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Browse our IL12 Proteins (IL12)

Full name:
Interleukin 12 Proteins (IL12)
On are 70 Interleukin 12 (IL12) Proteins from 15 different suppliers available. Additionally we are shipping IL12 Antibodies (244) and IL12 Kits (165) and many more products for this protein. A total of 497 IL12 products are currently listed.
CLMF, CLMF2, IL-12 p40, Il-12a, IL-12B, IL-12p35, IL-12p40, Il12, IL12B, il12p40.b, Ll12a, LOC100217488, NKSF, NKSF2, p35, zgc:152789
list all proteins Gene Name GeneID UniProt
IL12 16159 P43431
IL12 64546  
IL12 3593 P29460

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IL12 Proteins (IL12) by Origin

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Top referenced IL12 Proteins

  1. Human IL12 Protein expressed in Insect Cells - ABIN2666684 : Ireland, Palian, Reiss: Interleukin (IL)-12 receptor beta1 or IL-12 receptor beta 2 deficiency in mice indicates that IL-12 and IL-23 are not essential for host recovery from viral encephalitis. in Viral immunology 2005 (PubMed)
    Show all 7 references for ABIN2666684

  2. Mouse (Murine) IL12 Protein expressed in Sf-9 cells - ABIN2666686 : Moreno, Alves-Filho, Alfaya, da Silva, Ferreira, Liew: IL-12, but not IL-18, is critical to neutrophil activation and resistance to polymicrobial sepsis induced by cecal ligation and puncture. in Journal of immunology (Baltimore, Md. : 1950) 2006 (PubMed)
    Show all 6 references for ABIN2666686

  3. Human IL12 Protein expressed in Escherichia coli (E. coli) - ABIN1305065 : DAndrea, Aste-Amezaga, Valiante, Ma, Kubin, Trinchieri: Interleukin 10 (IL-10) inhibits human lymphocyte interferon gamma-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells. in The Journal of experimental medicine 1993 (PubMed)
    Show all 3 references for ABIN1305065

  4. Mouse (Murine) IL12 Protein expressed in Insect Cells - ABIN1033059 : Isler, de Rochemonteix, Songeon, Boehringer, Nicod: Interleukin-12 production by human alveolar macrophages is controlled by the autocrine production of interleukin-10. in American journal of respiratory cell and molecular biology 1999 (PubMed)

  5. Mouse (Murine) IL12 Protein expressed in Escherichia coli (E. coli) - ABIN1305066 : Schoenhaut, Chua, Wolitzky, Quinn, Dwyer, McComas, Familletti, Gately, Gubler: Cloning and expression of murine IL-12. in Journal of immunology (Baltimore, Md. : 1950) 1992 (PubMed)

More Proteins for IL12 Interaction Partners

Mouse (Murine) Interleukin 12 (IL12) interaction partners

  1. IL-12 (show IL12A Proteins) immunomodulation delays the onset of lethal peritoneal disease of ovarian cancer.

  2. There is a common program of effector T cell differentiation that is regulated by IL-2 and IL-12 signaling and the combined activities of the transcriptional regulators Blimp-1 and T-bet.

  3. Irradiation-induced IL-6 (show IL6 Proteins) can decrease IL-12 (show IL12A Proteins) production through the inhibition of C-Rel (show NFkBP65 Proteins) phosphorylation by the IL-6 (show IL6 Proteins)/STAT3 (show STAT3 Proteins) signaling pathway.

  4. The IL-12 (show IL12A Proteins) response by dendritic cells against S. aureus is highly growth phase dependent.

  5. These results provide a new pathway of Th1 (show HAND1 Proteins) response regulation where IL-12 (show IL12A Proteins) secreted by dendritic cellss is consumed by a sub-population of IL-12Rbeta2-expressing Treg cells.

  6. IL-12p35 has a protective role against pulmonary infection with methicillin-resistant Staphylococcus aureus.

  7. TBI (show TBPL1 Proteins)-induced IL12 (show IL12A Proteins) augments Tc17 cell-mediated tumor immunity and underline the substantial implications of in vitro preparation of antitumor Tc17 cells with IL12 (show IL12A Proteins) in the design of T-cell immunotherapies

  8. Interleukin-12-producing CD103 (show ITGAE Proteins)+ CD11b (show ITGAM Proteins)- CD8 (show CD8A Proteins)+ dendritic cells are responsible for eliciting gut (show GUSB Proteins) intraepithelial lymphocyte response against Encephalitozoon cuniculi.

  9. the PI3K pathway mediated IL-12 (show IL12A Proteins) inhibition but did not interfere with the inhibition of IL-23 (show IL23A Proteins) or stimulation of IL-10 (show IL10 Proteins).

  10. Interferon-gamma (IFN-gamma (show IFNG Proteins)) and interleukin-12 (IL-12 (show IL12A Proteins)) levels in the tumors and plasma were significantly enhanced after processing with recombinant mouse CCL19 (show CCL19 Proteins).

