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Browse our IL12 Proteins (IL12)

Full name:
Interleukin 12 Proteins (IL12)
On www.antibodies-online.com are 68 Interleukin 12 (IL12) Proteins from 14 different suppliers available. Additionally we are shipping IL12 Antibodies (243) and IL12 Kits (163) and many more products for this protein. A total of 492 IL12 products are currently listed.
Synonyms:
CLMF, CLMF2, IL-12 p40, Il-12a, IL-12B, IL-12p35, IL-12p40, Il12, IL12B, il12p40.b, Ll12a, LOC100217488, NKSF, NKSF2, p35, zgc:152789
list all proteins Gene Name GeneID UniProt
IL12 16159 P43431
IL12 64546  
IL12 3593 P29460

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IL12 Proteins (IL12) by Origin

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Top referenced IL12 Proteins

  1. Human IL12 Protein expressed in Insect Cells - ABIN2666684 : Ireland, Palian, Reiss: Interleukin (IL)-12 receptor beta1 or IL-12 receptor beta 2 deficiency in mice indicates that IL-12 and IL-23 are not essential for host recovery from viral encephalitis. in Viral immunology 2005 (PubMed)
    Show all 7 references for ABIN2666684

  2. Mouse (Murine) IL12 Protein expressed in Sf-9 cells - ABIN2666686 : Moreno, Alves-Filho, Alfaya, da Silva, Ferreira, Liew: IL-12, but not IL-18, is critical to neutrophil activation and resistance to polymicrobial sepsis induced by cecal ligation and puncture. in Journal of immunology (Baltimore, Md. : 1950) 2006 (PubMed)
    Show all 6 references for ABIN2666686

  3. Human IL12 Protein expressed in Escherichia coli (E. coli) - ABIN1305065 : DAndrea, Aste-Amezaga, Valiante, Ma, Kubin, Trinchieri: Interleukin 10 (IL-10) inhibits human lymphocyte interferon gamma-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells. in The Journal of experimental medicine 1993 (PubMed)
    Show all 3 references for ABIN1305065

  4. Mouse (Murine) IL12 Protein expressed in Escherichia coli (E. coli) - ABIN1305066 : Schoenhaut, Chua, Wolitzky, Quinn, Dwyer, McComas, Familletti, Gately, Gubler: Cloning and expression of murine IL-12. in Journal of immunology (Baltimore, Md. : 1950) 1992 (PubMed)

More Proteins for IL12 Interaction Partners

Mouse (Murine) Interleukin 12 (IL12) interaction partners

  1. Data suggest that interleukin-35 (Epstein-Barr virus-induced gene 3 (EBI3) and the interleukin-12 Subunit p35 (p35) subunit) contributes to the increased susceptibility to secondary pneumococcal pneumonia.

  2. Deficiency of IL-12p35 limited AMI (show CFD Proteins)-induced cardiac injury by promoting pro-angiogenesis and anti-inflammatory functions of monocytes

  3. IL-12 (show IL12A Proteins) immunomodulation delays the onset of lethal peritoneal disease of ovarian cancer.

  4. There is a common program of effector T cell differentiation that is regulated by IL-2 and IL-12 signaling and the combined activities of the transcriptional regulators Blimp-1 and T-bet.

  5. Irradiation-induced IL-6 (show IL6 Proteins) can decrease IL-12 (show IL12A Proteins) production through the inhibition of C-Rel (show NFkBP65 Proteins) phosphorylation by the IL-6 (show IL6 Proteins)/STAT3 (show STAT3 Proteins) signaling pathway.

  6. The IL-12 (show IL12A Proteins) response by dendritic cells against S. aureus is highly growth phase dependent.

  7. These results provide a new pathway of Th1 (show HAND1 Proteins) response regulation where IL-12 (show IL12A Proteins) secreted by dendritic cellss is consumed by a sub-population of IL-12Rbeta2-expressing Treg cells.

  8. IL-12p35 has a protective role against pulmonary infection with methicillin-resistant Staphylococcus aureus.

  9. TBI (show TBPL1 Proteins)-induced IL12 (show IL12A Proteins) augments Tc17 cell-mediated tumor immunity and underline the substantial implications of in vitro preparation of antitumor Tc17 cells with IL12 (show IL12A Proteins) in the design of T-cell immunotherapies

  10. Interleukin-12-producing CD103 (show ITGAE Proteins)+ CD11b (show ITGAM Proteins)- CD8 (show CD8A Proteins)+ dendritic cells are responsible for eliciting gut (show GUSB Proteins) intraepithelial lymphocyte response against Encephalitozoon cuniculi.

