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Human IL15 Protein expressed in Escherichia coli (E. coli) - ABIN2667461
Meresse, Chen, Ciszewski, Tretiakova, Bhagat, Krausz, Raulet, Lanier, Groh, Spies, Ebert, Green, Jabri: Coordinated induction by IL15 of a TCR-independent NKG2D signaling pathway converts CTL into lymphokine-activated killer cells in celiac disease. in Immunity 2004
Show all 10 references for ABIN2667461
Mouse (Murine) IL15 Protein expressed in Escherichia coli (E. coli) - ABIN2666689
Armitage, Macduff, Eisenman, Paxton, Grabstein: IL-15 has stimulatory activity for the induction of B cell proliferation and differentiation. in Journal of immunology (Baltimore, Md. : 1950) 1995
Show all 8 references for ABIN2666689
Human IL15 Protein expressed in Escherichia coli (E. coli) - ABIN2667463
Tang, Zhao, Jiang, Ba, Cui, He: Activity of recombinant human interleukin-15 against tumor recurrence and metastasis in mice. in Cellular & molecular immunology 2008
Show all 8 references for ABIN2667463
Human IL15 Protein expressed in Escherichia coli (E. coli) - ABIN1047241
Grabstein, Eisenman, Shanebeck, Rauch, Srinivasan, Fung, Beers, Richardson, Schoenborn, Ahdieh: Cloning of a T cell growth factor that interacts with the beta chain of the interleukin-2 receptor. in Science (New York, N.Y.) 1994
Show all 4 references for ABIN1047241
Mouse (Murine) IL15 Protein expressed in Escherichia coli (E. coli) - ABIN1033163
Gill, Ashkar: Overexpression of interleukin-15 compromises CD4-dependent adaptive immune responses against herpes simplex virus 2. in Journal of virology 2008
T cells in chimpanzees infected with human immunodeficiency virus express surface interleukin-15.
CD3 (show CD3 Proteins)(-) CD8 (show CD8A Proteins)(+) NK cells play a vital role in controlling HIV-1 infection by producing high levels of IFN-gamma (show IFNG Proteins), and that IL-15 elicits IFN-gamma (show IFNG Proteins) production in this subpopulation of NK cells in HIV-1-infected chimpanzees. [Il-15, CD8 (show CD8A Proteins) antigen, IFN-gamma (show IFNG Proteins)]
Under steady-state conditions, KLF2 (show KLF2 Proteins)-deficient NK cells alter their expression of homeostatic homing receptors and subsequently undergo apoptosis due to IL-15 starvation.
The induction of IgM (show CD40LG Proteins) and IgA, which can play pivotal roles in mucosal immunity, was promoted in the presence of IL-15. Collectively, the data implicate IL-15 as the master cytokine that induces B-1a cells to mount a mucosal immune response.
The novel mechanism of IL-15 transfer to the surface of antigen-processing DCs may explain the enhanced potency of IL-15:IL-15Ralpha-coated nanoparticles for antigen delivery.
Muscle FNDC5 (show FNDC5 Proteins) mRNA expression and irisin (show FNDC5 Proteins) release are not IL-15-dependent in mice.
Virtual memory T cells develop and mediate bystander protective immunity in an IL-15-dependent manner.
Impaired delivery of IL-15 to CD4 (show CD4 Proteins)+ T cells in the colon downmodulates Foxp3 (show FOXP3 Proteins) expression and enhances RORgammat expression. CD4 (show CD4 Proteins)+ T cells deprived of IL-15 trigger IBD characterized by production of pro-inflammatory cytokines and accumulation of Th1 (show HAND1 Proteins)/Th17 cells.
Most (86%) IL15 in serum resides in the free state, with a minor proportion (14%) residing in complex with IL15Ralpha. Results suggest that IL15 is released as a free molecule by an unknown mechanism rather than via cleavage of membrane-bound IL15/IL15Ralpha.
