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Human IL15 Protein expressed in Escherichia coli (E. coli) - ABIN2667461
Meresse, Chen, Ciszewski, Tretiakova, Bhagat, Krausz, Raulet, Lanier, Groh, Spies, Ebert, Green, Jabri: Coordinated induction by IL15 of a TCR-independent NKG2D signaling pathway converts CTL into lymphokine-activated killer cells in celiac disease. in Immunity 2004
Show all 10 references for ABIN2667461
Mouse (Murine) IL15 Protein expressed in Escherichia coli (E. coli) - ABIN2666689
Armitage, Macduff, Eisenman, Paxton, Grabstein: IL-15 has stimulatory activity for the induction of B cell proliferation and differentiation. in Journal of immunology (Baltimore, Md. : 1950) 1995
Show all 8 references for ABIN2666689
Human IL15 Protein expressed in Escherichia coli (E. coli) - ABIN2667463
Tang, Zhao, Jiang, Ba, Cui, He: Activity of recombinant human interleukin-15 against tumor recurrence and metastasis in mice. in Cellular & molecular immunology 2008
Show all 8 references for ABIN2667463
Human IL15 Protein expressed in Escherichia coli (E. coli) - ABIN1047241
Grabstein, Eisenman, Shanebeck, Rauch, Srinivasan, Fung, Beers, Richardson, Schoenborn, Ahdieh: Cloning of a T cell growth factor that interacts with the beta chain of the interleukin-2 receptor. in Science (New York, N.Y.) 1994
Show all 4 references for ABIN1047241
Mouse (Murine) IL15 Protein expressed in Escherichia coli (E. coli) - ABIN1033163
Gill, Ashkar: Overexpression of interleukin-15 compromises CD4-dependent adaptive immune responses against herpes simplex virus 2. in Journal of virology 2008
T cells in chimpanzees infected with human immunodeficiency virus express surface interleukin-15.
CD3 (show CD3 Proteins)(-) CD8 (show CD8A Proteins)(+) NK cells play a vital role in controlling HIV-1 infection by producing high levels of IFN-gamma (show IFNG Proteins), and that IL-15 elicits IFN-gamma (show IFNG Proteins) production in this subpopulation of NK cells in HIV-1-infected chimpanzees. [Il-15, CD8 (show CD8A Proteins) antigen, IFN-gamma (show IFNG Proteins)]
Muscle FNDC5 (show FNDC5 Proteins) mRNA expression and irisin (show FNDC5 Proteins) release are not IL-15-dependent in mice.
Virtual memory T cells develop and mediate bystander protective immunity in an IL-15-dependent manner.
Impaired delivery of IL-15 to CD4 (show CD4 Proteins)+ T cells in the colon downmodulates Foxp3 (show FOXP3 Proteins) expression and enhances RORgammat expression. CD4 (show CD4 Proteins)+ T cells deprived of IL-15 trigger IBD characterized by production of pro-inflammatory cytokines and accumulation of Th1 (show HAND1 Proteins)/Th17 cells.
Most (86%) IL15 in serum resides in the free state, with a minor proportion (14%) residing in complex with IL15Ralpha. Results suggest that IL15 is released as a free molecule by an unknown mechanism rather than via cleavage of membrane-bound IL15/IL15Ralpha.
IL-15 may influence mononuclear phagocytes subsets in the gut (show GUSB Proteins) in a novel way that alters the frequency of lamina propria Th17 cells.
Downregulation of STAT3 (show STAT3 Proteins) phosphorylation enhances tumoricidal effect of IL-15-activated dendritic cell against doxorubicin-resistant lymphoma and leukemia via TNF-alpha (show TNF Proteins).
Exercise-stimulated interleukin-15 is controlled by AMPK (show PRKAA1 Proteins) and regulates skin metabolism and aging.
IL-15 specifically down-regulates RARB (show RARB Proteins) expression, and RARB (show RARB Proteins) may play a protective role in lung injury caused by smoking or viral infections.
Hair follicle expression of IL-15 was required for CD8+ skin-resident memory T (TRM) cells to exert tropism for the epidermis.
High levels of IL-15 can promote tumor destruction and reduce metastasis in breast cancer via effects on NK1.1 positive cells.
results demonstrated the relative functional deficiencies of alpha-GalCer induced UCB iNKT cells, which can be ameliorated by IL-15
Protein, mRNA, and serum expression levels of MMP-7 (show MMP7 Proteins) and IL-15 in patients with osteoarthritis were all significantly increased in osteoarthritis patients compared with the control group.
Common gamma-chain (show IL2RG Proteins) cytokines IL-2 (show IL2 Proteins), IL-7 (show IL7 Proteins), and IL-15 prevent differentiation of naive T cells in vitro and limit activation of primed T cells in the absence of antigenic stimulus, which can contribute to the formation of cytokine imbalance.
Studeis indicate that expression of interleukin-15 (IL-15) in tissues promotes T helper 1 cell-mediated immunity.
These findings demonstrate a novel mechanism to attenuate IL-15-dependent NK cell proliferation and suggest that inhibitory NK cell receptors contribute to NK cell homeostasis.
IL15 was expressed primarily in the suprabulb of the hair follicle.
IL-15-derived dendritic cells elicited greater antigen-specific, primary and secondary CD8 (show CD8A Proteins) and CD4 (show CD4 Proteins) T-cell responses than did IL-4 (show IL4 Proteins)-derived ones
Myokine IL-15 regulates the crosstalk of co-cultured porcine skeletal muscle satellite cells and preadipocytes.
results demonstrate that porcine reproductive and respiratory syndrome virus (PRRSV)infection could induce IL-15 production in macrophages/dendritic cells; data further show that upregulation of IL-15 by PRRSV requires PKC (show FYN Proteins) and NF-kappaB (show NFKB1 Proteins) pathways
IFN-gamma (show IFNG Proteins) targets the adipocyte to induce IL-15 expression, thus indicating a possible role for the adipocyte in the regulation of T-cell function and muscle metabolism during the innate immune response
When induced by IFN-gamma (show IFNG Proteins) or other inflammatory mediators, IL-15 may be a significant homeorhetic factor that mobilizes and directs energy away from the adipocyte to other cells during the acute phase of the inflammatory response.
Increased function and survival of IL-15-transduced dendritic cells are mediated by up-regulation of IL-15Ralpha and Bcl-2 (show BCL2 Proteins).
IL 15 generates a dramatic expansion of short-lived memory CD8 (show CD8A Proteins) T cells and natural killer in immunocompetent macaques and has long-term effects on the balance of CD4 (show CD4 Proteins)(+) and CD8 (show CD8A Proteins)(+) T cells.
These data suggest that therapeutic use of IL-15 in the setting of antiretroviral therapy might facilitate specific restoration of the CD4 (show CD4 Proteins) + T cell compartment.
IL-15 secretion significantly correlates with the up-regulated expression of CD4 (show CD4 Proteins) on memory CD4 (show CD4 Proteins) T cells that is associated with increased permissiveness to simian immunodeficiency virus infection.
The protein encoded by this gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between this cytokine and IL2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. Studies of the mouse counterpart suggested that this cytokine may increase the expression of apoptosis inhibitor BCL2L1/BCL-x(L), possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. Alternatively spliced transcript variants of this gene have been reported.