Browse our IL12 Proteins (IL12)

Full name:
Interleukin 12 Proteins (IL12)
On www.antibodies-online.com are 64 Interleukin 12 (IL12) Proteins from 14 different suppliers available. Additionally we are shipping IL12 Antibodies (236) and IL12 Kits (184) and many more products for this protein. A total of 502 IL12 products are currently listed.
Synonyms:
CLMF, CLMF2, IL-12 p40, Il-12a, IL-12B, IL-12p35, IL-12p40, Il12, IL12B, il12p40.b, Ll12a, LOC100217488, NKSF, NKSF2, p35, zgc:152789
list all proteins Gene Name GeneID UniProt
IL12 16159 P43431
IL12 64546  
IL12 3593 P29460

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IL12 Proteins (IL12) by Origin

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Top referenced IL12 Proteins

  1. Human IL12 Protein expressed in Insect Cells - ABIN2666684 : Ireland, Palian, Reiss: Interleukin (IL)-12 receptor beta1 or IL-12 receptor beta 2 deficiency in mice indicates that IL-12 and IL-23 are not essential for host recovery from viral encephalitis. in Viral immunology 2005 (PubMed)
    Show all 7 references for 2666684

  2. Mouse (Murine) IL12 Protein expressed in Sf-9 cells - ABIN2666686 : Moreno, Alves-Filho, Alfaya, da Silva, Ferreira, Liew: IL-12, but not IL-18, is critical to neutrophil activation and resistance to polymicrobial sepsis induced by cecal ligation and puncture. in Journal of immunology (Baltimore, Md. : 1950) 2006 (PubMed)
    Show all 6 references for 2666686

  3. Human IL12 Protein expressed in Escherichia coli (E. coli) - ABIN1305065 : DAndrea, Aste-Amezaga, Valiante, Ma, Kubin, Trinchieri: Interleukin 10 (IL-10) inhibits human lymphocyte interferon gamma-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells. in The Journal of experimental medicine 1993 (PubMed)
    Show all 3 references for 1305065

  4. Mouse (Murine) IL12 Protein expressed in Escherichia coli (E. coli) - ABIN1305066 : Schoenhaut, Chua, Wolitzky, Quinn, Dwyer, McComas, Familletti, Gately, Gubler: Cloning and expression of murine IL-12. in Journal of immunology (Baltimore, Md. : 1950) 1992 (PubMed)

More Proteins for IL12 Interaction Partners

Mouse (Murine) Interleukin 12 (IL12) interaction partners

  1. findings show that IL-12 and other proinflammatory cytokines transduce signals through the TCR signalosome in a manner that requires Fyn activity and self-peptide-MHC (self-pMHC) interactions.

  2. this study shows that a systemic IL-12 (show IL12A Proteins) primes intestinal cells that became more prone to develop inflammatory responses, which is long-lasting because intestinal cells maintain their inflammatory potential and their ability to aggravate colitis

  3. These results suggest a correlation between CRMP2 (show DPYSL2 Proteins) phosphorylation and AD pathophysiology, and indicate the effectiveness of pioglitazone treatment at the pre-Abeta (show APP Proteins) accumulation stage in AD model mice.

  4. Data show that interleukin-35 (Epstein-Barr virus-induced gene 3 (EBI3) and the interleukin-12 Subunit p35 (p35) subunit) expressing plasmid downregulates the expression of pro-inflammatory cytokines and upregulates the expression of anti-inflammatory cytokines.

  5. Data suggest that interleukin-35 (Epstein-Barr virus-induced gene 3 (EBI3) and the interleukin-12 Subunit p35 (p35) subunit) contributes to the increased susceptibility to secondary pneumococcal pneumonia.

  6. Deficiency of IL-12p35 limited AMI (show CFD Proteins)-induced cardiac injury by promoting pro-angiogenesis and anti-inflammatory functions of monocytes

  7. IL-12 (show IL12A Proteins) immunomodulation delays the onset of lethal peritoneal disease of ovarian cancer.

  8. There is a common program of effector T cell differentiation that is regulated by IL-2 and IL-12 signaling and the combined activities of the transcriptional regulators Blimp-1 and T-bet.

  9. Irradiation-induced IL-6 (show IL6 Proteins) can decrease IL-12 (show IL12A Proteins) production through the inhibition of C-Rel (show NFkBP65 Proteins) phosphorylation by the IL-6 (show IL6 Proteins)/STAT3 (show STAT3 Proteins) signaling pathway.

  10. The IL-12 (show IL12A Proteins) response by dendritic cells against S. aureus is highly growth phase dependent.

Human Interleukin 12 (IL12) interaction partners

  1. NOD2 rs3135500 and IL12B (show IL12B Proteins) rs1368439 SNPs were not genetic risk factors for colorectal cancer in the studied Iranian population.

