which causes dendritic-cell-specific DNA demethylation

  3. The C allele of the +33 (C/T) polymorphism in the IL4 gene was associated with susceptibility to dental implant loss in Brazilians in the studied population.

  4. Studies indicate that cytokine interleukin-4 has an important role in pemphigus disease.

  5. Analysis of peripheral leucocytes, eosinophils, immunoglobulin E, and IL-4 and IL-10 (show IL10 Proteins) concentrations presented significantly higher values in children with radiologically confirmed liver granuloma than in uncomplicated hepatomegaly.

  6. Patients with occupational allergic dermatoses showed significantly higher frequency of polymorphic variants of cytokine genes IL4 C589T, IL10 (show IL10 Proteins) C819T, IL10 (show IL10 Proteins) G1082A, IL10 (show IL10 Proteins) C592A, and TNF (show TNF Proteins) G308A in comparison with the population control.

  7. However, no significant association was observed between the DDX39B (show DDX39 Proteins) -22 G/C polymorphism in the cases and controls. Furthermore, it is clarified that the protective effect of IL-4 -590 is independent from APOE (show APOE Proteins) protective genotypes

  8. There was an association of IL4 rs2227284 polymorphism with reduced asthma risk. IL-4 serum expression levels were significantly higher in M. pneumonia positive subjects.

  9. RGC-32 (show C13orf15 Proteins) expression on M2-polarized and tumor-associated macrophages is M-CSF (show CSF1 Proteins)-dependent and enhanced by tumor-derived IL-4.

  10. The IL-4 rs79071878 polymorphism, was associated whereas the IL-1Ra (show IL1RN Proteins) rs2234663 polymorphism was not associated with Familial Mediterranean Fever (show MEFV Proteins) risk in the Turkish population.

Mouse (Murine) Interleukin 4 (IL4) interaction partners

  1. indicate that Siglec-9 (show SIGLEC9 Proteins) affects several different signaling pathways in IL-4-stimulated macrophages, which resulted in enhanced induction of Arg1 (show ARG1 Proteins) in Siglec-9 (show SIGLEC9 Proteins)-expressing RAW264 cells

  2. Oct-1 and Oct-2 bound within the Il4 promoter region and the Th2 LCR

  3. Loss of IL-4 promoted expression of M1 microglia/macrophage markers and impaired expression of M2 markers after transient or permanent middle cerebral artery occlusion.

  4. review of IL-4 and IL-13 (show IL13 Proteins) mast cell immunity and detail of the differences that exist between mouse and human mast cell responses to IL-4 and IL-13 (show IL13 Proteins) [review]

  5. Data (including data from studies in knockout/transgenic mice) suggest T cell-derived IL4/IL13 are required for immunologic memory and IgE response to helminth Nippostrongylus brasiliensis but are not required for expansion/proliferation of B cells.

  6. Curcumin up-regulates mRNA and protein levels of IL-4 and IL-13 (show IL13 Proteins)

  7. These results indicate a positive role of Batf in promoting the generation of pro-allergic IL-4-producing T-follicular helper cells.

  8. IL-4 induces miR (show MLXIP Proteins)-142-5p and downregulates miR (show MLXIP Proteins)-130a-3p in macrophages, regulating macrophage profibrogenic gene expression in chronic inflammation.

  9. these findings underscore the important collaboration between IL-4 and IL-21 (show IL21 Proteins) in shaping T-dependent B cells antibody responses.

  10. IL-4 KO mice display state, but not trait, anxiety suggesting that reductions in endogenous anti-inflammatory bioactives can engender subtypes of anxiety

Cow (Bovine) Interleukin 4 (IL4) interaction partners

  1. These results support pregnancy as type 2 immune response biased, with increases of IFN-gamma (show IFNG Proteins) occurring after parturition and an increase in IL-4 production before calving.

  2. IL-4 may play a role in coordinating the adrenal response to inflammatory stress.

  3. T helper (Th) type 2 cell cytokine IL-4 modulates airway contraction by secreting matrix metalloproteinase-1 (show MMP1 Proteins) from the smooth muscle cells via phosphatidylinositol 3-kinase activation and changing cell-to-matrix interactions.

