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Human IL15 Protein expressed in Escherichia coli (E. coli) - ABIN988042
Suzuki, McCall, Choi, Sicklick, Huang, Qi, Zdanowicz, Camp, Li, Diehl: Interleukin-15 increases hepatic regenerative activity. in Journal of hepatology 2006
Show all 4 Pubmed References
T cells in chimpanzees infected with human immunodeficiency virus express surface interleukin-15.
CD3 (show CD3 Proteins)(-) CD8 (show CD8A Proteins)(+) NK cells play a vital role in controlling HIV-1 infection by producing high levels of IFN-gamma (show IFNG Proteins), and that IL-15 elicits IFN-gamma (show IFNG Proteins) production in this subpopulation of NK cells in HIV-1-infected chimpanzees. [Il-15, CD8 (show CD8A Proteins) antigen, IFN-gamma (show IFNG Proteins)]
results demonstrate that IL-15 and RANKL (show TNFSF11 Proteins) induce osteoclastogenesis synergistically, and IL-15 might play a novel and major role in destructive inflammatory bone diseases
This study provides mechanistic insight into how IL-15 controls the generation of memory CD8 (show CD8A Proteins) T cells and influences their trafficking and ability to take up residence within peripheral tissues.
findings extend understanding of the differential modes of action between IL-2 (show IL2 Proteins) and IL-15, and highlight how, although sharing the CD122 (show IL2RB Proteins)/CD132 (show IL2RG Proteins) receptor, they elicit such different immune actions
IL-15 induced by inflammatory signals in response to lymphodepletion drives lymphocyte responses, as memory CD8 (show CD8A Proteins) T cells proliferated in an IL-15-dependent manner.
these findings unveil a role for IL-15 as a critical mediator in defense against systemic candidiasis and hold promise for the design of IL-15-based antifungal immunotherapies.
developmental arrest of Natural killer cells results from a lack of IL-15 availability in the microenvironment.
IL-15 impacts butyrate-producing bacteria and lowers butyrate levels in the absence of overt pathology, which represent events that precede and promote intestinal inflammatory diseases.
endogenous IL-15 does not directly augment the pathogenesis of sepsis but enables the development of septic shock by maintaining NK cell numbers and integrity.
this study shows that IL-15-mediated control of the precursor population affects the development of virus-specific CD8 (show CD8A Proteins)+ T-cell memory
this study shows that unleashed trans-presentation of IL-15 on MyD88 (show MYD88 Proteins)-deficient fibroblastic reticular cells during viral infection fosters the activation of cytotoxic and non-cytotoxic group 1 innate lymphoid cells and accelerates clearance of the virus
membrane-anchored IL15 constitutively expressed on the cell surface of PC-3 (show PCSK1 Proteins) human prostate carcinoma cells and IFN-gamma (show IFNG Proteins)-activated human monocytes mediates reverse signaling upon stimulation with soluble IL-15 receptor-alpha (show IL15RA Proteins) or anti-IL-15 antibodies
High IL15 expression is associated with endometriosis.
IL-15 drives bystander activation of CD8 (show CD8A Proteins)+ T cells, which predicts disease progression in untreated HIV-1-infected patients and suggests that elevated IL-15 may also drive CD8 (show CD8A Proteins)+ T cell expansion that is linked to increased morbidity and mortality in treated patients
Sustained virologic response was significantly associated with IL15 rs10833 in chronic hepatitis C patients, treated with pegylated interferon-alpha (show IFNA Proteins) and ribavirin.
IL-15 mRNA and protein levels significantly increased in rhHBcAg stimulation group compared with non-stimulated group.
this work provides evidence that the sushi-IL-15Ralpha/IL-15 fusion protein RLI (show ABCE1 Proteins) enhances antitumor activity of anti-PD-1 (show PDCD1 Proteins) treatment and is a promising approach to stimulate host immunity
These results reveal a novel role of IL-7 (show IL7 Proteins) and IL-15 in maintaining human T cell function, provide an explanation for T cell dysfunction in humanized mice, and have significant implications for in vitro studies with human T cells.
This analysis revealed highly connected functional interaction networks with two candidate genes, IL15 and SEC14L5 highly enriched in networks. Overall, from these results, we concluded that these genes can be recommended as some of the potential targets for Post-Traumatic Stress Disorder.
These data support a potential role for IL-15 in the pathogenesis of HIV-associated immune activation.
Myokine IL-15 regulates the crosstalk of co-cultured porcine skeletal muscle satellite cells and preadipocytes.
results demonstrate that porcine reproductive and respiratory syndrome virus (PRRSV)infection could induce IL-15 production in macrophages/dendritic cells; data further show that upregulation of IL-15 by PRRSV requires PKC (show FYN Proteins) and NF-kappaB (show NFKB1 Proteins) pathways
IFN-gamma (show IFNG Proteins) targets the adipocyte to induce IL-15 expression, thus indicating a possible role for the adipocyte in the regulation of T-cell function and muscle metabolism during the innate immune response
When induced by IFN-gamma (show IFNG Proteins) or other inflammatory mediators, IL-15 may be a significant homeorhetic factor that mobilizes and directs energy away from the adipocyte to other cells during the acute phase of the inflammatory response.
Increased function and survival of IL-15-transduced dendritic cells are mediated by up-regulation of IL-15Ralpha and Bcl-2 (show BCL2 Proteins).
IL 15 generates a dramatic expansion of short-lived memory CD8 (show CD8A Proteins) T cells and natural killer in immunocompetent macaques and has long-term effects on the balance of CD4 (show CD4 Proteins)(+) and CD8 (show CD8A Proteins)(+) T cells.
These data suggest that therapeutic use of IL-15 in the setting of antiretroviral therapy might facilitate specific restoration of the CD4 (show CD4 Proteins) + T cell compartment.
IL-15 secretion significantly correlates with the up-regulated expression of CD4 (show CD4 Proteins) on memory CD4 (show CD4 Proteins) T cells that is associated with increased permissiveness to simian immunodeficiency virus infection.
The protein encoded by this gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between this cytokine and IL2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. Studies of the mouse counterpart suggested that this cytokine may increase the expression of apoptosis inhibitor BCL2L1/BCL-x(L), possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. Alternatively spliced transcript variants of this gene have been reported.