Human Interleukin 12 (IL12) interaction partners

  1. The IL23R (show IL23R Proteins) polymorphisms rs10889677, rs7517847, and the IL12B (show IL12B Proteins) polymorphism rs3212227 are not associated with multiple sclerosis risk.

  2. IL-12 (show IL12A Proteins) immunomodulation delays the onset of lethal peritoneal disease of ovarian cancer.

  3. the IL-12B (show IL12B Proteins) rs3212227 AC and AC+CC genotypes are associated with rheumatoid arthritis risk in older patients,rheumatoid factor positive patients and anti-cyclic peptide antibodies negative patients

  4. High serum IL-12 (show IL12A Proteins) levels associated with increased densities of peritumoral CD8 (show CD8A Proteins)(+) T cells, intraepithelial CD3 (show CD3 Proteins)(+) T cells and intratumoral neutrophils, while high serum CCL4 (show CCL4 Proteins) levels associated with increased densities of peritumoral CD68 (show CD68 Proteins)(+) cells

  5. Human IL-21 (show IL17C Proteins)+IFN-gamma (show IFNG Proteins)+CD4 (show CD4 Proteins)+ T cells in nasal polyps are regulated by IL-12 (show IL12A Proteins).

  6. No association was observed for IL-12B (show IL12B Proteins) and IFN-gamma (show IFNG Proteins) polymorphisms between the rheumatoid arthritis patients and controls.

  7. These observations indicate a HDAC1 (show HDAC1 Proteins)-mediated IL-12B (show IL12B Proteins) gene expression suppression by live, virulent Mycobacterium tuberculosis to subvert the immune system to survive and replicate in the host.

  8. Peripheral blood mononuclear cells from severe asthmatic children release lower amounts of IL-12 (show IL12A Proteins) and IL-4 (show IL4 Proteins) after LPS (show IRF6 Proteins) stimulation.

  9. Findings demonstrate that IL-12 (show IL12A Proteins) is increased significantly in chronic hepatitis B patients and that viral protein HBx induces IL-12 (show IL12A Proteins) expression in hepatocytes through the activation of the PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins) pathway.

  10. 8 SNPs (rs10045431, rs11167764, rs3212227, rs6556412, rs6556416, rs6871626, rs6887695 and rs7709212) were genotyped in Han ankylosing spondylitis patients and controls. rs6871626 may be associated AS susceptibility and activity.

Pig (Porcine) Interleukin 12 (IL12) interaction partners

  1. Data show that cysteine significantly reduced the expression of pro-inflammatory cytokines, including TNF-alpha (show TNF Proteins), IL-6 (show IL6 Proteins), IL-12p40, IL-1beta (show IL1B Proteins), and resulted in increased expression of the apoptosis initiator caspase-8 (show CASP8 Proteins) and bcl2L1 (show BCL2L1 Proteins).

IL12 Protein Profile

Protein Summary

This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children.

Alternative names and synonyms associated with IL12

  • interleukin 12Ba (il12ba)
  • interleukin 12B (LOC100217488)
  • interleukin 12 p40 subunit (IL-12)
  • interleukin 12a (Il12a)
  • interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35) (IL12A)
  • interleukin 12B (Il12b)
  • interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) (IL12B)
  • CLMF protein
  • CLMF2 protein
  • IL-12 p40 protein
  • Il-12a protein
  • IL-12B protein
  • IL-12p35 protein
  • IL-12p40 protein
  • Il12 protein
  • IL12B protein
  • il12p40.b protein
  • Ll12a protein
  • LOC100217488 protein
  • NKSF protein
  • NKSF2 protein
  • p35 protein
  • zgc:152789 protein

Protein level used designations for Interleukin 12 Proteins (IL12)

il-12p40.a , interleukin 12 p40.b , interleukin 12B , interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) , interleukin 12Ba (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) , interleukin-12 p40 subunit , CLMF p40 , Cytotoxic lymphocyte maturation factor 40 kDa subunit , IL-12 subunit p40 , Interleukin-12 subunit beta , CLMF p35 , IL-12 subunit p35 , cytotoxic lymphocyte maturation factor 35 kDa subunit , interleukin 12a p35 subunit , interleukin-12 subunit alpha , IL-12A , interleukin 12 , interleukin-12 p40 , interleukin-12 subunit beta , IL12, subunit p40 , NK cell stimulatory factor chain 2 , cytotoxic lymphocyte maturation factor 40 kDa subunit , interleukin 12, p40 , interleukin-12 beta chain , natural killer cell stimulatory factor, 40 kD subunit , IL-12B , IL-12 p40 subunit , interleukin-12p40

445373 Danio rerio
100217488 Taeniopygia guttata
100860845 Capra hircus
16159 Mus musculus
493741 Felis catus
64546 Rattus norvegicus
3593 Homo sapiens
397076 Sus scrofa
403976 Canis lupus familiaris
404671 Gallus gallus
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