Pig (Porcine) Interleukin 4 (IL4) interaction partners

  1. IL-4- and IL-10 (show IL10 Proteins)-producing invariant NKT (show SLC22A6 Proteins) cells inhibit the Th1 (show TH1L Proteins) cell response, but not the Th17 cell response

  2. IL-4 induced activation of Akt/SREBP-1/lipid biosynthesis in EC, resulting in protection against membrane attack complex and melittin, in association with mitochondrial protection.

  3. There was no significant difference of IL-4 production between fresh and frozen peripheral blood mononuclear cells.

  4. The endothelium and subendothelium of porcine iliac arteries that are transduced with recombinant pig IL-4 are effectively protected from complement-dependent immediate injury after perfusion with human blood.

  5. unlike in humans and mice, porcine IL-4 blocks antibody and IL-6 (show IL6 Proteins) secretion and suppresses antigen-stimulated proliferation of B cells

Guinea Pig Interleukin 4 (IL4) interaction partners

  1. Data indicate that animals exposed to high lead concentration, the levels of IFNgamma and IFNgamma/IL-4 ratio were significantly lower than those exposed to its low concentration.

  2. IL-4 and STAT6 (show STAT6 Proteins) are related to the pathogenesis of allergic rhinitis and may be the main factors for eosinophil infiltration in allergic rhinitis.

Horse (Equine) Interleukin 4 (IL4) interaction partners

  1. The data suggested in foals there is an impaired Th2 response, the immune response is Th1 (show TH1L Proteins) biased, interferon-gamma (show IFNG Proteins) production is qualitatively similar to adult horses, and regulatory IL-10 (show IL10 Proteins) production by T cells is mature.

  2. This study showed that pronounced lung eosinophilia in horses can be transient, abate without specific treatment, and in this instance, lack correlation to upregulation of expression of either IL-4 or IL-5 (show IL5 Proteins).

Rhesus Monkey Interleukin 4 (IL4) interaction partners

  1. Low Sociable animals showed alterations in lymph node expression of the immunoregulatory cytokine genes IL4.

  2. Mycobacterial infections of macaques induce mRNA encoding a variant IL-4 that functions as a growth factor to promote expansion of 4-hydroxy-3-methyl-but-2-enyl pyrophosphate-specific Vgamma2Vdelta2 T effector cells.

IL-4 (IL4) Protein Profile

Protein Summary

The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. This gene, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Alternative names and synonyms associated with IL-4 (IL4)

  • interleukin 4 (IL4)
  • interleukin 4 (Il4)
  • interleukin 4 (Il-4)
  • BCGF-1 protein
  • BCGF1 protein
  • BSF-1 protein
  • BSF1 protein
  • Il-4 protein
  • IL2 protein
  • IL4 protein
  • Il4e12 protein

Protein level used designations for Interleukin 4 Proteins (IL4)

interleukin 4 , B cell growth factor 1 , B_cell stimulatory factor 1 , binetrakin , interleukin-4 , lymphocyte stimulatory factor 1 , pitrakinra , B-cell IgG differentiation factor , B-cell growth factor 1 , B-cell stimulatory factor 1 , IGG1 induction factor , B-cell IGG differentiation factor , BSF-1 , IL-4 , Lymphocyte stimulatory factor 1

100126747 Papio anubis
3565 Homo sapiens
16189 Mus musculus
287287 Rattus norvegicus
280824 Bos taurus
397225 Sus scrofa
403785 Canis lupus familiaris
100860814 Capra hircus
443327 Ovis aries
416330 Gallus gallus
101801081 Anas platyrhynchos
100720403 Cavia porcellus
100302454 Oryctolagus cuniculus
100034225 Equus caballus
751514 Felis catus
574281 Macaca mulatta
100482473 Ailuropoda melanoleuca
101843742 Mesocricetus auratus
449565 Pan troglodytes
101338293 Tursiops truncatus
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