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Characterization of interleukin receptor beta/gamma-associated protein complex assembly in IL-2 (show IL2 Proteins)- and IL-15 (show IL15 Proteins)-activated T-cells has been reported.
Among patients with a low pretreatment sIL-2R level who exhibited a positive response to R-CHOP, the posttreatment sIL-2R level may help to identify those with a poor prognosis.
Studies indicate many potential uses of soluble interleukin-2 (show IL2 Proteins) receptor measurement in the diagnosis and treatment of hemophagocytic syndromes.
IL2RB thr (show TRH Proteins)-450 phosphorylation is a positive regulator for receptor-IL-2 (show IL2 Proteins) complex stability and activation of signaling molecules.
An association with the risk of erosion was observed for a haplotype of 2 single nucleotide polymorphisms of the IL-2RB gene in ACPA (show PRTN3 Proteins) positive Rheumatoid arthritis patients.
CD112 (show PVRL2 Proteins) downregulation resulted in a reduced ability of DNAM-1 (show CD226 Proteins) to bind to the surface of both virus-infected and gD-transfected cells.
IL-2 receptor beta chain expression is drastically diminished on T cells in ANCA-associated vasculitis.
in anti-citrullinated protein antibody positive rheumatoid arthritis, the haplotype AC of IL-2RB was associated with a higher rate of erosions at baseline and at 1 year follow-up in comparison to other haplotypes.
IL2RA (show IL2RA Proteins) and IL2RB as promising candidate genes for inflammatory bowel diseases(IBD) and suggesting a potential role of IL2R (show IL2RA Proteins) in the pathogenesis of IBD, likely involves regulatory T cells.
MiniSTR marker D22S1045 (locus 22q12.3) is localized near the breakpoint region of the Ewing Sarcoma gene, but was found to be neutral related to EWS (show EWSR1 Proteins) in a case-control study analyzing allele frequencies and linkage disequilibrium.
c-REL (show NFkBP65 Proteins), but not IkappaBNS (show NFKBID Proteins), controlled the generation of classical CD25 (show IL2RA Proteins)(+)Foxp3 (show FOXP3 Proteins)(-) precursors via direct binding to the Cd25 (show IL2RA Proteins) locus; propose that CD4 (show CD4 Proteins)(+)GITR (show TNFRSF18 Proteins)(+)CD122(+)CD25 (show IL2RA Proteins)(-)Foxp3 (show FOXP3 Proteins)(-) cells represent a Treg pre-precursor population, whose transition into Treg precursors is mediated via c-REL (show NFkBP65 Proteins)
Results indicate that conjugated-interleukin-2 (IL2 (show IL2 Proteins)) protein derived from NKTR (show NKTR Proteins)-214 occupy interleukin-2 (IL2 (show IL2 Proteins)) receptor complex (IL2Ralphabetagamma) to a greater extent compared to free-IL2 (show IL2 Proteins) protein.
Renal lesions are indeed modulated by intrinsic glomerular cells through the gamma-C/IL-2 (show IL2 Proteins)-beta receptor response, to date classically described only in immune cells.
CBP (show CREBBP Proteins) physically associates with the IL-2 receptor beta-chain. CBP (show CREBBP Proteins), found in the nucleus in resting CTLL-2 cells, relocates to the cytoplasm after IL-2 (show IL2 Proteins) stimulation in an MEK (show MDK Proteins)/ERK (show EPHB2 Proteins) pathway-dependent manner. Thus, IL-2 (show IL2 Proteins)-mediated acetylation plays an important role in the modulation of cytokine signaling and T cell fate.
Intratesticular inoculation with donor antigens promotes long-term skin allograft survival induced by conventional costimulatory blockade via the induction of both CD8 (show CD8A Proteins) + CD122+ and CD4 (show CD4 Proteins) + CD25 (show IL2RA Proteins)+ Treg cells.
IL-2Rbeta-dependent signaling and CD103 (show ITGAE Proteins) functionally cooperate to maintain tolerance in the gut (show GUSB Proteins) mucosa.
Thymic development of CD4 (show CD4 Proteins)+Foxp3 (show FOXP3 Proteins)+ regulatory T cells (Tregs) is highly dysregulated in IL-2 (show IL2 Proteins) receptor (2Rbeta)-deficient mice.
CDCD11c+B220 (show PTPRC Proteins)+CD122+ cells play an important role in xenograft rejection. Their absence in NOG (show NOG Proteins) mice may be critical in supporting the successful engraftment of xenotransplants.
This study demonstrated that IL-12 (show IL12A Proteins) signaling plays a complex role during the induction of tolerance as the presence of exogenous IL-12 (show IL12A Proteins) and the lack of IL-12 (show IL12A Proteins) signaling both prevent complete induction of tolerance.
Continuous activation of the CD122/STAT-5 (show STAT5A Proteins) signaling pathway characterize regulatory lineage differentiation in the murine thymus.
The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind interleukin 2. The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. The protein encoded by this gene represents the beta subunit and is a type I membrane protein.
IL 2/15 receptor beta chain
, interleukin 2 receptor, beta
, interleukin-2 receptor subunit beta
, CD122 antigen
, IL-2 receptor subunit beta
, IL-2R subunit beta
, high affinity IL-2 receptor beta subunit
, high affinity IL-2 receptor subunit beta
, interleukin 15 receptor, beta
, interleukin 2 receptor, beta chain
, IL-15 receptor beta chain
, IL-2 receptor beta chain
, IL-2/15 receptor-beta