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Human IL12 Protein expressed in Escherichia coli (E. coli) - ABIN1305065
DAndrea, Aste-Amezaga, Valiante, Ma, Kubin, Trinchieri: Interleukin 10 (IL-10) inhibits human lymphocyte interferon gamma-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells. in The Journal of experimental medicine 1993
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Mouse (Murine) IL12 Protein expressed in Escherichia coli (E. coli) - ABIN1305066
Schoenhaut, Chua, Wolitzky, Quinn, Dwyer, McComas, Familletti, Gately, Gubler: Cloning and expression of murine IL-12. in Journal of immunology (Baltimore, Md. : 1950) 1992
IL-35-transduced adipocyte-derived mesenchymal stem cells in vivo can enhance proliferation of CD4 (show CD4 Proteins)(+) CD25 (show IL2RA Proteins)(+) Treg cells and suppress the function of effector T cells such as T helper (Th) 1 (show TH1L Proteins), Th2 and Th17 cells and may reduce the development of allograft rejection.
findings show that IL-12 and other proinflammatory cytokines transduce signals through the TCR signalosome in a manner that requires Fyn activity and self-peptide-MHC (self-pMHC) interactions.
this study shows that a systemic IL-12 (show IL12A Proteins) primes intestinal cells that became more prone to develop inflammatory responses, which is long-lasting because intestinal cells maintain their inflammatory potential and their ability to aggravate colitis
These results suggest a correlation between CRMP2 (show DPYSL2 Proteins) phosphorylation and AD pathophysiology, and indicate the effectiveness of pioglitazone treatment at the pre-Abeta (show APP Proteins) accumulation stage in AD model mice.
Data show that interleukin-35 (Epstein-Barr virus-induced gene 3 (EBI3) and the interleukin-12 Subunit p35 (p35) subunit) expressing plasmid downregulates the expression of pro-inflammatory cytokines and upregulates the expression of anti-inflammatory cytokines.
Data suggest that interleukin-35 (Epstein-Barr virus-induced gene 3 (EBI3) and the interleukin-12 Subunit p35 (p35) subunit) contributes to the increased susceptibility to secondary pneumococcal pneumonia.
Deficiency of IL-12p35 limited AMI (show CFD Proteins)-induced cardiac injury by promoting pro-angiogenesis and anti-inflammatory functions of monocytes
IL-12 (show IL12A Proteins) immunomodulation delays the onset of lethal peritoneal disease of ovarian cancer.
There is a common program of effector T cell differentiation that is regulated by IL-2 and IL-12 signaling and the combined activities of the transcriptional regulators Blimp-1 and T-bet.
Irradiation-induced IL-6 (show IL6 Proteins) can decrease IL-12 (show IL12A Proteins) production through the inhibition of C-Rel (show NFkBP65 Proteins) phosphorylation by the IL-6 (show IL6 Proteins)/STAT3 (show STAT3 Proteins) signaling pathway.
IL-12B (show IL12B Proteins) -1188 C allele may be a protective factor against asthma in East Asians
The low expression of HDAC3 (show HDAC3 Proteins) and overexpession of inflammatory cytokines (IL-18 (show IL18 Proteins), IL-12 (show IL12A Proteins) and TNF-alpha (show TNF Proteins)) in intrahepatic cholestasis of pregnancy may be involved in liver cell apoptosis and in the pathophysiology of the disease.
Polymorphisms of IFNG (show IFNG Proteins), IL12B (show IL12B Proteins) and IL12RB1 (show IL12RB1 Proteins) genes in paracoccidioidomycosis Brazilian patients do not affect the susceptibility or resistance to the disease.
Identification of PARP-1 (show PARP1 Proteins) as a unique regulator of Il12b (show IL12B Proteins) transcription in response to inflammatory insults in an allele-differentiating manner
Pre-incubation with IL-12 (show IL12A Proteins) was able to restore IFN-gamma (show IFNG Proteins) production and the cytotoxicity capacities of NK cells. This cytokine may therefore be considered as a potential treatment candidate in traumatic brain injury patients with immune suppression.
NOD2 rs3135500 and IL12B (show IL12B Proteins) rs1368439 SNPs were not genetic risk factors for colorectal cancer in the studied Iranian population.
assembly-induced folding is key in IL-12 (show IL12A Proteins) family biogenesis and secretion; the identification of essential disulfide bonds that underlie this process lays the basis for a simplified yet functional IL-12 (show IL12A Proteins) cytokine
IL-12B (show IL12B Proteins) gene polymorphisms were not related with rheumatoid arthritis (RA). However, rs6887695 was associated with RA in Asian patients
this study shows that that IL-12 (show IL12A Proteins) and IL-4 (show IL4 Proteins) govern group 2 innate lymphoid cells functional identity and that their imbalance results in the perpetuation of type 1 or type 2 inflammation
The data suggested the association of IL12B (show IL12B Proteins) with the psoriasis, however no evidence was observed for the epistatic effect of IL12B (show IL12B Proteins) with HLA-Cw6 among the psoriasis patients in India.
Data show that cysteine significantly reduced the expression of pro-inflammatory cytokines, including TNF-alpha (show TNF Proteins), IL-6 (show IL6 Proteins), IL-12p40, IL-1beta (show IL1B Proteins), and resulted in increased expression of the apoptosis initiator caspase-8 (show CASP8 Proteins) and bcl2L1 (show BCL2L1 Proteins).
This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children.
, interleukin 12 p40.b
, interleukin 12B
, interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)
, interleukin 12Ba (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)
, interleukin-12 p40 subunit
, CLMF p40
, Cytotoxic lymphocyte maturation factor 40 kDa subunit
, IL-12 subunit p40
, Interleukin-12 subunit beta
, CLMF p35
, IL-12 subunit p35
, cytotoxic lymphocyte maturation factor 35 kDa subunit
, interleukin 12a p35 subunit
, interleukin-12 subunit alpha
, interleukin 12
, interleukin-12 p40
, interleukin-12 subunit beta
, IL12, subunit p40
, NK cell stimulatory factor chain 2
, cytotoxic lymphocyte maturation factor 40 kDa subunit
, interleukin 12, p40
, interleukin-12 beta chain
, natural killer cell stimulatory factor, 40 kD subunit
, IL-12 p40 subunit