IL2 Receptor beta Protein (AA 27-239) (Fc Tag)
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- Target See all IL2 Receptor beta (IL2RB) Proteins
- IL2 Receptor beta (IL2RB) (Interleukin 2 Receptor, beta (IL2RB))
- Protein Type
- Recombinant
- Biological Activity
- Active
- Protein Characteristics
- AA 27-239
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This IL2 Receptor beta protein is labelled with Fc Tag.
- Sequence
- AA 27-239
- Characteristics
- This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 50.7 kDa. The protein migrates as 60-65 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
- Purity
- >95 % as determined by SDS-PAGE.
- Sterility
- 0.22 μm filtered
- Endotoxin Level
- Less than 1.0 EU per μg by the LAL method.
- Top Product
- Discover our top product IL2RB Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- 50 mM Tris, 100 mM Glycine, pH 7.5
- Handling Advice
- Please avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
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- Target
- IL2 Receptor beta (IL2RB) (Interleukin 2 Receptor, beta (IL2RB))
- Alternative Name
- IL-2 R beta (IL2RB Products)
- Synonyms
- IL2RB Protein, il-2rb Protein, CD122 Protein, IL15RB Protein, P70-75 Protein, IL2RBC Protein, IL-15Rbeta Protein, IL15Rbeta Protein, Il-2/15Rbeta Protein, Il-2Rbeta Protein, p70 Protein, interleukin 2 receptor subunit beta Protein, interleukin-2 receptor subunit beta Protein, interleukin 2 receptor, beta Protein, interleukin 2 receptor, beta chain Protein, IL2RB Protein, LOC510185 Protein, il2rb Protein, Il2rb Protein
- Background
- Interleukin-2 receptor subunit beta (IL2RB) is also known as CD122, which Belongs to the type I cytokine receptor family. Type 4 subfamily. IL2RB contains 1 fibronectin type-III domain. IL2RB / CD122 is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind interleukin 2. The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2.
- Molecular Weight
- 50.7 kDa
- NCBI Accession
- NP_000869
- Pathways
- JAK-STAT Signaling, Growth Factor Binding
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