Human Interleukin 12 (IL12) interaction partners

  1. Il-12B (show IL12B Proteins) SNPs have an association with anti-HBs Ab production after vaccination in healthy Korean infants.

  2. Our results reveal that the IL12A rs568408 variant may be a marker SNP for risk of both HBV clearance and HBV-related hepatocellular carcinoma development

  3. this study shows that the Il-12 (show IL12A Proteins) genetic polymorphisms is associated with susceptibility to tuberculosis in patients and their household contacts in India

  4. High IL12 (show IL12A Proteins) levels can inhibit Candida albicans colonizing the gastrointestinal tract of children and adolescents with diabetes mellitus type 1.

  5. this study shows that IL-12B (show IL12B Proteins) gene polymorphism is genetic risk factor for systemic lupus erythematosus in the Polish population, and that it predicts disease phenotype

  6. analysis of cytokine gene polymorphisms suggests that IL-12 (show IL12A Proteins) gene may play impact on specific pathogenesis of ophthalmopathy in Korean children with early onset autoimmune thyroid disease.

  7. TLR3 (show TLR3 Proteins) is required to induce full IL-12p70 secretion.

  8. Data indicate that interferon-gamma (IFN-gamma (show IFNG Proteins)) and interleukin-12 (IL-12 (show IL12A Proteins)) cytokine production markedly decreased and that of interleukin-10 (IL-10 (show IL10 Proteins)) increased after Mycobacterium tuberculosis antigen Ag85A stimulation.

  9. IL-12 polymorphism rs3212227 might not be a critical risk factor for Preeclampsia in Chinese Han women.

  10. The IL23R (show IL23R Proteins) polymorphisms rs10889677, rs7517847, and the IL12B (show IL12B Proteins) polymorphism rs3212227 are not associated with multiple sclerosis risk.

Pig (Porcine) Interleukin 12 (IL12) interaction partners

  1. Data show that cysteine significantly reduced the expression of pro-inflammatory cytokines, including TNF-alpha (show TNF Proteins), IL-6 (show IL6 Proteins), IL-12p40, IL-1beta (show IL1B Proteins), and resulted in increased expression of the apoptosis initiator caspase-8 (show CASP8 Proteins) and bcl2L1 (show BCL2L1 Proteins).

IL12 Protein Profile

Protein Summary

This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children.

Alternative names and synonyms associated with IL12

  • interleukin 12Ba (il12ba)
  • interleukin 12B (LOC100217488)
  • interleukin 12 p40 subunit (IL-12)
  • interleukin 12a (Il12a)
  • interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35) (IL12A)
  • interleukin 12B (Il12b)
  • interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) (IL12B)
  • CLMF protein
  • CLMF2 protein
  • IL-12 p40 protein
  • Il-12a protein
  • IL-12B protein
  • IL-12p35 protein
  • IL-12p40 protein
  • Il12 protein
  • IL12B protein
  • il12p40.b protein
  • Ll12a protein
  • LOC100217488 protein
  • NKSF protein
  • NKSF2 protein
  • p35 protein
  • zgc:152789 protein

Protein level used designations for Interleukin 12 Proteins (IL12)

il-12p40.a , interleukin 12 p40.b , interleukin 12B , interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) , interleukin 12Ba (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) , interleukin-12 p40 subunit , CLMF p40 , Cytotoxic lymphocyte maturation factor 40 kDa subunit , IL-12 subunit p40 , Interleukin-12 subunit beta , CLMF p35 , IL-12 subunit p35 , cytotoxic lymphocyte maturation factor 35 kDa subunit , interleukin 12a p35 subunit , interleukin-12 subunit alpha , IL-12A , interleukin 12 , interleukin-12 p40 , interleukin-12 subunit beta , IL12, subunit p40 , NK cell stimulatory factor chain 2 , cytotoxic lymphocyte maturation factor 40 kDa subunit , interleukin 12, p40 , interleukin-12 beta chain , natural killer cell stimulatory factor, 40 kD subunit , IL-12B , IL-12 p40 subunit , interleukin-12p40

GENE ID SPECIES
445373 Danio rerio
100217488 Taeniopygia guttata
100860845 Capra hircus
16159 Mus musculus
493741 Felis catus
64546 Rattus norvegicus
3593 Homo sapiens
397076 Sus scrofa
403976 Canis lupus familiaris
404671 Gallus gallus
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