  2. assembly-induced folding is key in IL-12 (show IL12A Proteins) family biogenesis and secretion; the identification of essential disulfide bonds that underlie this process lays the basis for a simplified yet functional IL-12 (show IL12A Proteins) cytokine

  3. IL-12B (show IL12B Proteins) gene polymorphisms were not related with rheumatoid arthritis (RA). However, rs6887695 was associated with RA in Asian patients

  4. this study shows that that IL-12 (show IL12A Proteins) and IL-4 (show IL4 Proteins) govern group 2 innate lymphoid cells functional identity and that their imbalance results in the perpetuation of type 1 or type 2 inflammation

  5. The data suggested the association of IL12B (show IL12B Proteins) with the psoriasis, however no evidence was observed for the epistatic effect of IL12B (show IL12B Proteins) with HLA-Cw6 among the psoriasis patients in India.

  6. In summary, this meta-analysis finds that IL6 (show IL6 Proteins) rs1800795 and IL18 (show IL18 Proteins) rs1946518 polymorphisms decrease the risk of BD. However, IL12B (show IL12B Proteins) rs3212227 increases BD susceptibility. Further large-scale investigation of this association is necessary.

  7. Suggest Il12B (show IL12B Proteins) SNPs as genetic marker of disease severity in Takayasu arteritis severity.

  8. The results of this study suggested that rs6887695 SNP in IL12B (show IL12B Proteins) gene increase susceptibility to relapsing-remitting multiple sclerosis.

  9. The results of this case-control study suggest that IL-12A (show IL12A Proteins), IL-12B (show IL12B Proteins), IL12RB1 (show IL12RB1 Proteins), IL12RB2 (show IL12RB2 Proteins) and IL23R (show IL23R Proteins) make no genetic contribution to the susceptibility of Takayasu arteritis in Chinese populations

  10. these meta-analyses demonstrated that IL-12B (show IL12B Proteins) rs3212227 and rs6887695 polymorphisms do not confer susceptibility to rheumatoid arthritis [data synthesis]

Pig (Porcine) Interleukin 12 (IL12) interaction partners

  1. Data show that cysteine significantly reduced the expression of pro-inflammatory cytokines, including TNF-alpha (show TNF Proteins), IL-6 (show IL6 Proteins), IL-12p40, IL-1beta (show IL1B Proteins), and resulted in increased expression of the apoptosis initiator caspase-8 (show CASP8 Proteins) and bcl2L1 (show BCL2L1 Proteins).

IL12 Protein Profile

Protein Summary

This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children.

Alternative names and synonyms associated with IL12

  • interleukin 12Ba (il12ba)
  • interleukin 12B (LOC100217488)
  • interleukin 12 p40 subunit (IL-12)
  • interleukin 12a (Il12a)
  • interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35) (IL12A)
  • interleukin 12B (Il12b)
  • interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) (IL12B)
  • CLMF protein
  • CLMF2 protein
  • IL-12 p40 protein
  • Il-12a protein
  • IL-12B protein
  • IL-12p35 protein
  • IL-12p40 protein
  • Il12 protein
  • IL12B protein
  • il12p40.b protein
  • Ll12a protein
  • LOC100217488 protein
  • NKSF protein
  • NKSF2 protein
  • p35 protein
  • zgc:152789 protein

Protein level used designations for Interleukin 12 Proteins (IL12)

il-12p40.a , interleukin 12 p40.b , interleukin 12B , interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) , interleukin 12Ba (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) , interleukin-12 p40 subunit , CLMF p40 , Cytotoxic lymphocyte maturation factor 40 kDa subunit , IL-12 subunit p40 , Interleukin-12 subunit beta , CLMF p35 , IL-12 subunit p35 , cytotoxic lymphocyte maturation factor 35 kDa subunit , interleukin 12a p35 subunit , interleukin-12 subunit alpha , IL-12A , interleukin 12 , interleukin-12 p40 , interleukin-12 subunit beta , IL12, subunit p40 , NK cell stimulatory factor chain 2 , cytotoxic lymphocyte maturation factor 40 kDa subunit , interleukin 12, p40 , interleukin-12 beta chain , natural killer cell stimulatory factor, 40 kD subunit , IL-12B , IL-12 p40 subunit , interleukin-12p40

GENE ID SPECIES
445373 Danio rerio
100217488 Taeniopygia guttata
100860845 Capra hircus
16159 Mus musculus
493741 Felis catus
64546 Rattus norvegicus
3593 Homo sapiens
397076 Sus scrofa
403976 Canis lupus familiaris
404671 Gallus gallus
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