Browse our IL2 Receptor beta Proteins (IL2RB)

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Interleukin 2 Receptor, beta Proteins (IL2RB)
On are 38 Interleukin 2 Receptor, beta (IL2RB) Proteins from 12 different suppliers available. Additionally we are shipping IL2 Receptor beta Antibodies (342) and IL2 Receptor beta Kits (40) and many more products for this protein. A total of 433 IL2 Receptor beta products are currently listed.
CD122, Il-2/15Rbeta, il-2rb, Il-2Rbeta, IL-15Rbeta, IL2RB, IL2RBC, IL15RB, IL15Rbeta, p70, P70-75
list all proteins Gene Name GeneID UniProt
IL2RB 3560 P14784
IL2RB 25746 P26896
IL2RB 16185 P16297

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IL2 Receptor beta Proteins (IL2RB) by Origin

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Top referenced IL2 Receptor beta Proteins

  1. Human IL2 Receptor beta Protein expressed in Human Cells - ABIN2003251 : Shibuya, Yoneyama, Nakamura, Harada, Hatakeyama, Minamoto, Kono, Doi, White, Taniguchi: The human interleukin-2 receptor beta-chain gene: genomic organization, promoter analysis and chromosomal assignment. in Nucleic acids research 1990 (PubMed)
    Show all 5 references for 2003251

  2. Dog (Canine) IL2 Receptor beta Protein expressed in Human Cells - ABIN2008939 : Friedmann, Migone, Russell, Leonard: Different interleukin 2 receptor beta-chain tyrosines couple to at least two signaling pathways and synergistically mediate interleukin 2-induced proliferation. in Proceedings of the National Academy of Sciences of the United States of America 1996 (PubMed)
    Show all 5 references for 2008939

  3. Mouse (Murine) IL2 Receptor beta Protein expressed in Human Cells - ABIN2008307 : Burchill, Yang, Vogtenhuber, Blazar, Farrar: IL-2 receptor beta-dependent STAT5 activation is required for the development of Foxp3+ regulatory T cells. in Journal of immunology (Baltimore, Md. : 1950) 2006 (PubMed)
    Show all 5 references for 2008307

  4. Human IL2 Receptor beta Protein expressed in HEK-293 Cells - ABIN2181385 : Mulloy, Crownley, Fullen, Leonard, Franchini: The human T-cell leukemia/lymphotropic virus type 1 p12I proteins bind the interleukin-2 receptor beta and gammac chains and affects their expression on the cell surface. in Journal of virology 1996 (PubMed)
    Show all 2 references for 2181385

More Proteins for IL2 Receptor beta Interaction Partners

Human Interleukin 2 Receptor, beta (IL2RB) interaction partners

  1. Studies indicate many potential uses of soluble interleukin-2 (show IL2 Proteins) receptor measurement in the diagnosis and treatment of hemophagocytic syndromes.

  2. IL2RB thr (show TRH Proteins)-450 phosphorylation is a positive regulator for receptor-IL-2 (show IL2 Proteins) complex stability and activation of signaling molecules.

  3. An association with the risk of erosion was observed for a haplotype of 2 single nucleotide polymorphisms of the IL-2RB gene in ACPA (show PRTN3 Proteins) positive Rheumatoid arthritis patients.

  4. CD112 (show PVRL2 Proteins) downregulation resulted in a reduced ability of DNAM-1 (show CD226 Proteins) to bind to the surface of both virus-infected and gD-transfected cells.

  5. IL-2 receptor beta chain expression is drastically diminished on T cells in ANCA-associated vasculitis.

  6. in anti-citrullinated protein antibody positive rheumatoid arthritis, the haplotype AC of IL-2RB was associated with a higher rate of erosions at baseline and at 1 year follow-up in comparison to other haplotypes.

  7. IL2RA (show IL2RA Proteins) and IL2RB as promising candidate genes for inflammatory bowel diseases(IBD) and suggesting a potential role of IL2R (show IL2RA Proteins) in the pathogenesis of IBD, likely involves regulatory T cells.

  8. MiniSTR marker D22S1045 (locus 22q12.3) is localized near the breakpoint region of the Ewing Sarcoma gene, but was found to be neutral related to EWS (show EWSR1 Proteins) in a case-control study analyzing allele frequencies and linkage disequilibrium.

  9. Suggest that oxalate-induced activation of the renal IL-2Rbeta pathway may lead to a plethora of cellular changes, the most common of which is the induction of inflammation.

  10. Data indicate that the two genetic variants within IL-2RA and IL-2RB are not associated with genetic susceptibility to rheumatoid arthritis (RA) in Han Chinese.

