IL12 Products
(Interleukin 12 (IL12))
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This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children. [provided by RefSeq, Jul 2008].
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Featured IL12 Categories
IL12 Antibodies
High quality antibodies with extensive validation data.
IL12 ELISA Kits
Reliable ELISA kits for a wide range of species.
IL12 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended IL12 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IF (cc), IF (p), IHC (fro), IHC (p)
Validations
- (1)
- (5)
Cat. No.
ABIN734453
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, FACS, IHC
Validations
- (5)
Cat. No.
ABIN3031445
Quantity
0.4 mL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IF (cc), IF (p)
Validations
- (1)
Cat. No.
ABIN902152
Quantity
100 μL
Datasheet
Datasheet
Recommended IL12 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN6963675
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rabbit
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN6967849
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Chicken
Analytical Method
Quantitative Competition ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN6974146
Quantity
96 tests
Datasheet
Datasheet
Recommended IL12 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (4)
Cat. No.
ABIN7274898
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (4)
Cat. No.
ABIN7274899
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
HEK-293T Cells
Validations
- (3)
Cat. No.
ABIN2018013
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our IL12 products
: "Curcumin and ustekinumab cotherapy alleviates induced psoriasis in rats through their antioxidant, anti-inflammatory, and antiproliferative effects." in: Cutaneous and ocular toxicology, pp. 1-10, (2021) (PubMed).: "Immunomodulatory effect of papaya (Carica papaya) pulp and seed extracts as a potential natural treatment for bacterial stress." in: Journal of food biochemistry, Vol. 43, Issue 12, pp. e13050, (2020) (PubMed).
: "Targeting IL-17A Improves the Dysmotility of the Small Intestine and Alleviates the Injury of the Interstitial Cells of Cajal during Sepsis." in: Oxidative medicine and cellular longevity, Vol. 2019, pp. 1475729, (2020) (PubMed).
: "Fermented Morinda citrifolia (Noni) Alleviates DNCB-Induced Atopic Dermatitis in NC/Nga Mice through Modulating Immune Balance and Skin Barrier Function." in: Nutrients, Vol. 12, Issue 1, (2020) (PubMed).
: "Latexin deficiency in mice up-regulates inflammation and aggravates colitis through HECTD1/Rps3/NF-κB pathway." in: Scientific reports, Vol. 10, Issue 1, pp. 9868, (2020) (PubMed).
: "A probiotic treatment increases the immune response induced by the nasal delivery of spore-adsorbed TTFC." in: Microbial cell factories, Vol. 19, Issue 1, pp. 42, (2020) (PubMed).
: "Defibrotide inhibits donor leucocyte-endothelial interactions and protects against acute graft-versus-host disease." in: Journal of cellular and molecular medicine, Vol. 24, Issue 14, pp. 8031-8044, (2020) (PubMed).
: "Targeted delivery of zoledronic acid through the sialic acid - Siglec axis for killing and reversal of M2 phenotypic tumor-associated macrophages - A promising cancer immunotherapy." in: International journal of pharmaceutics, Vol. 590, pp. 119929, (2020) (PubMed).
: "Protective immunity induced by a DNA vaccine cocktail expressing TgSAG1, TgROP2, and the genetic adjuvant HBsAg against Toxoplasma gondii infection." in: Microbial pathogenesis, Vol. 147, pp. 104441, (2020) (PubMed).
: "An autologous dendritic cell vaccine polarizes a Th-1 response which is tumoricidal to patient-derived breast cancer cells." in: Cancer immunology, immunotherapy : CII, Vol. 68, Issue 1, pp. 71-83, (2019) (PubMed).
Synonyms and alternative names related to IL12
interleukin 12B (IL12B), interleukin 12A (IL12A), interleukin 12b (Il12b), interleukin 12B (Il12b), interleukin 12a (Il12a), interleukin 12A (Il12a), Interleukin 12 level (IL12), interleukin 12a (il12a), CLMF, CLMF2, IL-12, IL-12 p35, Il-12a, IL-12B, Il-12b, IL-12p35, Il-12p40, IL-12p40, Il12, IL12B, Il12p40, IL12p40, Ll12a, LOC100217488, NKSF, NKSF2, p35, p40Protein level used designations for IL12
- CLMF p40
- IL-12 subunit p40
- IL12, subunit p40
- NK cell stimulatory factor chain 2
- cytotoxic lymphocyte maturation factor 40 kDa subunit
- interleukin 12, p40
- interleukin-12 beta chain
- interleukin-12 subunit beta
- natural killer cell stimulatory factor, 40 kD subunit
- CLMF p35
- IL-12 subunit p35
- IL-12A
- cytotoxic lymphocyte maturation factor 35 kDa subunit
- interleukin 12
- interleukin-12 subunit alpha
- IL-12 p40
- IL-23 subunit p40
- interleukin-12 p40
- IL-12B
- interleukin-12 p40 subunit
- IL-12 p40 subunit
- interleukin-12p40
- interleukin 12B
- interleukin 12a p35 subunit
- interleukin 12 p35 subunit
- interleukin 12 40kDa subunit
- Cytotoxic lymphocyte maturation factor 40 kDa subunit
- Interleukin-12 subunit beta
- interleukin 12a
- interleukin-12 p35 subunit
- interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)
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