IL-15 may influence mononuclear phagocytes subsets in the gut (show GUSB Proteins) in a novel way that alters the frequency of lamina propria Th17 cells.
Downregulation of STAT3 (show STAT3 Proteins) phosphorylation enhances tumoricidal effect of IL-15-activated dendritic cell against doxorubicin-resistant lymphoma and leukemia via TNF-alpha (show TNF Proteins).
Exercise-stimulated interleukin-15 is controlled by AMPK (show PRKAA1 Proteins) and regulates skin metabolism and aging.
IL-15 is able to significantly regulate the inflammatory infiltration of macrophages in polymyositis patients through affecting the NF-kB pathway and MMP-9 (show MMP9 Proteins) expression levels.
IL-15 mRNA expression was significantly higher in patients with moderately severe viral bronchiolitis compared to controls and patients with severe disease. Serum IL15 correlated with disease severity.
These data underline the potential of "free" IL15 in the absence of Ralpha-complex as a powerful and specific immuno-modulator, which may be beneficial where selective immune-activation is desired.
Data indicate that high interleukin-16 (show IL16 Proteins) (IL-6 (show IL6 Proteins)), interferon-gamma (IFN-gamma (show IFNG Proteins)) and low interleukin-15 (IL-15) levels suggest active tuberculosis.
Culturing NK cells under hypoxia compared with ambient air (normoxia) and IL-15 priming synergistically augmented glycolytic gene expression without major changes in glycolytic flux and glucose consumption.
Findings suggest for co-targeting shedding-derived soluble MIC (sMIC) to enhance the therapeutic efficacy of ALT-803 or other interleukin 15 (IL-15) agonists.
Report improved antitumoral NK-cell activity in DC-based vaccine strategies through the use of IL-15/IL-15Ralpha mRNA-engineered designer DC.
results demonstrated the relative functional deficiencies of alpha-GalCer induced UCB iNKT cells, which can be ameliorated by IL-15
Myokine IL-15 regulates the crosstalk of co-cultured porcine skeletal muscle satellite cells and preadipocytes.
results demonstrate that porcine reproductive and respiratory syndrome virus (PRRSV)infection could induce IL-15 production in macrophages/dendritic cells; data further show that upregulation of IL-15 by PRRSV requires PKC (show FYN Proteins) and NF-kappaB (show NFKB1 Proteins) pathways
IFN-gamma (show IFNG Proteins) targets the adipocyte to induce IL-15 expression, thus indicating a possible role for the adipocyte in the regulation of T-cell function and muscle metabolism during the innate immune response
When induced by IFN-gamma (show IFNG Proteins) or other inflammatory mediators, IL-15 may be a significant homeorhetic factor that mobilizes and directs energy away from the adipocyte to other cells during the acute phase of the inflammatory response.
Increased function and survival of IL-15-transduced dendritic cells are mediated by up-regulation of IL-15Ralpha and Bcl-2 (show BCL2 Proteins).
IL 15 generates a dramatic expansion of short-lived memory CD8 (show CD8A Proteins) T cells and natural killer in immunocompetent macaques and has long-term effects on the balance of CD4 (show CD4 Proteins)(+) and CD8 (show CD8A Proteins)(+) T cells.
These data suggest that therapeutic use of IL-15 in the setting of antiretroviral therapy might facilitate specific restoration of the CD4 (show CD4 Proteins) + T cell compartment.
IL-15 secretion significantly correlates with the up-regulated expression of CD4 (show CD4 Proteins) on memory CD4 (show CD4 Proteins) T cells that is associated with increased permissiveness to simian immunodeficiency virus infection.
The protein encoded by this gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between this cytokine and IL2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. Studies of the mouse counterpart suggested that this cytokine may increase the expression of apoptosis inhibitor BCL2L1/BCL-x(L), possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. Alternatively spliced transcript variants of this gene have been reported.