Mouse (Murine) Interleukin 2 Receptor, beta (IL2RB) interaction partners

  1. CBP (show CREBBP Proteins) physically associates with the IL-2 receptor beta-chain. CBP (show CREBBP Proteins), found in the nucleus in resting CTLL-2 cells, relocates to the cytoplasm after IL-2 (show IL2 Proteins) stimulation in an MEK (show MDK Proteins)/ERK (show EPHB2 Proteins) pathway-dependent manner. Thus, IL-2 (show IL2 Proteins)-mediated acetylation plays an important role in the modulation of cytokine signaling and T cell fate.

  2. Intratesticular inoculation with donor antigens promotes long-term skin allograft survival induced by conventional costimulatory blockade via the induction of both CD8 (show CD8A Proteins) + CD122+ and CD4 (show CD4 Proteins) + CD25 (show IL2RA Proteins)+ Treg cells.

  3. IL-2Rbeta-dependent signaling and CD103 (show ITGAE Proteins) functionally cooperate to maintain tolerance in the gut (show GUSB Proteins) mucosa.

  4. Thymic development of CD4 (show CD4 Proteins)+Foxp3 (show FOXP3 Proteins)+ regulatory T cells (Tregs) is highly dysregulated in IL-2 (show IL2 Proteins) receptor (2Rbeta)-deficient mice.

  5. CDCD11c+B220 (show PTPRC Proteins)+CD122+ cells play an important role in xenograft rejection. Their absence in NOG (show NOG Proteins) mice may be critical in supporting the successful engraftment of xenotransplants.

  6. This study demonstrated that IL-12 (show IL12A Proteins) signaling plays a complex role during the induction of tolerance as the presence of exogenous IL-12 (show IL12A Proteins) and the lack of IL-12 (show IL12A Proteins) signaling both prevent complete induction of tolerance.

  7. Continuous activation of the CD122/STAT-5 (show STAT5A Proteins) signaling pathway characterize regulatory lineage differentiation in the murine thymus.

  8. Knockout mice exhibited deficit in prepulse inhibition of acoustic startle reflex, significant reductions in acoustic startle reactivity, and modest differences in behavior in elevated plus-maze test. (IL-2/15 receptor-beta)

  9. CD4 (show CD4 Proteins) regulatory T cells prevent lethal autoimmunity in IL-2Rbeta-deficient mice: implications for the nonredundant function of IL-2 (show IL2 Proteins)

  10. role of the interleukin-2 receptor beta chain region between the two Stat5 (show STAT5A Proteins) docking sites in induction of interleukin-2 receptor alpha (show IL2RA Proteins) expression by interleukin-2 (show IL2 Proteins)

IL2 Receptor beta (IL2RB) Protein Profile

Protein Summary

The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind interleukin 2. The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. The protein encoded by this gene represents the beta subunit and is a type I membrane protein.

Alternative names and synonyms associated with IL2 Receptor beta (IL2RB)

  • interleukin 2 receptor, beta (IL2RB)
  • interleukin-2 receptor subunit beta-like (LOC510185)
  • interleukin 2 receptor, beta (il2rb)
  • interleukin 2 receptor, beta (Il2rb)
  • interleukin 2 receptor, beta chain (Il2rb)
  • interleukin-2 receptor subunit beta-like (LOC100621776)
  • interleukin-2 receptor subunit beta-like (LOC100859707)
  • CD122 protein
  • Il-2/15Rbeta protein
  • il-2rb protein
  • Il-2Rbeta protein
  • IL-15Rbeta protein
  • IL2RB protein
  • IL2RBC protein
  • IL15RB protein
  • IL15Rbeta protein
  • p70 protein
  • P70-75 protein

Protein level used designations for IL2RB

IL 2/15 receptor beta chain , interleukin 2 receptor, beta , interleukin-2 receptor subunit beta , CD122 antigen , IL-2 receptor subunit beta , IL-2R subunit beta , IL-2RB , high affinity IL-2 receptor beta subunit , high affinity IL-2 receptor subunit beta , interleukin 15 receptor, beta , p75 , P70-75 , interleukin 2 receptor, beta chain , p70-75 , IL-15 receptor beta chain , IL-2 receptor beta chain , IL-2/15 receptor-beta

403439 Canis lupus familiaris
510185 Bos taurus
696331 Macaca mulatta
793920 Danio rerio
100581366 Nomascus leucogenys
3560 Homo sapiens
25746 Rattus norvegicus
100730639 Cavia porcellus
470203 Pan troglodytes
16185 Mus musculus
100621776 Sus scrofa
100859707 Gallus gallus
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